Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.

abstract：:A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...

journal_title：International journal of cancer

authors： Bertschmann M,Käsermann D,Keller R

更新日期：1990-10-15 00:00:00

abstract：:The molecular mechanisms underlying the genesis and progression of oligodendroglial tumors are poorly understood, since only restricted information on loss of heterozygosity from isolated cases is available. The commonest alterations appear to involve deletion of 1p and 19q, while loss of heterozygosity for 9p, chromo...

journal_title：International journal of cancer

authors： Bello MJ,Leone PE,Vaquero J,de Campos JM,Kusak ME,Sarasa JL,Pestaña A,Rey JA

更新日期：1995-06-22 00:00:00

abstract：:Moderate to high-dose radiotherapy is known to increase the risk of breast cancer. Uncertainties remain about the effects of low-dose chest X-rays, particularly in individuals at increased genetic risk. We analyzed case-control data from the Breast Cancer Family Registry. Self-reported data on therapeutic and diagnost...

journal_title：International journal of cancer

authors： John EM,Phipps AI,Knight JA,Milne RL,Dite GS,Hopper JL,Andrulis IL,Southey M,Giles GG,West DW,Whittemore AS

更新日期：2007-07-15 00:00:00

abstract：:It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents...

journal_title：International journal of cancer

authors： Vestergaard H,Westergaard T,Wohlfahrt J,Hjalgrim H,Melbye M

更新日期：2010-08-01 00:00:00

abstract：:By serologic identification of antigens by recombinant expression cloning (SEREX) analysis using an autologous lung adenocarcinoma cell line, OU-LU-6, as a cDNA library source, we demonstrated that XAGE-1 was the dominant antigen recognized by serum from a patient. By immunoscreening, we obtained 38 positive cDNA clon...

journal_title：International journal of cancer

authors： Ali Eldib AM,Ono T,Shimono M,Kaneko M,Nakagawa K,Tanaka R,Noguchi Y,Nakayama E

更新日期：2004-02-10 00:00:00

abstract：:Invasiveness is one of the key features of aggressive prostate cancer; however, our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors, causes an aggressive and invasive phenotype through downstream eff...

journal_title：International journal of cancer

authors： Beckham TH,Lu P,Cheng JC,Zhao D,Turner LS,Zhang X,Hoffman S,Armeson KE,Liu A,Marrison T,Hannun YA,Liu X

更新日期：2012-11-01 00:00:00

abstract：:Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

journal_title：International journal of cancer

authors： Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

更新日期：1999-04-12 00:00:00

abstract：:Hycanthone was administered to Schistosoma mansoni-infected and non-infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose. No tumors attributable to treatment were observed in hamsters. In infected mice, the overall incidence of hepato...

journal_title：International journal of cancer

authors： Bulay O,Urman H,Patil K,Clayson DB,Shubik P

更新日期：1979-01-15 00:00:00

abstract：:There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...

journal_title：International journal of cancer

authors： Solans M,Benavente Y,Saez M,Agudo A,Naudin S,Hosnijeh FS,Noh H,Freisling H,Ferrari P,Besson C,Mahamat-Saleh Y,Boutron-Ruault MC,Kühn T,Kaaks R,Boeing H,Lasheras C,Rodríguez-Barranco M,Amiano P,Huerta JM,Barricarte A

更新日期：2019-07-01 00:00:00

abstract：:MUC18/MCAM is a cell-surface glycoprotein that is strongly expressed on advanced human melanomas. Transfection of 3 MCAM-negative melanoma cell lines with MCAM cDNA led to cell-surface expression and to a MCAM-dependent homotypic adhesion. This adhesion was independent of divalent cations and was inhibited at 4 degree...

journal_title：International journal of cancer

authors： Johnson JP,Bar-Eli M,Jansen B,Markhof E

更新日期：1997-11-27 00:00:00

abstract：:Apc gene-deficient Min and Apc(1309) mice feature a hyperlipidemic state with a markedly low expression level of lipoprotein lipase (LPL) compared to their wild-type counterparts. We previously showed that induction of LPL mRNA by peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonists or an LPL sel...

