Abstract:
:Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer statistics in 185 countries. The validity of the national estimates depends upon the representativeness of the source information, and to take into account possible sources of bias, uncertainty intervals are now provided for the estimated sex- and site-specific all-ages number of new cancer cases and cancer deaths. We briefly describe the key results globally and by world region. There were an estimated 18.1 million (95% UI: 17.5-18.7 million) new cases of cancer (17 million excluding non-melanoma skin cancer) and 9.6 million (95% UI: 9.3-9.8 million) deaths from cancer (9.5 million excluding non-melanoma skin cancer) worldwide in 2018.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ferlay J,Colombet M,Soerjomataram I,Mathers C,Parkin DM,Piñeros M,Znaor A,Bray Fdoi
10.1002/ijc.31937subject
Has Abstractpub_date
2019-04-15 00:00:00pages
1941-1953issue
8eissn
0020-7136issn
1097-0215journal_volume
144pub_type
杂志文章abstract::The purpose of this study is to help clarify the use of prostate size as a selection factor for prostate brachytherapy. From 1997 to 1998, 33 patients with a TRUS-based prostate volume greater than 50 cc were treated at the University of Washington by I-125 (144 Gy) or Pd-103 (115 Gy) implantation for prostatic carcin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-08-20 00:00:00
abstract::Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33362
更新日期:2021-02-15 00:00:00
abstract::The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28987
更新日期:2015-01-15 00:00:00
abstract::The factors associated with risk of lung cancer among nonsmokers have not been fully elucidated, but dietary factors have consistently been shown to play a role. Chinese women are unique in having a high incidence of lung cancer despite a low smoking prevalence. This population is also known to have a high intake of s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1615
更新日期:2002-01-20 00:00:00
abstract::Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360602
更新日期:1985-12-15 00:00:00
abstract::Inhibition of programmed cell death (apoptosis) is associated with increased tumor aggressiveness. We hypothesized that a novel sensitive to apoptosis gene, SAG, may be expressed in tumors of patients with nonsmall cell lung cancer (NSCLC) and may affect their clinical outcome. Expression of SAG messenger RNA was eval...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20011120)95:6<375::aid-ijc1066>3
更新日期:2001-11-20 00:00:00
abstract::Infection with human papillomavirus-16 (HPV-16) is the cause of most anogenital carcinomas. This virus is also detected in about 20% of all head and neck squamous cell carcinomas. While there is strong evidence for a causal etiological role in the case of tonsillar carcinomas, causal association with malignant lesions...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22563
更新日期:2007-05-15 00:00:00
abstract::Transcriptional profiling was performed on 452 RNA preparations isolated from various types of pancreatic tissue from tumour patients and healthy donors, with a particular focus on peritumoral samples. Pancreatic ductal adenocarcinomas (PDAC) and cystic tumours were most different in these non-tumorous tissues surroun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31087
更新日期:2018-03-01 00:00:00
abstract::Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980302)75:5<721::aid-ijc
更新日期:1998-03-02 00:00:00
abstract::Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation and a relatively goo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990827)82:5<644::aid-ijc
更新日期:1999-08-27 00:00:00
abstract::Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29151
更新日期:2015-03-15 00:00:00
abstract::Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29933
更新日期:2016-04-15 00:00:00
abstract::Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31338
更新日期:2018-10-01 00:00:00
abstract::To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LO...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990531)81:5<705::aid-ijc
更新日期:1999-05-31 00:00:00
abstract::The effect of EGF on the soft agar colony-forming ability of fresh human tumor cells was assessed in 40 specimens obtained from various types of carcinoma including those of the breast, endometrium ovary, and other sites. Cells from four established human tumor cell lines (three breast and one endometrial) were also i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300611
更新日期:1982-12-15 00:00:00
abstract::Cytogenetic deletions of the short arm of chromosome 9, 9p, have been detected in cell lines of malignant mesothelioma as well as in tumor material. Many tumor types carry deletions of chromosome 9 or more specifically of 9p21. The tumor-suppressor genes, CDKN2A and CDKN2B, each of which encodes a structurally and fun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980209)75:4<649::aid-ijc
