Abstract：
:The population of Leningrad suffered from severe starvation, cold and psychological stress during the siege in World War II in 1941-1944. We investigated the long-term effects of the siege on cancer mortality in 3,901 men and 1,429 women, born between 1910 and 1940. All study subjects were residents of St. Petersburg, formerly Leningrad, between 1975 and 1982. One third of them had experienced the siege as children, adolescents or young adults (age range, 1-31 years at the peak of starvation in 1941-1942). Associations of siege exposure with risk of death from cancer were studied using a multivariable Cox regression, stratified by gender and period of birth, adjusted for age, smoking, alcohol and social characteristics, from 1975 to 1977 (men) and 1980 to 1982, respectively (women), until the end of 2005. Women who were 10-18 years old at the peak of starvation were taller as adults (age-adjusted difference, 1.7 cm; 95% CI, 0.5-3.0) and had a higher risk of dying from breast cancer compared with unexposed women born during the same period (age-adjusted HR, 9.9; 95% CI, 1.1-86.5). Mortality from prostate cancer was nonsignificantly higher in exposed men. The experience of severe starvation and stress during childhood and adolescence may have long-term effects on cancer in surviving men and women.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Koupil I,Plavinskaja S,Parfenova N,Shestov DB,Danziger PD,Vågerö Ddoi
10.1002/ijc.24093subject
Has Abstractpub_date
2009-03-15 00:00:00pages
1416-21issue
6eissn
0020-7136issn
1097-0215journal_volume
124pub_type
杂志文章abstract：:Of 6- and 3-week-old nude mice given intravenous injections of murine tumor cells with well-defined metastatic properties, only the 3-week-old mice developed lung tumor colonies in significant numbers. The quantitative differences in metastatic potential among tumor cell lines injected into syngeneic recipients were a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910260521
更新日期：1980-11-15 00:00:00
abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33181
更新日期：2021-01-01 00:00:00
abstract：:Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepa...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910230204
更新日期：1979-02-01 00:00:00
abstract：:Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of th...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-03-20 00:00:00
abstract：:A panel of eight conditionally immortal lines derived by infection of human breast epithelial cells with an amphotropic retrovirus transducing a ts mutant of SV40 large T-antigen was analyzed with respect to individual retroviral integration patterns. Each line contained multiple integration sites which were clonal an...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910570616
更新日期：1994-06-15 00:00:00
abstract：:The monoclonal antibody (MAb) 4F2 defines an oncofetal antigen in human fibroblastic cells. Two-dimensional electrophoretic analysis reveals that tumor cell lines from mesenchymal tissues co-express two or more heavy-chain molecular variants of the antigen whereas the light subunit (41 kDa) is not affected. Among norm...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910380206
更新日期：1986-08-15 00:00:00
abstract：:Active, structurally unrelated tumor promoters (12-0-tetradecanoyl-phorbol-13-acetate (TPA), teleocidin and aplysiatoxin) inhibit growth of mammary carcinoma cells (MCF7- greater than BT-20 greater than MDA-MB-231 greater than = ZR-75-1 greater than HBL-100). This efficiency in inhibiting cell growth correlates with t...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910370514
更新日期：1986-05-15 00:00:00
abstract：:The deleted in liver cancer 1 (DLC1) tumor suppressor is an important RhoGTP activating protein (RhoGAP) that plays a crucial role in many types of human cancers. Small GTPases regulate normal cellular processes but aberrant expression and activation of GTPases contribute to tumorigenesis. RhoGAP suppresses Rho activi...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.28505
更新日期：2014-07-15 00:00:00
abstract：:We have previously shown that sensory nerve peptides contribute to the pathogenesis of pulmonary hypersensitivity reactions (HSRs) to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the blockade of paclitaxel-induced ...
