Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.

abstract：:Metastasis is a critical problem in the treatment of human lung cancer. Thus, a suitable animal model of metastasis of human lung cancer is required for in vivo biological and preclinical studies. In this study, we tried to establish a suitable model for this, using SCID mice. Neither human SCLC H69/VP cells (5 x 10(6...

journal_title：International journal of cancer

authors： Yano S,Nishioka Y,Izumi K,Tsuruo T,Tanaka T,Miyasaka M,Sone S

更新日期：1996-07-17 00:00:00

abstract：:Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. We used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigeneti...

journal_title：International journal of cancer

authors： Wu CS,Lu YJ,Li HP,Hsueh C,Lu CY,Leu YW,Liu HP,Lin KH,Hui-Ming Huang T,Chang YS

更新日期：2010-06-01 00:00:00

abstract：:The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contrib...

journal_title：International journal of cancer

authors： Achen MG,Stacker SA

更新日期：2006-10-15 00:00:00

abstract：:No animal model exists for the in vivo growth of Hodgkin's-lymphoma-derived cells. Neither unmanipulated Hodgkin's-disease(HD)-derived cell lines nor primary biopsy tissue could be grown in nude mice. Since the severe combined immunodeficient (SCID) mouse has been reported to be a better recipient for transplanted hum...

journal_title：International journal of cancer

authors： von Kalle C,Wolf J,Becker A,Sckaer A,Munck M,Engert A,Kapp U,Fonatsch C,Komitowski D,Feaux de Lacroix W

更新日期：1992-12-02 00:00:00

abstract：:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...

journal_title：International journal of cancer

authors： Urhoj SK,Raaschou-Nielsen O,Hansen AV,Mortensen LH,Andersen PK,Nybo Andersen AM

更新日期：2017-06-01 00:00:00

abstract：:Two putative genes (termed pro 1 and pro 2) specifying sensitivity to induction of neoplastic transformation by TPA in mouse epidermal JB6 cells were cloned by sib selection from a size-selected genomic library of clonal cells sensitive to promotion of transformation. By restriction analysis, heteroduplex analysis, di...

journal_title：International journal of cancer

authors： Lerman MI,Hegamyer GA,Colburn NH

更新日期：1986-02-15 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the regulation of a variety of cellular processes, including cell growth, differentiation, apoptosis and carcinogenesis. The purpose of this study was to elucidate the molecular mechanisms by which miR-148b acts as a tumor suppressor in colorectal cancer. The expression of ...

journal_title：International journal of cancer

authors： Song Y,Xu Y,Wang Z,Chen Y,Yue Z,Gao P,Xing C,Xu H

更新日期：2012-09-01 00:00:00

abstract：:Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were studied to evaluate the reversibility of Adriamycin resistance in human colon cancer. Two groups of cell lines were studied. In the first, including a series o...

journal_title：International journal of cancer

authors： Lai GM,Chen YN,Mickley LA,Fojo AT,Bates SE

更新日期：1991-11-11 00:00:00

abstract：:Folate receptor alpha (FRA) is a GPI-anchored glycoprotein and encoded by the FOLR1 gene. High expression of FRA is observed in specific malignant tumors of epithelial origin, including ovarian cancer, but exhibits very limited normal tissue expression, making it as an attractive target for the ovarian cancer therapy....

journal_title：International journal of cancer

authors： Kurosaki A,Hasegawa K,Kato T,Abe K,Hanaoka T,Miyara A,O'Shannessy DJ,Somers EB,Yasuda M,Sekino T,Fujiwara K

更新日期：2016-04-15 00:00:00

abstract：:From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...

journal_title：International journal of cancer

authors： Tao TW,Burger MM

更新日期：1982-04-15 00:00:00

abstract：:Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25-50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv was measurable in plasma for up...

journal_title：International journal of cancer

authors： Borden EC,Carter WA,Sensenbrenner LL,Owens AH,Lichtenstein J,Gray GD,Neil GL,Nichol FR,Li LH

