Correlation between karyotypic pattern and clincopathologic features in 125 breast cancer cases.

abstract：:Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with...

journal_title：International journal of cancer

authors： Snijders PJ,Breuer RH,Sutedja TG,Egging M,Voorhorst FJ,Steenbergen RD,van der Linden HC,Risse EK,Berkhof J,de Vries EG,van der Zee AG,Postmus PE,Meijer CJ,Smit EF

更新日期：2004-04-10 00:00:00

abstract：:Indoor air pollution (IAP) caused by cooking has been associated with lung cancer risk in retrospective case-control studies in developing and rural countries. We report the association of cooking conditions, fuel use, oil use, and risk of lung cancer in a developed urban population in a prospective cohort of women in...

journal_title：International journal of cancer

authors： Kim C,Gao YT,Xiang YB,Barone-Adesi F,Zhang Y,Hosgood HD,Ma S,Shu XO,Ji BT,Chow WH,Seow WJ,Bassig B,Cai Q,Zheng W,Rothman N,Lan Q

更新日期：2015-02-01 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00

abstract：:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...

journal_title：International journal of cancer

authors： Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar

更新日期：2007-09-01 00:00:00

abstract：:We have previously shown that sensory nerve peptides contribute to the pathogenesis of pulmonary hypersensitivity reactions (HSRs) to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the blockade of paclitaxel-induced ...

journal_title：International journal of cancer

authors： Yahata H,Saito M,Sendo T,Itoh Y,Uchida M,Hirakawa T,Nakano H,Oishi R

更新日期：2006-05-15 00:00:00

abstract：:The water-soluble scavengers ascorbic acid (Asc), cysteine (Cys), glutathione (GSH) and uric acid (UA) as well as DNA content were determined in 40 breast tissue samples (neoplastic and non-neoplastic tissues from 20 patients). To allow proper homogenization to take place, a fixed number of sections was cut from a tis...

journal_title：International journal of cancer

authors： Honegger CG,Torhorst J,Langemann H,Kabiersch A,Krenger W

更新日期：1988-05-15 00:00:00

abstract：:Risks of 2nd primary cancer were assessed in all patients with cutaneous melanoma (12,460) and all patients with ocular melanoma (2,018) incident in Denmark from 1943 to 1989 and followed for totals of 88,667 person-years and 16,045 person-years, respectively. After cutaneous melanoma, 972 2nd cancers occurred. The ri...

journal_title：International journal of cancer

authors： Swerdlow AJ,Storm HH,Sasieni PD

更新日期：1995-06-09 00:00:00

abstract：:High circulating glucose, insulin resistance and obesity appear to be associated with increased risk of breast cancer (BC). We sought further insight into the relation of these variables to BC. We assessed associations of BC risk with serum fasting glucose, insulin, homeostasis model assessment-insulin resistance (HOM...

journal_title：International journal of cancer

authors： Sieri S,Muti P,Claudia A,Berrino F,Pala V,Grioni S,Abagnato CA,Blandino G,Contiero P,Schunemann HJ,Krogh V

更新日期：2012-02-15 00:00:00

abstract：:We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...

journal_title：International journal of cancer

authors： Van Dijck JA,Verbeek AL,Beex LV,Hendriks JH,Holland R,Mravunac M,Straatman H,Werre JM

更新日期：1996-06-11 00:00:00

abstract：:Allelic loss at the short arm of chromosome 11 is one of the most common and potent events in the progression and metastasis of breast cancer. Here, we present evidence that the Integrin-Linked Kinase (ILK) gene maps to the commonly deleted chromosome 11p15.5 and suppresses malignant growth of human breast cancer cell...

journal_title：International journal of cancer

authors： Chen P,Shen WZ,Karnik P

更新日期：2004-10-10 00:00:00

abstract：:Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...

