Abstract:
:Of 6- and 3-week-old nude mice given intravenous injections of murine tumor cells with well-defined metastatic properties, only the 3-week-old mice developed lung tumor colonies in significant numbers. The quantitative differences in metastatic potential among tumor cell lines injected into syngeneic recipients were also maintained following intravenous injection into young nude mice. Successful metastasis in 3-week-old nude mice is correlated with the low levels of natural killer cell activity detected in these young recipients. Boosting of the natural killer cell activity of 3-week-old nude mice by the administration of bacterial adjuvants and interferon inducers significantly inhibited metastasis formation. The differences in metastasis development could not be attributed to differences in the initial arrest of tumor cells in the pulmonary vascular bed, but rather to a better survival of the arrested cells in the lungs of 3-weeks-old nude mice as compared with 6-week-old counterparts. We concluded that low levels of NK cell activity are associated with increased incidence of experimental metastasis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Hanna Ndoi
10.1002/ijc.2910260521subject
Has Abstractpub_date
1980-11-15 00:00:00pages
675-80issue
5eissn
0020-7136issn
1097-0215journal_volume
26pub_type
杂志文章abstract::I-compounds are bulky indigenous DNA adducts that can be detected by (32)P-postlabeling. A subgroup, termed type II I-compounds, represents DNA lesions induced by oxidative stress. Several major type II I-compounds have been identified as dinucleotides containing 3'-terminal 8,5'-cyclo-2'-deoxyadenosine (cA). Levels o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20375
更新日期:2004-12-10 00:00:00
abstract::We investigated the inhibitory effect of sunitinib, a newly approved multitargeted tyrosine kinase inhibitor, against the progression of renal cell cancer (RCC) bone metastases in vivo. In vitro cell proliferation was determined using the MTS assay. To investigate the inhibitory effects of sunitinib in vivo, we establ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26034
更新日期:2012-02-01 00:00:00
abstract::Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI canc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26104
更新日期:2012-03-01 00:00:00
abstract::Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25766
更新日期:2011-09-01 00:00:00
abstract::The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when 52 clusters, with a total of 142,701 women aged 30-59 years in Os...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.21050
更新日期:2005-09-10 00:00:00
abstract::Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To describe the clonal nature of these tumors, 2 theories have been proposed. The monoclonality hypothesis describes the multiple tumors as descendants of a single...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.10544
更新日期:2002-09-01 00:00:00
abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30911
更新日期:2017-11-15 00:00:00
abstract::Epidermodysplasia verruciformis (EV) is considered as a model of genetic cancer due to unusual susceptibility to EV-specific human papillomaviruses (HPVs). We established an in vivo experimental system for long-term propagation of EV tissue which should facilitate the study of tumor progression in EV. Skin fragments f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560519
更新日期:1994-03-01 00:00:00
abstract::In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960904)67:5<690::AID-IJC
更新日期:1996-09-04 00:00:00
abstract::A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350107
更新日期:1985-01-15 00:00:00
abstract::Recombinant human (rhu) macrophage colony-stimulating factor (M-CSF) was evaluated for efficacy, either alone or in combination with local X-irradiation (LR), in mice inoculated subcutaneously (s.c.) with Lewis lung carcinoma (LLC) cells. The size of the primary tumor and numbers of lung metastases, 21 days after tumo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470125
更新日期:1991-01-02 00:00:00
abstract::Regulatory T cells (Treg) mediate amelioration of disease and immune homeostasis by inhibiting immune activation and maintaining peripheral immune tolerance. The suppressive mechanisms and clinical significance of Treg have not been completely elucidated in patients with acute myeloid leukemia (AML). Here, we demonstr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25791
更新日期:2011-09-15 00:00:00
abstract::Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22414
更新日期:2007-03-01 00:00:00
abstract::A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170617
更新日期:1976-06-15 00:00:00
abstract::Biopsies of 13 penile cancers (PC), from patients living in regions of Uganda with a high incidence of genital cancers, were studied for the presence, molecular characteristics and physical state of DNA related to that of human papillomavirus (HPV) types 6, 11, 16, 18, 31 and 33. HPV DNA sequences were detected in all...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510414
更新日期:1992-06-19 00:00:00
abstract::Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260405
更新日期:1980-10-15 00:00:00
abstract::Viruses that replicate selectively in cancer cells hold considerable promise as novel therapeutic agents for the treatment of malignancy. We report an orthotopic model of multi-focal colorectal cancer (CRC) metastases in the livers of syngeneic and immune-competent rats, which permitted rigorous testing of oncolytic v...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20772
更新日期:2005-04-20 00:00:00
abstract::The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610306
更新日期:1995-05-04 00:00:00
abstract::Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31058
更新日期:2018-01-15 00:00:00
abstract::The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23834
更新日期:2008-12-01 00:00:00
abstract::Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270310
更新日期:1981-03-15 00:00:00
abstract::Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32194
更新日期:2019-11-15 00:00:00
abstract::The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenera...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33262
更新日期:2020-12-01 00:00:00
abstract::Breast cancer is the cancer diagnosed most frequently in women worldwide. In Europe it is the most common cancer in the female population, with approximately 350,000 new cases diagnosed each year including 130,000 deaths. Incidence rates are increasing in the majority of European countries, whereas a decline in mortal...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20514
更新日期:2004-12-20 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25367
更新日期:2011-02-01 00:00:00
abstract::Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010120)95:1<44::aid-ijc1008>3.
更新日期:2001-01-20 00:00:00
abstract::The reported beverage habits of 569 lung cancer patients and 569 control patients admitted to Roswell Park Memorial Institute (RPMI) were studied, 355 male cases and 214 female cases being matched to controls within strata of age and residence. Smoking history and an index of vitamin A from vegetables had significant,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430412
更新日期:1989-04-15 00:00:00
abstract::The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280107
更新日期:1981-07-15 00:00:00
abstract::Following exposure to feline leukemia virus (FeLV), cats that resist leukemia produce complement dependent antibodies (CDA) which lyse leukemia cells in the presence of cat complement. The CDA activity has been shown to be directed to feline oncornavirus-associated cell membrane antigen (FOCMA) found on the surface of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280215
更新日期:1981-08-15 00:00:00
abstract::Treatment of lung cancer is often performed with cone-down oblique beams to spare spinal cord and normal structures. However, there is no optimum technique to determine oblique beam angles when a CT simulation is not available. Impact of oblique beam angle was investigated in this study. Fifteen patients with centrall...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001220)90:6<359::aid-ijc8>3.0.
更新日期:2000-12-20 00:00:00