Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China.


:Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione S-transferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined. Between 1986 and 1989, 18,244 middle-aged men in Shanghai, China were enrolled in a prospective study of diet and cancer and donated baseline urine and blood samples. Urinary ITC was quantified for 307 incident cases of gastric cancer that occurred during the first 16 years of follow-up, and 911 matched control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression methods. Seropositivity for antibodies to Helicobacter pylori and homozygous deletions of GSTM1 and GSTT1 were determined. Compared to the first tertile, ORs (95% CIs) of gastric cancer for the second and third tertiles of urinary total ITC were 0.83 (0.61-1.15) and 0.66 (0.47-0.94) (p(trend) = 0.02). A stronger protective effect of ITC against gastric cancer development was seen among men with homozygous deletion of GSTM1 (third tertile versus first tertile, OR = 0.50, 95% CI = 0.27-0.93) or GSTT1 (third tertile vs. first tertile, OR = 0.47, 95% CI = 0.25-0.88), and particularly with deletions of both GSTM1 and GSTT1 (second and third tertiles vs. first tertile, OR = 0.44, 95% CI = 0.21-0.93). In this cohort of Chinese men at high risk for gastric cancer, isothiocyanates may protect against the development of gastric cancer. The protection may be stronger for individuals genetically deficient in enzymes that metabolize these chemopreventive compounds.


Int J Cancer


Moy KA,Yuan JM,Chung FL,Wang XL,Van Den Berg D,Wang R,Gao YT,Yu MC




Has Abstract


2009-12-01 00:00:00












  • Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors.

    abstract::A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rudolph A,Milne RL,Truong T,Knight JA,Seibold P,Flesch-Janys D,Behrens S,Eilber U,Bolla MK,Wang Q,Dennis J,Dunning AM,Shah M,Munday HR,Darabi H,Eriksson M,Brand JS,Olson J,Vachon CM,Hallberg E,Castelao JE,Carrac

    更新日期:2015-03-15 00:00:00

  • Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma.

    abstract::The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bartel F,Meye A,Würl P,Kappler M,Bache M,Lautenschläger C,Grünbaum U,Schmidt H,Taubert H

    更新日期:2001-05-20 00:00:00

  • Histological subtypes of ovarian cancer associated with parity and breastfeeding in the prospective Million Women Study.

    abstract::Ovarian cancer risk is known to be reduced amongst women who have had children, but reported associations with breastfeeding are varied. Few studies have had sufficient power to explore reliably these associations by tumour histotype. In a prospective study of 1.1 million UK women, 8719 developed ovarian cancer during...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gaitskell K,Green J,Pirie K,Barnes I,Hermon C,Reeves GK,Beral V,Million Women Study Collaborators.

    更新日期:2018-01-15 00:00:00

  • Clinicopathological and prognostic significance of circulating tumor cells in patients with gastric cancer: a meta-analysis.

    abstract::The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Huang X,Gao P,Sun J,Chen X,Song Y,Zhao J,Xu H,Wang Z

    更新日期:2015-01-01 00:00:00

  • Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats.

    abstract::The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin-enhanced peritoneal metastases from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. Rats were given 10 weekly injections of azoxymethane (7.4 mg/kg body weight, s.c....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ishihara R,Tatsuta M,Iishi H,Baba M,Uedo N,Higashino K,Mukai M,Ishiguro S,Kobayashi S,Murakami-Murofushi K

    更新日期:2004-06-10 00:00:00

  • Uterine carcinosarcoma is derived from a single stem cell: an in vitro study.

    abstract::Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcino...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gorai I,Yanagibashi T,Taki A,Udagawa K,Miyagi E,Nakazawa T,Hirahara F,Nagashima Y,Minaguchi H

    更新日期:1997-09-04 00:00:00

  • Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11.

    abstract::Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

    更新日期:2013-11-01 00:00:00

  • MHC imbalance and metastatic spread in Lewis lung carcinoma clones.

    abstract::Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Eisenbach L,Segal S,Feldman M

    更新日期:1983-07-15 00:00:00

  • Interleukin-10 expression and cytotoxic-T-cell response in Epstein-Barr-virus-associated nasopharyngeal carcinoma.

    abstract::Interleukin-10 (IL-10) is an inhibitory cytokine produced by various cell types. It exhibits strong sequence homology to BCRF-1 (viral IL-10, vIL-10), an open reading frame in the Epstein-Barr-virus (EBV) genome. Using in situ hybridization (ISH), polymerase chain reaction (PCR) and immunohistochemistry, we checked 41...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yao M,Ohshima K,Suzumiya J,Kume T,Shiroshita T,Kikuchi M

