Abstract:
:An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV and was present at 2-3 genome copies per CP-81 cell. Gibbon lymphocytes transformed by H. pongo, Epstein-Barr virus (EBV), and H. papio (of baboon, Papio hamadryas, origin) were found to be virus antigen-positive B cells. Gibbon lymphocytes transformed by H. pongo and EBV and transplanted to nude mice by the intracranial (IC) route (had a 75% and a 45% success rate, respectively), while transplants of similar cells transformed by H. papio were only 10% successful. None of these lines transplanted subcutaneously (SC) nor manifested a high degree of colony formation in 0.33% agarose (less than or equal to 0.5%), Gibbon lymphocytes transformed by H. pongo were hypodiploid while those transformed by EBV or H. papio were diploid. CP-81 cells themselves could be transplanted both IC (100%) and SC (70%) and showed a relatively high degree of colony formation in agarose (6.4-7.6%). B95-8 cells (marmoset, Saguinus oedipus-EBV) could be transplanted IC (66%) but not SC and had a low but significant ability to grow in agarose (1.6%). 594S (baboon, P. hamadryas-H. papio) cells could be transplanted IC (25%) but not SC, and grew to very low levels in agarose (0.1%).
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Rabin H,Neubauer RH,Hopkins RF 3rd,Nonoyama Mdoi
10.1002/ijc.2910210614subject
Has Abstractpub_date
1978-06-15 00:00:00pages
762-7issue
6eissn
0020-7136issn
1097-0215journal_volume
21pub_type
杂志文章abstract::We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quanti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970703)72:1<174::aid-ijc
更新日期:1997-07-03 00:00:00
abstract::We evaluated the efficacy of a candidate melanoma vaccine approach in mice genetically prone to develop melanoma due to the introduction of an oncogenic mutation (R24C) in the germline sequence of the cyclin-dependent kinase 4 (cdk4), a protein critically involved in cell cycle regulation. Melanomas were induced in cd...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21349
更新日期:2006-01-15 00:00:00
abstract::A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcohol-formalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC). In the competitive...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0215(19991008)83:2<157::aid-ijc
更新日期:1999-10-08 00:00:00
abstract::In colorectal cancer (CRC), hepatic arterial infusion (HAI) chemotherapy may convert primarily unresectable CRC liver metastases (CLM) into resectability, although the risk of metastatic recurrence remains high after CLM ablation. We investigated the role of antitumour immunity invoked by first-line oxaliplatin-HAI fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32847
更新日期:2020-04-01 00:00:00
abstract::Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27417
更新日期:2012-10-01 00:00:00
abstract::Combining the specificity of tumor-targeting bacteria with the sensitivity of biomarker detection would create a screening method able to detect small tumors and metastases. To create this system, we genetically modified an attenuated strain of Salmonella enterica to release a recombinant fluorescent biomarker (or flu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32414
更新日期:2020-01-01 00:00:00
abstract::There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19981029)78:3<293::AID-IJC
更新日期:1998-10-29 00:00:00
abstract::To identify genes associated with radioresistant oral squamous cell carcinoma (OSCC), we compared gene expression signatures between OSCC cell lines exhibiting radioresistance and cells with radiosensitivity after X-ray irradiation in a dose-dependent manner using Affymetrix GeneChip analysis with Human Genome-U133 pl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22561
更新日期:2007-05-15 00:00:00
abstract::To study the drug delivery to tumor by utilization of an oligopeptide transport activity, we examined the accumulation of dipeptides and the peptide-mimetic anti-cancer drug, bestatin, a substrate of oligopeptide transporter PepT1. Firstly, we established HeLa cells stably expressing human peptide transporter (hPepT1)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-10-15 00:00:00
abstract::Src has been one of the most studied proto-oncogenes. The cellular Src (c-Src) holds a critical role in several human malignancies and has emerged as a key factor that promotes tumor progression during the multistep process of colorectal cancer (CRC) pathogenesis. The robust activation of Src in CRC of aggressive phen...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28299
更新日期:2014-05-01 00:00:00
abstract::A challenging task of the immune system is to fight cancer cells. However, a variety of human cancers educate immune cells to become tumor supportive. This is exemplified for tumor-associated macrophages (TAMs), which are polarized towards an anti-inflammatory and cancer promoting phenotype. Mechanistic explanations, ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24594
更新日期:2009-11-01 00:00:00
abstract::The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600420
更新日期:1995-02-08 00:00:00
abstract::Both retinoids and anti-estrogens inhibit breast cancer cell proliferation with accumulation of cells in the G1 phase of the cell cycle, but the effect of retinoids is delayed compared to that of anti-estrogens. To determine whether this temporal difference is due to a simple delay in the action of retinoids on a comm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970127)70:3<291::aid-ijc
