Suppression of natural killer (NK) activity by splenic adherent cells of low NK-reactive mice.

abstract：:Human papillomavirus (HPV) is an important factor for the development of tonsillar squamous cell carcinoma (TSCC). In addition, patients with HPV-positive TSCC have a better clinical outcome than patients with HPV-negative TSCC. Although, HPV is an important prognostic marker, additional biomarkers are needed to bette...

journal_title：International journal of cancer

authors： Näsman A,Andersson E,Nordfors C,Grün N,Johansson H,Munck-Wikland E,Massucci G,Dalianis T,Ramqvist T

更新日期：2013-01-01 00:00:00

abstract：:Two putative genes (termed pro 1 and pro 2) specifying sensitivity to induction of neoplastic transformation by TPA in mouse epidermal JB6 cells were cloned by sib selection from a size-selected genomic library of clonal cells sensitive to promotion of transformation. By restriction analysis, heteroduplex analysis, di...

journal_title：International journal of cancer

authors： Lerman MI,Hegamyer GA,Colburn NH

更新日期：1986-02-15 00:00:00

abstract：:Ganglioside functions in tumor metastasis were analyzed by carbohydrate remodeling of a mouse Lewis lung cancer (subline P29) by introducing beta1,4GalNAc-T cDNA. Although P29 was originally a low-metastatic subline in the s.c. injection system, it showed high potential in lung metastasis when i.v.-injected via the ta...

journal_title：International journal of cancer

authors： Chen HH,Fukumoto S,Furukawa K,Nakao A,Akiyama S,Urano T,Furukawa K

更新日期：2003-01-10 00:00:00

abstract：:In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N'-nitro-N-nitr...

journal_title：International journal of cancer

authors： Suleyman H,Cadirci E,Albayrak A,Halici Z,Gundogdu C,Hacimuftuoglu A

更新日期：2010-04-01 00:00:00

abstract：:Physical activity might reduce the risk for lung cancer by various mechanisms, but the evidence is inconclusive. We therefore examined the relationship between physical activity and risk for lung cancer in a large population-based Danish cohort with detailed information about number of hours per week spent on specific...

journal_title：International journal of cancer

authors： Bak H,Christensen J,Thomsen BL,Tjønneland A,Overvad K,Loft S,Raaschou-Nielsen O

更新日期：2005-09-01 00:00:00

abstract：:The human bowel contains a large and dynamic bacterial population that is not only essential for intestinal health, but also critical for the development of diseases such as cancer. In this respect, the Gram-positive bacterium Streptococcus bovis has been associated with colon cancer for many years. To investigate the...

journal_title：International journal of cancer

authors： Tjalsma H,Schöller-Guinard M,Lasonder E,Ruers TJ,Willems HL,Swinkels DW

更新日期：2006-11-01 00:00:00

abstract：:This study profiles testicular cancer incidence and mortality across Europe, and the effects of age, period and generational influences, using age-period-cohort modeling. Despite a 5-fold variation in incidence rates, there were consistent mean increases in incidence in each of the 12 European countries studied, rangi...

journal_title：International journal of cancer

authors： Bray F,Richiardi L,Ekbom A,Pukkala E,Cuninkova M,Møller H

更新日期：2006-06-15 00:00:00

abstract：:Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control stu...

journal_title：International journal of cancer

authors： Theodoratou E,Farrington SM,Tenesa A,McNeill G,Cetnarskyj R,Barnetson RA,Porteous ME,Dunlop MG,Campbell H

更新日期：2008-11-01 00:00:00

abstract：:The identification of (gamma-glutamyl)polyamines in proteolytic digest of proteins from the cytosolic and particulate fractions of B16-F10 and B16-F10Lr6 cell lines, originating from a spontaneous tumor in C57BL/6 mice, indicates that polyamines are incorporated into melanoma cell proteins by transglutaminases (TGases...

journal_title：International journal of cancer

authors： Beninati S,Abbruzzese A,Cardinali M

更新日期：1993-03-12 00:00:00

abstract：:APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...

