Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells.

abstract：:Herein, we show that γδT, CD8(+) αβT lymphocytes and natural killer (NK) cells display a different sensitivity to survival signals delivered via NKG2D surface receptor. All the three effector cell populations activate Akt1/PKBalpha through the engagement of this molecule. Upon binding to leukemic cells expressing NKG2...

journal_title：International journal of cancer

authors： Poggi A,Zancolli M,Boero S,Catellani S,Musso A,Zocchi MR

更新日期：2011-07-15 00:00:00

abstract：:We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ER...

journal_title：International journal of cancer

authors： Sefrioui D,Vermeulin T,Blanchard F,Chapusot C,Beaussire L,Armengol-Debeir L,Sesboué R,Gangloff A,Hebbar M,Copin MC,Houivet E,Schwarz L,Clatot F,Tuech JJ,Bénichou J,Martin L,Bouvier AM,Sabourin JC,Sarafan-Vasseur N,F

更新日期：2017-04-01 00:00:00

abstract：:The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (CIN2-3/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 random...

journal_title：International journal of cancer

authors： Haupt RM,Wheeler CM,Brown DR,Garland SM,Ferris DG,Paavonen JA,Lehtinen MO,Steben M,Joura EA,Giacoletti KE,Radley DR,James MK,Saah AJ,Sings HL,FUTURE I and II Investigators.

更新日期：2011-12-01 00:00:00

abstract：:The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast...

journal_title：International journal of cancer

authors： Bogdanova N,Enssen-Dubrowinskaja N,Feshchenko S,Lazjuk GI,Rogov YI,Dammann O,Bremer M,Karstens JH,Sohn C,Dörk T

更新日期：2005-08-20 00:00:00

abstract：:In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...

journal_title：International journal of cancer

authors： Sutcliffe S,Giovannucci E,Leitzmann MF,Rimm EB,Stampfer MJ,Willett WC,Platz EA

更新日期：2007-04-01 00:00:00

abstract：:Recent analyses have suggested decreases over time in colorectal cancer incidence at older ages (≥55 years) but increases at younger ages (20-54 years). Understanding the geographic heterogeneity of incidence facilitates resource allocation for potential interventions and advances our knowledge of differential etiolog...

journal_title：International journal of cancer

authors： Chernyavskiy P,Kennerley VM,Jemal A,Little MP,Rosenberg PS

更新日期：2019-04-15 00:00:00

abstract：:We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (0.01-1 microg/ml) r...

journal_title：International journal of cancer

authors： Williams BA,Makrigiannis AP,Blay J,Hoskin DW

更新日期：1997-11-04 00:00:00

abstract：:5-Fluorouracil (5-FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5-FU is considered the major obstacle for successful chemotherapy. NF-kappaB is a transcription factor. Cancer cells with high NF-kappaB nuclear activity demonstrate...

journal_title：International journal of cancer

authors： Wang W,McLeod HL,Cassidy J

更新日期：2003-04-20 00:00:00

abstract：:Studies have shown an increased risk of malignancies in women with endometriosis. Little is known about the impact of endometriosis on cancer survival. We investigated whether the survival after a diagnosis of a malignancy differs in women with a previously diagnosed endometriosis compared to other women. Women with a...

journal_title：International journal of cancer

authors： Melin A,Lundholm C,Malki N,Swahn ML,Sparen P,Bergqvist A

更新日期：2011-08-15 00:00:00

abstract：:Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...

journal_title：International journal of cancer

authors： Shimizu Y,Zhu JJ,Han F,Ishikawa T,Oda H

更新日期：1999-07-19 00:00:00

abstract：:A postal survey addressed to 2,083 general practitioners of childhood cancer survivors of reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk of several adverse pregnancy outcomes as compared with female survivors of...

journal_title：International journal of cancer

authors： Hawkins MM,Smith RA

更新日期：1989-03-15 00:00:00

abstract：:The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...

journal_title：International journal of cancer

authors： Keck B,Wach S,Taubert H,Zeiler S,Ott OJ,Kunath F,Hartmann A,Bertz S,Weiss C,Hönscheid P,Schellenburg S,Rödel C,Baretton GB,Sauer R,Fietkau R,Wullich B,Krause FS,Datta K,Muders MH

更新日期：2015-01-15 00:00:00

abstract：:Emerging evidence suggests that diffusion-weighted magnetic resonance imaging (DW MRI) could be useful for tumor detection with N and M staging of lung cancer in place of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). DW MRI at 3.0 T and FDG PET/CT were performed before t...

journal_title：International journal of cancer

authors： Zhang J,Cui LB,Tang X,Ren XL,Shi JR,Yang HN,Zhang Y,Li ZK,Wu CG,Jian W,Zhao F,Ti XY,Yin H

更新日期：2014-02-01 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00

abstract：:A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and mo...

journal_title：International journal of cancer

authors： Pandis N,Idvall I,Bardi G,Jin Y,Gorunova L,Mertens F,Olsson H,Ingvar C,Beroukas K,Mitelman F,Heim S

更新日期：1996-04-10 00:00:00

abstract：:Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...

