Abstract:
:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western blot analysis. Upon immunoprecipitation of metabolically labeled cells, one such variant-specific 20-kDa antigen was shown to be related to retroviral envelope protein p15E. When injected intrasplenically into recipient mice, the electroblotted nitrocellulose-bound 20-kDa antigen resulted in increased frequency in CTL precursors to P815/DTIC cells. In addition to previous data in the L5178Y/DTIC tumor-model system, these data suggest that expression of aberrant, retrovirus-related proteins may be a common finding in different parental tumors xenogenized by triazene treatment.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti Pdoi
10.1002/ijc.2910550227subject
Has Abstractpub_date
1993-09-09 00:00:00pages
344-50issue
2eissn
0020-7136issn
1097-0215journal_volume
55pub_type
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