Carcinogenic potential of hycanthone in mice and hamsters.

abstract：:A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...

journal_title：International journal of cancer

authors： Yao QY,Rickinson AB,Epstein MA

更新日期：1985-01-15 00:00:00

abstract：:Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is increasing evidence for a role in breast cancer as a regulator of signal transducers and activators ...

journal_title：International journal of cancer

authors： Barclay JL,Anderson ST,Waters MJ,Curlewis JD

更新日期：2009-04-15 00:00:00

abstract：:Gain of chromosome 1q is a hallmark of breast cancer, and likely reflects oncogene amplification. We previously identified mitotic kinesin KIF14 (kinesin family member 14) as an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines. KIF14 also showed high expr...

journal_title：International journal of cancer

authors： Corson TW,Gallie BL

更新日期：2006-09-01 00:00:00

abstract：:Cells of the human lymphoblastoid non-producer line Raji were cloned in soft agar. Individual colonies were isolated and analyzed for their inducibility of the Epstein-Barr virus-associated early antigen (EA). The induction of EA by the tumor promoter TPA varied among the different cell clones. Clones with very high a...

journal_title：International journal of cancer

authors： Bister K,Yamamoto N,zur Hausen H

更新日期：1979-06-15 00:00:00

abstract：:CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism of the Ab to which t...

journal_title：International journal of cancer

authors： Mattes MJ,Shih LB,Govindan SV,Sharkey RM,Ong GL,Xuan H,Goldenberg DM

更新日期：1997-05-02 00:00:00

abstract：:Thermal injury resulting from drinking very hot beverages has been incriminated as a risk factor for oesophageal cancer, although no information is available on the lesions caused by this injury in human or experimental animals. The drinking of hot maté tea is very common in areas of moderately high incidence of oesop...

journal_title：International journal of cancer

authors： Muñoz N,Victora CG,Crespi M,Saul C,Braga NM,Correa P

更新日期：1987-06-15 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing ...

journal_title：International journal of cancer

authors： Lu CC,Chen JC,Tsai ST,Jin YT,Tsai JC,Chan SH,Su IJ

更新日期：2005-07-10 00:00:00

abstract：:Hamster embryos were exposed in utero to the action of sodium nitrite (NaNO2) and morpholine (Mo) administered simultaneously by stomach tube to the mothers on the 11th or 12th day of pregnancy. Embryo cells were examined for chromosomal aberrations, micronuclear formation, morphological or malignant transformation an...

journal_title：International journal of cancer

authors： Inui N,Nishi Y,Taketomi M,Mori M,Yamamoto M,Yamada T,Tanimura A

更新日期：1979-09-15 00:00:00

abstract：:The granulin-epithelin precursor (GEP/PCDGF), a 68-88 kDa secreted glycoprotein, has been shown to be an important growth and survival factor for ovarian cancer cells. Furthermore, GEP expression is a predictor of patient survival in metastatic ovarian cancer cells. Up to this point, however, the molecular mechanisms ...

journal_title：International journal of cancer

authors： Pizarro GO,Zhou XC,Koch A,Gharib M,Raval S,Bible K,Jones MB

更新日期：2007-06-01 00:00:00

abstract：:The effect of all-trans-retinoic acid (RA) was examined on (1) transformation induced in C127 cells by transfection with plasmid pdBPV-1 (142-6), which contains DNA of bovine papillomavirus (BPV), (2) the capacity of transformed BPV DNA-containing clones to form colonies with transformed properties (e.g., piling up in...

journal_title：International journal of cancer

authors： Tsang SS,Li G,Stich HF

更新日期：1988-07-15 00:00:00

abstract：:BW 5147 lymphoma cells are non-invasive tumor cells which do not generate experimental metastases following i.v. inoculation. In contrast, s.c. and intra-splenic (i.s.) growth of BW cells resulted in widespread colonization of liver and spleen. Cells derived from either s.c. tumors or metastatic lesions did generate m...

journal_title：International journal of cancer

authors： De Baetselier P,Roos E,van Hecke D,Verschaeve L,Brys L,Verschueren H

更新日期：1988-05-15 00:00:00

abstract：:Barrett's esophagus (BE) is a metaplastic condition caused by chronic gastroesophageal reflux which represents an early step in the development of esophageal adenocarcinoma (EAC). Single-nucleotide polymorphism microarray (SNP-chip) analysis is a novel, precise, high-throughput approach to examine genomic alterations ...

journal_title：International journal of cancer

authors： Akagi T,Ito T,Kato M,Jin Z,Cheng Y,Kan T,Yamamoto G,Olaru A,Kawamata N,Boult J,Soukiasian HJ,Miller CW,Ogawa S,Meltzer SJ,Koeffler HP

更新日期：2009-11-15 00:00:00

abstract：:Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 sa...

journal_title：International journal of cancer

authors： Patard JJ,Brasseur F,Gil-Diez S,Radvanyi F,Marchand M,François P,Abi-Aad A,Van Cangh P,Abbou CC,Chopin D

更新日期：1995-02-20 00:00:00

abstract：:Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

journal_title：International journal of cancer

authors： Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

更新日期：2008-03-01 00:00:00

abstract：:Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...

journal_title：International journal of cancer

authors： Hoang-Xuan K,Merel P,Vega F,Hugot JP,Cornu P,Delattre JY,Poisson M,Thomas G,Delattre O

