Mouse mammary tumor virus production stimulated by hormones and polyamines in cells grown in semi-synthetic in vitro conditions.

abstract：:The modulating effect on drug resistance of amiodarone (AM) and its metabolite desethylamiodarone (DEA) was studied in a P-glycoprotein-positive human colon carcinoma cell line COLO 320, and a human small-cell lung carcinoma cell line GLC4 and its adriamycin (Adr)-resistant subline GLC4-Adr (both P-glycoprotein-negati...

journal_title：International journal of cancer

authors： van der Graaf WT,de Vries EG,Uges DR,Nanninga AG,Meijer C,Vellenga E,Mulder PO,Mulder NH

更新日期：1991-06-19 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an aggressive tumour of multifactorial aetiology that, although rare in most parts of the world, poses a significant mortality problem in its high incidence area of Southern China. Improved therapies are an urgent requirement and, towards this end, immunotherapeutic methods are being ...

journal_title：International journal of cancer

authors： Yao Y,Minter HA,Chen X,Reynolds GM,Bromley M,Arrand JR

更新日期：2000-12-15 00:00:00

abstract：:Fine-needle aspiration cytology (FNAC) is currently used in evaluating the nature of breast nodules. In the present study we have examined whether monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) can be employed in FNAC for the diagnosis of breast cancer. For this purpose we have used 2 murine M...

journal_title：International journal of cancer

authors： Nuti M,Mottolese M,Viora M,Donnorso RP,Schlom J,Natali PG

更新日期：1986-04-15 00:00:00

abstract：:Biopsies obtained from 74 Tunisian women with breast cancer (33 cases), benign breast disease (17 cases), and cervical cancer (24 cases) were assayed for the presence of an antigen cross-reacting with gp52 of the mouse mammary tumor virus (MMTV) in order to determine the frequency and possible prognostic significance ...

journal_title：International journal of cancer

authors： Levine PH,Mesa-Tejada R,Keydar I,Tabbane F,Spiegelman S,Mourali N

更新日期：1984-03-15 00:00:00

abstract：:Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...

journal_title：International journal of cancer

authors： Van Waardenburg RC,Meijer C,Burger H,Nooter K,De Vries EG,Mulder NH,De Jong S

更新日期：1997-11-14 00:00:00

abstract：:Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being the most prevalent genotype associated with it. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV 16 besides being of phylogenetic importance, are associated with risk of viral persistence and progressio...

journal_title：International journal of cancer

authors： Pillai MR,Hariharan R,Babu JM,Lakshmi S,Chiplunkar SV,Patkar M,Tongaonkar H,Dinshaw K,Jayshree RS,Reddy BK,Siddiqui M,Roychoudury S,Saha B,Abraham P,Gnanamony M,Peedicayil A,Subhashini J,Ram TS,Dey B,Sharma C,Jain

更新日期：2009-07-01 00:00:00

abstract：:The occurrence of resistance to cytotoxic agents in tumor cells, associated with several phenotypic alterations, is one of the major obstacles to successful anticancer chemotherapy. A new strategy to overcome MDR of human cancer cells was studied, using BSAO, which generates cytotoxic products from spermine, H(2)O(2) ...

journal_title：International journal of cancer

authors： Calcabrini A,Arancia G,Marra M,Crateri P,Befani O,Martone A,Agostinelli E

更新日期：2002-05-01 00:00:00

abstract：:Malignant lymphomas frequently develop in the pleural cavity of patients with long-standing pyothorax. The term pyothorax-associated lymphoma (PAL) has been proposed for this type of tumor. Most PALs are diffuse lymphomas of the B-cell type and contain Epstein-Barr virus (EBV) DNA. We have established 2 lymphoma cell ...

journal_title：International journal of cancer

authors： Kanno H,Yasunaga Y,Ohsawa M,Taniwaki M,Iuchi K,Naka N,Torikai K,Shimoyama M,Aozasa K

更新日期：1996-07-03 00:00:00

abstract：:The expression of two discrete cell properties related to the host natural effector mechanisms, i.e., resistance to damage by H2O2, a cytotoxic product of activated macrophages, and the ability to secrete PGE, which inhibits NK-cell cytotoxicity, has been examined in parental Syrian hamster embryo cells spontaneously ...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Matveeva VA,Kushlinsky NE,Bassalyk LS,Vendrov EL

更新日期：1989-11-15 00:00:00

abstract：:The recently discovered human polyomavirus (MCPyV) is frequently found in Merkel cell carcinoma (MCC) tissue and is believed to be causally linked to MCC pathogenesis. While cell lines established from MCC represent a valuable tool to study the contribution of MCPyV to MCC pathogenesis, hitherto only 1 MCPyV-positive ...