journal_title：International journal of cancer

authors： Daniel D,Kuchava V,Bondarenko I,Ivashchuk O,Reddy S,Jaal J,Kudaba I,Hart L,Matitashvili A,Pritchett Y,Morris SR,Sorrentino JA,Antal JM,Goldschmidt J

更新日期：2020-12-21 00:00:00

abstract：:Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox reg...

journal_title：International journal of cancer

authors： Nielsen K,Måsbäck A,Olsson H,Ingvar C

更新日期：2012-08-01 00:00:00

abstract：:Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition and the extent of the...

journal_title：International journal of cancer

authors： Chiu CC,Kang YL,Yang TH,Huang CH,Fang K

更新日期：2002-12-01 00:00:00

abstract：:We investigated the ability of endogenous and recombinant interleukin-2 (IL-2)-stimulated NK cells from normal donors and ovarian cancer patients to mediate lysis of ovarian tumors, and found that peripheral blood (PB) mononuclear cells of normal donors or cancer patients did not display tumoricidal activity against o...

journal_title：International journal of cancer

authors： Lotzová E,Savary CA,Freedman RS,Edwards CL,Wharton JT

更新日期：1988-08-15 00:00:00

abstract：:In this review, we evaluate key molecular pathways and markers of muscle-invasive bladder cancer (MIBC). Overexpression and activation of EGFR, p63, and EMT genes are suggestive of basal MIBC subtype generally responsive to chemotherapy. Alterations in PPARγ, ERBB2/3, and FGFR3 gene products and their signaling along ...

journal_title：International journal of cancer

authors： Kiselyov A,Bunimovich-Mendrazitsky S,Startsev V

更新日期：2016-06-01 00:00:00

abstract：:The recently described PGM-2 leukemia displays a hierarchical structure with bipotential stem cells, B-lymphocyte and macrophage progenitor cells, and post-mitotic end cells. Because the different cell types can easily be identified in vitro by clonal culture assays and simple staining procedures, this leukemia is a u...

journal_title：International journal of cancer

authors： Dührsen U,Knieling G,Hossfeld DK

更新日期：1995-03-03 00:00:00

abstract：:A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inhere...

journal_title：International journal of cancer

authors： Olsen CM,Zens MS,Stukel TA,Sacerdote C,Chang YM,Armstrong BK,Bataille V,Berwick M,Elwood JM,Holly EA,Kirkpatrick C,Mack T,Bishop JN,Østerlind A,Swerdlow AJ,Zanetti R,Green AC,Karagas MR,Whiteman DC

更新日期：2009-02-15 00:00:00

abstract：:MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...

journal_title：International journal of cancer

authors： Chang SS,Jiang WW,Smith I,Poeta LM,Begum S,Glazer C,Shan S,Westra W,Sidransky D,Califano JA

更新日期：2008-12-15 00:00:00

abstract：:Cancer cells have the capacity to lyse erythrocytes by a cell-contact-requiring phenomenon. Subcellular fractionation procedures have revealed that the hemolytic principle resides in the cancer cell plasma membrane. In this study we report the detergent extraction of a potent hemolytic factor from the plasma membranes...

journal_title：International journal of cancer

authors： Zucker S,DiMassimo BI,Lysik RM,Vuaridel-Bonanomi E

更新日期：1991-01-21 00:00:00

abstract：:In a case-control study on lung cancer, risk was analysed in relation to smoking habits and frequency of vegetable and fruit consumption. Lung cancer cases in West Sweden and population controls were interviewed using a questionnaire where the frequency of consumption of dietary items and smoking habits were assessed....

journal_title：International journal of cancer

authors： Rylander R,Axelsson G

更新日期：2006-02-01 00:00:00

abstract：:Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...

journal_title：International journal of cancer

authors： Hwang JH,Yoon J,Cho YH,Cha PH,Park JC,Choi KY

更新日期：2020-05-15 00:00:00

abstract：:The cell-cycle regulator p16 inhibits the complex cdk4-cyclin D1 and controls G1-S transition. In human tumors, p16 inactivation is often accomplished by homozygous deletion (HD) of its encoding gene, CDKN2A. Methylation of the 5' CpG island promoter has been proposed as an alternative mechanism of inactivation. Expre...