journal_title：International journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1002/ijc.21680
更新日期：2006-05-15 00:00:00
abstract：:Serum CA 125 concentrations were raised in 90.4% of 115 southern African black patients with hepatocellular carcinoma. Seventy-four percent of 62 patients with amebic hepatic abscess, 60% of 40 patients with chronic hepatic parenchymal disease (chronic hepatitis or cirrhosis), and 60.9% of 41 patients with acute viral...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910460510
更新日期：1990-11-15 00:00:00
abstract：:Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21212
更新日期：2005-11-20 00:00:00
abstract：:A mammographic breast cancer screening programme has been ongoing in the Florence District (Italy) since 1970 and a favourable impact of screening on breast cancer mortality of women aged 50-70 has been shown by means of a case-control study. Two hundred and eleven screen- and 116 interval-detected cancers in the peri...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910460209
更新日期：1990-08-15 00:00:00
abstract：:Adherent cells with the ability to inhibit NK activity were found in the spleens of young 8-week-old SJL/J mice. Such suppressor cells were also found in the spleens of other low-NK-reactive strains, but not in the spleen of age-matched high-NK-reactive strains. These suppressor cells had the characteristics of macrop...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910280621
更新日期：1981-12-01 00:00:00
abstract：:Therapies targeted to human epidermal growth factor receptor 2 (HER2) have proven effective against tumors positive for HER2 amplification, but there is an unmet clinical need for the treatment of tumors that express HER2 protein in the absence of HER2 amplification. [fam-] trastuzumab deruxtecan (DS-8201a) is a novel...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32408
更新日期：2019-12-15 00:00:00
abstract：:Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the associa...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25628
更新日期：2011-06-15 00:00:00
abstract：:Loss of heterozygosity (LOH) on 10q is associated with late-stage events in urothelial neoplastic progression. The tumor suppressor gene PTEN, which is mutated or homozygously deleted in numerous cancers, maps to a region of 10q within the reported region of minimal loss in bladder tumors. In two recent studies altera...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(20001115)88:4<620::aid-ijc16>3.0
更新日期：2000-11-15 00:00:00
abstract：:Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11732
更新日期：2004-04-10 00:00:00
abstract：:In order to study the mechanisms responsible for resistance to CDDP, 5 human tumor cell lines were made resistant to CDDP by repeated in vitro exposures. After cloning it was found that the cell lines developed were between 3.3-fold and 17-fold more resistant to CDDP than the parental cell lines at the IC90. These lin...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910470214
更新日期：1991-01-21 00:00:00
abstract：:DNA synthesis in heterokaryons of mouse peritoneal macrophages and various proliferating cultured cells was analyzed. Macrophages did not inhibit replication in the nuclei of non-immortalized and spontaneously immortalized cells (rat fibroblasts and macrophages, mouse pre-macrophages, NIH3T3 cells). On the contrary, t...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910440611
更新日期：1989-12-15 00:00:00
abstract：:Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910310516
更新日期：1983-05-15 00:00:00
abstract：:There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers of diagnostic and prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung cancer patients before surgery a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29822
更新日期：2016-02-15 00:00:00
abstract：:Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25367
更新日期：2011-02-01 00:00:00
abstract：:Three polycyclic hydrocarbons, benz(a)anthracene, 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene, have been studied in a cell-mediated mutagenesis system using BHK 21 cells to metabolize the hydrocarbons and V-79 cells as targets for detecting induced cytotoxicity and mutation. In large-scale experiments, the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910230516
更新日期：1979-05-15 00:00:00
abstract：:Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.27846
更新日期：2013-04-15 00:00:00
abstract：:We have examined the effects of the synthetic matrix metalloproteinase inhibitor, batimastat (BB-94) and the angiotensin-converting enzyme inhibitor, captopril, on metalloproteinase activity of murine Lewis-lung-carcinoma cells (3LL) in vitro, and on local growth and lung metastasis of the same tumor implanted intramu...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990531)81:5<761::aid-ijc
更新日期：1999-05-31 00:00:00
abstract：:Intraductal papillary-mucinous carcinoma (IPMC) of the pancreas, a new entity of pancreatic cancer with a favorable prognosis, has shown a gradual increase in the number of reported cases. Patients with high-frequency microsatellite instability (MSI-H) tumors have been shown to survive longer than those with low-frequ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10771
更新日期：2002-12-20 00:00:00
abstract：:miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25452
更新日期：2011-03-15 00:00:00
abstract：:The expression of fibronectin (FN) isoforms containing the extradomains A and B (ED-A+ and ED-B+ FNs) as well as a differentially O-glycosylated oncofetal form of the protein (onf-FN) was investigated in 6 normal human anterior pituitaries and 25 human pituitary adenomas. In normal tissue, immunohistochemical experime...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910610106
更新日期：1995-03-29 00:00:00
abstract：:A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in PR and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conduc...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24477
更新日期：2009-10-01 00:00:00
abstract：:CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910480213
更新日期：1991-05-10 00:00:00
