Abstract：
:The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasis, a cancer that is known to be dependent on the IGF-I axis. To test this hypothesis, we evaluated the primary tumour growth and metastatic progression of K7M2 murine osteosarcoma cells injected to a genetically engineered mouse [liver-specific IGF-I deficient (LID)] in which serum IGF-I levels are reduced by 75%, while maintaining expression of IGF-I in normal tissues. We first demonstrated that IGF-I in the tumour and the tumour-microenvironment were maintained in the LID mice. Within this designed model, there was no difference in primary tumour growth or in pulmonary metastasis in LID mice compared to control mice. Furthermore, there was no difference in the number or localization of single metastatic cells immediately after their arrival in the lungs of LID mice and control mice, as analysed by single cell video microscopy. Collectively, these data suggest that marked reduction in serum IGF-I is not sufficient to slow the progression of either primary or metastatic models of osteosarcoma.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna Cdoi
10.1002/ijc.24169subject
Has Abstractpub_date
2009-05-01 00:00:00pages
2042-9issue
9eissn
0020-7136issn
1097-0215journal_volume
124pub_type
杂志文章abstract：:The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28987
更新日期：2015-01-15 00:00:00
abstract：:We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph n...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970611)71:6<978::aid-ijc
更新日期：1997-06-11 00:00:00
abstract：:In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910450321
更新日期：1990-03-15 00:00:00
abstract：:The sialosyl Lewis a antigen was identified in a ganglioside extract from a malignant human urothelial cell line (Hu 1703He) by fast atom bombardment mass spectrometry. The presence of this antigen in urothelial cell lines with varying tumorigenic properties was further studied using the 19-9 monoclonal antibody (MAb)...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910450635
更新日期：1990-06-15 00:00:00
abstract：:By using a functional complementation approach, suppression of tumorigenicity was observed after transfer of intact or truncated copies of chromosome 3 into a nasopharyngeal carcinoma (NPC) HONE1 cell line. The extra exogenous chromosome 3 in the microcell hybrids (MCHs) significantly extended the lag period of tumor ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23528
更新日期：2008-07-15 00:00:00
abstract：:Parvoviruses of rodents are endowed with oncosuppressive properties. In particular, parvoviral infections protect host animals from spontaneous and chemical- or virus-induced tumour initiation in laboratory animals. The present study was undertaken to substantiate the capacity of parvovirus H-1 to inhibit therapeutica...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980209)75:4<584::aid-ijc
更新日期：1998-02-09 00:00:00
abstract：:Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivariate analysis identified 4 factors...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20491
更新日期：2004-12-10 00:00:00
abstract：:A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970611)71:6<924::aid-ijc
更新日期：1997-06-11 00:00:00
abstract：:We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910510516
更新日期：1992-07-09 00:00:00
abstract：:Clinical and experimental scintigraphic studies have found that radiolabelled antibodies are not only taken up by tumour(s) but also by normal liver. The accumulation of radionuclides in this organ poses a major problem to the use of radiolabelled antibodies as diagnostic and therapeutic tools. In an attempt to unders...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910500616
更新日期：1992-04-01 00:00:00
abstract：:A population-based case-control study was conducted to examine the effect of ingestion of vitamin C, carotenoids and retinol on risk of pharyngeal cancer. Data were available from 166 cases of pharyngeal cancer or their next-of-kin, and from 547 controls similar in age and sex to the cases. Odds ratios (ORs) relating ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910440406
更新日期：1989-10-15 00:00:00
abstract：:B700 and B50 are melanoma-specific antigens originally isolated from B16 murine melanoma. B700, which elicits a strong tumor rejection response, is present on all murine melanomas tested to date. We now demonstrate the presence of B50 in the other murine melanomas and find that the 2 molecules are non-covalently compl...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910430326
更新日期：1989-03-15 00:00:00