更新日期：1974-12-15 00:00:00

abstract：:By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns of uptake and biolocalization of 5-aminolevulinic acid (ALA)-induced porphyrins in s.c. transplanted tumors, adjacent normal skin and muscle, and liver of mice bearing mammary carcinoma, after i.p. ...

journal_title：International journal of cancer

authors： Peng Q,Moan J,Warloe T,Nesland JM,Rimington C

更新日期：1992-09-30 00:00:00

abstract：:Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...

journal_title：International journal of cancer

authors： Lee HS,Lee S,Cho KH

更新日期：2020-11-15 00:00:00

abstract：:We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the numbe...

journal_title：International journal of cancer

authors： Piechocki MP,Dibbley SK,Lonardo F,Yoo GH

更新日期：2008-04-15 00:00:00

abstract：:The early arrest patterns of a methylcholanthrene-induced fibrosarcoma were determined after injection of 125IUdR-labelled cells into the systemic circulation of mice bearing transplanted lymphosarcomas, and of normal animals. Similar experiments were performed using radiolabelled lymphosarcoma cells and normal or fib...

journal_title：International journal of cancer

authors： Weiss L,Glaves D

更新日期：1976-12-15 00:00:00

abstract：:A subgroup of medulloblastomas shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1. We identified the subset of GLI1 transforming target genes specifically expressed in medulloblastomas by comparing GLI1 targets in RK3E cells transformed by GLI1 with the gene expression profile of Sonic...

journal_title：International journal of cancer

authors： Yoon JW,Gilbertson R,Iannaccone S,Iannaccone P,Walterhouse D

更新日期：2009-01-01 00:00:00

abstract：:Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subseq...

journal_title：International journal of cancer

authors： Duell EJ,Lujan-Barroso L,Sala N,Deitz McElyea S,Overvad K,Tjonneland A,Olsen A,Weiderpass E,Busund LT,Moi L,Muller D,Vineis P,Aune D,Matullo G,Naccarati A,Panico S,Tagliabue G,Tumino R,Palli D,Kaaks R,Katzke VA,

更新日期：2017-09-01 00:00:00

abstract：:We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...

journal_title：International journal of cancer

authors： Van Dijck JA,Verbeek AL,Beex LV,Hendriks JH,Holland R,Mravunac M,Straatman H,Werre JM

更新日期：1996-06-11 00:00:00

abstract：:No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18-59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) accordi...

journal_title：International journal of cancer

authors： Khodakarami N,Clifford GM,Yavari P,Farzaneh F,Salehpour S,Broutet N,Bathija H,Heideman DA,van Kemenade FJ,Meijer CJ,Hosseini SJ,Franceschi S

更新日期：2012-07-15 00:00:00

abstract：:The antiproliferative effect of 2',5' A3 core and 2',5'-3'dA3 (cordycepin trimer) core was measured in 8 human tumor cell lines. Cells were treated in a dose-response manner for 72 hr and the concentration of drug necessary to inhibit cell growth 50% (GI50) was determined. A wide range of sensitivities to these drugs ...

journal_title：International journal of cancer

authors： Hubbell HR,Pequignot EC,Willis DH,Lee C,Suhadolnik RJ

更新日期：1985-09-15 00:00:00

abstract：:In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases...

journal_title：International journal of cancer

authors： Sobue T,Yamamoto S,Hara M,Sasazuki S,Sasaki S,Tsugane S,JPHC Study Group. Japanese Public Health Center.

