Abstract:
:Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the development of cancer. These declines may be assessed through biomarkers that measure biological age and through the related concept of "age acceleration". Epigenetic clocks, assessed through DNA methylation levels, are among the most widely used biological age markers in cancer studies. In this review, we discuss the use of DNA methylation ageing measures to predict population cancer incidence, mortality and survival. Blood-based DNA methylation age estimators appear to be promising measures of increased cancer risk and mortality, although their reported effects are generally weak, thus its clinical relevance remains to be validated in large case-cohort and longitudinal studies. Future development of epigenetic and other biological age biomarkers will likely further elucidate the links between ageing and cancer.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lau CE,Robinson Odoi
10.1002/ijc.33451subject
Has Abstractpub_date
2021-01-04 00:00:00eissn
0020-7136issn
1097-0215pub_type
杂志文章,评审abstract::To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LO...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990531)81:5<705::aid-ijc
更新日期:1999-05-31 00:00:00
abstract::The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25726
更新日期:2011-08-01 00:00:00
abstract::A mammographic breast cancer screening programme has been ongoing in the Florence District (Italy) since 1970 and a favourable impact of screening on breast cancer mortality of women aged 50-70 has been shown by means of a case-control study. Two hundred and eleven screen- and 116 interval-detected cancers in the peri...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460209
更新日期:1990-08-15 00:00:00
abstract::Dickkopf1 (DKK1), a secreted inhibitor of the Wnt/β-catenin pathway, is a negative regulator of bone formation. DKK1 acts as a switch that transitions prostate cancer bone metastases from osteolytic to osteoblastic and also is an active indicator of poor outcome for multiple myeloma. However, in other tumor types, DKK...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.26449
更新日期:2012-04-01 00:00:00
abstract::Creatinine-adjusted levels of estrone, estradiol and estriol were determined in overnight urine specimens from 220 post-menopausal women, aged 54 to 66 years, from Boston (121 women) and Athens (99 women). The associations of individual and total estrogens with various characteristics of the women (age at menopause, y...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400602
更新日期:1987-12-15 00:00:00
abstract::We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960611)66:6<727::AID-IJC
更新日期:1996-06-11 00:00:00
abstract::Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we sys...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550520
更新日期:1993-11-11 00:00:00
abstract::Cyclin D1 is a major positive regulator of the G1 restriction point promoting inactivation of the retinoblastoma protein (RB). The cyclin D1 gene is rearranged, amplified and/or over-expressed in several human neoplasms. In the present series of 64 human breast carcinomas, cyclin D1 amplification (4- to 8-fold) was se...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970422)74:2<171::aid-ijc
更新日期:1997-04-22 00:00:00
abstract::An inverse association between smoking and endometrial cancer has generally been observed, primarily among current smokers. To assess this association, we analyzed data from the prospective Nurses' Health Study. From 1976 to 2000, 702 cases of invasive endometrial cancer were identified during 1.8 million person-years...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20821
更新日期:2005-05-10 00:00:00
abstract::Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically-induced colon carcinomas, 3 chemically-induced sarcoma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230317
更新日期:1979-03-15 00:00:00
abstract::We conducted a retrospective cohort study to investigate the colorectal cancer (CRC) incidence and mortality prevention achievable in clinical practice with an optimized colonoscopy protocol targeting near-complete polyp clearance. The protocol consisted of: (i) telephonic reinforcement of bowel preparation instructio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29228
更新日期:2015-03-15 00:00:00
abstract::Monoclonal antibody (MAb) B72.3 has been previously shown, by in vitro assays, to have a high degree of specificity for carcinomas of the colon, ovary and breast versus normal adult tissues. B72.3 IgG was labelled with 131I and injected i.v. into 20 patients with known or suspected colorectal cancer. All patients subs...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390110
更新日期:1987-01-15 00:00:00
abstract::Three polycyclic hydrocarbons, benz(a)anthracene, 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene, have been studied in a cell-mediated mutagenesis system using BHK 21 cells to metabolize the hydrocarbons and V-79 cells as targets for detecting induced cytotoxicity and mutation. In large-scale experiments, the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230516
更新日期:1979-05-15 00:00:00
abstract::Esophageal cancer is ranked as the eighth most common cancer and the sixth leading cause of cancer deaths worldwide. To identify candidate tumor suppressor genes related to esophageal squamous cell carcinoma (ESCC) development, a cDNA microarray analysis was performed using paired tumor and nontumor tissue samples fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30034
更新日期:2016-06-15 00:00:00
abstract::For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs-based vacc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31795
更新日期:2019-02-15 00:00:00
abstract::Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history of colorectal cancer in which the polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome of colonoscopic surveillance is studied using data from six centers. DNA mismatc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.28397
更新日期:2014-02-15 00:00:00
abstract::Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. We investigated the role of cytotoxic T-lymphocytes (CTL) counteracting and recognizing LSC. Leukemia-associated antigens ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29583
更新日期:2015-11-01 00:00:00
abstract::T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusion (DLI) due to graft-versus-leukemia effect. For better characterization of the T cell responses, we assessed frequency ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31753
更新日期:2019-03-01 00:00:00
abstract::We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21923
更新日期:2006-10-01 00:00:00
abstract::Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with the main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples. However, its role in RMS biology is not yet well understood. Here, we identified a new role of LSD1 in regulating adhesion of RMS cells. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32806
更新日期:2020-06-15 00:00:00
abstract::India has the highest burden of cervical cancer in the world. To estimate the consequences of delaying implementation of organized cervical cancer screening, we projected the avertable burden of disease under different implementation scenarios of a screening program. We used an individual-based microsimulation model o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31823
更新日期:2019-02-15 00:00:00
abstract::The partition-defective 3 (PAR-3) protein is implicated in the development and maintenance of cell polarity and is associated with proteins that mediate the changes in cytoskeleton organization required for cell polarity establishment. In this work, we used two original primary cell lines (R-180 and R-305) derived fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28548
更新日期:2014-05-01 00:00:00
abstract::Although treatment of Hodgkin's lymphoma (HL) with a multi-drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Therefore, the current goal in HL treatment is to find new therapies that specifically target the deregulated signali...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23477
更新日期:2008-07-01 00:00:00
abstract::Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32064
更新日期:2019-06-15 00:00:00
abstract::A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550107
更新日期:1993-08-19 00:00:00
abstract::Cervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which is disturbing for patients and increases costs for health care providers. The i...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28900
更新日期:2015-06-15 00:00:00
abstract::The light microscopic distinction between complex atypical hyperplasia (CAH) and invasive endometrioid carcinoma (UEC) on endometrial sampling is problematic and often has significant clinical implications. Using mouse models of endometrial tumorigenesis based on two of the most common molecular alterations found in p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24022
更新日期:2009-03-15 00:00:00
abstract::IgG binding to purified mouse mammary tumor virus (MuMTV) was quantitated by an enzyme-linked immunoassay (ELISA) using sera from patients with breast cancer or benign breast disease, or from healthy age-matched controls. Significantly greater binding (p<0.01) was found in breast-cancer-derived sera than in the other ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250606
更新日期:1980-06-15 00:00:00
abstract::Inbred rats were treated with extranuclear tumour membrane fractions or 3 M KCl-solubilized extracts of two antigenically distinct 3-methylcholanthrene-induced sarcomas, Mc7 and Mc57. The rats developed tumour-specific humoral antibody responses, but were not immune to tumour challenge. Moreover, they were unresponsiv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180511
更新日期:1976-11-15 00:00:00
abstract::Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32728
更新日期:2020-05-15 00:00:00