Abstract：
:A multi-national, hospital-based, case-control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral contraceptives was estimated to be 0.71 (95% CI 0.4-1.2). No consistent trend in risk with months of use or time since first or last use was observed. Separate analyses also revealed no association between use of combined oral contraceptives and hepatocellular carcinoma (RR = 0.60) or cholangiocarcinoma (RR = 1.22). Most women in this study came from areas in which hepatitis B is endemic and rates of liver cancer are relatively high, and in most cases use of oral contraceptives was of short duration. These results provide no evidence that short-term use of oral contraceptives enhances risk of liver cancer in countries where the determinants of this disease are similar to those observed in the countries where this study was conducted.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
subject
Has Abstractpub_date
1989-02-15 00:00:00pages
254-9issue
2eissn
0020-7136issn
1097-0215journal_volume
43pub_type
临床试验,杂志文章,多中心研究abstract：:Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 pla...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.25489
更新日期：2010-10-15 00:00:00
abstract：:Using individual subject data from 10 case-control studies, comprising over 3000 cases and almost 4000 controls, we have estimated the relative risk of melanoma associated with aspects of complexion, namely, hair, eye and skin colour and freckling in adulthood, and have examined the relationships between these factors...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910620402
更新日期：1995-08-09 00:00:00
abstract：:Chemotherapy-induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict an individual patient's risk of CIGT. It is believed the gut microbiome...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.31836
更新日期：2019-05-15 00:00:00
abstract：:Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-c...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28852
更新日期：2014-11-01 00:00:00
abstract：:In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22498
更新日期：2007-04-01 00:00:00
abstract：:WAVE3, an actin cytoskeleton remodeling protein, is highly expressed in advanced stages of breast cancer and influences tumor cell invasion. Loss of miR-31 has been associated with cancer progression and metastasis. Here, we show that the activity of WAVE3 to promote cancer cell invasion is regulated by miR-31. An inv...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25793
更新日期：2011-09-15 00:00:00
abstract：:It is unclear which chromosome arms frequently show loss of heterozygosity (LOH) in adenocarcinoma of the uterine cervix. To identify such chromosomal arms, LOH on 52 different chromosome loci was examined using laser capture microdissection and PCR-LOH analysis in 25 common-type adenocarcinomas, comprising 13 cases o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10228
更新日期：2002-04-10 00:00:00
abstract：:Expression of the monocyte chemoattractant protein-1 (MCP-1) was examined in human central nervous system tumours (glioblastomas and astrocytomas) and normal human brain. Northern blot analysis demonstrated constitutive expression of MCP-1 mRNA in 6 of 12 glioblastoma cell lines. Expression could be stimulated by inte...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910580216
更新日期：1994-07-15 00:00:00
abstract：:Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910340111
更新日期：1984-07-15 00:00:00
abstract：:Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990719)82:2<187::aid-ijc
更新日期：1999-07-19 00:00:00
abstract：:We evaluated the efficacy of a candidate melanoma vaccine approach in mice genetically prone to develop melanoma due to the introduction of an oncogenic mutation (R24C) in the germline sequence of the cyclin-dependent kinase 4 (cdk4), a protein critically involved in cell cycle regulation. Melanomas were induced in cd...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21349
更新日期：2006-01-15 00:00:00
abstract：:Complement-dependent cytotoxicity against melanoma cells was demonstrated with a microassay in sera from melanoma patients. The response was tumor-specific and histologic type-specific since 16 out of 52 (30%) melanoma patient sera taken before surgery reacted against melanoma cells, whereas 3 out of 43 (7%) control s...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910160504
更新日期：1975-11-15 00:00:00
abstract：:Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...
