Abstract:
:We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. For the present case-control study, women were selected who were over 64 years of age at the most recent invitation. Eighty-two of them had died from breast cancer. For these cases, 410 age-matched population controls were selected. The ratio of breast cancer mortality rates of the women who had participated regularly (ie., in the 2 most recent screening rounds prior to diagnosis) vs. the women who had not participated in the screening was 0.56 (95% CI = 0.28-1.13). The rate ratio was 0.45 in the women aged 65-74 years at the most recent invitation (95% CI = 0.20-1.02), whereas it was 1.05 in the women aged 75 years and older (95% CI = 0.27- 4.14). While the breast cancer survival rate of the non-participant patients was fairly equal to that of patients from a control population, the underlying incidence rate of breast cancer was higher in the participants than in the non-participants. Therefore, we conclude that bias was present, but that it had decreased our effect estimate. The real reduction in breast cancer mortality due to regular screening will be even larger. Regular mammographic screening of women over age 65 (at least up to 75 years) can reduce breast cancer mortality by approximately 45%.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Van Dijck JA,Verbeek AL,Beex LV,Hendriks JH,Holland R,Mravunac M,Straatman H,Werre JMdoi
10.1002/(SICI)1097-0215(19960611)66:6<727::AID-IJCsubject
Has Abstractpub_date
1996-06-11 00:00:00pages
727-31issue
6eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19960611)66:6<727::AID-IJCjournal_volume
66pub_type
杂志文章abstract::The lck gene encodes a lymphocyte-specific tyrosine protein kinase, p56lck, the expression of which is almost exclusive in T-cells. The expression of lck in human T-cell leukemia virus type I (HTLV-I)-transformed T-cell lines is closely associated with interleukin-2 (IL-2) dependence for their growth. That is, IL-2-de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480526
更新日期:1991-07-09 00:00:00
abstract::The poly(ADP-ribose) polymerases (PARP) play important roles in repairing damaged DNA during intrinsic cell death. We recently linked PARP-1 to death receptor (DR)-activated extrinsic apoptosis, the present studies sought to elucidate the function of cytoplasmic PARP-1 in pancreatic cancer tumorigenesis and therapy. U...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32108
更新日期:2019-07-15 00:00:00
abstract::In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. However, whereas IL-6 phosphorylates STAT3 within 15 min, stimulat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30892
更新日期:2017-11-15 00:00:00
abstract::Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used United States Environmental Protection Agency National Ambient Toxics Assessment (NATA) estimates of low-level ambient benzene to examine potential associations f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32202
更新日期:2019-11-15 00:00:00
abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500605
更新日期:1992-04-01 00:00:00
abstract::Obesity is associated with an increased risk of fatal prostate cancer. We aimed to elucidate the importance and relevant timing of obesity and weight change for prostate cancer progression. We identified 5,158 men diagnosed with localized prostate cancer (clinical stage T1/T2) from 1986 to 2012 in the Health Professio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30803
更新日期:2017-09-01 00:00:00
abstract::This study reports the induction of interferon (IFN) in human mononuclear cells (MNC) by hematopoietic tumor cells. Only 3 out of 15 cell lines were capable of inducing IFN in the mixed leukocyte/tumor-cell reaction (MLTR). K562, a pluripotent stem cell line and DUTKO-I, a hybrid between K562 and Daudi (Burkitt lympho...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340108
更新日期:1984-07-15 00:00:00
abstract::The mismatch repair (MMR) genes are involved in the maintenance of genomic integrity. Recently, we showed that common variants in these genes are unlikely to contribute significantly to colorectal cancer risk. The aim of this study was to investigate the role of common variants in the mismatch repair pathway as progno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24120
更新日期:2009-04-15 00:00:00
abstract::In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermenta...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29012
更新日期:2015-10-01 00:00:00
abstract::The major obstacle preventing effective treatment of melanoma is the biological heterogeneity of tumor cells. This study was performed to determine clonal genetic heterogeneity within primary melanoma and the evolution of these heterogeneous sub-clones during disease progression. DNA samples were obtained from 44 morp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-02-15 00:00:00
abstract::A population-based case-control study of esophageal cancer was conducted in urban Shanghai involving interviews with 902 cases and 1,552 controls. Risk of esophageal cancer was increased among tobacco smokers and alcohol drinkers. Odds ratios (OR) for smoking were 2.1 and 1.6 for men and women, respectively, and incre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580208
更新日期:1994-07-15 00:00:00
abstract::Ocimum sp. is a traditionally used medicinal herb, which shows anti-oxidant, anti-carcinogenic, radio-protective and free radical scavenging properties. So far no detailed studies have been reported on its effects on human cancers. Thus, we analyzed its effects on human breast cancer utilizing in vitro and in vivo met...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22733
