Early indicators of efficacy of breast cancer screening programmes. Results of the Florence District Programme.

abstract：:Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase of the cell cycle and trigger apoptosis. To investigate apoptosis induced by paclitaxel in nasopharyngeal carcinoma (NPC), and its possible molecular mechanism of action, the human NPC cell lines HNE-1 (bea...

journal_title：International journal of cancer

authors： Tan G,Heqing L,Jiangbo C,Ming J,Yanhong M,Xianghe L,Hong S,Li G

更新日期：2002-01-10 00:00:00

abstract：:Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovari...

journal_title：International journal of cancer

authors： Nicholson LJ,Smith PR,Hiller L,Szlosarek PW,Kimberley C,Sehouli J,Koensgen D,Mustea A,Schmid P,Crook T

更新日期：2009-09-15 00:00:00

abstract：:Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that sever...

journal_title：International journal of cancer

authors： Cadenas C,Vosbeck S,Edlund K,Grgas K,Madjar K,Hellwig B,Adawy A,Glotzbach A,Stewart JD,Lesjak MS,Franckenstein D,Claus M,Hayen H,Schriewer A,Gianmoena K,Thaler S,Schmidt M,Micke P,Pontén F,Mardinoglu A,Zhang C,K

更新日期：2019-08-15 00:00:00

abstract：:A significant proportion of screen-detected men with prostate cancer is likely to be overtreated, especially in older age groups. We aim to find which groups of screen-detected older men (65+) benefit the most from Immediate Radical Treatment or Active Surveillance (AS) for prostate cancer, depending on age, screening...

journal_title：International journal of cancer

authors： de Carvalho TM,Heijnsdijk EA,de Koning HJ

更新日期：2016-05-15 00:00:00

abstract：:The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n-3 and n-6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three US prospective cohorts ...

journal_title：International journal of cancer

authors： Wang L,Hang D,He X,Lo CH,Wu K,Chan AT,Ogino S,Giovannucci EL,Song M

更新日期：2021-01-01 00:00:00

abstract：:Angiogenesis and inflammation are the 2 major stroma reactions in colorectal carcinoma (CRC). Guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation. Therefore, we hypothesized that GBP-1 may be a biomarker of intrinsic angiostasis associated with an improved outcome in CRC patien...

journal_title：International journal of cancer

authors： Naschberger E,Croner RS,Merkel S,Dimmler A,Tripal P,Amann KU,Kremmer E,Brueckl WM,Papadopoulos T,Hohenadl C,Hohenberger W,Stürzl M

更新日期：2008-11-01 00:00:00

abstract：:We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quanti...

journal_title：International journal of cancer

authors： Nagashima S,Kashii Y,Reichert TE,Suminami Y,Suzuki T,Whiteside TL

更新日期：1997-07-03 00:00:00

abstract：:We have established a number of cell lines from Merkel cell carcinoma (MCC) of the skin. In many respects these cell lines resemble those established from small cell lung cancer (SCLC) and it is difficult to differentiate between metastatic MCC and SCLC on morphological or histochemical criteria. Both are thought to b...

journal_title：International journal of cancer

authors： Thomson JA,Leonard JH,McGregor K,Sturm RA,Parsons PG

更新日期：1994-07-15 00:00:00

abstract：:Our objective was to examine whether parental exposure to atomic bomb radiation has led to increased cancer and/or noncancer mortality rates among the offspring. We studied 41,010 subjects born from May 1946 through December 1984 (i.e., conceived between 1 month and 38 years after the bombings) and surviving for at le...

journal_title：International journal of cancer

authors： Izumi S,Suyama A,Koyama K

更新日期：2003-11-01 00:00:00

abstract：:In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Frameshift mutations,...

journal_title：International journal of cancer

authors： Salomons GS,Buitenhuis CK,Martínez Muñoz C,Verwijs-Jassen M,Behrendt H,Zsiros J,Smets LA

更新日期：1998-06-19 00:00:00

abstract：:Interleukin-11(rhIL-11) is a cytokine that has been shown to enhance the recovery of bone marrow and intestinal crypt cells after cytotoxic insult with radiation or anticancer drugs. The current study examined the effects of rhIL-11 on the response of CEM human lymphoblastic leukemia cells and on the EMT-6 murine mamm...

