Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer.

abstract：:Women affected by gross cystic disease of the breast have an increased risk of breast cancer. We report here the incidence of breast cancer by cyst type and intracystic epidermal growth factor (EGF) concentration. Our retrospective study included 504 women who had at least 1 cyst aspiration between 1985 and 1993. Cyst...

journal_title：International journal of cancer

authors： Boccardo F,Marenghi C,Ghione G,Pepe A,Parodi S,Rubagotti A

更新日期：2001-07-20 00:00:00

abstract：:Cytogenetic deletions of the short arm of chromosome 9, 9p, have been detected in cell lines of malignant mesothelioma as well as in tumor material. Many tumor types carry deletions of chromosome 9 or more specifically of 9p21. The tumor-suppressor genes, CDKN2A and CDKN2B, each of which encodes a structurally and fun...

journal_title：International journal of cancer

authors： Prins JB,Williamson KA,Kamp MM,Van Hezik EJ,Van der Kwast TH,Hagemeijer A,Versnel MA

更新日期：1998-02-09 00:00:00

abstract：:Dose-dense adjuvant chemotherapy is standard of care in high-risk early breast cancer patients. However, its role in HER2-positive patients is still uncertain. In this exploratory analysis of the GIM2 trial, we investigated the efficacy of dose-dense chemotherapy in HER2-positive breast cancer patients with or without...

journal_title：International journal of cancer

authors： Lambertini M,Poggio F,Bruzzone M,Conte B,Bighin C,de Azambuja E,Giuliano M,De Laurentiis M,Cognetti F,Fabi A,Bisagni G,Durando A,Turletti A,Urracci Y,Garrone O,Puglisi F,Montemurro F,Ceppi M,Del Mastro L,GIM2 invest

更新日期：2020-07-01 00:00:00

abstract：:Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide 3 (APOBEC3, A3) fa...

journal_title：International journal of cancer

authors： Kano M,Kondo S,Wakisaka N,Wakae K,Aga M,Moriyama-Kita M,Ishikawa K,Ueno T,Nakanishi Y,Hatano M,Endo K,Sugimoto H,Kitamura K,Muramatsu M,Yoshizaki T

更新日期：2019-09-15 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...

journal_title：International journal of cancer

authors： Foong YT,Cheng HM,Sam CK,Dillner J,Hinderer W,Prasad U

更新日期：1990-06-15 00:00:00

abstract：:Breast cancer is one of the most common and feared cancers faced by women. The prognosis of patients with advanced or recurrent breast cancer remains poor despite refinements in multimodality therapies involving chemotherapeutic and hormonal agents. Multimodal therapy with more specific and effective strategy is urgen...

journal_title：International journal of cancer

authors： Tan G,Kasuya H,Sahin TT,Yamamura K,Wu Z,Koide Y,Hotta Y,Shikano T,Yamada S,Kanzaki A,Fujii T,Sugimoto H,Nomoto S,Nishikawa Y,Tanaka M,Tsurumaru N,Kuwahara T,Fukuda S,Ichinose T,Kikumori T,Takeda S,Nakao A,Kode

更新日期：2015-04-01 00:00:00

abstract：:A significant proportion of screen-detected men with prostate cancer is likely to be overtreated, especially in older age groups. We aim to find which groups of screen-detected older men (65+) benefit the most from Immediate Radical Treatment or Active Surveillance (AS) for prostate cancer, depending on age, screening...

journal_title：International journal of cancer

authors： de Carvalho TM,Heijnsdijk EA,de Koning HJ

更新日期：2016-05-15 00:00:00

abstract：:Responses to the genotoxic effect of bleomycin in lymphocytes of blood cultures, expressed as the average number of chromatid breaks per cell (b/c), varied from less than 0.20 to more than 2.00 in 335 normal individuals. More than 11% of the subjects tested showed a b/c rate above 1.00 and more than 22% showed a b/c r...

journal_title：International journal of cancer

authors： Hsu TC,Johnston DA,Cherry LM,Ramkissoon D,Schantz SP,Jessup JM,Winn RJ,Shirley L,Furlong C

更新日期：1989-03-15 00:00:00

abstract：:Over-expression of the c-erbB-2 (HER-2/neu) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibit growth of tumor cells in the absence of cellular or humoral e...