journal_title：International journal of cancer
pub_type： 撤回出版物
doi：10.1002/ijc.32281
更新日期：2019-08-15 00:00:00
abstract：:Expression of sialyl Lewis(x) (sLe(x)) and sLe(a) on tumor cells is thought to facilitate metastasis by promoting cell adhesion to selectins on vascular endothelial cells. Experiments supporting this concept usually bypass the early steps of the metastatic process by employing tumor cells that are injected directly in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21192
更新日期：2005-11-10 00:00:00
abstract：:Sister chromatid exchange (SCE) is a genetic indicator of DNA damage in mammalian cells and may afford a sensitive monitor to follow genomic instability of some individuals with fragile chromosomal diseases or malignancies. In studies on the effect of dinitrosopiperazine (DNP), aflatoxin B1 (AFB1), methyl-nitro-nitros...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910430413
更新日期：1989-04-15 00:00:00
abstract：:Recent clinical trials have indicated that addition of tamoxifen (TAM) to a combination of cisplatin (DDP), carmustine and dacarbazine markedly increases the overall objective response rate of patients with metastatic malignant melanoma. Previous studies have determined that there is remarkable synergy between TAM and...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910550623
更新日期：1993-12-02 00:00:00
abstract：:In this study we investigated the effect of Tax on nucleotide excision repair (NER) in human T-cell lines by using the host cell repair analysis of UVC-irradiated reporter plasmid. This analysis revealed a p53-dependent NER activity in wild type (w.t.) p53-containing T-cells and p53-independent NER in w.t. p53-lacking...
journal_title：International journal of cancer
pub_type： 杂志文章,收录出版
doi：10.1002/ijc.23091
更新日期：2008-01-15 00:00:00
abstract：:Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepa...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910230204
更新日期：1979-02-01 00:00:00
abstract：:Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910350207
更新日期：1985-02-15 00:00:00
abstract：:Current literature on cancer epidemiology typically discusses etiology of cancer by cancer type. Risks of different cancer types are, however, correlated at population level and may provide etiological clues. We showed previously an unexpected very high positive correlation between breast cancer (BC) and young-adult H...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23595
更新日期：2008-09-01 00:00:00
abstract：:Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. The efficacy of its antitumor activity largely depends on the level of intracellular ASS, whi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22322
更新日期：2007-02-15 00:00:00
abstract：:In a series of 135 patients with renal-cell carcinomas (followed up for a mean of 9.5 years), a variety of clinical and histological factors were analyzed in relation to morphometric measurements of the nuclear parameters in the primary tumours to establish their value as prognostic factors. Clinical, histological and...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910550405
更新日期：1993-10-21 00:00:00
abstract：:Lymphoma EL-4 of B6 origin was inoculated into lethally-irradiated syngeneic B6 or resistant BD2F1 hybrid recipients. Marked impairment of lymphoma cell proliferation (i.e. hybrid resistance, HR) occurred in the spleen but not in the liver or lung of BD2F1 hosts. Treatment with DTIC at the optimal dose of 80 mg/kg i.p...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910280416
更新日期：1981-10-15 00:00:00
abstract：:Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(20000601)86:5<741::aid-ijc
更新日期：2000-06-01 00:00:00
abstract：:Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome transfer (MMCT) to establish the functional effects of transferring normal copies of these chromosomes ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24058
更新日期：2009-03-01 00:00:00
abstract：:Loss of heterozygosity (LOH) at the site of the retinoblastoma (RB1) gene, at 13q14, has been shown to occur in a high proportion of ovarian cancer patients. Based on this, RB1 gene inactivation was studied in primary tumor cells from 15 patients with ovarian cancer. Structural changes as well as expression of the RB1...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910580508
更新日期：1994-09-01 00:00:00
abstract：:The recently described PGM-2 leukemia displays a hierarchical structure with bipotential stem cells, B-lymphocyte and macrophage progenitor cells, and post-mitotic end cells. Because the different cell types can easily be identified in vitro by clonal culture assays and simple staining procedures, this leukemia is a u...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910600515
更新日期：1995-03-03 00:00:00
abstract：:The case-fatality rate following a diagnosis of prostate cancer is higher for Black men compared to White men. How this elevated rate arises is uncertain, with differences in disease biology, presentation, treatment and comorbidity having been suggested. A systematic search was conducted for articles that reported eth...
journal_title：International journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1002/ijc.23500
更新日期：2008-07-15 00:00:00
abstract：:The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contrib...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.21899
更新日期：2006-10-15 00:00:00
abstract：:The involvement of 12-lipoxygenase (12-LOX) expression and function in tumor metastasis has been demonstrated in several murine tumor cell lines. In addition, 12-LOX expression was detected in human prostatic tumors and correlated to the clinical stage of disease. Here we provide data that human prostate cancer cell l...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(20000701)87:1<37::aid-ijc6>3.0.c
更新日期：2000-07-01 00:00:00
