Abstract:
:The kinetics of the immune response of hamsters transplanted with virus-free SV40 tumor cells (TSV5) to two SV40-coded non-structural proteins of 94,000 daltons (T antigen) and 17,000 daltons (t antigen) was studied in order to determine if the variation in the immune reactivity of serum from tumor-bearing animals towards these proteins can be explained on the basis of differential immune response during various stages of tumor growth. The results demonstrate that individual animals vary in their capacity to respond immunologically to T and t antigens in SV40-transformed cells and that, further, the immune response to T and t antigens is influenced by the stage of tumor development.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ransom JH,Thompson DL,Tevethia SSdoi
10.1002/ijc.2910290218subject
Has Abstractpub_date
1982-02-15 00:00:00pages
217-22issue
2eissn
0020-7136issn
1097-0215journal_volume
29pub_type
杂志文章abstract::A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in PR and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conduc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24477
更新日期:2009-10-01 00:00:00
abstract::The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific luminometric immunoa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980821)79:4<376::aid-ijc
更新日期:1998-08-21 00:00:00
abstract::A single treatment of chick embryo fibroblasts with DNA recovered from chick embryo fibroblasts productively infected and transformed with four different strains of RSV, or productively infected with two different strains of RAV, resulted in virus production and cell transformation (in the case of RSV) two or three p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150109
更新日期:1975-01-15 00:00:00
abstract::Previous studies have reported that poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum (Por & Muc) show a low incidence and poor prognosis. However, genetic alterations and tumourigenesis of Por & Muc remain unclear. In our study, we analyzed the genetic and epigenetic alterations of P...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10690
更新日期:2002-11-20 00:00:00
abstract::In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, respon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470102
更新日期:1991-01-02 00:00:00
abstract::Tissue factor (TF)-mediated protease-activated receptor (PAR)-2 signaling is associated with a promigratory, invasive and proangiogenic phenotype in experimental models of breast cancer and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24921
更新日期:2010-05-15 00:00:00
abstract::Statin use has been suggested to improve prognosis in cancer patients, however, for ovarian cancer, the evidence is sparse. From the Danish Cancer Registry, we identified patients aged 30-84 years with a histologically verified first diagnosis of epithelial ovarian cancer between 2000 and 2013. Data on filled prescrip...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30738
更新日期:2017-07-15 00:00:00
abstract::Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were studied to evaluate the reversibility of Adriamycin resistance in human colon cancer. Two groups of cell lines were studied. In the first, including a series o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490512
更新日期:1991-11-11 00:00:00
abstract::AKR-2B mouse fibroblasts were treated with 50 micrograms/ml of crude transforming growth factor (TGF) of human origin. Cell surface proteins of treated cells were radioiodinated and compared to untreated cells at various times after the addition of TGF. Treated cells showed a severalfold increase (approximately 6-fold...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330121
更新日期:1984-01-15 00:00:00
abstract::We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Apc(+/+)), colon epithelial cells by inducing autocrine IL-6 production and trans-IL-6 signaling. Low serum adiponectin is associated with colon, prostate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23436
更新日期:2008-06-01 00:00:00
abstract::We show that siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines. Src and PTP alpha RNAi induced apoptosis in estrogen receptor (ER)-negative breast cancer and colon cancer cells, but not in immortalized noncan...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23321
更新日期:2008-05-01 00:00:00
abstract::The diagnostic specificity of the detection of disseminated prostatic cells by reverse-transcriptase polymerase chain reaction (RT-PCR) of PSA mRNA was investigated. A sensitive nested PCR was developed. In blood samples from 10 healthy female and 10 healthy male persons examined by RT-PCR, mRNA of PSA was detected 3 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970106)70:1<52::aid-ijc8
更新日期:1997-01-06 00:00:00
abstract::Cetuximab in combination with an irinotecan-containing regimen is a standard treatment in patients with KRAS wild-type (KRAS WT), metastatic colorectal cancer (mCRC). We investigated the addition of the oral MET inhibitor tivantinib to cetuximab + irinotecan (CETIRI) based on preclinical evidence that activation of th...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.30049