journal_title：International journal of cancer

authors： De Giovanni C,Landuzzi L,Nicoletti G,Astolfi A,Croci S,Micaroni M,Nanni P,Lollini PL

更新日期：2004-03-20 00:00:00

abstract：:This study reports the induction of interferon (IFN) in human mononuclear cells (MNC) by hematopoietic tumor cells. Only 3 out of 15 cell lines were capable of inducing IFN in the mixed leukocyte/tumor-cell reaction (MLTR). K562, a pluripotent stem cell line and DUTKO-I, a hybrid between K562 and Daudi (Burkitt lympho...

journal_title：International journal of cancer

authors： Berger R,Knapp W,Kirchner H

更新日期：1984-07-15 00:00:00

abstract：:Under the aegis of EUROCARE, a European Union project to assemble survival data from population-based cancer registries and analyze them according to standardized procedures, we have investigated and compared colon-cancer survival in 10 European countries. We analyzed 68,283 colon-cancer cases diagnosed between 1978 a...

journal_title：International journal of cancer

authors： Sant M,Capocaccia R,Verdecchia A,Gatta G,Micheli A,Mariotto A,Hakulinen T,Berrino F

更新日期：1995-09-27 00:00:00

abstract：:To investigate the genetic changes that occur during establishment of gastric cancer cell lines, 4 gastric cancer cell lines and their original tumor tissues were examined for microsatellite instability (MSI), loss of heterozygosity (LOH), and p53 mutation. MSI status did not change during the establishment, though th...

journal_title：International journal of cancer

authors： Bae SI,Park JG,Kim YI,Kim WH

更新日期：2000-08-15 00:00:00

abstract：:It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...

journal_title：International journal of cancer

authors： Hemminki K,Zhang H,Czene K

更新日期：2003-07-10 00:00:00

abstract：:A glycolipid extract was prepared from an SV40-transformed hamster cell line (EH-SV) according to the Folch partition procedure. The glycolipids from the aqueous layer were incorporated in liposomal membranes composed of lecithin/sphingomyelin/cholesterol (1:1:2 by weight). This liposomal preparation was inoculated in...

journal_title：International journal of cancer

authors： Ansel S,Huet C

更新日期：1980-06-15 00:00:00

abstract：:In sub-Saharan Africa, invasive cervical cancer (ICC) incidence and mortality are among the highest in the world. This cross-sectional epidemiological study assessed human papillomavirus (HPV) prevalence and type distribution in women with ICC in Ghana, Nigeria, and South Africa. Cervical biopsy specimens were obtaine...

journal_title：International journal of cancer

authors： Denny L,Adewole I,Anorlu R,Dreyer G,Moodley M,Smith T,Snyman L,Wiredu E,Molijn A,Quint W,Ramakrishnan G,Schmidt J

更新日期：2014-03-15 00:00:00

abstract：:Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, i...

journal_title：International journal of cancer

authors： Helgadottir H,Höiom V,Tuominen R,Jönsson G,Månsson-Brahme E,Olsson H,Hansson J

更新日期：2015-11-01 00:00:00

abstract：:The relation between human papillomavirus type 16 (HPV 16) viral load in cervical scrapes and development of high-grade cervical intraepithelial neoplasia (CIN II or III) was studied in a nested case-control study of women with normal cytology (group A) and in a cohort of women with abnormal cytology (group B). HPV 16...

journal_title：International journal of cancer

authors： van Duin M,Snijders PJ,Schrijnemakers HF,Voorhorst FJ,Rozendaal L,Nobbenhuis MA,van den Brule AJ,Verheijen RH,Helmerhorst TJ,Meijer CJ

更新日期：2002-04-01 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction including DNA transcription, RNA splicing, RNA stability and translation. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions s...

journal_title：International journal of cancer

authors： Zhou R,Shanas R,Nelson MA,Bhattacharyya A,Shi J

更新日期：2010-01-15 00:00:00

abstract：:Data are limited regarding cancer risk in human immunodeficiency virus (HIV)-infected persons with modest immunosuppression, before the onset of acquired immunodeficiency syndrome (AIDS). For some cancers, risk may be affected by highly active antiretroviral therapy (HAART) widely available since 1996. We linked HIV/A...

