Different points of action of retinoids and anti-estrogens in G1 phase identified in synchronized T-47D breast cancer cells.

abstract：:Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried o...

journal_title：International journal of cancer

authors： Lynch HT,Kosoko-Lasaki O,Leslie SW,Rendell M,Shaw T,Snyder C,D'Amico AV,Buxbaum S,Isaacs WB,Loeb S,Moul JW,Powell I

更新日期：2016-06-01 00:00:00

abstract：:We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the numbe...

journal_title：International journal of cancer

authors： Piechocki MP,Dibbley SK,Lonardo F,Yoo GH

更新日期：2008-04-15 00:00:00

abstract：:Triple-negative breast cancer [TNBC, which is negative for the estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2] is a high-risk form of the disease without a specific therapy. DNA microarray and immunohistochemical analyses have shown that most TNBCs fall within the basal-lik...

journal_title：International journal of cancer

authors： Arima Y,Hayashi N,Hayashi H,Sasaki M,Kai K,Sugihara E,Abe E,Yoshida A,Mikami S,Nakamura S,Saya H

更新日期：2012-06-01 00:00:00

abstract：:A recent 2-dimensional gel electrophoresis study revealed several polypeptide differences between a strongly metastatic and a weakly metastatic clone from a single chemically induced murine fibrosarcoma (Jellum et al., 1984). To exclude the possibility that this was merely coincidental, the study is extended here to 2...

journal_title：International journal of cancer

authors： Grimstad IA,Thorsrud AK,Varani J,Ward PA,Jellum E

更新日期：1988-04-15 00:00:00

abstract：:Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet a...

journal_title：International journal of cancer

authors： Brandt J,Borgquist S,Almgren P,Försti A,Huss L,Melander O,Manjer J

更新日期：2018-04-01 00:00:00

abstract：:The development of cervical carcinoma is closely associated with HPV infection. However, other genetic alterations also play an important role. In this study, we analyzed copy number alterations of several oncogene loci in a panel of 84 cervical tumors. Sixty-five (77%) tumors were HPV DNA-positive, and most were infe...

journal_title：International journal of cancer

authors： Zhang A,Månér S,Betz R,Angström T,Stendahl U,Bergman F,Zetterberg A,Wallin KL

更新日期：2002-10-10 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChR) are expressed on bronchial epithelial and non-small cell lung cancer cells and are involved in cell growth regulation. Nicotine (classical nAChR agonist) induced cell proliferation, whereas nAChR antagonists, d- tubocurarine or alpha-cobratoxin (alpha-CbT), induced cell death....

journal_title：International journal of cancer

authors： Paleari L,Sessa F,Catassi A,Servent D,Mourier G,Doria-Miglietta G,Ognio E,Cilli M,Dominioni L,Paolucci M,Calcaterra A,Cesario A,Margaritora S,Granone P,Russo P

更新日期：2009-07-01 00:00:00

abstract：:The aim of this study was to investigate the ability of the new liver organotropic complex of cisplatin with glycocholate (GC), Bamet-R2, to interact with DNA, inhibit its replication and hence reduce tumor-cell proliferation. Changes in the electrophoretic mobility of the open and covalently closed circular forms of ...

journal_title：International journal of cancer

authors： Marin JJ,Macias RI,Criado JJ,Bueno A,Monte MJ,Serrano MA

更新日期：1998-10-29 00:00:00

abstract：:Transducer of ErbB-2 (TOB) is a member of the TOB/Btg gene family. A role for TOB in the suppression of human tumorigenesis has been proposed, based on the observations that TOB-knockout mice spontaneously form tumors and TOB expression is lost in human lung and thyroid cancers. However, the role of TOB in human breas...

journal_title：International journal of cancer

authors： O'Malley S,Su H,Zhang T,Ng C,Ge H,Tang CK

更新日期：2009-10-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an angiogenic factor that also functions as an autocrine growth factor for VEGF receptor (VEGFR)-2(+) melanomas. In multiple studies, VEGFR-2 was detected by immunostaining in 78-89% of human melanoma cells, suggesting that most patients with melanoma would benefit from an...

