Transcription factor co-repressors in cancer biology: roles and targeting.

abstract：:Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...

journal_title：International journal of cancer

authors： Cui Y,Whiteman MK,Flaws JA,Langenberg P,Tkaczuk KH,Bush TL

更新日期：2002-03-10 00:00:00

abstract：:The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants f...

journal_title：International journal of cancer

authors： Cooke KR,Fraser J

更新日期：1985-08-15 00:00:00

abstract：:The role of IL-33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time-dependent increase of endogenous IL-33 at both the mRNA and protein levels in primary tumors and metastatic lungs during cancer progression. Administration of IL-33 accelerated tumor growth and development...

journal_title：International journal of cancer

authors： Jovanovic IP,Pejnovic NN,Radosavljevic GD,Pantic JM,Milovanovic MZ,Arsenijevic NN,Lukic ML

更新日期：2014-04-01 00:00:00

abstract：:These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...

journal_title：International journal of cancer

authors： Tanaka E,Sendo F

更新日期：1993-04-22 00:00:00

abstract：:Screening for cancer has to be carefully organized for maximum effectiveness, and introduced in full understanding of the natural history of the disease. There are major potential harms as well as benefits from screening. The current state of art for breast, cervix and prostate cancer screening is reviewed, only for b...

journal_title：International journal of cancer

authors： Miller AB

更新日期：2010-03-01 00:00:00

abstract：:The purpose of our study was to investigate a novel therapeutic approach for rhabdomyosarcoma (RMS) in an animal model. The pursuit of new therapeutic modalities for RMS is critically important since this type of tumor is the most common soft tissue sarcoma in children and because patients with metastatic disease may ...

journal_title：International journal of cancer

authors： Kalebic T,Tsokos M,Helman LJ

更新日期：1996-11-27 00:00:00

abstract：:Colorectal cancer is the third most common form of malignancy, behind prostate and lung cancers. Despite recent advances in medicine, mortality from colorectal cancer remains high, highlighting the need for improved therapies. Numerous studies have demonstrated increased activation of EGFR and its family members (EGFR...

journal_title：International journal of cancer

authors： Nautiyal J,Banerjee S,Kanwar SS,Yu Y,Patel BB,Sarkar FH,Majumdar AP

更新日期：2011-02-15 00:00:00

abstract：:Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...

journal_title：International journal of cancer

authors： Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ

更新日期：2018-04-01 00:00:00

abstract：:Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

journal_title：International journal of cancer

authors： Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

更新日期：2012-10-15 00:00:00

abstract：:Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell polarity and proliferation control comes from studies on the Drosophila tumor suppressors discs large (Dlg), scribble (Scrib) and lethal giant larvae (lgl). Mammalian homologues of these protein...

journal_title：International journal of cancer

authors： Gardiol D,Zacchi A,Petrera F,Stanta G,Banks L

更新日期：2006-09-15 00:00:00

abstract：:We evaluated the therapeutic potential of the replication competent vector VA7-EGFP, which is based on the avirulent Semliki Forest virus (SFV) strain A7 (74) carrying the EGFP marker gene in an orthotopic lung cancer tumor model in nude mice. We have previously shown that this oncolytic vector destroys tumor cells ef...

journal_title：International journal of cancer

authors： Määttä AM,Mäkinen K,Ketola A,Liimatainen T,Yongabi FN,Vähä-Koskela M,Pirinen R,Rautsi O,Pellinen R,Hinkkanen A,Wahlfors J

更新日期：2008-10-01 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with...

journal_title：International journal of cancer

authors： Snijders PJ,Breuer RH,Sutedja TG,Egging M,Voorhorst FJ,Steenbergen RD,van der Linden HC,Risse EK,Berkhof J,de Vries EG,van der Zee AG,Postmus PE,Meijer CJ,Smit EF

更新日期：2004-04-10 00:00:00

abstract：:The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced a...

journal_title：International journal of cancer

authors： Leon DA

更新日期：1989-06-15 00:00:00

abstract：:Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...

journal_title：International journal of cancer

authors： Gudnason V,Ingvarsson S,Jonasdottir A,Andresdottir V,Egilsson V

更新日期：1984-07-15 00:00:00

abstract：:The paired-like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β-catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement of PITX2 in human tumorigenesis remains unclear. In this study, we extend its function in human esopha...

journal_title：International journal of cancer

authors： Zhang JX,Tong ZT,Yang L,Wang F,Chai HP,Zhang F,Xie MR,Zhang AL,Wu LM,Hong H,Yin L,Wang H,Wang HY,Zhao Y