journal_title：International journal of cancer

authors： Bortolotto S,Chiadò-Piat L,Cavalla P,Bosone I,Chiò A,Mauro A,Schiffer D

更新日期：2000-11-15 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threate...

journal_title：International journal of cancer

authors： To YF,Sun RW,Chen Y,Chan VS,Yu WY,Tam PK,Che CM,Lin CL

更新日期：2009-04-15 00:00:00

abstract：:Mutations of the p53 tumor-suppressor gene universally occur on exons 5-8 in human cancer. We analyzed these mutations in esophageal cancer tissue from 207 patients in China using 2 methods, single-strand conformation polymorphism (SSCP), one of the most frequently used methods, and the recently developed denaturing h...

journal_title：International journal of cancer

authors： Yamanoshita O,Kubota T,Hou J,Ping YM,Zhang XL,Li XP,Li SS,Li XX,Zhu DC,Fukushima Y,Nakajima T

更新日期：2005-03-10 00:00:00

abstract：:Previously, we have identified aloe-emodin (AE) as a new type of anticancer agent, with activity that is based on apoptotic cell death promoted by a neuroectodermal tumor-specific drug uptake. We attempt to clarify the intracellular target of AE and the apoptosis-signaling pathway activated by AE in neuroblastoma cell...

journal_title：International journal of cancer

authors： Pecere T,Sarinella F,Salata C,Gatto B,Bet A,Dalla Vecchia F,Diaspro A,Carli M,Palumbo M,Palù G

更新日期：2003-10-10 00:00:00

abstract：:Expression of the monocyte chemoattractant protein-1 (MCP-1) was examined in human central nervous system tumours (glioblastomas and astrocytomas) and normal human brain. Northern blot analysis demonstrated constitutive expression of MCP-1 mRNA in 6 of 12 glioblastoma cell lines. Expression could be stimulated by inte...

journal_title：International journal of cancer

authors： Desbaillets I,Tada M,de Tribolet N,Diserens AC,Hamou MF,Van Meir EG

更新日期：1994-07-15 00:00:00

abstract：:The active form of vitamin D(3), 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), induces caspase-independent apoptosis in MCF-7 and T47D breast cancer cells. Before the appearance of apoptotic cells at Day 4 after the addition of 1,25(OH)(2)D(3), the MCF-7 cells are sensitized to the caspase-mediated apoptosis induced b...

journal_title：International journal of cancer

authors： Mathiasen IS,Hansen CM,Foghsgaard L,Jäättelä M

更新日期：2001-07-15 00:00:00

abstract：:Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone EO9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of EO9 and mitomycin C in...

journal_title：International journal of cancer

authors： Plumb JA,Workman P

更新日期：1994-01-02 00:00:00

abstract：:The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin-enhanced peritoneal metastases from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. Rats were given 10 weekly injections of azoxymethane (7.4 mg/kg body weight, s.c....

journal_title：International journal of cancer

authors： Ishihara R,Tatsuta M,Iishi H,Baba M,Uedo N,Higashino K,Mukai M,Ishiguro S,Kobayashi S,Murakami-Murofushi K

更新日期：2004-06-10 00:00:00

abstract：:Cytotoxic antibodies against glioblastoma-associated antigen(s) have been sought for in glioma patient sera. Complement-dependent cytotoxicity (CDC) I and antibody-dependent cell-mediated cytotoxicity (ADCC) assays were used to test sera from 80 patients using 51 Cr labelled target cells derived from eight different g...

journal_title：International journal of cancer

authors： Martin-Achard A,Diserens AC,de Tribolet N,Carrel S

更新日期：1980-02-15 00:00:00