Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase.

abstract：:LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

journal_title：International journal of cancer

authors： To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

更新日期：2005-07-01 00:00:00

abstract：:Data on the incidence of 15 cancers in the Jewish population of Israel from the period 1961-1981 have been studied with emphasis on the risk of disease in relation to birthplace, calendar time, and duration of residence in Israel. The results show wide variations in incidence by birthplace, from less than 2-fold for p...

journal_title：International journal of cancer

authors： Parkin DM,Steinitz R,Khlat M,Kaldor J,Katz L,Young J

更新日期：1990-04-15 00:00:00

abstract：:In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

journal_title：International journal of cancer

authors： Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

更新日期：1999-09-24 00:00:00

abstract：:Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...

journal_title：International journal of cancer

authors： Thomson DM

更新日期：1975-06-15 00:00:00

abstract：:A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79...

journal_title：International journal of cancer

authors： Kullander J,Handisurya A,Forslund O,Geusau A,Kirnbauer R,Dillner J

更新日期：2008-01-15 00:00:00

abstract：:Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...

journal_title：International journal of cancer

authors： Platz EA,Drake CG,Wilson KM,Sutcliffe S,Kenfield SA,Mucci LA,Stampfer MJ,Willett WC,Camargo CA Jr,Giovannucci E

更新日期：2015-08-15 00:00:00

abstract：:MART-1/MelanA and Pmel17/gp100 are melanoma-associated antigens (MAAs) that can be recognized by tumor-infiltrating lymphocytes (TILs) capable of mediating successful adoptive therapy in vivo. Analysis of melanoma cell lines in vitro has demonstrated that heterogeneous antigen expression in the context of class I MHC ...

journal_title：International journal of cancer

authors： Cormier JN,Hijazi YM,Abati A,Fetsch P,Bettinotti M,Steinberg SM,Rosenberg SA,Marincola FM

更新日期：1998-02-09 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy with high acquisition costs, and it has raised concerns about affordability and sustainability in many countries. Furthermore, the current centralized production paradigm for the T cells is less than satisfactory. Therefore, several countries ...

journal_title：International journal of cancer

authors： Ran T,Eichmüller SB,Schmidt P,Schlander M

更新日期：2020-12-15 00:00:00

abstract：:Breast cancer is one of the most common and feared cancers faced by women. The prognosis of patients with advanced or recurrent breast cancer remains poor despite refinements in multimodality therapies involving chemotherapeutic and hormonal agents. Multimodal therapy with more specific and effective strategy is urgen...

journal_title：International journal of cancer

authors： Tan G,Kasuya H,Sahin TT,Yamamura K,Wu Z,Koide Y,Hotta Y,Shikano T,Yamada S,Kanzaki A,Fujii T,Sugimoto H,Nomoto S,Nishikawa Y,Tanaka M,Tsurumaru N,Kuwahara T,Fukuda S,Ichinose T,Kikumori T,Takeda S,Nakao A,Kode

更新日期：2015-04-01 00:00:00

abstract：:The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...

journal_title：International journal of cancer

authors： Haranaka K,Satomi N,Sakurai A

更新日期：1984-08-15 00:00:00

abstract：:To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Can...

journal_title：International journal of cancer

authors： Saberi Hosnijeh F,Casabonne D,Nieters A,Solans M,Naudin S,Ferrari P,Mckay JD,Benavente Y,Weiderpass E,Freisling H,Severi G,Boutron Ruault MC,Besson C,Agnoli C,Masala G,Sacerdote C,Tumino R,Huerta JM,Amiano P,Rodrigu

更新日期：2020-10-31 00:00:00

abstract：:Genomic instability plays a key role in hereditary nonpolyposis colorectal cancer and in a significant sub-set of non-hereditary colorectal tumors. Recent evidence suggests that microsatellite instability also occurs in various sub-sets of common, non-hereditary forms of extra-colorectal carcinoma. To investigate the ...

journal_title：International journal of cancer

authors： Contegiacomo A,Palmirotta R,De Marchis L,Pizzi C,Mastranzo P,Delrio P,Petrella G,Figliolini M,Bianco AR,Frati L

更新日期：1995-08-22 00:00:00

abstract：:Cancer Procoagulant (CP), a cysteine proteinase which triggers blood coagulation by directly activating Factor X (FX) in the absence of Factor VII (F VII), has recently been isolated from rabbit V2 carcinoma and biochemically characterized. We have studied the procoagulant activity of tissue extracts from 4 murine exp...

journal_title：International journal of cancer

authors： Falanga A,Bolognese Dalessandro AP,Casali B,Roncaglioni MC,Donati MB

更新日期：1987-06-15 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...

journal_title：International journal of cancer

authors： Biran A,Brownstein M,Haklai R,Kloog Y

更新日期：2011-02-01 00:00:00

abstract：:To examine the immunological mechanisms involved in cancer gene therapy using the herpes simplex virus thymidine kinase (HSV-tk) gene and ganciclovir (GCV), murine hepatocellular carcinoma (HCC) cells, BNL1ME A.7R.1, were transduced retrovirally with the HSV-tk gene. HSV-tk-transduced cells exhibited a more than 2,000...

journal_title：International journal of cancer

authors： Kuriyama S,Kikukawa M,Masui K,Okuda H,Nakatani T,Akahane T,Mitoro A,Tominaga K,Tsujinoue H,Yoshiji H,Okamoto S,Fukui H,Ikenaka K

更新日期：1999-10-29 00:00:00

abstract：:Somatic mutations in the E-cadherin (CDH1) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate ca...