journal_title：International journal of cancer

authors： Molhoek KR,Erdag G,Rasamny JK,Murphy C,Deacon D,Patterson JW,Slingluff CL Jr,Brautigan DL

更新日期：2011-12-15 00:00:00

abstract：:We have analysed expression of the first 7 members of the family of heparin-binding fibroblast growth factor (FGFs) and their 4 high-affinity receptors (FGFRs) in human pancreatic carcinoma cell lines, both at the mRNA and protein levels. In cell lines expressing FGFRs, 2 typical patterns were observed: (i) expression...

journal_title：International journal of cancer

authors： Leung HY,Gullick WJ,Lemoine NR

更新日期：1994-12-01 00:00:00

abstract：:Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...

journal_title：International journal of cancer

authors： Lou PJ,Lai PS,Shieh MJ,Macrobert AJ,Berg K,Bown SG

更新日期：2006-12-01 00:00:00

abstract：:CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of ar...

journal_title：International journal of cancer

authors： Woo SH,Park IC,Park MJ,An S,Lee HC,Jin HO,Park SA,Cho H,Lee SJ,Gwak HS,Hong YJ,Hong SI,Rhee CH

更新日期：2004-11-20 00:00:00

abstract：:Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...

journal_title：International journal of cancer

authors： Sun CY,Chu ZB,She XM,Zhang L,Chen L,Ai LS,Hu Y

更新日期：2012-02-15 00:00:00

abstract：:Novel classes of drug that interfere with the signalling of the small G-protein Ras, the so-called Ras antagonists, are showing much promise as novel anti-cancer agents. In this study, we demonstrate that the novel Ras antagonist farnesylthiosalicylic acid (FTS) inhibits the growth of Colo 853 melanoma cells through a...

journal_title：International journal of cancer

authors： Smalley KS,Eisen TG

更新日期：2002-04-01 00:00:00

abstract：:In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...

journal_title：International journal of cancer

authors： Hombach A,Jung W,Pohl C,Renner C,Sahin U,Schmits R,Wolf J,Kapp U,Diehl V,Pfreundschuh M

更新日期：1993-11-11 00:00:00

abstract：:Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families...

journal_title：International journal of cancer

authors： Hartley AL,Birch JM,Blair V,Kelsey AM,Morris Jones PH

更新日期：1994-03-01 00:00:00

abstract：:Treatment of mouse Lewis lung carcinoma with razoxane or dacarbazine was protracted for 10 transplant generations. While the capacity of the treated tumors to grow locally in immuno-competent or in immuno-depressed hosts was retained and not significantly modified, the metastatic phenotype was eliminated when the trea...

journal_title：International journal of cancer

authors： Garbisa S,Onisto M,Peron A,Perissin L,Rapozzi V,Zorzet S,Giraldi T

更新日期：1997-09-17 00:00:00

abstract：:Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is...

journal_title：International journal of cancer

authors： Garwicz S,Anderson H,Olsen JH,Winther JF,Sankila R,Langmark F,Tryggvadóttir L,Möller TR,Association of the Nordic Cancer Registries.,Nordic Society for Pediatric Hematology Oncology.