更新日期：2013-06-01 00:00:00

abstract：:A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and t...

journal_title：International journal of cancer

authors： Smith SD,Rosen D

更新日期：1979-04-15 00:00:00

abstract：:Leukocyte functions (superoxide production and phagocytosis) were evaluated in patients with testicular cancer who had undergone super-high-dose chemotherapy (SHDT) with peripheral blood stem cell transplantation (PBSCT). In 5 patients with advanced or relapsed testicular cancer who received 8 cycles of SHDT with PBSC...

journal_title：International journal of cancer

authors： Yamada Y,Hara I,Gohji K,Okada H,Arakawa S,Kamidono S

更新日期：1997-07-03 00:00:00

abstract：:We previously determined that human papillomavirus (HPV) virus-like particles (VLPs) and pseudovirions (PsV) did not, respectively, bind to or infect intact epithelium of the cervicovaginal tract. However, they strongly bound heparan sulfate proteoglycans (HSPG) on the basement membrane of disrupted epithelium and inf...

journal_title：International journal of cancer

authors： Kines RC,Cerio RJ,Roberts JN,Thompson CD,de Los Pinos E,Lowy DR,Schiller JT

更新日期：2016-02-15 00:00:00

abstract：:Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...

journal_title：International journal of cancer

authors： Landgren O,Pfeiffer RM,Stewart L,Gridley G,Mellemkjaer L,Hemminki K,Goldin LR,Travis LB

更新日期：2007-03-01 00:00:00

abstract：:The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific luminometric immunoa...

journal_title：International journal of cancer

authors： Norberg T,Lennerstrand J,Inganäs M,Bergh J

更新日期：1998-08-21 00:00:00

abstract：:The importance of tumor associated neutrophils (TANs) in cancer development is in the meantime well established. Numerous of clinical data document the adverse prognostic effects of neutrophil infiltration in solid tumors. However, certain tumor therapies need functional neutrophils to be effective, suggesting altered...

journal_title：International journal of cancer

authors： Andzinski L,Kasnitz N,Stahnke S,Wu CF,Gereke M,von Köckritz-Blickwede M,Schilling B,Brandau S,Weiss S,Jablonska J

更新日期：2016-04-15 00:00:00

abstract：:Ninety-eight cases of transitional-cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type-16 and type-18 DNA by in situ hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 ex...

journal_title：International journal of cancer

authors： Furihata M,Yamasaki I,Ohtsuki Y,Sonobe H,Morioka M,Yamamoto A,Terao N,Kuwahara M,Fujisaki N

更新日期：1995-10-20 00:00:00

abstract：:Expression of sialyl Lewis(x) (sLe(x)) and sLe(a) on tumor cells is thought to facilitate metastasis by promoting cell adhesion to selectins on vascular endothelial cells. Experiments supporting this concept usually bypass the early steps of the metastatic process by employing tumor cells that are injected directly in...

journal_title：International journal of cancer

authors： Monzavi-Karbassi B,Whitehead TL,Jousheghany F,Artaud C,Hennings L,Shaaf S,Slaughter A,Korourian S,Kelly T,Blaszczyk-Thurin M,Kieber-Emmons T

更新日期：2005-11-10 00:00:00

abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

journal_title：International journal of cancer

authors： Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

更新日期：1997-05-29 00:00:00

abstract：:From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...

journal_title：International journal of cancer

authors： Tao TW,Burger MM

更新日期：1982-04-15 00:00:00

abstract：:Emerging evidence suggests that the transcription factor Forkhead Box M1 (FoxM1) is associated with aggressive human carcinomas, including breast cancer. Because elevated expression of FoxM1 has been observed in human breast cancers, FoxM1 has attracted much attention in recent years as a potential target for the prev...

journal_title：International journal of cancer

authors： Ahmad A,Ali S,Wang Z,Ali AS,Sethi S,Sakr WA,Raz A,Rahman KM

更新日期：2011-10-01 00:00:00

abstract：:We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9,...

journal_title：International journal of cancer

authors： Kawamata H,Nakashiro K,Uchida D,Harada K,Yoshida H,Sato M

更新日期：1997-01-06 00:00:00

abstract：:Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...

journal_title：International journal of cancer

authors： Mizuguchi A,Takai A,Shimizu T,Matsumoto T,Kumagai K,Miyamoto S,Seno H,Marusawa H

更新日期：2018-10-15 00:00:00

abstract：:Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...

journal_title：International journal of cancer

authors： Kuczyk M,Machtens S,Stief C,Jonas U

更新日期：1999-12-10 00:00:00