Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.

abstract：:Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A ...

journal_title：International journal of cancer

authors： Guo D,Lui GYL,Lai SL,Wilmott JS,Tikoo S,Jackett LA,Quek C,Brown DL,Sharp DM,Kwan RYQ,Chacon D,Wong JH,Beck D,van Geldermalsen M,Holst J,Thompson JF,Mann GJ,Scolyer RA,Stow JL,Weninger W,Haass NK,Beaumont KA

更新日期：2019-06-15 00:00:00

abstract：:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

journal_title：International journal of cancer

authors： Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

更新日期：2020-10-15 00:00:00

abstract：:Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

journal_title：International journal of cancer

authors： Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

更新日期：2012-10-15 00:00:00

abstract：:Thiazolidinedione derivatives with potent antiarthritic activity, such as CGP 52608, have been suggested to exert their biological effects through the activation of the orphan nuclear receptor RORalpha. Since response elements for this receptor are present in the promoter region of cell cycle-related genes (i.e., p21(...

journal_title：International journal of cancer

authors： Moretti RM,Montagnani Marelli M,Motta M,Limonta P

更新日期：2001-06-01 00:00:00

abstract：:Lysine-specific demethylase-1 (LSD1) removes the methyl groups from mono- and di-methylated lysine 4 of histone H3. Previous studies have linked LSD1 to malignancy in several human tumors, and LSD1 is considered to epigenetically regulate the energy metabolism genes in adipocytes and hepatocellular carcinoma. This stu...

journal_title：International journal of cancer

authors： Kosumi K,Baba Y,Sakamoto A,Ishimoto T,Harada K,Nakamura K,Kurashige J,Hiyoshi Y,Iwatsuki M,Iwagami S,Sakamoto Y,Miyamoto Y,Yoshida N,Oki E,Watanabe M,Hino S,Nakao M,Baba H

更新日期：2016-01-15 00:00:00

abstract：:We report the incidence of cervical intraepithelial neoplasia (CIN) among HIV-infected women who did not have any colposcopic or histopathological evidence of CIN at baseline. Of the 1,023 women without any CIN at baseline, 855 (83.6%) have been followed up to a maximum of 6.4 years contributing 2,875 person years of ...

journal_title：International journal of cancer

authors： Joshi S,Muwonge R,Kulkarni V,Deodhar K,Mandolkar M,Lucas E,Sankaranarayanan R

更新日期：2019-03-01 00:00:00

abstract：:With low cure rates but increasing diverse treatment options that provide variable remission times, ovarian cancer is increasingly being recognized as a chronic disease. This reality indicates the need for a better understanding of factors influencing disease progression. In a previous global analysis of gene expressi...

journal_title：International journal of cancer

authors： Ouellet V,Le Page C,Guyot MC,Lussier C,Tonin PN,Provencher DM,Mes-Masson AM

更新日期：2006-11-01 00:00:00

abstract：:Metastatic tumor formation via vessel route begins with cancer cell extravasation from vessel lumen, migration into the connective tissue surrounding vessels, and invasion into target organ parenchyma. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) have been recognized to play an i...

journal_title：International journal of cancer

authors： Aokage K,Ishii G,Ohtaki Y,Yamaguchi Y,Hishida T,Yoshida J,Nishimura M,Nagai K,Ochiai A

更新日期：2011-04-01 00:00:00

abstract：:A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum-cell neoplasm (RCN) is growing. The killer cells are non-adherent, non-phagocytic, relatively resistant to X-ray, and scarcely or only partially inacti...

journal_title：International journal of cancer

authors： Chang KS,Log T

更新日期：1980-03-15 00:00:00

abstract：:Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gene, leading to amino...

journal_title：International journal of cancer

authors： Mehl AM,Fischer N,Rowe M,Hartmann F,Daus H,Trümper L,Pfreundschuh M,Müller-Lantzsch N,Grässer FA

更新日期：1998-04-13 00:00:00

abstract：:Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinic...

journal_title：International journal of cancer

authors： Zellweger T,Günther S,Zlobec I,Savic S,Sauter G,Moch H,Mattarelli G,Eichenberger T,Curschellas E,Rüfenacht H,Bachmann A,Gasser TC,Mihatsch MJ,Bubendorf L

更新日期：2009-05-01 00:00:00

abstract：:The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...

journal_title：International journal of cancer

authors： Di Vinci A,Perdelli L,Banelli B,Salvi S,Casciano I,Gelvi I,Allemanni G,Margallo E,Gatteschi B,Romani M

更新日期：2005-04-10 00:00:00

abstract：:To assess the excess risk of HPV-associated cancer (HPVaC) in two at-risk groups-women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated for non-cervical pre-invasive anogenital disease. All CIN3 cases diagnosed in 1989-2015 in Scotland were extracted from...

journal_title：International journal of cancer

authors： Pan J,Kavanagh K,Cuschieri K,Pollock KG,Gilbert DC,Millan D,Bell S,Graham SV,Williams ARW,Cruickshank ME,Palmer T,Wakeham K

更新日期：2019-07-15 00:00:00

abstract：:The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher...