journal_title：International journal of cancer

authors： Engels EA,Biggar RJ,Hall HI,Cross H,Crutchfield A,Finch JL,Grigg R,Hylton T,Pawlish KS,McNeel TS,Goedert JJ

更新日期：2008-07-01 00:00:00

abstract：:Prostate-specific antigen (PSA) has been characterized as a specific prostate marker, although recent studies have suggested the existence of PSA of nonprostatic sources. We have assessed the presence of PSA by an ultrasensitive assay in 276 serum and nonserum samples from women. Our data show the presence of PSA in 9...

journal_title：International journal of cancer

authors： Filella X,Molina R,Alcover J,Carretero P,Ballesta AM

更新日期：1996-11-15 00:00:00

abstract：:The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...

journal_title：International journal of cancer

authors： Erez A,Chaussepied M,Castiel A,Colaizzo-Anas T,Aplan PD,Ginsberg D,Izraeli S

更新日期：2008-10-01 00:00:00

abstract：:JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation. Notabl...

journal_title：International journal of cancer

authors： Wang Y,Xia Y,Hu K,Zeng M,Zhi C,Lai M,Wu L,Liu S,Zeng S,Huang Z,Ma S,Yuan Z

更新日期：2019-11-01 00:00:00

abstract：:Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...

journal_title：International journal of cancer

authors： Brasoveanu LI,Altomonte M,Gloghini A,Fonsatti E,Coral S,Gasparollo A,Montagner R,Cattarossi I,Simonelli C,Cattelan A

更新日期：1995-05-16 00:00:00

abstract：:To evaluate the role of chromosome 13 deletions in oral squamous cell carcinoma (SCC) progression and to define the precise localization of putative tumor suppressor genes, we studied tumors from 34 unrelated patients with oral SCC by the polymerase chain reaction (PCR)-loss of heterozygosity (LOH) assay, using 18 dif...

journal_title：International journal of cancer

authors： Ogawara K,Miyakawa A,Shiba M,Uzawa K,Watanabe T,Wang XL,Sato T,Kubosawa H,Kondo Y,Tanzawa H

更新日期：1998-08-21 00:00:00

abstract：:Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study...

journal_title：International journal of cancer

authors： Béraud C,Dormoy V,Danilin S,Lindner V,Béthry A,Hochane M,Coquard C,Barthelmebs M,Jacqmin D,Lang H,Massfelder T

更新日期：2015-10-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a frequent complication of the acquired immunodeficiency syndrome (AIDS) in homosexual men. Risk factors for developing this malignancy are uncertain, other than immunosuppression and coinfection with human herpesvirus 8 (HHV-8). We therefore examined factors associated with KS in a cross-sect...

journal_title：International journal of cancer

authors： Nawar E,Mbulaiteye SM,Gallant JE,Wohl DA,Ardini M,Hendershot T,Goedert JJ,Rabkin CS,AIDS Cancer Cohort (ACC) Study Collaborators.

更新日期：2005-06-10 00:00:00

abstract：:The relationship between chemosensitivity and p53 is currently considered from two mutually exclusive points of view: (1) wt p53 increases chemosensitivity due to apoptosis and (2) wt p53 decreases chemosensitivity due to growth arrest and DNA repair. We used p53-expressing adenovirus (Ad-p53) to directly evaluate eff...

journal_title：International journal of cancer

authors： Blagosklonny MV,El-Deiry WS

更新日期：1998-03-16 00:00:00

abstract：:Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM leve...

journal_title：International journal of cancer

authors： Gào X,Wilsgaard T,Jansen EH,Holleczek B,Zhang Y,Xuan Y,Anusruti A,Brenner H,Schöttker B

更新日期：2019-07-01 00:00:00

abstract：:Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...

journal_title：International journal of cancer

authors： Kreuzer KA,Lass U,Nagel S,Ellerbrok H,Pauli G,Pawlaczyk-Peter B,Siegert W,Huhn D,Schmidt CA

更新日期：2000-06-01 00:00:00