journal_title：International journal of cancer

authors： Niho N,Mutoh M,Komiya M,Ohta T,Sugimura T,Wakabayashi K

更新日期：2007-10-15 00:00:00

abstract：:Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the ...

journal_title：International journal of cancer

authors： Fest S,Soldati R,Christiansen NM,Zenclussen ML,Kilz J,Berger E,Starke S,Lode HN,Engel C,Zenclussen AC,Christiansen H

更新日期：2016-04-15 00:00:00

abstract：:Nickel-2,3,7,8,12,13,17,18-octaacetic acid-5,10,15,20-tetra-[3-carboranyl-methoxyphenyl]-porphyrin octamethylester (NiTCP) was given in a Cremophor EL, a polyethoxylated castor oil, and propylene glycol emulsion to BALB/c mice bearing transplanted s.c. KHJJ mammary carcinomas. A total dose of 244 microg NiTCP/gram bod...

journal_title：International journal of cancer

authors： Miura M,Micca PL,Fisher CD,Heinrichs JC,Donaldson JA,Finkel GC,Slatkin DN

更新日期：1996-09-27 00:00:00

abstract：:In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases,...

journal_title：International journal of cancer

authors： van der Beek JN,Hol JA,Coulomb-l'Hermine A,Graf N,van Tinteren H,Pritchard-Jones K,Houwing ME,de Krijger RR,Vujanic GM,Dzhuma K,Schenk JP,Littooij AS,Ramírez-Villar GL,Murphy D,Ray S,Al-Saadi R,Gessler M,Godzinski J,R

更新日期：2021-01-18 00:00:00

abstract：:An important method for silencing tumor suppressor genes in cancers is by aberrant methylation (referred to as methylation) of CpG islands in gene promoter regions. In lung cancer, methylation of the genes retinoic acid receptor beta-2 (RARbeta-2), CDH13 (H-cadherin), p16(INK4a) (p16), RASSF1A (RAS association domain ...

journal_title：International journal of cancer

authors： Zöchbauer-Müller S,Lam S,Toyooka S,Virmani AK,Toyooka KO,Seidl S,Minna JD,Gazdar AF

更新日期：2003-11-20 00:00:00

abstract：:The relation between physical activity and renal cell cancer is unclear. High occupational physical activity has been associated with a decreased risk of renal cell cancer among men-but not among women-in two previous studies, while no association has been found for leisure time physical activity. Our aim was to inves...

journal_title：International journal of cancer

authors： Bergström A,Terry P,Lindblad P,Lichtenstein P,Ahlbom A,Feychting M,Wolk A

更新日期：2001-04-01 00:00:00

abstract：:Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer-associated fibroblasts, in cancer development and progression. In our study, we developed a novel, visually based method to identify new immunohistochemical signatures of these fibroblasts. The method employed a protein li...

journal_title：International journal of cancer

authors： Bozóky B,Savchenko A,Csermely P,Korcsmáros T,Dúl Z,Pontén F,Székely L,Klein G

更新日期：2013-07-15 00:00:00

abstract：:Retinoic acid (RA) and its natural and synthetic analogs, the retinoids, regulate many biological processes, including development, differentiation, cell growth, morphogenesis, metabolism and homeostasis. Retinoid effects are mediated by specific nuclear receptors, the RARs and RXRs. Because of their ability to contro...

journal_title：International journal of cancer

authors： Lu XP,Fanjul A,Picard N,Shroot B,Pfahl M

更新日期：1999-01-18 00:00:00

abstract：:A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...

journal_title：International journal of cancer

authors： Giannoudis A,Graham DA,Southern SA,Herrington CS

更新日期：1999-09-24 00:00:00

abstract：:Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...

journal_title：International journal of cancer

authors： Vineis P,Thomas T,Hayes RB,Blot WJ,Mason TJ,Pickle LW,Correa P,Fontham ET,Schoenberg J

更新日期：1988-12-15 00:00:00

abstract：:ARID1A has been identified as a novel tumor suppressor gene in ovarian cancer and subsequently in various other tumor types. ARID1A belongs to the ARID domain containing gene family, which comprises of 15 genes involved, for example, in transcriptional regulation, proliferation and chromatin remodeling. In this study,...

