Abstract:
:Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The percentage of lung cancers attributable to occupations entailing potential exposure to well-recognized carcinogens ranged, by study area, from 3 to 17%. The further inclusion of occupational groups with suspect carcinogenic exposures changed these estimates very little. Exclusion of data derived from next-of-kin interviews influenced the estimates of attributable risks, but not in a systematic fashion. The estimates also varied according to ethnic group, smoking status and birth cohort, with higher values in non-whites, non-smokers and among members of more recent birth cohorts. Possible errors in exposure classification, which may make these estimates conservative, are discussed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Vineis P,Thomas T,Hayes RB,Blot WJ,Mason TJ,Pickle LW,Correa P,Fontham ET,Schoenberg Jdoi
10.1002/ijc.2910420610subject
Has Abstractpub_date
1988-12-15 00:00:00pages
851-6issue
6eissn
0020-7136issn
1097-0215journal_volume
42pub_type
杂志文章abstract::We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ER...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.30584
更新日期:2017-04-01 00:00:00
abstract::Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.31345
更新日期:2018-08-01 00:00:00
abstract::Previous studies have proved that a certain acidic isoform of ferritin is specifically synthesized by the placenta and breast-cancer tissue. In this context it has been further reported that the determination of this so-called placental isoferritin (PLF) on the surface of a subset of peripheral lymphocytes is highly s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520213
更新日期:1992-09-09 00:00:00
abstract::To evaluate the role of chromosome 13 deletions in oral squamous cell carcinoma (SCC) progression and to define the precise localization of putative tumor suppressor genes, we studied tumors from 34 unrelated patients with oral SCC by the polymerase chain reaction (PCR)-loss of heterozygosity (LOH) assay, using 18 dif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980821)79:4<312::aid-ijc
更新日期:1998-08-21 00:00:00
abstract::von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative prognostic factor f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000115)85:2<281::aid-ijc
更新日期:2000-01-15 00:00:00
abstract::Resveratrol, which may occur in wine, was suggested to act as a chemopreventive agent against the carcinogenic effects of ethanol. The assumption was based on data from experimental animals, which have shown that resveratrol above certain thresholds may reduce the incidence of tumours in several of the alcohol-related...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28336
更新日期:2014-01-01 00:00:00
abstract::A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospecti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30630
更新日期:2017-05-01 00:00:00
abstract::ET-743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is hepatotoxic in animals and patients. We tested the hypothesis that indole-3-carbinol (I3C), the hydrolysis product of glucosinolates occurring in cruciferous ve...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20356
更新日期:2004-10-10 00:00:00
abstract::In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outcome remains limited. In our study, we aim to assess the outcome of screen-detected lesions diagnose...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25801
更新日期:2011-09-15 00:00:00
abstract::A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum-cell neoplasm (RCN) is growing. The killer cells are non-adherent, non-phagocytic, relatively resistant to X-ray, and scarcely or only partially inacti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250316
更新日期:1980-03-15 00:00:00
abstract::Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome-wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylated CpG island within the first in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22705
更新日期:2007-08-01 00:00:00
abstract::To examine the immunological mechanisms involved in cancer gene therapy using the herpes simplex virus thymidine kinase (HSV-tk) gene and ganciclovir (GCV), murine hepatocellular carcinoma (HCC) cells, BNL1ME A.7R.1, were transduced retrovirally with the HSV-tk gene. HSV-tk-transduced cells exhibited a more than 2,000...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991029)83:3<374::aid-ijc
更新日期:1999-10-29 00:00:00
abstract::Ovarian cancer risk is known to be reduced amongst women who have had children, but reported associations with breastfeeding are varied. Few studies have had sufficient power to explore reliably these associations by tumour histotype. In a prospective study of 1.1 million UK women, 8719 developed ovarian cancer during...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31063
更新日期:2018-01-15 00:00:00
abstract::alpha beta+ TCR T cells recognize peptide fragments displayed by MHC-class I or -class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1-mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, i.e., ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10141
更新日期:2002-03-20 00:00:00
abstract::Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28228
更新日期:2013-11-01 00:00:00
abstract::A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230409
更新日期:1979-04-15 00:00:00
abstract::Deletion of chromosome 5q is common in prostate cancer and is linked to aggressive disease. Most previous studies focused on 5q21 where CHD1 is located, but deletion of mapping studies has identified a second deletion hotspot at 5q13. To clarify the prevalence and clinical relevance of 5q13 deletions and to determine ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33344
更新日期:2021-02-01 00:00:00
abstract::To elucidate the relationship, if any, of p53 gene expression according to smoking and drinking habits, 135 subjects with cancer of the upper aero-digestive tract were sampled from a case-control investigation conducted in Pordenone province, Northeast Italy, between 1986 and 1991. Adequate pathological material for i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600625
更新日期:1995-03-16 00:00:00
abstract::Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC). The mechanism of antitumor action of gnidimacrin and the possible involvement of PKC were examined using sensitive K562 and refractory HLE cells. Gnidimacrin did bind...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980717)77:2<243::aid-ijc
更新日期:1998-07-17 00:00:00
abstract::The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22126
更新日期:2006-12-01 00:00:00
abstract::Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently needed. Efflux pumps belonging to the ATP-binding cassette (ABC) family of transporters ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33005
更新日期:2020-10-15 00:00:00
abstract::Ewing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents and young adults. There is unmet medical need to develop and test novel pharmacological targets and novel therapies to treat EWS. Here, we found that EWS expresses high levels of a p53 isoform, delta133p53. We fur...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32743
更新日期:2020-06-01 00:00:00
abstract::The LIM 1863 colon carcinoma cell line grows in the form of morphologically and functionally organized organoids. Cells are arranged around a central lumen with a brush border and nuclei are polarized to the periphery. The organoids contain 3 morphological cell types (columnar, goblet and caveolated cells). By agar cl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500515
更新日期:1992-03-12 00:00:00
abstract::Cord blood transplantation (CBT) is an effective option for treating hematological malignancies, but graft failure (GF) remains the primary cause of therapy failure. Thus, based on myeloablative conditioning (MAC) of busulfan with cyclophosphamide (Bu/Cy) or total body irradiation with Cy (TBI/Cy), fludarabine (Flu) w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31339
更新日期:2018-08-01 00:00:00
abstract::While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC ass...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28016
更新日期:2013-07-01 00:00:00
abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30911
更新日期:2017-11-15 00:00:00
abstract::A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990924)83:1<66::aid-ijc1
更新日期:1999-09-24 00:00:00
abstract::We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370105
更新日期:1986-01-15 00:00:00
abstract::A panel of eight conditionally immortal lines derived by infection of human breast epithelial cells with an amphotropic retrovirus transducing a ts mutant of SV40 large T-antigen was analyzed with respect to individual retroviral integration patterns. Each line contained multiple integration sites which were clonal an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570616
更新日期:1994-06-15 00:00:00
abstract::Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione S-transferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined. Between 1986 and 1989, 18,244 midd...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24583
更新日期:2009-12-01 00:00:00