journal_title：International journal of cancer

authors： Jonsson BA,Bergh A,Stattin P,Emmanuelsson M,Grönberg H

更新日期：2002-04-20 00:00:00

abstract：:We recently reported that standardized quantitative immunohistochemical (IHC) assays allowed prediction of an adverse outcome among 572 node negative (N-) patients with breast carcinoma (BrCa). To further validate our prior findings, we repeated the IHC stains including a second series of BrCa diagnosed at Yale Univer...

journal_title：International journal of cancer

authors： Charpin C,Tavassoli F,Secq V,Giusiano S,Villeret J,Garcia S,Birnbaum D,Bonnier P,Lavaut MN,Boubli L,Carcopino X,Iovanna J

更新日期：2012-08-01 00:00:00

abstract：:The presented results show the effect of targeting of collagen receptor, alpha1beta1 integrin expressed on the endothelial cells on the development of experimental melanoma and pathological angiogenesis. Obtustatin, a snake venom KTS-disintegrin, was applied as a specific inhibitor of this integrin. This low molecular...

journal_title：International journal of cancer

authors： Brown MC,Staniszewska I,Del Valle L,Tuszynski GP,Marcinkiewicz C

更新日期：2008-11-01 00:00:00

abstract：:Breast cancer (BC) and diabetes mellitus (DM) are major health problems. We examined the association between DM and BC stage at diagnosis and subsequent survival in a Finnish cohort of female BC patients. All BC cases (N = 73,170) diagnosed in 1995-2013 with dates and causes of death were identified from the Finnish C...

journal_title：International journal of cancer

authors： Murto MO,Artama M,Pukkala E,Visvanathan K,Murtola TJ

更新日期：2018-06-01 00:00:00

abstract：:The population of Leningrad suffered from severe starvation, cold and psychological stress during the siege in World War II in 1941-1944. We investigated the long-term effects of the siege on cancer mortality in 3,901 men and 1,429 women, born between 1910 and 1940. All study subjects were residents of St. Petersburg,...

journal_title：International journal of cancer

authors： Koupil I,Plavinskaja S,Parfenova N,Shestov DB,Danziger PD,Vågerö D

更新日期：2009-03-15 00:00:00

abstract：:Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....

journal_title：International journal of cancer

authors： Huovinen R,Wärri A,Collan Y

更新日期：1993-10-21 00:00:00

abstract：:A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and t...

journal_title：International journal of cancer

authors： Smith SD,Rosen D

更新日期：1979-04-15 00:00:00

abstract：:Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

journal_title：International journal of cancer

authors： Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

更新日期：2007-10-15 00:00:00

abstract：:Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell polarity and proliferation control comes from studies on the Drosophila tumor suppressors discs large (Dlg), scribble (Scrib) and lethal giant larvae (lgl). Mammalian homologues of these protein...

journal_title：International journal of cancer

authors： Gardiol D,Zacchi A,Petrera F,Stanta G,Banks L

更新日期：2006-09-15 00:00:00

abstract：:Although reproductive factors have been shown to be related to the composition of bile and functioning of the biliary system, their relationship with biliary tract cancer has not been studied in detail. Between 1984 and 1987 we conducted a case-control study of 75 women with cancer of the biliary tract and 252 control...

journal_title：International journal of cancer

authors： Moerman CJ,Berns MP,Bueno de Mesquita HB,Runia S

更新日期：1994-04-15 00:00:00

abstract：:Progress against cancer through prevention and treatment is often measured by survival statistics only instead of analyzing trends in incidence, survival and mortality simultaneously because of interactive influences. This study combines these parameters of major cancers to provide an overview of the progress achieved...

journal_title：International journal of cancer

authors： Karim-Kos HE,Kiemeney LA,Louwman MW,Coebergh JW,de Vries E

更新日期：2012-06-15 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC), and is involved in the invasive characteristics of OSCC, such as growth, antiapoptotic activity and protease production. However, the cellular mechanism underlying NF-κB's promotion of bone invasion by...

journal_title：International journal of cancer

authors： Furuta H,Osawa K,Shin M,Ishikawa A,Matsuo K,Khan M,Aoki K,Ohya K,Okamoto M,Tominaga K,Takahashi T,Nakanishi O,Jimi E

更新日期：2012-09-01 00:00:00

abstract：:The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inve...

journal_title：International journal of cancer

authors： McGrath M,Lee IM,Hankinson SE,Kraft P,Hunter DJ,Buring J,De Vivo I

更新日期：2006-03-01 00:00:00

abstract：:We describe the selection of 3 new multidrug-resistant cell lines derived from tumor cells of different metastatic phenotypes within the Dunning R3327 model of rat prostatic carcinoma. Cell lines of weak (AT2) and strong (AT3 and MAT-LyLu) metastatic behavior were cultured in vitro and challenged with doxorubicin at p...

journal_title：International journal of cancer

authors： Bashir I,Sikora K,Abel P,Foster CS

更新日期：1994-06-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity, representing 90% of all oral carcinomas and accounting for 3-5% of all malignancies. The WWOX gene (WW-domain containing oxidoreductase) is a candidate tumor suppressor gene located at 16q23.3-24.1, spanning the second most c...

journal_title：International journal of cancer

authors： Pimenta FJ,Gomes DA,Perdigão PF,Barbosa AA,Romano-Silva MA,Gomez MV,Aldaz CM,De Marco L,Gomez RS

更新日期：2006-03-01 00:00:00