更新日期:2007-08-15 00:00:00
abstract::The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000615)86:6<848::aid-ijc
更新日期:2000-06-15 00:00:00
abstract::MUC18/MCAM is a cell-surface glycoprotein that is strongly expressed on advanced human melanomas. Transfection of 3 MCAM-negative melanoma cell lines with MCAM cDNA led to cell-surface expression and to a MCAM-dependent homotypic adhesion. This adhesion was independent of divalent cations and was inhibited at 4 degree...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971127)73:5<769::aid-ijc
更新日期:1997-11-27 00:00:00
abstract::Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy with high acquisition costs, and it has raised concerns about affordability and sustainability in many countries. Furthermore, the current centralized production paradigm for the T cells is less than satisfactory. Therefore, several countries ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33156
更新日期:2020-12-15 00:00:00
abstract::E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10879
更新日期:2003-03-10 00:00:00
abstract::The insulin-like growth factors (IGF-I and IGF-II) play a key role in cellular proliferation and are involved in cellular transformation. The expression of the IGF-I receptor has been demonstrated in a variety of human tumor cell lines including ovarian cancer cells. Phosphorothioate antisense oligodeoxynucleotides (S...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980812)77:4<567::aid-ijc
更新日期:1998-08-12 00:00:00
abstract::High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000801)87:3<360::aid-ijc8>3.0.
更新日期:2000-08-01 00:00:00
abstract::Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260516
更新日期:1980-11-15 00:00:00
abstract::The aim of this prospective study was to assess the uptake of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC) and its associations with sociodemographic and other factors, and long-term satisfaction with taking the test. The test was offered to all high-risk members (n = 446) of 36 Fi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-01-20 00:00:00
abstract::ATL is a fatal malignancy of T lymphocytes caused by HTLV-I infection and remains incurable. Galectins are a family of animal lectins that function both extracellularly (by interacting with cell surface and extracellular matrix glycoproteins and glycolipids) and intracellularly (by interacting with cytoplasmic and nuc...
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.22534
更新日期:2007-05-15 00:00:00
abstract::A highly immunogenic variant of the murine L1210 leukemia cell (L1210/LN-1) for generation of tumor immunity has been obtained from culture of L1210 cells originally fused with human Lesch-Nyhan fibroblasts. In L1210/LN-1 cells, no human chromosomes were identified and chromosomes M1 and No. 1 carried by the parent L1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320419
更新日期:1983-10-15 00:00:00
abstract::The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340219
更新日期:1984-08-15 00:00:00
abstract::CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26365
更新日期:2012-07-01 00:00:00
abstract::It is unclear which chromosome arms frequently show loss of heterozygosity (LOH) in adenocarcinoma of the uterine cervix. To identify such chromosomal arms, LOH on 52 different chromosome loci was examined using laser capture microdissection and PCR-LOH analysis in 25 common-type adenocarcinomas, comprising 13 cases o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10228
更新日期:2002-04-10 00:00:00
abstract::We studied dietary risk factors for lung cancer among never-smokers in a population-based case-control study in Stockholm, 1989-1995. Study subjects were older than 30 years of age and had never smoked regularly. A total of 124 cases (35 men, 89 women) and 235 controls (72 men, 163 women) participated. Exposure inform...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981109)78:4<430::aid-ijc
更新日期:1998-11-09 00:00:00
abstract::Metastasis-associated protein MTA1 and histone deacetylase form a protein complex with histone deacetylase activity that plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control. The precise role of the MTA1 protein in the malignant progression of human cancers re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20154
更新日期:2004-06-20 00:00:00
abstract::Clinical trials utilizing strategies to manipulate tumor oxygenation, blood flow and angiogenesis are under way, although limited quantitative information exists regarding basic tumor pathophysiology. The current study utilized murine KHT fibrosarcomas, spontaneous mammary carcinomas and first-generation spontaneous t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1401
更新日期:2001-09-01 00:00:00
abstract::Our aim was to analyze the expression of the serine protease HtrA1 in human bladder tissue and urine in order to point out its possible association with the presence of urothelial bladder cancer. Bladder tissue and urine specimens from cancer patients with different tumor grades and stages (n = 68) and from individual...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28280
更新日期:2013-12-01 00:00:00
abstract::An inverse association between smoking and endometrial cancer has generally been observed, primarily among current smokers. To assess this association, we analyzed data from the prospective Nurses' Health Study. From 1976 to 2000, 702 cases of invasive endometrial cancer were identified during 1.8 million person-years...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20821
更新日期:2005-05-10 00:00:00