Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts.

abstract：:We previously reported that some single nucleotide polymorphisms (SNPs) of candidate genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric cancer (GCa). In the present study, we further evaluated associations of eight potentially functional SNPs of MTOR, MLST8 and RPTOR with survival of 100...

journal_title：International journal of cancer

authors： Cheng L,Qiu L,Zhang R,Qian D,Wang M,Sun M,Zhu X,Wang Y,Guo W,Wei Q

更新日期：2019-01-15 00:00:00

abstract：:Therapeutic effectiveness against metastatic or even locally advanced pancreatic ductal adenocarcinoma (PDAC) is dismal, with 5-year survival less than 5%. Even in patients who undergo potentially curative resection, most patients' tumors recur in the liver. Improving therapies targeting or preventing liver metastases...

journal_title：International journal of cancer

authors： Kurahara H,Bohl C,Natsugoe S,Nishizono Y,Harihar S,Sharma R,Iwakuma T,Welch DR

更新日期：2016-08-01 00:00:00

abstract：:Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...

journal_title：International journal of cancer

authors： Kuczyk M,Machtens S,Stief C,Jonas U

更新日期：1999-12-10 00:00:00

abstract：:Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...

journal_title：International journal of cancer

authors： Abdallah EA,Fanelli MF,Buim ME,Machado Netto MC,Gasparini Junior JL,Souza E Silva V,Dettino AL,Mingues NB,Romero JV,Ocea LM,Rocha BM,Alves VS,Araújo DV,Chinen LT

更新日期：2015-09-15 00:00:00

abstract：:Galunisertib (LY2157299), a promising small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor, is currently in mono- and combination therapy trials for various cancers including glioblastoma, hepatocellular carcinoma and breast cancer. Using genetically modified mouse models, we investigated t...

journal_title：International journal of cancer

authors： Li W,Tibben M,Wang Y,Lebre MC,Rosing H,Beijnen JH,Schinkel AH

更新日期：2020-03-15 00:00:00

abstract：:Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...

journal_title：International journal of cancer

authors： Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

更新日期：2009-04-01 00:00:00

abstract：:Expression of sialyl Lewis(x) (sLe(x)) and sLe(a) on tumor cells is thought to facilitate metastasis by promoting cell adhesion to selectins on vascular endothelial cells. Experiments supporting this concept usually bypass the early steps of the metastatic process by employing tumor cells that are injected directly in...

journal_title：International journal of cancer

authors： Monzavi-Karbassi B,Whitehead TL,Jousheghany F,Artaud C,Hennings L,Shaaf S,Slaughter A,Korourian S,Kelly T,Blaszczyk-Thurin M,Kieber-Emmons T

更新日期：2005-11-10 00:00:00

abstract：:Little is known about age-dependent variation in outcomes of cervical cytology with modern technologies. This population-based study evaluated age-dependent changes after routine implementation of ThinPrep and SurePath technology in two independent laboratories, and controlled for time trends in a third laboratory usi...

journal_title：International journal of cancer

authors： Rask J,Lynge E,Franzmann M,Hansen B,Hjortebjerg A,Rygaard C,Schledermann D,Wåhlin A,Rebolj M

更新日期：2014-05-01 00:00:00

abstract：:A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...

journal_title：International journal of cancer

authors： Stone KR,Mickey DD,Wunderli H,Mickey GH,Paulson DF

更新日期：1978-03-15 00:00:00

abstract：:Retinoids play essential roles in the regulation of cell differentiation and in the proliferation of various epithelial tissues, and atRA is one such active metabolite of retinoids. However, despite the known functions of atRA, its clinical applications are limited due to the induced metabolism by the specific cytochr...

journal_title：International journal of cancer

authors： Choi Y,Kim SY,Kim SH,Yang J,Park K,Byun Y

更新日期：2003-10-20 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00

abstract：:The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (CIN2-3/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 random...

journal_title：International journal of cancer

authors： Haupt RM,Wheeler CM,Brown DR,Garland SM,Ferris DG,Paavonen JA,Lehtinen MO,Steben M,Joura EA,Giacoletti KE,Radley DR,James MK,Saah AJ,Sings HL,FUTURE I and II Investigators.