    更新日期:1997-07-29 00:00:00

  • Oncogenic PIK3CA mutations in colorectal cancers and polyps.

    abstract::Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Whitehall VL,Rickman C,Bond CE,Ramsnes I,Greco SA,Umapathy A,McKeone D,Faleiro RJ,Buttenshaw RL,Worthley DL,Nayler S,Zhao ZZ,Montgomery GW,Mallitt KA,Jass JR,Matsubara N,Notohara K,Ishii T,Leggett BA

    更新日期:2012-08-15 00:00:00

  • Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.

    abstract::We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

    更新日期:2010-04-01 00:00:00

  • Tamoxifen modulation of cisplatin cytotoxicity in human malignancies.

    abstract::Recent clinical trials have indicated that addition of tamoxifen (TAM) to a combination of cisplatin (DDP), carmustine and dacarbazine markedly increases the overall objective response rate of patients with metastatic malignant melanoma. Previous studies have determined that there is remarkable synergy between TAM and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McClay EF,Albright KD,Jones JA,Christen RD,Howell SB

    更新日期:1993-12-02 00:00:00

  • Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously.

    abstract::Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Belardelli F,Gresser I,Maury C,Duvillard P,Prade M,Maunoury MT

    更新日期:1983-05-15 00:00:00

  • Growth of Hodgkin cell lines in severely combined immunodeficient mice.

    abstract::No animal model exists for the in vivo growth of Hodgkin's-lymphoma-derived cells. Neither unmanipulated Hodgkin's-disease(HD)-derived cell lines nor primary biopsy tissue could be grown in nude mice. Since the severe combined immunodeficient (SCID) mouse has been reported to be a better recipient for transplanted hum...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: von Kalle C,Wolf J,Becker A,Sckaer A,Munck M,Engert A,Kapp U,Fonatsch C,Komitowski D,Feaux de Lacroix W

    更新日期:1992-12-02 00:00:00

  • Chromosome-9 loss detected by fluorescence in situ hybridization in bladder cancer.

    abstract::A loss of chromosome-9 material is one of the most frequent genomic aberrations known in bladder cancer. In order to better understand the role of chromosome-9 losses in bladder cancer, 125 formalin-fixed and 37 unfixed bladder tumors were examined using fluorescence in situ hybridization (FISH). A repetitive probe fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sauter G,Moch H,Carroll P,Kerschmann R,Mihatsch MJ,Waldman FM

    更新日期:1995-04-21 00:00:00

  • Signal processing in migrating T24 human bladder carcinoma cells: role of the autocrine interleukin-8 loop.

    abstract::T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lang K,Niggemann B,Zanker KS,Entschladen F

    更新日期:2002-06-10 00:00:00

  • Expression of HLA-DR antigens in nasopharyngeal carcinoma: an immunohistological analysis of the tumour cells and infiltrating lymphocytes.

    abstract::A panel of conventional and monoclonal antibodies was used to examine the immunohistological characteristics of malignant epithelial cells and infiltrating lymphocytes in frozen sections of nasopharyngeal carcinoma (NPC) biopsies from 10 Tunisian patients. Three main categories of cells were identified. (1) Tumour cel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thomas JA,Iliescu V,Crawford DH,Ellouz R,Cammoun M,de-Thé G

    更新日期:1984-06-15 00:00:00

  • The macrophage electrophoretic mobility test: Results on carcinoma of the colon and rectum.

    abstract::The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reducti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Glaves D,Harlos JP,Weiss L

    更新日期:1977-04-15 00:00:00

  • High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages.

    abstract::Expression of the candidate metastasis-suppressor gene nm23-H1 has been shown to correlate inversely with metastatic potential in some human tumors, but not in all. Until now, few studies have been carried out on the activity of the homologous nm23-H2 gene in human cancer. No nm23 transcription studies exist for human...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Engel M,Theisinger B,Seib T,Seitz G,Huwer H,Zang KD,Welter C,Dooley S

    更新日期:1993-09-30 00:00:00

  • Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.

    abstract::The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guerreiro AS,Boller D,Shalaby T,Grotzer MA,Arcaro A

    更新日期:2006-12-01 00:00:00

  • In vitro and in vivo modulation of multi-drug resistance with amiodarone.

    abstract::The modulating effect on drug resistance of amiodarone (AM) and its metabolite desethylamiodarone (DEA) was studied in a P-glycoprotein-positive human colon carcinoma cell line COLO 320, and a human small-cell lung carcinoma cell line GLC4 and its adriamycin (Adr)-resistant subline GLC4-Adr (both P-glycoprotein-negati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Graaf WT,de Vries EG,Uges DR,Nanninga AG,Meijer C,Vellenga E,Mulder PO,Mulder NH

