Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells.


:We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Apc(+/+)), colon epithelial cells by inducing autocrine IL-6 production and trans-IL-6 signaling. Low serum adiponectin is associated with colon, prostate and breast cancer. Adiponectin is secreted by white adipose tissue; the levels of adiponectin in the blood decrease as body mass index (and leptin) increases. In our study, we tested whether murine recombinant globular adiponectin (gArcp30) could modulate leptin-induced cell proliferation, autocrine IL-6 production, trans-IL-6 signaling and other leptin-induced cell signaling events previously observed in IMCE cells but not YAMC cells. Under serum-free conditions, adiponectin (1 mug/ml) inhibited leptin-induced autocrine IL-6 production, soluble IL-6 receptor shedding, trans-IL-6 signaling and subsequent STAT3 phosphorylation in IMCE cells. Adiponectin inhibited leptin-induced cell proliferation in the IMCE cells and this inhibition was associated with I kappa B-alpha phosphorylation, I kappa B-alpha degradation and decreased NF-kappaB p65 DNA activation and binding. These data indicate that adiponectin acts on preneoplastic colon epithelial cells to regulate cell growth via 2 distinct pathways inhibiting leptin-induced NF-kappaB-dependent autocrine IL-6 production and trans-IL-6 signaling. We hypothesize that adiponectin may be an important regulator of colon epithelial cell homeostasis by linking the observed reduced risk for cancer in populations with high serum adiponectin concentrations to specific mechanisms of cell number homeostasis in a model of preneoplastic colon epithelial cells. These data may have broad implications for diet and lifestyle strategies for the prevention and treatment of obesity-associated cancers.


Int J Cancer


Fenton JI,Birmingham JM,Hursting SD,Hord NG




Has Abstract


2008-06-01 00:00:00












  • Novel signatures of cancer-associated fibroblasts.

    abstract::Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer-associated fibroblasts, in cancer development and progression. In our study, we developed a novel, visually based method to identify new immunohistochemical signatures of these fibroblasts. The method employed a protein li...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bozóky B,Savchenko A,Csermely P,Korcsmáros T,Dúl Z,Pontén F,Székely L,Klein G

    更新日期:2013-07-15 00:00:00

  • Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck.

    abstract::Fresh-frozen biopsies were obtained from 61 patients at diagnosis of squamous cell carcinoma of the head and neck (HNSCC) for study of the prevalence and physical status of human papillomavirus (HPV) DNA. The frequency of HPV DNA and genotypes were determined by SPF10 PCR screening with a general probe hybridization a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Koskinen WJ,Chen RW,Leivo I,Mäkitie A,Bäck L,Kontio R,Suuronen R,Lindqvist C,Auvinen E,Molijn A,Quint WG,Vaheri A,Aaltonen LM

    更新日期:2003-11-10 00:00:00

  • galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas.

    abstract::Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal uroth...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cindolo L,Benvenuto G,Salvatore P,Pero R,Salvatore G,Mirone V,Prezioso D,Altieri V,Bruni CB,Chiariotti L

    更新日期:1999-02-19 00:00:00

  • Type of alcoholic beverage and cancer of the oral cavity, pharynx and oesophagus in an Italian area with high wine consumption.

    abstract::The role of different types of alcoholic beverage on cancer of the upper digestive tract was investigated in a case-control study conducted in the northern part of Italy on 305 male cases of cancer of the oral cavity and pharynx, 288 of oesophageal cancer and 1621 controls admitted to hospital for acute, non-neoplasti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Barra S,Franceschi S,Negri E,Talamini R,La Vecchia C

    更新日期:1990-12-15 00:00:00

  • Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.

    abstract::Allelic losses on the chromosome arms 1p and 19q have been associated with favorable response to chemotherapy and good prognosis in anaplastic oligodendroglioma patients, but the molecular mechanisms responsible for this relationship are as yet unknown. The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (M...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Möllemann M,Wolter M,Felsberg J,Collins VP,Reifenberger G

    更新日期:2005-01-20 00:00:00

  • Molecular basis and current strategies of therapeutic arginine depletion for cancer.

    abstract::Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Fultang L,Vardon A,De Santo C,Mussai F

    更新日期:2016-08-01 00:00:00

  • Innate lymphoid cells involve in tumorigenesis.

    abstract::Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Tian Z,van Velkinburgh JC,Wu Y,Ni B

    更新日期:2016-01-01 00:00:00

  • Murine spontaneous T-cell leukemia constitutively expressing IL-2 receptor--a model for human T-cell malignancies expressing IL-2 receptor.