journal_title：International journal of cancer

authors： Suter L,Brüggen J,Bröcker EB,Sorg C

更新日期：1985-06-15 00:00:00

abstract：:We have established 3 new EBV-negative cell lines, designated Sc-1, Ri-1 and Ci-1, from patients with B-cell lymphoma/leukemia. We characterized them by cytogenetics and by study of surface membrane antigens with a panel of monoclonal antibodies (MAbs), surface and cytoplasmic immunoglobulin (Ig) expression and Ig hea...

journal_title：International journal of cancer

authors： Th'ng KH,Garewal G,Kearney L,Rassool F,Melo JV,White H,Catovsky D,Foroni L,Luzzatto L,Goldman JM

更新日期：1987-01-15 00:00:00

abstract：:Our case-control study was conducted to investigate whether residential and occupational exposure to magnetic fields increased the risk for brain tumours in adults. Data from an occupational exposure matrix was also evaluated. The study population in this nested case-control study was made up of subjects aged 16 years...

journal_title：International journal of cancer

authors： Klaeboe L,Blaasaas KG,Haldorsen T,Tynes T

更新日期：2005-05-20 00:00:00

abstract：:We have previously shown that sensory nerve peptides contribute to the pathogenesis of pulmonary hypersensitivity reactions (HSRs) to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the blockade of paclitaxel-induced ...

journal_title：International journal of cancer

authors： Yahata H,Saito M,Sendo T,Itoh Y,Uchida M,Hirakawa T,Nakano H,Oishi R

更新日期：2006-05-15 00:00:00

abstract：:The hepatitis B virus (HBV) is a major causative agent of chronic liver disease and subsequent liver cirrhosis worldwide. The reduced sensitivity of virus-infected liver cells to apoptosis may play a role in the failure to remove virus-infected cells and eventually promote viral chronicity. The purpose of our study wa...

journal_title：International journal of cancer

authors： Barreiros AP,Sprinzl M,Rosset S,Höhler T,Otto G,Theobald M,Galle PR,Strand D,Strand S

更新日期：2009-01-01 00:00:00

abstract：:To further examine the association between oral hygiene and esophageal squamous cell carcinoma (ESCC) risk and the effect modification of other exposures, we conducted a population-based case-control study between 2010 and 2012 in Taixing, China, a high-risk area for ESCC. Cases were primarily recruited from endoscopy...

journal_title：International journal of cancer

authors： Chen X,Yuan Z,Lu M,Zhang Y,Jin L,Ye W

更新日期：2017-02-01 00:00:00

abstract：:In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to-child transmission, a retrospective study of HTLV-I infection among children born to HTLV-I-seropositive women was carried out in a highly HTLV-I-endemic population of African origin living in...

journal_title：International journal of cancer

authors： Ureta-Vidal A,Angelin-Duclos C,Tortevoye P,Murphy E,Lepère JF,Buigues RP,Jolly N,Joubert M,Carles G,Pouliquen JF,de Thé G,Moreau JP,Gessain A

更新日期：1999-09-09 00:00:00

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocytic and oligodendroglial tumors, we quantitatively assessed methylatio...

journal_title：International journal of cancer

authors： Mulholland S,Pearson DM,Hamoudi RA,Malley DS,Smith CM,Weaver JM,Jones DT,Kocialkowski S,Bäcklund LM,Collins VP,Ichimura K

更新日期：2012-09-01 00:00:00

abstract：:We conducted a retrospective cohort study to investigate the colorectal cancer (CRC) incidence and mortality prevention achievable in clinical practice with an optimized colonoscopy protocol targeting near-complete polyp clearance. The protocol consisted of: (i) telephonic reinforcement of bowel preparation instructio...

journal_title：International journal of cancer

authors： Xirasagar S,Li YJ,Hurley TG,Tsai MH,Hardin JW,Hurley DM,Hebert JR,de Groen PC

更新日期：2015-03-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux medi...

journal_title：International journal of cancer

authors： König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D

更新日期：2005-06-20 00:00:00

abstract：:Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

journal_title：International journal of cancer

authors： Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

更新日期：2007-10-15 00:00:00

abstract：:An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...

journal_title：International journal of cancer

authors： Rabin H,Neubauer RH,Hopkins RF 3rd,Nonoyama M

更新日期：1978-06-15 00:00:00

abstract：:Epigenetic silencing of MLH1 is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers. We hypothesized that variation in the MLH1 gene might contribute to the risk for MLH1 methylation and epigenetic silencing. We undertook a case-control study to test for the association between...

journal_title：International journal of cancer

authors： Chen H,Taylor NP,Sotamaa KM,Mutch DG,Powell MA,Schmidt AP,Feng S,Hampel HL,de la Chapelle A,Goodfellow PJ

更新日期：2007-04-15 00:00:00

abstract：:It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents...

journal_title：International journal of cancer

authors： Vestergaard H,Westergaard T,Wohlfahrt J,Hjalgrim H,Melbye M

更新日期：2010-08-01 00:00:00

abstract：:To estimate the annual incidence of adult T-cell leukemia/lymphoma (ATL) by district in Japan, a large-scale nationwide survey of ATL and of non-Hodgkin's lymphoma was performed in 1988. Questionnaires for the registration of ATL and of T-cell and non-T-cell lymphoma were distributed to the physicians in charge of thi...

journal_title：International journal of cancer

authors： Tajima K

更新日期：1990-02-15 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasi...

journal_title：International journal of cancer

authors： Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna C

更新日期：2009-05-01 00:00:00