abstract：:We examined cancer-associated fibroblasts (CAFs) and a panel of immunohistochemical markers of epithelial-mesenchymal transition (EMT) in 19 pair-matched oral tongue squamous cell carcinoma (SCC) and metastatic tumors to regional lymph nodes (RLNs). alpha-Smooth muscle actin (alpha-SMA) was studied to identify CAFs. E...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25358
更新日期：2010-09-01 00:00:00
abstract：:Flavone acetic acid (FAA) is a potentially useful anti-tumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulant properties leadi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910490219
更新日期：1991-09-09 00:00:00
abstract：:The effect of EGF on the soft agar colony-forming ability of fresh human tumor cells was assessed in 40 specimens obtained from various types of carcinoma including those of the breast, endometrium ovary, and other sites. Cells from four established human tumor cell lines (three breast and one endometrial) were also i...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910300611
更新日期：1982-12-15 00:00:00
abstract：:We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer - Disparities in Outcomes (ABC-DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda, and Zambia. The baseline interview in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33400
更新日期：2020-11-16 00:00:00
abstract：:The role of cetuximab in treatment-related hematologic toxicity is not clear. We performed a meta-analysis of published randomized controlled trials (RCTs) to determine the overall risk of ≥grade 3 hematologic toxicity events (HTEs) associated with cetuximab. PubMed, EMBASE, and Web of Knowledge databases as well as a...
journal_title：International journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1002/ijc.29045
更新日期：2015-02-15 00:00:00
abstract：:Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910350207
更新日期：1985-02-15 00:00:00
abstract：:The role of plasma oxidant-antioxidant status in survival after breast cancer surgery was investigated in a cohort of patients (n = 363) hospitalized in Southern France between 1989 and 1992. The median follow-up was 8 years after surgery for histologically confirmed breast cancer. Plasma analyses were performed after...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10099
更新日期：2002-02-10 00:00:00
abstract：:The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25726
更新日期：2011-08-01 00:00:00
abstract：:Lymphocyte blastogenesis induced by autologous tumor biopsy cells, by allogeneic lymphocytes and by PHA, was performed in the presence of autologous or allogeneic serum collected from normal blood donors. In 13 of the 15 cases lymphocyte stimulation by autologous tumor cells was inhibited in the presence of autologous...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910160517
更新日期：1975-11-15 00:00:00
abstract：:Allogeneic mixed leukocytes reaction has been reported to activate vast numbers of T lymphocytes and produce large amounts of type 1 cytokines that are linked to an initiation of antitumor immunity. Using poor immunogeneic B16-F10 and Lewis lung carcinoma (LLC) tumor model, we evaluated the effects of inactivated allo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24045
更新日期：2009-03-01 00:00:00
abstract：:In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down-regulation of Bcl-X(L) expression and apoptosis, whereas recurrence...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24787
更新日期：2010-02-15 00:00:00
abstract：:When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910200106
更新日期：1977-07-15 00:00:00
abstract：:A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A ch...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910540524
更新日期：1993-07-09 00:00:00
abstract：:Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...
journal_title：International journal of cancer
pub_type： 撤回出版物
doi：10.1002/ijc.32281
更新日期：2019-08-15 00:00:00
abstract：:The human polyomaviruses JC virus (JCV) and BK virus (BKV) are oncogenic in experimental systems and commonly infect humans. JCV DNA has been reported to be present in human colon mucosa and in colorectal cancers. To investigate whether the risk for colorectal cancer is associated with JCV or BKV infection, we perform...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22770
更新日期：2007-09-01 00:00:00
abstract：:BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910210413
更新日期：1978-04-15 00:00:00
abstract：:Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to have a common pathogenetic mechanism. H19 was found to be inactivated in WT and eRMS either by loss of heterozygosity or by hypermethylation of the maternal allele. We show here that the expression of ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990812)82:4<490::aid-ijc
更新日期：1999-08-12 00:00:00
abstract：:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22807
更新日期：2007-09-01 00:00:00