journal_title：International journal of cancer

authors： Xu F,Lupu R,Rodriguez GC,Whitaker RS,Boente MP,Berchuck A,Yu Y,DeSombre KA,Boyer CM,Bast RC Jr

更新日期：1993-02-01 00:00:00

abstract：:Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we sys...

journal_title：International journal of cancer

authors： Imai T,Tanaka Y,Fukudome K,Takagi S,Araki K,Yoshie O

更新日期：1993-11-11 00:00:00

abstract：:A syngeneic tumor system in DBA/2 mice consisting of a methyl-cholanthrene-induced, weakly metastatic lymphoma, L5178YE (= Eb), its spontaneous strongly metastatic variant, L5178YES (= ESb), and an unrelated, methylcholanthrene-induced, metastasizing tumor, MDAY-D2, were used to study the relationship between metastat...

journal_title：International journal of cancer

authors： Schwartz R,Kniep B,Müthing J,Mühlradt PF

更新日期：1985-11-15 00:00:00

abstract：:The effects of androgen manipulation on epidermal growth factor (EGF) receptor, p185erbB-2 and transforming growth factor-alpha (TGF-alpha) levels were examined in prostatic adenocarcinoma. Male nude mice were inoculated with the CWR22 androgen-dependent human prostatic tumor or an androgen-independent (CWR22R) deriva...

journal_title：International journal of cancer

authors： Myers RB,Oelschlager D,Manne U,Coan PN,Weiss H,Grizzle WE

更新日期：1999-07-30 00:00:00

abstract：:Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...

journal_title：International journal of cancer

authors： Kuczyk M,Machtens S,Stief C,Jonas U

更新日期：1999-12-10 00:00:00

abstract：:Infection with erbB-2 (E) of Ha-ras (H) oncogene-transfected cells has been previously shown to cooperatively induce anchorage-independent growth of the MCF10A human mammary epithelial cell line in vitro, but not to induce nude mouse tumorigenicity. Here we show that oncogene-transformed MCF10A are able to halt in the...

journal_title：International journal of cancer

authors： Giunciuglio D,Culty M,Fassina G,Masiello L,Melchiori A,Paglialunga G,Arand G,Ciardiello F,Basolo F,Thompson EW

更新日期：1995-12-11 00:00:00

abstract：:Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...

journal_title：International journal of cancer

authors： Shanmugam MK,Manu KA,Ong TH,Ramachandran L,Surana R,Bist P,Lim LH,Kumar AP,Hui KM,Sethi G

更新日期：2011-10-01 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasi...

journal_title：International journal of cancer

authors： Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna C

更新日期：2009-05-01 00:00:00

abstract：:We investigated the inhibitory effect of sunitinib, a newly approved multitargeted tyrosine kinase inhibitor, against the progression of renal cell cancer (RCC) bone metastases in vivo. In vitro cell proliferation was determined using the MTS assay. To investigate the inhibitory effects of sunitinib in vivo, we establ...

journal_title：International journal of cancer

authors： Maita S,Yuasa T,Tsuchiya N,Mitobe Y,Narita S,Horikawa Y,Hatake K,Fukui I,Kimura S,Maekawa T,Habuchi T

更新日期：2012-02-01 00:00:00

abstract：:We present data on test positivity, relative sensitivity, rates of detection and relative specificity for primary human papillomavirus (HPV) testing with different cutoff levels for test positivity, in comparison to conventional cytology. In 2003-2004, 18,438 women were screened primarily with Hybrid Capture 2 (HC 2) ...

journal_title：International journal of cancer

authors： Kotaniemi-Talonen L,Malila N,Nieminen P,Anttila A,Tarkkanen J,Laurila P,Hakama M

更新日期：2008-12-15 00:00:00

abstract：:Mortality rates for cancer of all sites combined and for 12 selected sites or site groups in Estonia from 1965 to 1989 were studied to assess overall progress in controlling cancer. Between 1965-1969 and 1985-1989, age-standardized mortality (world population) increased by 12.0% among males and decreased by 5.1% among...

journal_title：International journal of cancer

authors： Leinsalu M,Rahu M

更新日期：1993-04-01 00:00:00

abstract：:Combretastatin A4 (CA4) is a novel vascular disrupting agent that has promising clinical efficacy because of its ability to inhibit microtubule assembly and subsequently disrupt tumor blood flow. In this study, we demonstrate that mitogen-activated protein kinases (MAPKs) are critically involved in the cytotoxicity of...