更新日期:1997-01-27 00:00:00
abstract::Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29680
更新日期:2016-01-01 00:00:00
abstract::Acrylamide, a probable human carcinogen, is formed during the cooking of many commonly consumed foods. Data are scant on whether dietary acrylamide represents an important cancer risk in humans. We studied the association between acrylamide and prostate cancer risk using 2 measures of acrylamide exposure: intake from ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24175
更新日期:2009-05-15 00:00:00
abstract::The identification of (gamma-glutamyl)polyamines in proteolytic digest of proteins from the cytosolic and particulate fractions of B16-F10 and B16-F10Lr6 cell lines, originating from a spontaneous tumor in C57BL/6 mice, indicates that polyamines are incorporated into melanoma cell proteins by transglutaminases (TGases...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530515
更新日期:1993-03-12 00:00:00
abstract::We have previously shown that anti-Ly-6C monoclonal antibody (MAb) 2B6-F2 identifies a subset of (CBA +/- C57BL/6)F1 splenic NK-1.1+ natural T (NT) cells which kill the NK-sensitive YAC-1 target in vitro. Furthermore, these Ly-6C+ cells are responsible for 40-50% of in vitro YAC-1 killing in all mouse strains tested. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960516)66:4<532::AID-IJC
更新日期:1996-05-16 00:00:00
abstract::The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11670
更新日期:2004-03-20 00:00:00
abstract::CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of ar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20433
更新日期:2004-11-20 00:00:00
abstract::The following studies were undertaken to determine the levels of serum carotene and vitamin A (retinol) in Egyptian patients with intestinal, urinary, hepatosplenic schistosomiasis, and bladder cancer. These studies have shown that both serum carotene and serum retinol levels are significantly reduced in patients with...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300203
更新日期:1982-08-15 00:00:00
abstract::Matrix metalloproteinases, and notably the gelatinases MMP-2 and MMP-9, have important roles in tumour invasion, metastasis and angiogenesis. Our study investigates the distribution of MMP-2 and MMP-9 in colorectal cancer, the correlation with plasma levels, changes following surgical resection and whether plasma leve...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11436
更新日期:2003-11-20 00:00:00
abstract::In 1979, a hypothesis-generating, population-based case-control study was undertaken in Montreal, Canada, to explore the association between occupational exposure to 294 substances, 130 occupations and industries, and various cancers. Interviews were carried out with 3, 630 histologically confirmed cancer cases, of wh...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000915)87:6<874::aid-ijc18>3.0
更新日期:2000-09-15 00:00:00
abstract::Dietary carbohydrates have different glycemic and insulinemic potentials depending on type (glycemic index, GI) and amount (glycemic load, GL) of carbohydrate consumed or both. Insulin in turn has been implicated as a risk factor for several cancers, including that of the prostate. We assessed the relationship of GI a...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.20416
更新日期:2004-11-10 00:00:00
abstract::Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in indirect immunofluorescence tests ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170102
更新日期:1976-01-15 00:00:00
abstract::Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) trans...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220114
更新日期:1978-07-15 00:00:00
abstract::One hundred patients with Ph1-chromosome-positive chronic myelogenous leukemia (CML) with t(9;22) are included in the present investigation. The position of the Ph1 chromosome in relation to the normal as well as the abnormal chromosomes 9 was localized at metaphase in 1,000 bone-marrow cells. Our study suggests that ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410609
更新日期:1988-06-15 00:00:00
abstract::Regression of EB-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus-infected T-cell-depleted population in order to e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230505
更新日期:1979-05-15 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T(regs)) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24664
更新日期:2009-11-15 00:00:00
abstract::Cytological screening for cervical cancer is hampered by high false negative rates. Inter-observer reproducibility needs optimizing. The potential of p16(INK4a) as a biomarker for cervical lesions was examined in a study of liquid-based cytology (LBC), HPV DNA testing by MY09/MY11 consensus PCR and type-specific PCRs ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11589
更新日期:2004-03-01 00:00:00
abstract::CD44 is a transmembrane glycoprotein that binds hyaluronan, extracellular matrix proteins and growth factors. Multiple isoforms of CD44 are generated by alternative splicing of 10 separate exons (V1-V10). Expression of the variable exons has been correlated with tumour progression and metastasis in a range of cell typ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960516)66:4<457::AID-IJC
更新日期:1996-05-16 00:00:00