更新日期:2016-07-01 00:00:00
abstract::The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inve...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21436
更新日期:2006-03-01 00:00:00
abstract::The objective of this study was to assess the utility of a second generation human papillomavirus (HPV) virus-like particle (VLP)-based ELISA as an adjunct to HPV DNA testing to identify women at risk for high-grade cervical intraepithelial neoplasia (CIN). Participants provided blood, cervical samples and interviewer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22176
更新日期:2007-01-01 00:00:00
abstract::The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n-3 and n-6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three US prospective cohorts ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33190
更新日期:2021-01-01 00:00:00
abstract::The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP-high colorectal cancers (CRCs) with BRAF mutation are considered to arise from serrated pathway. We recently reported that microRNA-31 (miR-31) is associated with BRAF mutation in colorectal tumors. Emerging new approach...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28920
更新日期:2014-12-01 00:00:00
abstract::Kidney cancer often diagnosed at late stages when treatment options are severely limited. Thus, greater understanding of tumor metabolism leading ultimately to novel approaches to diagnosis is needed. Our laboratory has been utilizing metabolomics to evaluate compounds appearing in kidney cancer patients' biofluids at...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26274
更新日期:2012-06-15 00:00:00
abstract::Intratumoural (i.t.) injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma. Here, biodistribution of [(125)I]IdUrd was evaluated 5 hr after i.t. injection in subcutaneous human glioblastoma xenografts LN229 after di...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20112
更新日期:2004-05-20 00:00:00
abstract::Serum vitamin D3-binding protein (Gc protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of breast cancer patients was lost or reduced because Gc protein was deglycosylated by serum alpha-N-acetylgalactosaminidase (Nagalase) secreted from cance...
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.23107
更新日期:2008-01-15 00:00:00
abstract::Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome transfer (MMCT) to establish the functional effects of transferring normal copies of these chromosomes ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24058
更新日期:2009-03-01 00:00:00
abstract::The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450614
更新日期:1990-06-15 00:00:00
abstract::Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10(3) inter-national units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220307
更新日期:1978-09-15 00:00:00
abstract::Reactive oxygen species (ROS) are known to be involved in different pro- and anticarcinogenic mechanisms. However, their influence on the maintenance of the transformed phenotype has not been studied so far. Here we show that the anchorage-independent growth of transformed murine fibroblasts is inhibited by antioxidan...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970304)70:5<587::aid-ijc
更新日期:1997-03-04 00:00:00
abstract::Selenium is a promising chemopreventive agent for prostate cancer, possibly via an induction of apoptosis. Earlier studies have shown that selenite induces DNA single strand breaks (SSBs), reactive oxygen species (ROS), p53 Ser-15 phosphorylation and caspase-dependent and -independent apoptosis, whereas a methylseleno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22480
更新日期:2007-05-01 00:00:00
abstract::The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270616
更新日期:1981-06-15 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is an aggressive tumour of multifactorial aetiology that, although rare in most parts of the world, poses a significant mortality problem in its high incidence area of Southern China. Improved therapies are an urgent requirement and, towards this end, immunotherapeutic methods are being ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001215)88:6<949::aid-ijc18>3.0
更新日期:2000-12-15 00:00:00
abstract::Several mouse models studying the MLL fusion-induced leukemic transformation showed that a myeloproliferation stage precedes leukemia or occurred as the only phenotype of hematological disorder in mice. We established 6 MLL/AF10(OM-LZ)-immortalized cell lines by retrovirally transducing the fusion gene into bone marro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24867
更新日期:2010-04-01 00:00:00
abstract::To assess the relation between air pollution with airway irritants, including sulfuric acid and lung cancer, a case-control study was performed near an industry producing sulfuric acid and fertilizers in Kedainiai county, central Lithuania. The county had the highest lung cancer rates of the country among men. Between...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10314
更新日期:2002-05-01 00:00:00
abstract::A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210106
更新日期:1978-01-15 00:00:00