更新日期：1995-02-08 00:00:00

abstract：:Three polycyclic hydrocarbons, benz(a)anthracene, 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene, have been studied in a cell-mediated mutagenesis system using BHK 21 cells to metabolize the hydrocarbons and V-79 cells as targets for detecting induced cytotoxicity and mutation. In large-scale experiments, the...

journal_title：International journal of cancer

authors： Wigley CB,Newbold RF,Amos J,Brookes P

更新日期：1979-05-15 00:00:00

abstract：:Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...

journal_title：International journal of cancer

authors： McMichael AJ,McCall MG,Hartshorne JM,Woodings TL

更新日期：1980-04-15 00:00:00

abstract：:The population of Leningrad suffered from severe starvation, cold and psychological stress during the siege in World War II in 1941-1944. We investigated the long-term effects of the siege on cancer mortality in 3,901 men and 1,429 women, born between 1910 and 1940. All study subjects were residents of St. Petersburg,...

journal_title：International journal of cancer

authors： Koupil I,Plavinskaja S,Parfenova N,Shestov DB,Danziger PD,Vågerö D

更新日期：2009-03-15 00:00:00

abstract：:Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA-induced growth arrest and differentiation of these...

journal_title：International journal of cancer

authors： Nishioka C,Ikezoe T,Yang J,Gery S,Koeffler HP,Yokoyama A

更新日期：2009-10-01 00:00:00

abstract：:Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...

journal_title：International journal of cancer

authors： Altmeyer A,Maki RG,Feldweg AM,Heike M,Protopopov VP,Masur SK,Srivastava PK

更新日期：1996-08-22 00:00:00

abstract：:Our aim was to evaluate whether serum concentrations of squamous cell carcinoma antigen (SCC-Ag) are an independent prognostic factor in patients with vulvar cancer. We measured SCC-Ag in pretreatment serum samples of 55 patients with squamous cell vulvar cancer, 30 patients with vulvar intraepithelial neoplasia (VIN)...

journal_title：International journal of cancer

authors： Hefler L,Obermair A,Tempfer C,van Houte M,Maenner G,Reinthaller A,Leodolter S,Kainz C

更新日期：1999-06-21 00:00:00

abstract：:A series of 42 patients with malignant melanoma treated with BCG adjuvant immunotherapy were studied for sequential changes in cellular immune reactivity to non-specific mitogens. Lymphocyte preparations were made monthly and stored in a viable condition in liquid nitrogen. After 6 months of treatment, all lymphocyte ...

journal_title：International journal of cancer

authors： Golub SH,Forsythe AB,Morton DL

更新日期：1977-01-01 00:00:00

abstract：:A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...

journal_title：International journal of cancer

authors： Stone KR,Mickey DD,Wunderli H,Mickey GH,Paulson DF

更新日期：1978-03-15 00:00:00

abstract：:Cervical carcinogenesis is a consequence of persistent infection with high-risk human papillomaviruses (HPVs). Recent studies indicate that HPV-transformed cells actively instruct their microenvironment to promote carcinogenesis. Here, we demonstrate that cervical cancer cells activate monocytes to produce their own C...

journal_title：International journal of cancer

authors： Pahne-Zeppenfeld J,Schröer N,Walch-Rückheim B,Oldak M,Gorter A,Hegde S,Smola S

更新日期：2014-05-01 00:00:00

abstract：:Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...

journal_title：International journal of cancer

authors： Amstutz H,Rytz C,Novak-Hofer I,Spycher M,Schubiger PA,Blaser K,Morgenthaler JJ

更新日期：1993-01-02 00:00:00

abstract：:Normal sera of Japanese quails caused lysis of tumor cells from a Rous sarcoma virus (RSV)-induced quail tumor (QT cells). Other tumor cell lines, including RSV-transformed quail embryo cells and methylcholanthrene-induced quail tumors, were not lysed. This naturally occurring cytolytic factor (NCLF) was sensitive to ...

journal_title：International journal of cancer

authors： Yoshikawa Y,Yamanouchi K,Hishiyama M,Kobune K

更新日期：1978-05-15 00:00:00

abstract：:Dickkopf1 (DKK1), a secreted inhibitor of the Wnt/β-catenin pathway, is a negative regulator of bone formation. DKK1 acts as a switch that transitions prostate cancer bone metastases from osteolytic to osteoblastic and also is an active indicator of poor outcome for multiple myeloma. However, in other tumor types, DKK...

journal_title：International journal of cancer

authors： Menezes ME,Devine DJ,Shevde LA,Samant RS

更新日期：2012-04-01 00:00:00

abstract：:Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...

journal_title：International journal of cancer

authors： Belardelli F,Gresser I,Maury C,Duvillard P,Prade M,Maunoury MT

更新日期：1983-05-15 00:00:00

abstract：:Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...

journal_title：International journal of cancer

authors： Franco J,Pérez-Hoyos S,Plaza P

更新日期：2002-01-01 00:00:00

abstract：:Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with disease progression. ...

journal_title：International journal of cancer

authors： Edwards SM,Badzioch MD,Minter R,Hamoudi R,Collins N,Ardern-Jones A,Dowe A,Osborne S,Kelly J,Shearer R,Easton DF,Saunders GF,Dearnaley DP,Eeles RA

更新日期：1999-10-22 00:00:00