更新日期：2002-05-10 00:00:00

abstract：:Angiogenesis and inflammation are the 2 major stroma reactions in colorectal carcinoma (CRC). Guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation. Therefore, we hypothesized that GBP-1 may be a biomarker of intrinsic angiostasis associated with an improved outcome in CRC patien...

journal_title：International journal of cancer

authors： Naschberger E,Croner RS,Merkel S,Dimmler A,Tripal P,Amann KU,Kremmer E,Brueckl WM,Papadopoulos T,Hohenadl C,Hohenberger W,Stürzl M

更新日期：2008-11-01 00:00:00

abstract：:This paper deals with a spontaneous malignant transformation in one of our XP fibroblast lines. This cell line, designated XP29MA, was derived from a 14-year-old boy who did not show skin tumors or precancerous alterations either at the time of clinical examination or when the biopsy was taken. We have compared the fo...

journal_title：International journal of cancer

authors： Thielmann HW,Fischer E,Dzarlieva RT,Komitowski D,Popanda O,Edler L

更新日期：1983-06-15 00:00:00

abstract：:Pancreatic cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the Hsp90, making it a potential therapeutic target. We investigated the oxidative stress-mediated dysfunction of Hsp90 and the hindrance of it...

journal_title：International journal of cancer

authors： Sarkar S,Dutta D,Samanta SK,Bhattacharya K,Pal BC,Li J,Datta K,Mandal C,Mandal C

更新日期：2013-02-01 00:00:00

abstract：:This large population-based study compared breast-conserving surgery with radiation therapy (BCT) with mastectomy on (long-term) breast cancer-specific (BCSS) and overall survival (OS), and investigated the influence of several prognostic factors. Patients with primary T1-2N0-2M0 breast cancer, diagnosed between 1999 ...

journal_title：International journal of cancer

authors： Lagendijk M,van Maaren MC,Saadatmand S,Strobbe LJA,Poortmans PMP,Koppert LB,Tilanus-Linthorst MMA,Siesling S

更新日期：2018-01-01 00:00:00

abstract：:A continuous lymphoma cell line, BJAB, derived from the tumour of an exceptional African case of Burkitt's lymphoma, has previously been described. Unlike 97% of African BL cases studied, neither the original tumour cells nor the cell line contained detectable amounts of EBV (Epstein-Barr virus) DNA, nor did they expr...

journal_title：International journal of cancer

authors： Clements GB,Klein G,Povey S

更新日期：1975-07-15 00:00:00

abstract：:Emerging reports now implicate alterations of arachidonic acid (AA) metabolism with prostate carcinogenesis. To test this hypothesis, androgen-primed benign hyperplastic (BHC) and malignant tumorigenic (MTC) cells derived from the Lobund-Wistar rat model of autochthonous prostate adenocarcinoma were incubated with (14...

journal_title：International journal of cancer

authors： Pham H,Banerjee T,Ziboh VA

更新日期：2004-08-20 00:00:00

abstract：:Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to ...

journal_title：International journal of cancer

authors： Trichopoulos D,Day NE,Kaklamani E,Tzonou A,Muñoz N,Zavitsanos X,Koumantaki Y,Trichopoulou A

更新日期：1987-01-15 00:00:00

abstract：:BRCA1 and BRCA2 play essential roles in maintaining the genome stability. Pathogenic germline mutations in these two genes disrupt their function, lead to genome instability and increase the risk of developing breast and ovarian cancers. BRCA mutations have been extensively screened in Caucasian populations, and the r...

journal_title：International journal of cancer

authors： Bhaskaran SP,Chandratre K,Gupta H,Zhang L,Wang X,Cui J,Kim YC,Sinha S,Jiang L,Lu B,Wu X,Qin Z,Huang T,Wang SM

更新日期：2019-08-15 00:00:00

abstract：:Metastasis of colorectal cancer (CRC) is the leading cause of CRC-associated mortality. Angiogenin (ANG), a member of the ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets tumor cells to promote cell survival, proliferation and/or migration. However, its cl...

journal_title：International journal of cancer

authors： Li S,Shi X,Chen M,Xu N,Sun D,Bai R,Chen H,Ding K,Sheng J,Xu Z

更新日期：2019-09-01 00:00:00