Abstract:
:Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blood samples from 82 locally advanced CC (LACC) or MRCC patients and when possible during treatment. We identified five notable nonsynonymous mutant genes (PIK3CA, BRAF, GNA11, FBXW7 and CDH1) in the MRCC samples as the metastatic relapse significantly mutated (MSG) genes and found that MRCC patients with any detectable MSG mutations had significantly shorter progression-free survival (PFS) (P = .005) and overall survival (OS) (P = .007) times than those without detectable MSG mutations. Additionally, analyses of matched prechemotherapy and postchemotherapy plasma revealed that a reduction in the number of MSG mutations after chemotherapy was significantly associated with partial remission (PR) and stable disease (SD) (P = .007). Among the patients included in the longitudinal tracking ctDNA analysis, an increase in MSG mutations was observed earlier in response to disease progression than radiological imaging. Our results outline the mutation profiles of MRCC. We show how longitudinal monitoring with ctDNA in liquid biopsy samples provides both predictive and prognostic information during treatment.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou Ldoi
10.1002/ijc.33362subject
Has Abstractpub_date
2021-02-15 00:00:00pages
921-931issue
4eissn
0020-7136issn
1097-0215journal_volume
148pub_type
杂志文章abstract::The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25726
更新日期:2011-08-01 00:00:00
abstract::The role of cetuximab in treatment-related hematologic toxicity is not clear. We performed a meta-analysis of published randomized controlled trials (RCTs) to determine the overall risk of ≥grade 3 hematologic toxicity events (HTEs) associated with cetuximab. PubMed, EMBASE, and Web of Knowledge databases as well as a...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.29045
更新日期:2015-02-15 00:00:00
abstract::Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivariate analysis identified 4 factors...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20491
更新日期:2004-12-10 00:00:00
abstract::Parvoviruses of rodents are endowed with oncosuppressive properties. In particular, parvoviral infections protect host animals from spontaneous and chemical- or virus-induced tumour initiation in laboratory animals. The present study was undertaken to substantiate the capacity of parvovirus H-1 to inhibit therapeutica...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980209)75:4<584::aid-ijc
更新日期:1998-02-09 00:00:00
abstract::Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33323
更新日期:2021-03-15 00:00:00
abstract::The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. MicroRNAs are involved in crucial biological processes like carcinogenesis by regulating gen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28828
更新日期:2014-10-15 00:00:00
abstract::The tumor microenvironment consists of an immunosuppressive niche created by the complex interactions between cancer cells and surrounding stromal cells. A critical component of this environment are myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells arrested at different stages o...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30232
更新日期:2016-11-01 00:00:00
abstract::In this study we investigated the effect of Tax on nucleotide excision repair (NER) in human T-cell lines by using the host cell repair analysis of UVC-irradiated reporter plasmid. This analysis revealed a p53-dependent NER activity in wild type (w.t.) p53-containing T-cells and p53-independent NER in w.t. p53-lacking...
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.23091
更新日期:2008-01-15 00:00:00
abstract::The presence of carcinogen-DNA adducts in human tissues is evidence of exposure to carcinogens and may be an indicator of cancer risk. DNA was isolated from non-tumorous bronchial tissue of 37 cigarette smokers, 8 former smokers and 8 non-smokers and analyzed for the presence of aromatic and/or hydrophobic DNA adducts...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460403
更新日期:1990-10-15 00:00:00
abstract::The identification of specific tumor mRNA markers by reverse transcription-polymerase chain reaction might be a valuable diagnostic adjunct for the detection of breast cancer metastases in axillary sentinel lymph nodes (SLNs). In this study we have compared the diagnostic accuracy of an extensive histopathologic exami...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010920)95:5<307::aid-ijc0153>3
更新日期:2001-09-20 00:00:00
abstract::Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase (ALK) rearrangement. We used knockout mice to study the roles of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) in plasma pharmacokinetics...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28475
更新日期:2014-03-15 00:00:00
abstract::Several tumour-derived factors have recently been identified which induce tissue factor (TF) expression in endothelial cells in vitro. However, there is only limited evidence that endothelial cells lining tumour blood vessels express elevated procoagulant activity (PCA) in vivo. We have investigated the effects of hum...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960611)66:6<784::AID-IJC
更新日期:1996-06-11 00:00:00
abstract::The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960410)66:2<249::AID-IJC
更新日期:1996-04-10 00:00:00