    更新日期:1991-06-19 00:00:00

  • Population-based prevalence, type- and age-specific distribution of HPV in women before introduction of an HPV-vaccination program in Denmark.

    abstract::Knowledge about the prevalence of human papillomavirus (HPV) on a population level is important. We conducted a large population-based study in Denmark to determine the overall and age-specific HPV prevalence, and HPV type distribution in women. Liquid-based cytology samples (SurePath) were collected consecutively. HP...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kjaer SK,Breugelmans G,Munk C,Junge J,Watson M,Iftner T

    更新日期:2008-10-15 00:00:00

  • Antibodies reactive with the mouse mammary tumor virus in sera of breast cancer patients.

    abstract::IgG binding to purified mouse mammary tumor virus (MuMTV) was quantitated by an enzyme-linked immunoassay (ELISA) using sera from patients with breast cancer or benign breast disease, or from healthy age-matched controls. Significantly greater binding (p<0.01) was found in breast-cancer-derived sera than in the other ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Witkin SS,Sarkar NH,Kinne DW,Good RA,Day NK

    更新日期:1980-06-15 00:00:00

  • No association between HPV infection and the neoplastic progression of esophageal squamous cell carcinoma: result from a cross-sectional study in a high-risk region of China.

    abstract::Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gao GF,Roth MJ,Wei WQ,Abnet CC,Chen F,Lu N,Zhao FH,Li XQ,Wang GQ,Taylor PR,Pan QJ,Chen W,Dawsey SM,Qiao YL

    更新日期:2006-09-15 00:00:00

  • Use of monoclonal antibodies to human breast-tumor-associated antigens in fine-needle aspirate cytology.

    abstract::Fine-needle aspiration cytology (FNAC) is currently used in evaluating the nature of breast nodules. In the present study we have examined whether monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) can be employed in FNAC for the diagnosis of breast cancer. For this purpose we have used 2 murine M...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nuti M,Mottolese M,Viora M,Donnorso RP,Schlom J,Natali PG

    更新日期:1986-04-15 00:00:00

  • Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: classical Hodgkin lymphoma vs. Hodgkin-like ATLL.

    abstract::Classical Hodgkin lymphoma (HL) is characterized by the presence of Hodgkin and Reed-Sternberg cells (H&RS) and a prominent lymphocytic infiltration. We previously reported Hodgkin-like adult T-cell leukemia/lymphoma (HL-like ATLL) (new WHO classification). Various CXC and CC chemokines are expressed on H&RS cells and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ohshima K,Karube K,Hamasaki M,Suefuji H,Tutiya T,Yamaguchi T,Suzumiya J,Kikuchi M

    更新日期:2003-09-20 00:00:00

  • Establishment, characterization and virus expression of cell lines derived from radiation- and virus-induced lymphomas of C57BL/Ka mice.

    abstract::Permanent cell lines have been established in vitro from lymphoid tumors induced in C57BH/Ka mice by fractionated X-irradiation or by inoculation of the radiation leukemia virus (RadOV). The cultured cells are lymphoblastic, replicate rapidly in vitro, and are tumorigenic in vivo. The cell surface markers Thy 1, Ly 1,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lieberman M,Declève A,Ricciardi-Castagnoli P,Boniver J,Finn OJ,Kaplan HS

    更新日期:1979-08-01 00:00:00

  • IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines.

    abstract::Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)-6 is a key factor by driving tumor progression from benign to malignant, invasive tumors in the HaCaT-model of human skin carcinoma. IL-6 activates STAT3 and directly stimulates proliferation and migration of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lederle W,Depner S,Schnur S,Obermueller E,Catone N,Just A,Fusenig NE,Mueller MM

    更新日期:2011-06-15 00:00:00

  • Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model.

    abstract::Bcl-2 expression is up-regulated in prostate cancer cells after androgen ablation and associated with development of androgen independence and chemoresistance. We recently reported that antisense Bcl-2 oligodeoxynucleotides (ODNs) delay progression to androgen independence in the androgen-dependent (AD) human LNCaP pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leung S,Miyake H,Zellweger T,Tolcher A,Gleave ME

    更新日期:2001-03-15 00:00:00

  • Presence of EBV-DNA sequences in nasopharyngeal cells of individuals without IgA-VCA antibodies.

    abstract::Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Desgranges C,Pi GH,Bornkamm GW,Legrand C,Zeng Y,de-Thé G

    更新日期:1983-11-15 00:00:00