更新日期:1998-02-09 00:00:00
abstract::Breast cancer is one of the leading causes of cancer death in women. It is a complex and heterogeneous disease with different clinical outcomes. Stratifying patients into subgroups with different outcomes could help guide clinical decision making. In this study, we used two opposing groups of genes, Yin and Yang, to d...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30556
更新日期:2017-03-15 00:00:00
abstract::BW 5147 lymphoma cells are non-invasive tumor cells which do not generate experimental metastases following i.v. inoculation. In contrast, s.c. and intra-splenic (i.s.) growth of BW cells resulted in widespread colonization of liver and spleen. Cells derived from either s.c. tumors or metastatic lesions did generate m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410514
更新日期:1988-05-15 00:00:00
abstract::In colorectal cancer (CRC), hepatic arterial infusion (HAI) chemotherapy may convert primarily unresectable CRC liver metastases (CLM) into resectability, although the risk of metastatic recurrence remains high after CLM ablation. We investigated the role of antitumour immunity invoked by first-line oxaliplatin-HAI fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32847
更新日期:2020-04-01 00:00:00
abstract::Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970304)70:5<524::aid-ijc
更新日期:1997-03-04 00:00:00
abstract::Retinoids modulate several cell functions and especially inhibit the growth of a wide variety of cells including breast cancer. Retinoic acid receptor-gamma (RAR-gamma) has been shown to mediate the antiproliferative activity of retinoids. To further test this hypothesis we examined the effects of different RAR-gamma ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970502)71:3<497::aid-ijc
更新日期:1997-05-02 00:00:00
abstract::Cryopreserved tumour cells obtained from the ascitic fluid of a patient with an ovarian carcinoma were employed to determine the effect on in vitro drug cytotoxicities of varying both drug concentration and exposure time. Four antitumour drugs, in common clinical usage, were selected for study. Tumour-cell survival fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320103
更新日期:1983-07-15 00:00:00
abstract::Dietary factors in the aetiology of stomach cancer were investigated using data from a case-control study conducted in Northern Italy on 206 histologically confirmed carcinomas and 474 control subjects in hospital for acute, non-digestive conditions, unrelated to any of the potential risk factors for gastric cancer. D...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400409
更新日期:1987-10-15 00:00:00
abstract::There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25479
更新日期:2011-04-01 00:00:00
abstract::Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29558
更新日期:2015-10-15 00:00:00
abstract::The expression patterns of glycolipids of human renal-cell carcinoma were studied in primary tumors from 23 cases and 5 metastatic lesions from 4 cases using HPTLC (high-performance thin-layer chromatography). The expression pattern of glycolipids in primary tumors was characteristic of the histological cell type. In ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490303
更新日期:1991-09-30 00:00:00
abstract::V-ATPases are proton-translocating enzymes, which are found not only in numerous intracellular organelles but also in the plasma membranes of many eukaryotic cells. Using differential display, we have identified one of the proton pump subunit genes, ATP6C, as a cisplatin-inducible gene. Northern blot analysis demonstr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1418
更新日期:2001-09-01 00:00:00
abstract::In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are li...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32822
更新日期:2020-06-15 00:00:00
abstract::Cervical cancer and many other anogenital and oropharyngeal carcinomas are strongly associated with high-risk human papillomavirus (HPV) persistent infections. HPV E7 oncoprotein is the major viral transforming factor, emerging as a natural candidate for immunotherapy, since it is constitutively expressed in HPV-induc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26294
更新日期:2012-04-15 00:00:00
abstract::Adherent cells with the ability to inhibit NK activity were found in the spleens of young 8-week-old SJL/J mice. Such suppressor cells were also found in the spleens of other low-NK-reactive strains, but not in the spleen of age-matched high-NK-reactive strains. These suppressor cells had the characteristics of macrop...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280621
更新日期:1981-12-01 00:00:00