更新日期：2011-12-01 00:00:00

abstract：:Numerous studies have suggested that excess body weight is associated with increased cancer risk. To examine this putative association, we performed a systematic review and quantitative meta-analysis of cohort studies reporting body mass index (BMI) and the risk of 23 cancer types. PubMed, Embase, and Web of Science w...

journal_title：International journal of cancer

authors： Fang X,Wei J,He X,Lian J,Han D,An P,Zhou T,Liu S,Wang F,Min J

更新日期：2018-10-01 00:00:00

abstract：:Luteolin is a polyphenolic flavone and has antitumor activity for many cancers. The prostate-derived Ets factor (PDEF), a novel epithelium-specific Ets transcription factor, acts as an androgen-independent transcriptional activator of the prostate-specific antigen (PSA) promoter. We determined the antitumor function o...

journal_title：International journal of cancer

authors： Tsui KH,Chung LC,Feng TH,Chang PL,Juang HH

更新日期：2012-06-15 00:00:00

abstract：:In 1984 the GBSG started a multicenter randomized trial to compare the effectiveness of 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) with or without radiotherapy (RT) as adjuvant treatment in node-positive breast-cancer patients treated by mastectomy. During 5 years, 199 patients were randomized. ...

journal_title：International journal of cancer

authors： Schmoor C,Bastert G,Dunst J,Bojar H,Christmann D,Unbehaun V,Tümmers G,Bauer W,Sauerbrei W,Schumacher M

更新日期：2000-05-01 00:00:00

abstract：:We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocytic and oligodendroglial tumors, we quantitatively assessed methylatio...

journal_title：International journal of cancer

authors： Mulholland S,Pearson DM,Hamoudi RA,Malley DS,Smith CM,Weaver JM,Jones DT,Kocialkowski S,Bäcklund LM,Collins VP,Ichimura K

更新日期：2012-09-01 00:00:00

abstract：:The purpose of our study was to develop specific, sensitive, objective assays for early detection of disseminated tumour cells in patients with colorectal cancer (CRC). Carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20) were chosen as markers because they are selectively expressed in epithelial cells with mainta...

journal_title：International journal of cancer

authors： Oberg AN,Lindmark GE,Israelsson AC,Hammarström SG,Hammarström ML

更新日期：2004-08-10 00:00:00

abstract：:A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and...

journal_title：International journal of cancer

authors： Elwood JM,Pearson JC,Skippen DH,Jackson SM

更新日期：1984-11-15 00:00:00

abstract：:Oncolytic adenoviruses are being developed as novel anticancer therapeutics and currently undergoing clinical trials. We previously demonstrated that telomerase-specific replication-competent adenovirus (Telomelysin: OBP-301), in which the human telomerase reverse transcriptase (hTERT) promoter regulates viral replica...

journal_title：International journal of cancer

authors： Fujiwara T,Kagawa S,Kishimoto H,Endo Y,Hioki M,Ikeda Y,Sakai R,Urata Y,Tanaka N,Fujiwara T

更新日期：2006-07-15 00:00:00

abstract：:We investigated whether the concentration of fibronectin (FN) in the cerebrospinal fluid (CSF) could be used for identifying patients with subclinical blast-cell infiltration in the central nervous system (CNS) and an increased risk of CNS relapse later in the course of their leukemia. Our series comprised 36 children...