journal_title：International journal of cancer

authors： Cajuso T,Hänninen UA,Kondelin J,Gylfe AE,Tanskanen T,Katainen R,Pitkänen E,Ristolainen H,Kaasinen E,Taipale M,Taipale J,Böhm J,Renkonen-Sinisalo L,Mecklin JP,Järvinen H,Tuupanen S,Kilpivaara O,Vahteristo P

更新日期：2014-08-01 00:00:00

abstract：:The relationship of a basement membrane collagen degrading enzyme (BM collagenase) and plasminogen activator (PA) was studied in a number of non-malignant and malignant human and murine cell lines. Several non-malignant cell lines secreted significant amounts of PA but not detectable BM collagenase activity whereas th...

journal_title：International journal of cancer

authors： Salo T,Liotta LA,Keski-Oja J,Turpeenniemi-Hujanen T,Tryggvason K

更新日期：1982-11-15 00:00:00

abstract：:Isolated limb perfusion (ILP) with melphalan and tumor necrosis factor (TNF)-α is used to treat bulky, locally advanced melanoma and sarcoma. However, TNF toxicity suggests a need for better-tolerated drugs. Cilengitide (EMD 121974), a novel cyclic inhibitor of alpha-V integrins, has both anti-angiogenic and direct an...

journal_title：International journal of cancer

authors： Ten Hagen TL,Seynhaeve AL,de Wiel-Ambagtsheer Ga,de Bruijn EA,van Tiel ST,Ruegg C,Meyring M,Grell M,Goodman SL,Eggermont AM

更新日期：2013-06-01 00:00:00

abstract：:The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...

journal_title：International journal of cancer

authors： Caca K,Feisthammel J,Klee K,Tannapfel A,Witzigmann H,Wittekind C,Mössner J,Berr F

更新日期：2002-02-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, seem to have chemopreventive properties against several types of cancer, particularly colon cancer. Persons with rheumatoid arthritis, an autoimmune disease for which NSAIDs are used commonly, have been reported to be at lower risk of colon cancer but ...

journal_title：International journal of cancer

authors： Cerhan JR,Anderson KE,Janney CA,Vachon CM,Witzig TE,Habermann TM

更新日期：2003-09-20 00:00:00

abstract：:Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...

journal_title：International journal of cancer

authors： D'Souza G,Burk RD,Zhong Y,Minkoff H,Massad LS,Xue X,Watts DH,Anastos K,Palefsky JM,Levine AM,Colie C,Castle PE,Strickler HD

更新日期：2012-09-15 00:00:00

abstract：:Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...

journal_title：International journal of cancer

authors： Narayan A,Ji W,Zhang XY,Marrogi A,Graff JR,Baylin SB,Ehrlich M

更新日期：1998-09-11 00:00:00

abstract：:People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer dia...

journal_title：International journal of cancer

authors： Trickey A,May MT,Gill MJ,Grabar S,Vehreschild J,Wit FWNM,Bonnet F,Cavassini M,Abgrall S,Berenguer J,Wyen C,Reiss P,Grabmeier-Pfistershammer K,Guest JL,Shepherd L,Teira R,d'Arminio Monforte A,Del Amo J,Justice A,Cost

更新日期：2020-06-01 00:00:00

abstract：:International comparisons of interval cancers (IC) are important to better understand the relationship between programmes' performance and screening practices. In this respect, differences in (i) definition, (ii) identification and (iii) quantification of IC have received little attention. To examine these 3 comparabi...

journal_title：International journal of cancer

authors： Bulliard JL,Sasieni P,Klabunde C,De Landtsheer JP,Yankaskas BC,Fracheboud J

更新日期：2006-09-01 00:00:00

abstract：:Irinotecan-based chemotherapy with bevacizumab is one of the first-line standard therapies for metastatic colorectal cancer (mCRC). TEGAFIRI (UFT/LV + irinotecan) is an irinotecan-based chemotherapy regimen. Currently, few clinical data regarding TEGAFIRI are available. This study evaluated the efficacy and safety of ...

journal_title：International journal of cancer

authors： Shigeta K,Hasegawa H,Okabayashi K,Tsuruta M,Ishii Y,Endo T,Ochiai H,Kondo T,Kitagawa Y

更新日期：2016-08-15 00:00:00