Correlation between karyotypic pattern and clincopathologic features in 125 breast cancer cases.


:A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and modal chromosome number were also found to correlate with the histologic type, grade and mitotic activity of the tumor. Whereas all lobular carcinomas were karyotypically normal or near-diploid, more than 3 aberrations and sometimes near-triploid or near-tetraploid karyotypes were common findings in ductal carcinomas, especially in grade-III tumors and in tumors showing high mitotic activity in vivo. Karyotypes with cytogenetically unregulated clones and unbalanced structural chromosomal rearrangements were more frequent in infiltrating than in in situ carcinomas but, at least as far as the second of these 2 characteristics is concerned, especially in infiltrating carcinomas that also had an in situ component. The presence of cytogenetic polyclonality correlated with tumor grade. Although recurrent chromosome aberrations were significantly more common in ductal than in lobular carcinomas, none of these breast cancer-associated anomalies seemed to be specific for any particular clinicopathologic parameter. The associations between modal chromosome number and mitotic activity and between cytogenetic polyclonality and tumor grade were found to be statistically significant in multivariate models. No correlations was seen between the karyotypic findings and tumor size or the presence of axillary-lymph-node metastases.


Int J Cancer


Pandis N,Idvall I,Bardi G,Jin Y,Gorunova L,Mertens F,Olsson H,Ingvar C,Beroukas K,Mitelman F,Heim S




Has Abstract


1996-04-10 00:00:00














  • Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.

    abstract::The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Menendez JA,Vellon L,Colomer R,Lupu R

    更新日期:2005-05-20 00:00:00

  • Mixed lymphocyte/tumor-cell interaction in a murine sarcoma virus (Moloney)-induced tumor system. Comparison between lymphoproliferation and lymphocyte cytotoxicity.

    abstract::Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kirchner H,Glaser M,Holden HT,Herberman RB

    更新日期:1976-03-15 00:00:00

  • Binding of some metastatic tumor cell lines to fibrous elastin and elastin peptides.

    abstract::Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Svitkina TM,Parsons DF

    更新日期:1993-03-12 00:00:00

  • DNA ploidy and clonal selection in ras + myc-induced mouse prostate cancer.

    abstract::An important goal in prostate cancer research is to define specific molecular and cellular alterations that are associated with malignant progression. The mouse prostate reconstitution model is a relevant and useful system as it allows the study of early events in cancer progression under conditions where oncogene-ini...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Greene DR,Taylor SR,Aihara M,Yoshida K,Egawa S,Park SH,Timme TL,Yang G,Scardino PT,Thompson TC

    更新日期:1995-01-27 00:00:00

  • Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer.

    abstract::Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dong Y,Walsh MD,McGuckin MA,Cummings MC,Gabrielli BG,Wright GR,Hurst T,Khoo SK,Parsons PG

    更新日期:1997-08-22 00:00:00

  • Osteopontin expression in a group of lymph node negative breast cancer patients.

    abstract::The aim of this study was to examine the cellular distribution of osteopontin (OPN) protein [by immunohistochemical (IHC) analysis] and mRNA [by in situ hybridization (ISH)] in the primary tumors of lymph node negative (LNN) breast cancer patients and to determine whether the level of immunodetectable OPN may be assoc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tuck AB,O'Malley FP,Singhal H,Harris JF,Tonkin KS,Kerkvliet N,Saad Z,Doig GS,Chambers AF

    更新日期:1998-10-23 00:00:00

  • Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA).

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Larsson R,Kristensen J,Sandberg C,Nygren P

    更新日期:1992-01-21 00:00:00

  • A portion of the feline leukaemia virus genome is not endogenous in cat cells.

    abstract::Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) trans...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Okabe H,DuBuy J,Gilden RV,Gardner MB

    更新日期:1978-07-15 00:00:00

  • Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.

    abstract::We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

    更新日期:2010-04-01 00:00:00

  • Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Divine KK,Pulling LC,Marron-Terada PG,Liechty KC,Kang T,Schwartz AG,Bocklage TJ,Coons TA,Gilliland FD,Belinsky SA

    更新日期:2005-04-10 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Baruch A,Hartmann M,Zrihan-Licht S,Greenstein S,Burstein M,Keydar I,Weiss M,Smorodinsky N,Wreschner DH

    更新日期:1997-05-29 00:00:00

  • Detection of integrated papillomavirus sequences by ligation-mediated PCR (DIPS-PCR) and molecular characterization in cervical cancer cells.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Luft F,Klaes R,Nees M,Dürst M,Heilmann V,Melsheimer P,von Knebel Doeberitz M

