Abstract:
:A recent 2-dimensional gel electrophoresis study revealed several polypeptide differences between a strongly metastatic and a weakly metastatic clone from a single chemically induced murine fibrosarcoma (Jellum et al., 1984). To exclude the possibility that this was merely coincidental, the study is extended here to 2 other fibrosarcomas recently and similarly induced in mice of the same inbred strain. Metastatic potential was defined by the number of lung metastases spontaneously formed from a transplanted primary footpad tumor. One strongly (or moderately) metastatic cell line and I weakly metastatic line from each of the 3 fibrosarcomas were examined in the same experiments. In confirmation of our previous results, the same polypeptides consistently occurred in considerably greater amounts in the weakly metastatic than in the strongly metastatic cells. One of these marker polypeptides was absent from the strongly metastatic cell lines. In comparison with 2 of the 3 most metastatic lines, the third line was only moderately metastatic, and differed least strongly from the 3 weakly metastatic cell lines with regard to expression of th marker polypeptides. Marker polypeptide expression showed no consistent correlation with tumorigenicity. No other consistent polypeptide differences between strongly metastatic and weakly metastatic cells could be identified among the approximately 2,000 cellular polypeptides separated on the gels.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Grimstad IA,Thorsrud AK,Varani J,Ward PA,Jellum Edoi
10.1002/ijc.2910410416subject
Has Abstractpub_date
1988-04-15 00:00:00pages
568-72issue
4eissn
0020-7136issn
1097-0215journal_volume
41pub_type
杂志文章abstract::Bcl-2 expression is up-regulated in prostate cancer cells after androgen ablation and associated with development of androgen independence and chemoresistance. We recently reported that antisense Bcl-2 oligodeoxynucleotides (ODNs) delay progression to androgen independence in the androgen-dependent (AD) human LNCaP pr...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2001-03-15 00:00:00
abstract::CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1991-05-10 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2008-07-15 00:00:00
abstract::The clonotypic T-cell receptor (TCR) is a potential target antigen for specific immunotherapy of cutaneous T-cell lymphoma (CTCL). We identified T-cell epitopes from the rearranged TCR beta chain of the malignant T-cell population by the "reverse immunology" approach. Peptide-specific T-cell lines were generated again...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1981-03-15 00:00:00
abstract::Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...
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pub_type: 临床试验,杂志文章
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journal_title:International journal of cancer
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更新日期:1997-08-22 00:00:00
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1976-04-15 00:00:00
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更新日期:2000-11-15 00:00:00
abstract::In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outcome remains limited. In our study, we aim to assess the outcome of screen-detected lesions diagnose...
journal_title:International journal of cancer
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更新日期:2011-09-15 00:00:00
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更新日期:1999-04-12 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...
journal_title:International journal of cancer
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doi:10.1002/ijc.22040
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1998-08-21 00:00:00
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更新日期:2005-04-20 00:00:00
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更新日期:2020-10-15 00:00:00
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