    abstract::We describe a new, spontaneously occurring BALB/c-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-1+, Lyt-2+, L3T4-, CD3- class-I+, CD25+ (IL-2 receptor, IL-2R), class...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lugasi H,Hajos S,Murphy JR,Strom TB,Nichols J,Peñarroja C,Naor D

    更新日期:1990-01-15 00:00:00

  • Head and neck tumor sites differ in prevalence and spectrum of p53 alterations but these have limited prognostic value.

    abstract::The tumor site is a strong clinical factor in head and neck squamous cell carcinoma (HNSCC). To clarify the biologic and clinical role of p53 alterations in HNSCC, we have examined the prevalence and the nature of p53 alterations in a large cohort of tumors from the different sites. For immunohistochemical analysis of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bosch FX,Ritter D,Enders C,Flechtenmacher C,Abel U,Dietz A,Hergenhahn M,Weidauer H

    更新日期:2004-09-10 00:00:00

  • Targeting of heme oxygenase-1 as a novel immune regulator of neuroblastoma.

    abstract::Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fest S,Soldati R,Christiansen NM,Zenclussen ML,Kilz J,Berger E,Starke S,Lode HN,Engel C,Zenclussen AC,Christiansen H

    更新日期:2016-04-15 00:00:00

  • Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence.

    abstract::The putative tumor suppressors RASSF1A and BLU are mapped adjacent to one another on chromosome 3p21.3, a region frequently deleted in lung cancer. These genes are often inactivated by promoter hypermethylation, but the association of this inactivation with clinical features of the disease or with carcinogen exposure ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Marsit CJ,Kim DH,Liu M,Hinds PW,Wiencke JK,Nelson HH,Kelsey KT

    更新日期:2005-03-20 00:00:00

  • Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells.

    abstract::The relationship between chemosensitivity and p53 is currently considered from two mutually exclusive points of view: (1) wt p53 increases chemosensitivity due to apoptosis and (2) wt p53 decreases chemosensitivity due to growth arrest and DNA repair. We used p53-expressing adenovirus (Ad-p53) to directly evaluate eff...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Blagosklonny MV,El-Deiry WS

    更新日期:1998-03-16 00:00:00

  • High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers.

    abstract::Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dent BM,Ogle LF,O'Donnell RL,Hayes N,Malik U,Curtin NJ,Boddy AV,Plummer ER,Edmondson RJ,Reeves HL,May FE,Jamieson D

    更新日期:2016-01-01 00:00:00

  • Interleukin-6 produced by pancreatic carcinoma cells enhances humoral immune responses against tumor cells: a possible event in tumor regression.

    abstract::Production of interleukin-6 (IL-6) by human pancreatic carcinoma cells inversely correlates with potentials for blood-borne metastasis to the liver in nude mice. IL-6 cDNA was transfected to PCI-43, one of our cultured pancreatic carcinoma cell lines that does not produce IL-6 and generates numerous metastases to the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saito K,Ishikura H,Kishimoto T,Kawarada Y,Yano T,Takahashi T,Kato H,Yoshiki T

    更新日期:1998-01-19 00:00:00

  • Tumorigenicity of Epstein-Barr virus (EBV)-transformed lymphoid line cells in autologous squirrel monkeys.

    abstract::Eight squirrel monkeys (Saimiri sciureus) challenged with EBV or EBV-transformed SLCL were naturally or experimentally infected with Plasmodium knowlesi or Pl. brasilianum. Most of the animals had been splenectomized and unilaterally nephrectomized. Three of these monkeys received one dose of 6 to 12 X 10(8) autologou...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leibold W,Huldt G,Flanagan TD,Andersson M,Dalens M,Wright DH,Voller A,Klein G

    更新日期:1976-04-15 00:00:00

  • Elevated stromelysin-1 and reduced collagenase-IV expression in invasive rat embryo fibroblasts expressing E1A deletion mutants + T24-H-ras.

    abstract::We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Engel G,Popowicz P,Marshall H,Norling G,Svensson C,Auer G,Akusjärvi G,Linder S

    更新日期:1992-07-09 00:00:00

  • Racial/ethnic differences in colorectal cancer risk: the multiethnic cohort study.

    abstract::Incidence rates in the United States show clear racial/ethnic disparities for colorectal cancer. We examined the extent to which ethnic differences in risk factors could explain the age-adjusted variation in the risk of colorectal cancer, overall and by stage at diagnosis, among 165,711 African Americans, Japanese Ame...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ollberding NJ,Nomura AM,Wilkens LR,Henderson BE,Kolonel LN

    更新日期:2011-10-15 00:00:00

  • Thyroid-associated genetic polymorphisms in relation to breast cancer risk in the Malmö Diet and Cancer Study.

    abstract::Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brandt J,Borgquist S,Almgren P,Försti A,Huss L,Melander O,Manjer J