    更新日期:2001-04-01 00:00:00

  • Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yano M,Ouchida M,Shigematsu H,Tanaka N,Ichimura K,Kobayashi K,Inaki Y,Toyooka S,Tsukuda K,Shimizu N,Shimizu K

    更新日期:2004-10-20 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Heller S,Scheibenpflug L,Westermark B,Nistér M

    更新日期:2000-01-15 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • Breast cancer survival in sub-Saharan Africa by age, stage at diagnosis and human development index: A population-based registry study.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Joko-Fru WY,Miranda-Filho A,Soerjomataram I,Egue M,Akele-Akpo MT,N'da G,Assefa M,Buziba N,Korir A,Kamate B,Traore C,Manraj S,Lorenzoni C,Carrilho C,Hansen R,Finesse A,Somdyala N,Wabinga H,Chingonzoh T,Borok M,Chok

    更新日期:2020-03-01 00:00:00

  • Inhibition of protein kinase C-dependent protein phosphorylation correlates with increased polarity and locomotion in Walker 256 carcinosarcoma cells.

    abstract::Signal transduction pathways controlling tumor cell locomotion are not yet well understood. We have studied the role of protein kinase C (PKC)-dependent protein phosphorylation associated with changes in cell shape and locomotor activity of Walker carcinosarcoma cells in culture. We show that the inhibitory effect of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Niggli V,Zimmermann A,Keller H

    更新日期:1996-02-08 00:00:00

  • Association between circulating concentrations of 25(OH)D and colorectal adenoma: a pooled analysis.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jacobs ET,Hibler EA,Lance P,Sardo CL,Jurutka PW

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  • Several genes encoding ribosomal proteins are over-expressed in prostate-cancer cell lines: confirmation of L7a and L37 over-expression in prostate-cancer tissue samples.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vaarala MH,Porvari KS,Kyllönen AP,Mustonen MV,Lukkarinen O,Vihko PT

    更新日期:1998-09-25 00:00:00

  • Biodistribution of 111In-labelled SCN-bz-DTPA-BC-2 MAb following loco-regional injection into glioblastomas.

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    pub_type: 杂志文章


    authors: Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

    更新日期:1997-05-29 00:00:00

  • The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: López-Fauqued M,Gil R,Grueso J,Hernandez-Losa J,Pujol A,Moliné T,Recio JA

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Knight RD,Parshad R,Price FM,Tarone RE,Sanford KK

    更新日期:1993-06-19 00:00:00

  • The prevalence and concordance of human papillomavirus infection in different anogenital sites among men and women in Liuzhou, China: A population-based study.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wei F,Li M,Wu X,Yin K,Lan J,Sheng W,Guo M,Huang S,Wang Y,Li Y,Li R,Su Y,Wu T,Zhang J,Xia N

    更新日期:2018-03-15 00:00:00

  • Inverse regulation of neuronal cellular adhesion molecule (NCAM) by IFN-gamma in melanoma cell cultures established from CNS lesions.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

    更新日期:1999-09-24 00:00:00

  • Application of differential display to identify genes for lung cancer detection in peripheral blood.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Matsunaga H,Hangai N,Aso Y,Okano K,Kawamura M,Kobayashi K,Kambara H,Hoger JH,Mitsuhashi M

    更新日期:2002-08-10 00:00:00

  • Geospatial barriers to health care access for breast cancer diagnosis in sub-Saharan African settings: the African Breast Cancer - Disparities in Outcomes (ABC-DO) Cohort Study.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Togawa K,Anderson BO,Foerster M,Galukande M,Zietsman A,Pontac J,Anele A,Adisa C,Parham G,Pinder LF,McKenzie F,Schüz J,Dos-Santos-Silva I,McCormack V

    更新日期:2020-11-16 00:00:00

  • Mammographic screening after the age of 65 years: evidence for a reduction in breast cancer mortality.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Van Dijck JA,Verbeek AL,Beex LV,Hendriks JH,Holland R,Mravunac M,Straatman H,Werre JM

    更新日期:1996-06-11 00:00:00

  • Steroid hormone receptors in human squamous carcinoma cell lines.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Virolainen E,Vanharanta R,Carey TE

    更新日期:1984-01-15 00:00:00

  • Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers.

    abstract::Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Piipari R,Savela K,Nurminen T,Hukkanen J,Raunio H,Hakkola J,Mäntylä T,Beaune P,Edwards RJ,Boobis AR,Anttila S

    更新日期:2000-06-01 00:00:00

  • Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma.

    abstract::The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ge K,Minhas F,Duhadaway J,Mao NC,Wilson D,Buccafusca R,Sakamuro D,Nelson P,Malkowicz SB,Tomaszewski J,Prendergast GC

    更新日期:2000-04-15 00:00:00