journal_title：International journal of cancer

authors： Fischer N,Brandner J,Fuchs F,Moll I,Grundhoff A

更新日期：2010-05-01 00:00:00

abstract：:The relationship between chemosensitivity and p53 is currently considered from two mutually exclusive points of view: (1) wt p53 increases chemosensitivity due to apoptosis and (2) wt p53 decreases chemosensitivity due to growth arrest and DNA repair. We used p53-expressing adenovirus (Ad-p53) to directly evaluate eff...

journal_title：International journal of cancer

authors： Blagosklonny MV,El-Deiry WS

更新日期：1998-03-16 00:00:00

abstract：:We have examined the effects of the synthetic matrix metalloproteinase inhibitor, batimastat (BB-94) and the angiotensin-converting enzyme inhibitor, captopril, on metalloproteinase activity of murine Lewis-lung-carcinoma cells (3LL) in vitro, and on local growth and lung metastasis of the same tumor implanted intramu...

journal_title：International journal of cancer

authors： Prontera C,Mariani B,Rossi C,Poggi A,Rotilio D

更新日期：1999-05-31 00:00:00

abstract：:The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and Adna...

journal_title：International journal of cancer

authors： Andreopoulou E,Yang LY,Rangel KM,Reuben JM,Hsu L,Krishnamurthy S,Valero V,Fritsche HA,Cristofanilli M

更新日期：2012-04-01 00:00:00

abstract：:In order to establish the role of human papillomavirus (HPV) in carcinogenesis of epidermodysplasia verruciformis (EV), the presence, the molecular characteristics and the physical state of HPV DNA in a benign lesion, a primary carcinoma and a metastatic carcinoma developing in the same EV patient were studied and com...

journal_title：International journal of cancer

authors： Yabe Y,Tanimura Y,Sakai A,Hitsumoto T,Nohara N

更新日期：1989-06-15 00:00:00

abstract：:In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...

journal_title：International journal of cancer

authors： Sutcliffe S,Giovannucci E,Leitzmann MF,Rimm EB,Stampfer MJ,Willett WC,Platz EA

更新日期：2007-04-01 00:00:00

abstract：:PDT has been reported to induce cancer cell expression of cytokines, such as IL-6 and TNF-alpha, but it has been unclear whether cytokine expression by cancer cells is directly related to the antitumor effect of PDT. We treated Lewis lung carcinoma (LLC) cells with a new photosensitizer, mono-L-aspartyl chlorin e6 (NP...

journal_title：International journal of cancer

authors： Usuda J,Okunaka T,Furukawa K,Tsuchida T,Kuroiwa Y,Ohe Y,Saijo N,Nishio K,Konaka C,Kato H

更新日期：2001-08-15 00:00:00

abstract：:Effects of therapeutic and supratherapeutic concentrations of bosutinib, a dual Src/Abl tyrosine kinase inhibitor, on the corrected QT interval (QTc) in 60 healthy adults were assessed, according to ICH-E14 guidelines, in this 2-part, randomized, single-dose, double-blind, crossover, placebo- and open-label moxifloxac...

journal_title：International journal of cancer

authors： Abbas R,Hug BA,Leister C,Sonnichsen D

更新日期：2012-08-01 00:00:00

abstract：:In STU mice bearing metastasizing SV40-transformed 51A-232B-M tumors, an immune response against a cellular 60kDa protein (p60) developed in about 50% of the tumor-bearing animals, in addition to the response against SV40 large T-antigen and cellular protein p53. The anti-p60 auto-immune response could be observed as ...

journal_title：International journal of cancer

authors： Manneck HE,Pfaff M,Anderer FA

更新日期：1988-12-15 00:00:00

abstract：:Effects of 12-O-tetradecanoyl phorbol 13-acetate (TPA) and the hepatic peroxisome proliferators (HPPs) clofibrate, methyl clofenapate (MCP), di(2-ethylhexyl)phthalate (DEHP) and mono(2-ethylhexyl)phthalate (MEHP) were studied in 2 gap junctional intercellular communication (GJIC) systems, metabolic cooperation in V79 ...

journal_title：International journal of cancer

authors： Cruciani V,Mikalsen SO,Vasseur P,Sanner T

更新日期：1997-10-09 00:00:00

abstract：:Colorectal cancer remains a leading cause of cancer death worldwide, despite markedly improved response rates to current systemic therapies. Oxaliplatin either alone or incorporated into 5-fluorouracil/leucovorin regimes has resulted in increased survival rates, particularly with regards to metastatic colorectal carci...