    更新日期:2018-04-01 00:00:00

  • Nanomedicine in management of hepatocellular carcinoma: Challenges and opportunities.

    abstract::Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Mohamed NK,Hamad MA,Hafez MZ,Wooley KL,Elsabahy M

    更新日期:2017-04-01 00:00:00

  • Epstein-Barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties.

    abstract::When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lai PK,Alpers MP,MacKay-Scollay EM

    更新日期:1977-07-15 00:00:00

  • Factors that influence the penetration of methotrexate through solid tissue.

    abstract::Limited penetration of anticancer drugs through tumour tissue is an important factor that may limit therapeutic effects against solid tumours. Here we report studies of the penetration of radiolabelled methotrexate through multicellular layers (MCL) of murine EMT-6 and human MCF-7 cells grown on semiporous teflon memb...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cowan DS,Tannock IF

    更新日期:2001-01-01 00:00:00

  • Differences in the post-translational modification of proteins by polyamines between weakly and highly metastatic B16 melanoma cells.

    abstract::The identification of (gamma-glutamyl)polyamines in proteolytic digest of proteins from the cytosolic and particulate fractions of B16-F10 and B16-F10Lr6 cell lines, originating from a spontaneous tumor in C57BL/6 mice, indicates that polyamines are incorporated into melanoma cell proteins by transglutaminases (TGases...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Beninati S,Abbruzzese A,Cardinali M

    更新日期:1993-03-12 00:00:00

  • Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model.

    abstract::The modifying effects of a Kunitz trypsin inhibitor (KTI) and a Bowman-Birk trypsin inhibitor (BBI), purified from soybean trypsin inhibitor, as dietary supplements on experimental and spontaneous pulmonary metastasis of murine Lewis lung carcinoma 3LL cells as well as peritoneal disseminated metastasis model in human...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kobayashi H,Fukuda Y,Yoshida R,Kanada Y,Nishiyama S,Suzuki M,Kanayama N,Terao T

    更新日期:2004-11-10 00:00:00

  • Increased expression of the transcription factors CCAAT-enhancer binding protein-beta (C/EBBeta) and C/EBzeta (CHOP) correlate with invasiveness of human colorectal cancer.

    abstract::Regulation of cell differentiation is most often impaired in malignant tumors and may represent a key mechanism for the progression of the disease. CCAAT-enhancer binding protein (C/EBP) is a family of transcription factors involved in the regulation of embryonic gut development in rodents, which has also been detecte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rask K,Thörn M,Pontén F,Kraaz W,Sundfeldt K,Hedin L,Enerbäck S

    更新日期:2000-05-01 00:00:00

  • Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo.

    abstract::In addition to the known function in the glycolytic pathway, phosphoglycerate kinase 1 (PGK-1) promotes reduction of plasmin disulfide bonds leading to angiostatin formation and inhibition of tumor angiogenesis. In this study, the effects of PGK-1 on anti- tumor immunity against lung cancer were evaluated using the Te...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tang SJ,Ho MY,Cho HC,Lin YC,Sun GH,Chi KH,Wang YS,Jhou RS,Yang W,Sun KH

    更新日期:2008-12-15 00:00:00

  • Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.

    abstract::Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Deng L,Kimmel M,Foy M,Spitz M,Wei Q,Gorlova O

    更新日期:2009-05-01 00:00:00

  • Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells.

    abstract::Folate receptor-alpha (FR-alpha) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-alpha over-expression and its role in the 5-methyltetrahydrofolic acid (N5-CH3-H4PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC), the other k...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Corona G,Giannini F,Fabris M,Toffoli G,Boiocchi M

    更新日期:1998-01-05 00:00:00

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    abstract::In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

    更新日期:2011-11-01 00:00:00

  • Risk of lung cancer among cigarette and pipe smokers in southern China.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lubin JH,Li JY,Xuan XZ,Cai SK,Luo QS,Yang LF,Wang JZ,Yang L,Blot WJ

    更新日期:1992-05-28 00:00:00

  • Meta-iodobenzylguanidine induces growth inhibition and apoptosis of neuroendocrine gastrointestinal tumor cells.

    abstract::Neuroendocrine gastrointestinal tumors take up, decarboxylate and store large amounts of monoamines. Radioactive-labeled monoamines like the norepinephrine analogue meta-iodobenzylguanidine (MIBG) have been used for the imaging of neuroendocrine tumors for many years. MIBG is selectively taken up via norepinephrine tr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Höpfner M,Sutter AP,Beck NI,Barthel B,Maaser K,Jockers-Scherübl MC,Zeitz M,Scherübl H

    更新日期:2002-09-20 00:00:00