Abstract:
:Intraductal papillary-mucinous carcinoma (IPMC) of the pancreas, a new entity of pancreatic cancer with a favorable prognosis, has shown a gradual increase in the number of reported cases. Patients with high-frequency microsatellite instability (MSI-H) tumors have been shown to survive longer than those with low-frequency MSI (MSI-L) or microsatellite stable (MSS) tumors in colorectal and gastric cancer. We investigated whether MSI-H in patients with IPMC can contribute to a good prognosis. The formalin-fixed paraffin-embedded tumors and surrounding normal pancreatic tissues from 10 patients with IPMCs and 16 with intraductal papillary-mucinous adenomas (IPMAs) were provided for DNA extraction after microdissection. Polymerase chain reaction (PCR) was carried out using 8 microsatellite primer marker sets. The mixed PCR samples were analyzed using a genetic analyzer. MSI-H was determined by assessment of microsatellite variations in 3 or more of the 8 tested markers. Immunohistochemical staining of the MSI-responsible proteins hMLH1 and hMSH2 was conducted for both the IPMC and IPMA samples. Ten percent of IPMC harbored MSI-H tumors, whereas no MSI-H tumors were detected in the IPMAs. Thirty percent of IPMC tumors and 25% of IPMA tumors showed MSI-L. All IPMCs and IPMAs showed normal expression of both hMLH1 and hMSH2. MSI-H and loss of hMLH1 and hMSH2 are very rare events in both IPMCs and IPMAs. We conclude that a good prognosis for patients with IPMC is not associated with MSI-H.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Nakata B,Yashiro M,Nishioka N,Aya M,Yamada S,Takenaka C,Ohira M,Ishikawa T,Nishino H,Wakasa K,Seki S,Hirakawa Kdoi
10.1002/ijc.10771keywords:
subject
Has Abstractpub_date
2002-12-20 00:00:00pages
655-9issue
6eissn
0020-7136issn
1097-0215journal_volume
102pub_type
杂志文章abstract::The kinetics of the immune response of hamsters transplanted with virus-free SV40 tumor cells (TSV5) to two SV40-coded non-structural proteins of 94,000 daltons (T antigen) and 17,000 daltons (t antigen) was studied in order to determine if the variation in the immune reactivity of serum from tumor-bearing animals tow...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290218
更新日期:1982-02-15 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice were severely hypoxic (pO(2) app...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24601
更新日期:2009-11-01 00:00:00
abstract::In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540302
更新日期:1993-05-28 00:00:00
abstract::A considerable public concern about cancer risk from acrylamide-rich foods followed the announcement that high concentrations of acrylamide are found in fried potatoes and potato chips and, more generally, in starch-containing foods cooked at high temperatures. From a series of hospital-based case-control studies cond...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11118
更新日期:2003-07-01 00:00:00
abstract::Hormonal regulation of mouse mammary tumor virus (MMTV) synthesis was studied in the CCL-51-SF cell subline derived from the Sykes' mammary tumor cell line CCL-51 and adapted to grow in semi-synthetic in vitro conditions. The virus was quantitated by measuring the supernatant reverse transcriptase activity in exogenou...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190215
更新日期:1977-02-15 00:00:00
abstract::Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may thereby influence an individual's susceptibility to smoking-related cancer. We investigated the association between the -93G-->A polymorphism in the hMLH1 gene and the risk of lung cancer in a Korean popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20359
更新日期:2004-11-20 00:00:00
abstract::The modifying effects of a Kunitz trypsin inhibitor (KTI) and a Bowman-Birk trypsin inhibitor (BBI), purified from soybean trypsin inhibitor, as dietary supplements on experimental and spontaneous pulmonary metastasis of murine Lewis lung carcinoma 3LL cells as well as peritoneal disseminated metastasis model in human...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20430
更新日期:2004-11-10 00:00:00
abstract::Maspin is a Class II tumor suppressor protein and plays a role in tumor growth by inhibiting cellular invasion and motility. It is a member of the serpin family of protease inhibitors and has been shown to reduce angiogenesis. Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-relat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20766
更新日期:2005-04-20 00:00:00
abstract::Breast cancer can be classified into molecular sub-types that have distinct survival patterns. We evaluated the prognostic significance of breast cancer sub-types in a cohort of women taking part in the NEAT and BR9601 clinical trials comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with ECMF (epirubici...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28150
更新日期:2013-09-15 00:00:00
abstract::Commercial cow milk contains considerable amounts of estrogens. Our study assessed the effect of commercial low-fat milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. Eighty 6-week-old female Sprague-Dawley rats received a single oral dose of 5 mg DMBA. Twenty-four hours l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20172