journal_title：International journal of cancer

authors： Lou PJ,Lai PS,Shieh MJ,Macrobert AJ,Berg K,Bown SG

更新日期：2006-12-01 00:00:00

abstract：:Triple-negative breast cancer [TNBC, which is negative for the estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2] is a high-risk form of the disease without a specific therapy. DNA microarray and immunohistochemical analyses have shown that most TNBCs fall within the basal-lik...

journal_title：International journal of cancer

authors： Arima Y,Hayashi N,Hayashi H,Sasaki M,Kai K,Sugihara E,Abe E,Yoshida A,Mikami S,Nakamura S,Saya H

更新日期：2012-06-01 00:00:00

abstract：:Infection with human papillomavirus-16 (HPV-16) is the cause of most anogenital carcinomas. This virus is also detected in about 20% of all head and neck squamous cell carcinomas. While there is strong evidence for a causal etiological role in the case of tonsillar carcinomas, causal association with malignant lesions...

journal_title：International journal of cancer

authors： Balderas-Loaeza A,Anaya-Saavedra G,Ramirez-Amador VA,Guido-Jimenez MC,Kalantari M,Calleja-Macias IE,Bernard HU,Garcia-Carranca A

更新日期：2007-05-15 00:00:00

abstract：:Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results ...

journal_title：International journal of cancer

authors： Zhou H,Shen T,Luo Y,Liu L,Chen W,Xu B,Han X,Pang J,Rivera CA,Huang S

更新日期：2010-11-15 00:00:00

abstract：:In this study we investigated the effect of Tax on nucleotide excision repair (NER) in human T-cell lines by using the host cell repair analysis of UVC-irradiated reporter plasmid. This analysis revealed a p53-dependent NER activity in wild type (w.t.) p53-containing T-cells and p53-independent NER in w.t. p53-lacking...

journal_title：International journal of cancer

authors： Schavinsky-Khrapunsky Y,Priel E,Aboud M

更新日期：2008-01-15 00:00:00

abstract：:There are no reliable serologic tumor markers for transitional cell carcinoma (TCC) of the urinary bladder and noninvasive urine investigations are inadequate. We used fluorescent microsatellite analysis (MSA) to detect serum DNA and urine-sediment DNA alterations in patients with bladder cancer and prospectively coll...

journal_title：International journal of cancer

authors： von Knobloch R,Hegele A,Brandt H,Olbert P,Heidenreich A,Hofmann R

更新日期：2001-10-01 00:00:00

abstract：:The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer ...

journal_title：International journal of cancer

authors： Raskov H,Orhan A,Salanti A,Gögenur I

更新日期：2020-06-15 00:00:00

abstract：:A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...

journal_title：International journal of cancer

authors： Pearce NE,Sheppard RA,Smith AH,Teague CA

更新日期：1987-02-15 00:00:00

abstract：:Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...

journal_title：International journal of cancer

authors： Ziegler HW,Kay NE,Zarling JM

更新日期：1981-03-15 00:00:00

abstract：:Risks of 2nd primary cancer were assessed in all patients with cutaneous melanoma (12,460) and all patients with ocular melanoma (2,018) incident in Denmark from 1943 to 1989 and followed for totals of 88,667 person-years and 16,045 person-years, respectively. After cutaneous melanoma, 972 2nd cancers occurred. The ri...

journal_title：International journal of cancer

authors： Swerdlow AJ,Storm HH,Sasieni PD

更新日期：1995-06-09 00:00:00

abstract：:Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is increasing evidence for a role in breast cancer as a regulator of signal transducers and activators ...

journal_title：International journal of cancer

authors： Barclay JL,Anderson ST,Waters MJ,Curlewis JD

更新日期：2009-04-15 00:00:00

abstract：:Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...

journal_title：International journal of cancer

authors： Vineis P,Thomas T,Hayes RB,Blot WJ,Mason TJ,Pickle LW,Correa P,Fontham ET,Schoenberg J

更新日期：1988-12-15 00:00:00

abstract：:Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/molecular interactions leading to TNF gene expression in macrophages are unknown. The in vitro system in which human blood monocytes are stimulated with human cancer cells for TNF release was used ...

journal_title：International journal of cancer

authors： Zembala M,Siedlar M,Ruggiero I,Wieckiewicz J,Mytar B,Mattei M,Colizzi V

更新日期：1994-01-15 00:00:00

abstract：:As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...

journal_title：International journal of cancer

authors： Wilkinson MJ,Howell A,Harris M,Taylor-Papadimitriou J,Swindell R,Sellwood RA

更新日期：1984-03-15 00:00:00

abstract：:An investigation was carried out to establish whether the reduction in catalase, glutathione peroxidase and superoxide dismutase activity, normally observed in liver tumours, is an early event and therefore of pathogenetic importance, or whether it is a late occurrence. Experiments performed on dimethylnitrosamine-tre...

journal_title：International journal of cancer

authors： Liotti FS,Menghini AR,Guerrieri P,Mariucci G,Locci P,Bruschelli G

更新日期：1988-11-15 00:00:00