journal_title：International journal of cancer

authors： Howells LM,Mitra A,Manson MM

更新日期：2007-07-01 00:00:00

abstract：:Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

journal_title：International journal of cancer

authors： Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

更新日期：1999-03-01 00:00:00

abstract：:We investigated the marker profile of human ascitic and cultured mesothelial cells, and compared it to that of ovarian carcinoma cells which are related in terms of their histogenesis, unrelated colon carcinomas being used as reference. Mesothelial and ovarian carcinoma cells could not be distinguished by (intermediat...

journal_title：International journal of cancer

authors： van Niekerk CC,Jap PH,Thomas CM,Smeets DF,Ramaekers FC,Poels LG

更新日期：1989-06-15 00:00:00

abstract：:HtrA1, a member of serine protease family, has been previously found to be involved in resistance to chemotherapy in ovarian cancer although the underlying mechanism is not clear. Using mixture-based oriented peptide library approach, previously we identified X-linked inhibitor of apoptosis protein (XIAP), a member of...

journal_title：International journal of cancer

authors： He X,Khurana A,Maguire JL,Chien J,Shridhar V

更新日期：2012-03-01 00:00:00

abstract：:In a proportion of patients presenting mismatch repair (MMR)-deficient tumors, no germline MMR mutations are identified, the so-called Lynch-like syndrome (LLS). Recently, MMR-deficient tumors have been associated with germline mutations in POLE and MUTYH or double somatic MMR events. Our aim was to elucidate the mole...

journal_title：International journal of cancer

authors： Vargas-Parra GM,González-Acosta M,Thompson BA,Gómez C,Fernández A,Dámaso E,Pons T,Morak M,Del Valle J,Iglesias S,Velasco À,Solanes A,Sanjuan X,Padilla N,de la Cruz X,Valencia A,Holinski-Feder E,Brunet J,Feliubadaló L

更新日期：2017-10-01 00:00:00

abstract：:Twenty-seven human colorectal adenocarcinomas were implanted s.c. into nude mice. A comparative study of chromosomes and DNA between fresh tumor (FT) and xenografted tumor cells (XT) could be performed in 9 cases. Losses or deletions were consistently found in FTs as well as in XTs, particularly on chromosomes 17 and/...

journal_title：International journal of cancer

authors： Lefrançois D,Olschwang S,Delattre O,Muleris M,Dutrillaux AM,Thomas G,Dutrillaux B

更新日期：1989-11-15 00:00:00

abstract：:A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....

journal_title：International journal of cancer

authors： Welander CE,Morgan TM,Homesley HD,Trotta PP,Spiegel RJ

更新日期：1985-06-15 00:00:00

abstract：:Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history of colorectal cancer in which the polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome of colonoscopic surveillance is studied using data from six centers. DNA mismatc...

journal_title：International journal of cancer

authors： Mesher D,Dove-Edwin I,Sasieni P,Vasen H,Bernstein I,Royer-Pokora B,Holinski-Feder E,Lalloo F,Evans DG,Forsberg A,Lindblom A,Thomas H

更新日期：2014-02-15 00:00:00

abstract：:The aim of our study was to further explore the use of anti-angiogenic therapy targeting the vascular endothelial growth factor receptor (VEGFR) on endothelial cells while simultaneously targeting platelet-derived growth factor receptors (PDGFRs) on adjacent pericytes. B16 mouse melanoma tumors exogenously expressing ...

journal_title：International journal of cancer

authors： Hasumi Y,Kłosowska-Wardega A,Furuhashi M,Ostman A,Heldin CH,Hellberg C

更新日期：2007-12-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...

journal_title：International journal of cancer

authors： Li S,Dai W,Mo W,Li J,Feng J,Wu L,Liu T,Yu Q,Xu S,Wang W,Lu X,Zhang Q,Chen K,Xia Y,Lu J,Zhou Y,Fan X,Xu L,Guo C

更新日期：2017-12-15 00:00:00

abstract：:Increased secretion of matrix metalloproteinases and serine proteinases is well known to be associated with cancer invasion and metastasis. We aimed to elucidate the implication of trypsin, a serine proteinase and a representative digestive enzyme in invasion and metastasis of human carcinomas. Northern blot, RT-PCR a...

journal_title：International journal of cancer

authors： Hirahara F,Miyagi Y,Miyagi E,Yasumitsu H,Koshikawa N,Nagashima Y,Kitamura H,Minaguchi H,Umeda M,Miyazaki K

更新日期：1995-10-09 00:00:00