journal_title：International journal of cancer

authors： Rautonen J,Koskiniemi M,Siimes MA,Salonen EM,Vaheri A

更新日期：1989-01-15 00:00:00

abstract：:Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

journal_title：International journal of cancer

authors： Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

更新日期：1998-05-18 00:00:00

abstract：:Detectable post-therapy plasma Epstein-Barr virus (EBV) DNA predicts poor survival in non-metastatic nasopharyngeal carcinoma (NPC). However, some patients subsequently experience spontaneous remission of residual EBV DNA during follow-up and it was unclear whether these patients were still at high risk of disease fai...

journal_title：International journal of cancer

authors： Zhang Y,Tang LL,Li YQ,Liu X,Liu Q,Ma J

更新日期：2019-05-01 00:00:00

abstract：:Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

journal_title：International journal of cancer

authors： Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

更新日期：2000-10-01 00:00:00

abstract：:In the perspective of in vivo therapeutic applications, the monoclonal antibody (MAb) MOv18 was selected for its restricted reactivity with human ovarian carcinoma. Using the pH 2.8 desorption assay, we found that the antigen recognized by MOv18 had a high stability on the cell membrane and poor internalization. There...

journal_title：International journal of cancer

authors： Mezzanzanica D,Canevari S,Ménard S,Pupa SM,Tagliabue E,Lanzavecchia A,Colnaghi MI

更新日期：1988-04-15 00:00:00

abstract：:The ability of endogenously synthesized protoporphyrin IX (PpIX) to damage Chinese hamster lung fibroblasts of the line V79 by exposure to light was examined. This treatment induced reduction of cellular ATP, GTP, of the NADH/NAD+ ratio and of oxygen consumption. The present results indicate a close relationship betwe...

journal_title：International journal of cancer

authors： Shevchuk I,Chekulayev V,Moan J,Berg K

更新日期：1996-09-17 00:00:00

abstract：:We studied plasmin receptors on 3 MCF-7 sublines: MCF7, MCF7R which was derived by transfection with v-Ha-ras oncogene, and MCF7MF which has been studied for the secretion of procathepsin D in the presence of estrogen. All 3 sublines bound plasmin (Pli) with a much higher affinity than plasminogen (Pg). The number of ...

journal_title：International journal of cancer

authors： Correc P,Fondanèche MC,Bracke M,Burtin P

更新日期：1990-10-15 00:00:00

abstract：:MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degradation and other processes impor...

journal_title：International journal of cancer

authors： Van Valckenborgh E,Bakkus M,Munaut C,Noël A,St Pierre Y,Asosingh K,Van Riet I,Van Camp B,Vanderkerken K

更新日期：2002-10-20 00:00:00

abstract：:Epidemiological evidence suggests that intake of folate and other B-vitamins and genetic variants in the one-carbon metabolism pathway could influence the risk of breast cancer. Previous studies have focused on 2 polymorphisms in the methylenetetrahydrofolate gene (MTHFR A222V and E429A); however, findings are inconcl...

journal_title：International journal of cancer

authors： Lissowska J,Gaudet MM,Brinton LA,Chanock SJ,Peplonska B,Welch R,Zatonski W,Szeszenia-Dabrowska N,Park S,Sherman M,Garcia-Closas M

更新日期：2007-06-15 00:00:00

abstract：:A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcohol-formalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC). In the competitive...

journal_title：International journal of cancer

authors： de Cremoux P,Martin EC,Vincent-Salomon A,Dieras V,Barbaroux C,Liva S,Pouillart P,Sastre-Garau X,Magdelenat H

更新日期：1999-10-08 00:00:00

abstract：:The tumor site is a strong clinical factor in head and neck squamous cell carcinoma (HNSCC). To clarify the biologic and clinical role of p53 alterations in HNSCC, we have examined the prevalence and the nature of p53 alterations in a large cohort of tumors from the different sites. For immunohistochemical analysis of...

journal_title：International journal of cancer

authors： Bosch FX,Ritter D,Enders C,Flechtenmacher C,Abel U,Dietz A,Hergenhahn M,Weidauer H

更新日期：2004-09-10 00:00:00