Abstract:
:Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was initiated utilizing a transgenic mouse mammary tumor model that exhibits a high incidence of pulmonary metastases. The transgenic animal was bred to 27 different inbred strains of mice and scored for the metastatic organ tropism and metastatic density. Thirteen strains were identified that had a statistically significant reduction in the numbers of pulmonary metastases. In addition, 10 strains were identified that altered the kinetics of induction of the primary mammary tumor. These strains will likely provide useful model systems for the analysis of genetic interactions in the initiation and progression of mammary adenocarcinomas.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KWdoi
10.1002/(sici)1097-0215(19980812)77:4<640::aid-ijcsubject
Has Abstractpub_date
1998-08-12 00:00:00pages
640-4issue
4eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19980812)77:4<640::AID-IJCjournal_volume
77pub_type
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