更新日期：2012-10-01 00:00:00

abstract：:Antibodies to the 27 kDa heat shock protein (hsp27) are present in some women with ovarian and endometrial cancers but not in women with nonmalignant conditions or healthy women. The appearance of these antibodies suggests that the corresponding protein (hsp27) may be present in an extracellular form in gynecologic ca...

journal_title：International journal of cancer

authors： Korneeva I,Caputo TA,Witkin SS

更新日期：2002-12-10 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. In vitro proliferation assays demonstrated that belinostat potently inhibited the growth of prostate canc...

journal_title：International journal of cancer

authors： Qian X,Ara G,Mills E,LaRochelle WJ,Lichenstein HS,Jeffers M

更新日期：2008-03-15 00:00:00

abstract：:Turkey poults were inoculated with lymphoproliferative disease virus (LPDV) of turkey, and the organotropism of the inoculated virus was determined from the kinetics of virus expression and tumor formation. Molecular hybridization experiments, conducted to determine the level of viral RNA expression in the various org...

journal_title：International journal of cancer

authors： Gazit A,Schwarzbard Z,Yaniv A,Ianconescu M,Perk K,Zimber A

更新日期：1982-05-15 00:00:00

abstract：:Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

journal_title：International journal of cancer

authors： Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

更新日期：2013-11-01 00:00:00

abstract：:Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To describe the clonal nature of these tumors, 2 theories have been proposed. The monoclonality hypothesis describes the multiple tumors as descendants of a single...

journal_title：International journal of cancer

authors： Hafner C,Knuechel R,Stoehr R,Hartmann A

更新日期：2002-09-01 00:00:00

abstract：:Numerous studies have suggested that excess body weight is associated with increased cancer risk. To examine this putative association, we performed a systematic review and quantitative meta-analysis of cohort studies reporting body mass index (BMI) and the risk of 23 cancer types. PubMed, Embase, and Web of Science w...

journal_title：International journal of cancer

authors： Fang X,Wei J,He X,Lian J,Han D,An P,Zhou T,Liu S,Wang F,Min J

更新日期：2018-10-01 00:00:00

abstract：:A clonal cell line, 1-1ras1000, transformed by the activated c-Ha-ras oncogene, does not form metastases after i.v. injection into mice (experimental metastasis assay). Here, we show that this cell line is useful as a recipient to detect metastasis-inducing genes, using a transfection assay. Cells (1-1ras1000) were su...

journal_title：International journal of cancer

authors： Tatsuka M,Ota T,Maeda M,Wada M,Yamagishi N,Taniguchi S,Seiki M,Odashima S

更新日期：1997-03-28 00:00:00

abstract：:We present data on test positivity, relative sensitivity, rates of detection and relative specificity for primary human papillomavirus (HPV) testing with different cutoff levels for test positivity, in comparison to conventional cytology. In 2003-2004, 18,438 women were screened primarily with Hybrid Capture 2 (HC 2) ...

journal_title：International journal of cancer

authors： Kotaniemi-Talonen L,Malila N,Nieminen P,Anttila A,Tarkkanen J,Laurila P,Hakama M

更新日期：2008-12-15 00:00:00

abstract：:To elucidate the relationship, if any, of p53 gene expression according to smoking and drinking habits, 135 subjects with cancer of the upper aero-digestive tract were sampled from a case-control investigation conducted in Pordenone province, Northeast Italy, between 1986 and 1991. Adequate pathological material for i...

journal_title：International journal of cancer

authors： Franceschi S,Gloghini A,Maestro R,Barzan L,Bidoli E,Talamini R,Vukosavljevic T,Carbone A,Boiocchi M

更新日期：1995-03-16 00:00:00

abstract：:Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estroge...

journal_title：International journal of cancer

authors： Grioni S,Agnoli C,Krogh V,Pala V,Rinaldi S,Vinceti M,Contiero P,Vescovi L,Malavolti M,Sieri S

更新日期：2019-05-01 00:00:00

abstract：:MaTu is a novel agent which may be of relevance in human oncogenesis, and has 2 components. One of them, the exogenous MX (coding for protein p58X), is transmissible to human fibroblasts, to HeLa and to HeLa x fibroblast (H/F) hybrids. The other component, MN, is a cellular gene. Its product, the protein p54/58N, is i...

journal_title：International journal of cancer

authors： Závada J,Závadová Z,Pastoreková S,Ciampor F,Pastorek J,Zelník V

更新日期：1993-05-08 00:00:00