更新日期:2004-07-01 00:00:00
abstract::Dichlorodiphenyltrichloroethane (p,p'-DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that p,p'-DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (p,p'-DDE), may also b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27459
更新日期:2012-11-01 00:00:00
abstract::It has been established that the Hedgehog (Hh) and epithelial-mesenchymal transition (EMT) signals act on morphogenesis of embryonic and adult tissues. Recently, both signals have been involved in tumor malignancy. However, little is known as to whether Hh and EMT signals act on normal and malignant epithelial cells i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24400
更新日期:2009-09-01 00:00:00
abstract::We have developed novel 3-dimensional in vitro and in vivo tissue models that mimic premalignant disease of human stratified epithelium in order to analyze the stromal contribution of extracellular matrix and basement membrane proteins to the progression of intraepithelial neoplasia. Three-dimensional, organotypic cul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11525
更新日期:2004-01-20 00:00:00
abstract::MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycyti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26254
更新日期:2012-06-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20946
更新日期:2005-07-10 00:00:00
abstract::Breast cancer is one of the most common and feared cancers faced by women. The prognosis of patients with advanced or recurrent breast cancer remains poor despite refinements in multimodality therapies involving chemotherapeutic and hormonal agents. Multimodal therapy with more specific and effective strategy is urgen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29163
更新日期:2015-04-01 00:00:00
abstract::Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32908
更新日期:2020-09-01 00:00:00
abstract::The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270616
更新日期:1981-06-15 00:00:00
abstract::Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway whose epigenetic downregulation have been shown to be involved in hepatocarcinogenesis. However, dysregulation of SFRPs induced by hepatitis B virus (HBV) X protein (HBx) has never been studied in HBV-related hepatocellular carcino...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28697
更新日期:2014-08-01 00:00:00
abstract::The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter factor (HGF/SF), a multifunctional cytokine able to mediate morphogenesis as well as mitogenesis, motogenesis and invasiveness of epithelial cells. HGF/SF has been implicated in branching tubulogenesis of the developing kidney and in regenera...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960621)69:3<212::AID-IJC
更新日期:1996-06-21 00:00:00
abstract::Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendri...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30002
更新日期:2016-06-01 00:00:00
abstract::The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Immunohistochemical studies have shown that this overexpression is linked to higher aggressiveness of colorectal carcinoma and to enhanced metastatic potential of melanoma cells. However, the antibodies so far developed against Nup88 have the draw...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20034
更新日期:2004-05-01 00:00:00
abstract::Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22098
更新日期:2006-12-01 00:00:00
abstract::For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs-based vacc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31795
更新日期:2019-02-15 00:00:00
abstract::Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971114)73:4<544::aid-ijc
更新日期:1997-11-14 00:00:00
abstract::APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11690
更新日期:2004-03-20 00:00:00
abstract::While platelet-derived growth factor, PDGF, is not regularly expressed in mesenchymal tissues, PDGF B mRNA is often found in tumors derived from these tissues. PDGF B protein is also present, but the protein levels in individual tumors do not appear to correlate well with those of the mRNA. PDGF B is homologous to the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-01-15 00:00:00
abstract::The growth properties of a human melanoma cell line (MeWo) and of a variant (MeWo-LC1) endowed with higher metastatic potential in nude mice were compared using hormonally-defined serum-free media. The two cell lines failed to arrest in G0 following serum deprivation, and responded to INS and MSA but not to EGF, PDGF ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370120
更新日期:1986-01-15 00:00:00
abstract::We investigated the expression pattern of the breast cancer associated gene LIV-1 on mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21235
更新日期:2005-12-20 00:00:00
abstract::Development of targeted therapeutics is still at its early stage for hepatocellular carcinoma (HCC) due to the incomplete understanding of the confounding regulations at signaling pathway level. In this investigation, gene co-expression-based networking and integrative functional genomic modeling of HCC mRNA profiles ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30195
更新日期:2016-10-01 00:00:00