journal_title：International journal of cancer

authors： Quan H,Xu Y,Lou L

更新日期：2008-04-15 00:00:00

abstract：:This paper reports the results of 8 years of HLA typing of newly diagnosed nasopharyngeal carcinoma (NPC) patients among Chinese in Singapore, and compares the HLA profile of NPC cases with that of the normal Chinese population. Earlier results had indicated an association with A2 and BW46, but the heterogeneity of th...

journal_title：International journal of cancer

authors： Chan SH,Day NE,Kunaratnam N,Chia KB,Simons MJ

更新日期：1983-08-15 00:00:00

abstract：:The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast ...

journal_title：International journal of cancer

authors： Reed MJ,Beranek PA,Cheng RW,Ghilchik MW,James VH

更新日期：1985-04-15 00:00:00

abstract：:Human mammary tumours which are histologically well differentiated are more likely to synthesize receptors for estrogen (ER) and progesterone (PR) and to respond to systemic endocrine therapy. The aim of this study was to explore the relationship between differentiation, receptors and endocrine responsiveness in more ...

journal_title：International journal of cancer

authors： Baildam AD,Howell A,Barnes DM,Redford J,Healy K,Swindell R,Sellwood RA

更新日期：1988-08-15 00:00:00

abstract：:Although tobacco habits have been associated with the risk of oral leukoplakia, alcohol drinking and body mass index (BMI) as risk factors have not been well established. The purpose of this study is to evaluate the independent effects of drinking, BMI, tobacco chewing and smoking on the risk of oral leukoplakia. A ca...

journal_title：International journal of cancer

authors： Hashibe M,Sankaranarayanan R,Thomas G,Kuruvilla B,Mathew B,Somanathan T,Parkin DM,Zhang ZF

更新日期：2000-10-01 00:00:00

abstract：:Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...

journal_title：International journal of cancer

authors： Mancuso P,Martin-Padura I,Calleri A,Marighetti P,Quarna J,Rabascio C,Braidotti P,Bertolini F

更新日期：2011-09-15 00:00:00

abstract：:Tamoxifen is an important selective estrogen receptor (ER) modulator for treatment of steroid hormone positive breast cancer. In addition to the beneficial effect, tamoxifen is one risk factor for endometrial carcinoma (EnCa) development. We hypothesized that, (1) dysregulation of gene expression and protein phosphory...

journal_title：International journal of cancer

authors： Strissel PL,Ellmann S,Loprich E,Thiel F,Fasching PA,Stiegler E,Hartmann A,Beckmann MW,Strick R

更新日期：2008-12-15 00:00:00

abstract：:Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...

journal_title：International journal of cancer

authors： Henson KE,McGale P,Darby SC,Parkin M,Wang Y,Taylor CW

更新日期：2020-09-01 00:00:00

abstract：:Persistent infection with high-risk human papillomavirus (HPV) is central to cervical carcinogenesis. Certain high-risk types, such as HPV16, may be more persistent than other HPV types, and type-specific HPV persistence may differ by HIV serostatus. This study evaluated the association between HPV type and clearance ...

journal_title：International journal of cancer

authors： Koshiol JE,Schroeder JC,Jamieson DJ,Marshall SW,Duerr A,Heilig CM,Shah KV,Klein RS,Cu-Uvin S,Schuman P,Celentano D,Smith JS

更新日期：2006-10-01 00:00:00

abstract：:The high burden of cervical cancer and inadequate/suboptimal cytology screening in developing countries led to the evaluation of visual screening tests, like visual inspection with acetic acid (VIA) and Lugol's iodine (VILI). We describe the performance of VIA, VILI and cytology, carried out in a multinational project...

journal_title：International journal of cancer

authors： Deodhar K,Sankaranarayanan R,Jayant K,Jeronimo J,Thorat R,Hingmire S,Muwonge R,Chiwate A,Deshpande R,Ajit D,Kelkar R,Rekhi B,Ruben I,Malvi SG,Chinoy R,Jambhekar N,Nene BM

更新日期：2012-09-15 00:00:00

abstract：:IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D122 clone. Both high and low D122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumorigenicity as compared...

journal_title：International journal of cancer

authors： Porgador A,Gansbacher B,Bannerji R,Tzehoval E,Gilboa E,Feldman M,Eisenbach L

更新日期：1993-02-01 00:00:00