abstract::V79 cells incubated with di- or tetrasulfonated aluminium phthalocyanines (AlPcS2 or AlPcS4) showed a granular fluorescence pattern. Co-staining with the lysosomotropic dye acridine orange (AO) indicated that the granules that were stained by these photoactive phthalocyanines were identical to lysosomes. Small light e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580620
更新日期:1994-09-15 00:00:00
abstract::In addition to the known function in the glycolytic pathway, phosphoglycerate kinase 1 (PGK-1) promotes reduction of plasmin disulfide bonds leading to angiostatin formation and inhibition of tumor angiogenesis. In this study, the effects of PGK-1 on anti- tumor immunity against lung cancer were evaluated using the Te...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23888
更新日期:2008-12-15 00:00:00
abstract::Intraductal papillary-mucinous carcinoma (IPMC) of the pancreas, a new entity of pancreatic cancer with a favorable prognosis, has shown a gradual increase in the number of reported cases. Patients with high-frequency microsatellite instability (MSI-H) tumors have been shown to survive longer than those with low-frequ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10771
更新日期:2002-12-20 00:00:00
abstract::Using comparative genomic hybridisation, we investigated chromosomal imbalances in 28 cases of thymic epithelial neoplasms including type A, B2, B3, the A component of type AB and different subtypes of type C thymoma. To identify different patterns of chromosomal aberrations associated with the biological behaviour an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11101
更新日期:2003-07-01 00:00:00
abstract::A population-based case-control study was conducted to evaluate risk of developing multiple myeloma (MM) associated with personal history of autoimmune diseases and occurrence of autoimmune and selected hematologic disorders in first-degree relatives. Data were obtained for all (n = 8,406) MM cases diagnosed in Sweden...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21745
更新日期:2006-06-15 00:00:00
abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960503)66:3<374::AID-IJC
更新日期:1996-05-03 00:00:00
abstract::Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971210)73:6<880::aid-ijc
更新日期:1997-12-10 00:00:00
abstract::Polymorphisms in nucleotide oligomerization domain 2 gene (NOD2) have been associated with increased susceptibility to Crohn's disease. Recently, possible association of the NOD2 variants R702W, G908R and 3020insC with colorectal cancer (CRC) has been studied among Polish, Greek, Finnish and New Zealand Caucasian CRC ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22651
更新日期:2007-07-01 00:00:00
abstract::The purpose of this study is to help clarify the use of prostate size as a selection factor for prostate brachytherapy. From 1997 to 1998, 33 patients with a TRUS-based prostate volume greater than 50 cc were treated at the University of Washington by I-125 (144 Gy) or Pd-103 (115 Gy) implantation for prostatic carcin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-08-20 00:00:00
abstract::Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer-associated fibroblasts, in cancer development and progression. In our study, we developed a novel, visually based method to identify new immunohistochemical signatures of these fibroblasts. The method employed a protein li...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28035
更新日期:2013-07-15 00:00:00
abstract::Previously, the induction of pancreatic carcinogenesis in the rat using azaserine has involved a multiple-dose treatment protocol. The objective of the present study was to determine the effect of multiple azaserine treatments on pancreatic DNA synthesis and to develop a protocol for a single-dose initiation of pancre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280511
更新日期:1981-11-15 00:00:00
abstract::To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910620105
更新日期:1995-07-04 00:00:00
abstract::Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31717
更新日期:2018-12-15 00:00:00
abstract::Electroporation-based mono-gene therapy has received great interest in recent years but coadministration of different therapeutic genes for treatment of tumors has not been well explored. We hypothesize that electroporation is capable of delivering multiple genes that induce an additive or synergistic antitumor effect...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22100
更新日期:2006-11-01 00:00:00
abstract::TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10540
更新日期:2002-08-20 00:00:00
abstract::Mortality rates for cancer of all sites combined and for 12 selected sites or site groups in Estonia from 1965 to 1989 were studied to assess overall progress in controlling cancer. Between 1965-1969 and 1985-1989, age-standardized mortality (world population) increased by 12.0% among males and decreased by 5.1% among...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530608
更新日期:1993-04-01 00:00:00
abstract::Interferon-beta (IFN-beta) has been used as an antitumor drug against human glioma, melanoma and medulloblastoma since the 1980s. Recently, we developed a new gene therapy using the IFN-beta gene against malignant gliomas and then began clinical trials in 2000. Since stimulation of immune system was one mechanism of a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20331
更新日期:2004-09-20 00:00:00