Abstract:
:A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and the cell line were remarkably similar. The growth characteristics, chromosome pattern, cell-surface receptors and Epstein-Barr pattern, cell-surface receptors and Epstein-Barr virus studies clearly differentiated this cell line from non-malignant lymphoblastoid cell lines. The assay technique used was able to correlate in vitro colony growth with the patient's clinical course. The cells grew on the agar as colonies rather than as a single-cell suspension, and individual colonies could be aspirated and successfully passaged. The K-LL-3 cells lacked cell-surface markers (cytoplasmic and surface immunoglobulins, Fc receptors, C3 receptors, SRBC) except HL-A and thus were classified as null cells. These cells were EBNA (Epstein-Barr virus-specific nuclear antigen) negative and had a pseudodiploid 46XY karyotype.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Smith SD,Rosen Ddoi
10.1002/ijc.2910230409subject
Has Abstractpub_date
1979-04-15 00:00:00pages
494-503issue
4eissn
0020-7136issn
1097-0215journal_volume
23pub_type
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2019-08-15 00:00:00
abstract::We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to differe...
journal_title:International journal of cancer
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abstract::Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
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更新日期:2005-02-20 00:00:00
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journal_title:International journal of cancer
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更新日期:2010-04-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
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更新日期:1996-07-17 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2009-07-01 00:00:00
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journal_title:International journal of cancer
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更新日期:2008-03-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24320
更新日期:2009-07-01 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.22574
更新日期:2007-06-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10463
更新日期:2002-07-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30227
更新日期:2016-10-15 00:00:00
abstract::A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epitheli...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2005-10-20 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2007-01-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2018-11-15 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1996-06-21 00:00:00
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journal_title:International journal of cancer
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更新日期:2012-10-01 00:00:00
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更新日期:2006-12-01 00:00:00