Abstract:
:To determine whether variations in DNA repair genes are related to host DNA damage, we investigated the association between polymorphism in the XPD gene (codon 199, 312, 751) and the XRCC1 gene (codon 194, 399) and the presence of benzo(a)pyrene diolepoxide adducts to lymphocyte DNA (BPDE-DNA) in a group of male patients with incident lung cancer, all current smokers. BPDE-DNA adducts were analyzed by high-resolution gas chromatography-negative ion chemical ionization-mass spectrometry. XPD and XRCC1 genotypes were identified by PCR-RFLP. XRCC1 and XPD genotypes did not affect the levels and proportion of detectable BPDE-DNA adducts. The patients were also genotyped for the GSTM1 polymorphism, given its role in the detoxification of BPDE. Individuals with the GSTM1 deletion had significantly higher levels of BPDE-DNA adducts when they were XPD-Asp312Asp+Lys751Lys than carriers of at least one variant allele. No such association was found with the XRCC1 genotypes. Because of the small study population (n = 60), further statistical analysis of possible gene-gene and gene-environment would not be informative. This is the first study analysing the specific BPDE-DNA adduct in vivo with regard to polymorphic repair genes (XPD, XRCC1) and xenobiotic metabolizing gene (GSTM1). Our results raise the possibility that the XPD-Asp312Asp+Lys751Lys genotype may increase BPDE-DNA damage; this effect might be evident in individuals who are especially likely to have accumulated damage, probably because of lower detoxification capacity and high environmental exposure.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Pastorelli R,Cerri A,Mezzetti M,Consonni E,Airoldi Ldoi
10.1002/ijc.10463keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
9-13issue
1eissn
0020-7136issn
1097-0215journal_volume
100pub_type
杂志文章abstract::Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.21933
更新日期:2006-08-15 00:00:00
abstract::An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metabolic activation in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1517
更新日期:2001-12-01 00:00:00
abstract::5-Fluorouracil (5-FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5-FU is considered the major obstacle for successful chemotherapy. NF-kappaB is a transcription factor. Cancer cells with high NF-kappaB nuclear activity demonstrate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10972
更新日期:2003-04-20 00:00:00
abstract::Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 microm UCF1-C immediately and reversibly inhibited growth in these cells, without modifyin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980518)76:4<601::aid-ijc
更新日期:1998-05-18 00:00:00
abstract::Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560608
更新日期:1994-03-15 00:00:00
abstract::The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25342
更新日期:2011-01-15 00:00:00
abstract::Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31937
更新日期:2019-04-15 00:00:00
abstract::Rabbit V2 carcinoma cells and normal rabbit skin fibroblasts produced cysteine proteinases with properties similar to those of purified rabbit liver cathepsin B. Both cell types secreted into the culture medium enzymes with an apparent Mr of 43,000, which reacted with synthetic substrates commonly used for cathepsin B...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380520
更新日期:1986-11-15 00:00:00
abstract::Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20502
更新日期:2005-01-01 00:00:00
abstract::Sister chromatid exchange (SCE) is a genetic indicator of DNA damage in mammalian cells and may afford a sensitive monitor to follow genomic instability of some individuals with fragile chromosomal diseases or malignancies. In studies on the effect of dinitrosopiperazine (DNP), aflatoxin B1 (AFB1), methyl-nitro-nitros...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430413
更新日期:1989-04-15 00:00:00
abstract::We previously reported that DX-8951f, a novel water-soluble camptothecin analog, significantly inhibits the growth of various human and murine tumors in vitro and in vivo. The antitumor effects and topoisomerase I inhibitory activity of DX-8951f are stronger than those of other current camptothecin analogs. In this st...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970807)72:4<680::aid-ijc
更新日期:1997-08-07 00:00:00
abstract::In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous forma...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29888
更新日期:2016-05-15 00:00:00
abstract::Treatment of mouse Lewis lung carcinoma with razoxane or dacarbazine was protracted for 10 transplant generations. While the capacity of the treated tumors to grow locally in immuno-competent or in immuno-depressed hosts was retained and not significantly modified, the metastatic phenotype was eliminated when the trea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970917)72:6<1056::aid-ij
更新日期:1997-09-17 00:00:00
abstract::Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30017
更新日期:2016-06-15 00:00:00
abstract::Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33230
更新日期:2021-02-01 00:00:00
abstract::An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative ris...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11466
更新日期:2003-12-10 00:00:00
abstract::Cell cycle regulation is dependent on multiple cellular and molecular events. Cell proliferation requires metabolic sources for the duplication of DNA and cell size. However, nucleotide reservoirs are not sufficient to support cell duplication and, therefore, biosynthetic pathways should be upregulated during cell cyc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24262
更新日期:2009-06-15 00:00:00
abstract::Up to 2016, low- and middle-income countries mostly introduced routine human papillomavirus (HPV) vaccination for just a single age-cohort of girls each year. However, high-income countries have reported large reductions in HPV prevalence following "catch-up" vaccination of multiple age-cohorts in the year of HPV vacc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.31321
更新日期:2018-07-15 00:00:00
abstract::There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19981029)78:3<293::AID-IJC
更新日期:1998-10-29 00:00:00
abstract::The family of protein kinases includes many oncogenes and growth-factor receptors, as well as genes that are involved in cell-cycle regulation. We have identified protein kinases expressed in a human breast-cancer cell line, 600PEI, and a primary human breast carcinoma, using PCR cloning techniques based on consensus ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540409
更新日期:1993-06-19 00:00:00
abstract::The population of Leningrad suffered from severe starvation, cold and psychological stress during the siege in World War II in 1941-1944. We investigated the long-term effects of the siege on cancer mortality in 3,901 men and 1,429 women, born between 1910 and 1940. All study subjects were residents of St. Petersburg,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24093
更新日期:2009-03-15 00:00:00
abstract::Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.26352
更新日期:2012-07-01 00:00:00
abstract::A multi-national, hospital-based, case-control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral c...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1989-02-15 00:00:00
abstract::Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23922
更新日期:2009-01-15 00:00:00
abstract::We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (0.01-1 microg/ml) r...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971104)73:3<416::aid-ijc
更新日期:1997-11-04 00:00:00
abstract::Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310518
更新日期:1983-05-15 00:00:00
abstract::2-methoxyestradiol (2ME(2)) is an endogenous metabolite of estradiol with estrogen-receptor-independent antitumor and antiangiogenic activity. We examined the effects of 2ME(2) on the cellular proliferation of 8 human melanoma cell lines. We show that 2ME(2) inhibited cell proliferation by inducing apoptosis and an ar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20473
更新日期:2004-12-10 00:00:00
abstract::Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In approximately 85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are the most common soft-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23412
更新日期:2008-06-01 00:00:00
abstract::The aim of this study was to examine the cellular distribution of osteopontin (OPN) protein [by immunohistochemical (IHC) analysis] and mRNA [by in situ hybridization (ISH)] in the primary tumors of lymph node negative (LNN) breast cancer patients and to determine whether the level of immunodetectable OPN may be assoc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981023)79:5<502::aid-ijc
更新日期:1998-10-23 00:00:00
abstract::N-Nitroso compounds (NOCs) have been proposed as possible bladder carcinogens. The main sources of exogenous exposure to NOCs are cigarette smoke and diet, particularly processed (i.e., nitrite-treated) meats. Perhaps more importantly, NOCs can be formed endogenously from dietary precursors such as nitrate, nitrite an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28331
更新日期:2014-01-01 00:00:00