journal_title：International journal of cancer

authors： Teicher BA,Chen YN,Ara G,Emi Y,Kakeji Y,Maehara Y,Keyes S,Northey D

更新日期：1996-09-17 00:00:00

abstract：:Altered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer. In this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridizati...

journal_title：International journal of cancer

authors： Hu Y,Correa AM,Hoque A,Guan B,Ye F,Huang J,Swisher SG,Wu TT,Ajani JA,Xu XC

更新日期：2011-01-01 00:00:00

abstract：:A new human cell line, designated Ty-82, was established from the pleural effusion of a 22-year-old woman with undifferentiated thymic carcinoma. This cell line consisted of primitive cells that were positive for alpha-naphthyl butyrate esterase and acid phosphatase. The cells were shown to express epithelial membrane...

journal_title：International journal of cancer

authors： Kuzume T,Kubonishi I,Takeuchi S,Takeuchi T,Iwata J,Sonobe H,Ohtsuki Y,Miyoshi I

更新日期：1992-01-21 00:00:00

abstract：:Isolated limb perfusion (ILP) with melphalan and tumor necrosis factor (TNF)-α is used to treat bulky, locally advanced melanoma and sarcoma. However, TNF toxicity suggests a need for better-tolerated drugs. Cilengitide (EMD 121974), a novel cyclic inhibitor of alpha-V integrins, has both anti-angiogenic and direct an...

journal_title：International journal of cancer

authors： Ten Hagen TL,Seynhaeve AL,de Wiel-Ambagtsheer Ga,de Bruijn EA,van Tiel ST,Ruegg C,Meyring M,Grell M,Goodman SL,Eggermont AM

更新日期：2013-06-01 00:00:00

abstract：:Limited success has been achieved in extending the survival of patients with metastatic and hormone-refractory prostate cancer (HRPC). There is a strong need for novel agents in the treatment and prevention of HRPC. We have shown that flavokawain B (FKB), a kava chalcone, is about 4- to 12-fold more effective in reduc...

journal_title：International journal of cancer

authors： Tang Y,Li X,Liu Z,Simoneau AR,Xie J,Zi X

更新日期：2010-10-15 00:00:00

abstract：:Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...

journal_title：International journal of cancer

authors： Buergy D,Wenz F,Groden C,Brockmann MA

更新日期：2012-06-15 00:00:00

abstract：:Polyisoprenylated benzophenones derived from Garcinia xanthochymus have cytotoxic activity in vitro and antitumor activity in rodent models, but the mechanism is unknown. The purpose of our study was to examine in parallel molecular pathways that are targeted by 3 Garcinia-derived benzophenones-xanthochymol (X), gutti...

journal_title：International journal of cancer

authors： Protiva P,Hopkins ME,Baggett S,Yang H,Lipkin M,Holt PR,Kennelly EJ,Bernard WI

更新日期：2008-08-01 00:00:00

abstract：:Burkitt's lymphoma cells that vary in their phenotypic characteristics show significantly different degrees of susceptibility to radiation-induced apoptosis. Propensity to undergo apoptosis is reflected in the degradation of substrates such as DNA-dependent protein kinase but the status of bcl-2, c-myc and p53 has bee...

journal_title：International journal of cancer

authors： Zhao EG,Song Q,Cross S,Misko I,Lees-Miller SP,Lavin MF

更新日期：1998-08-31 00:00:00

abstract：:Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...

journal_title：International journal of cancer

authors： Vineis P,Thomas T,Hayes RB,Blot WJ,Mason TJ,Pickle LW,Correa P,Fontham ET,Schoenberg J

更新日期：1988-12-15 00:00:00

abstract：:The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...

journal_title：International journal of cancer

authors： Keck B,Wach S,Taubert H,Zeiler S,Ott OJ,Kunath F,Hartmann A,Bertz S,Weiss C,Hönscheid P,Schellenburg S,Rödel C,Baretton GB,Sauer R,Fietkau R,Wullich B,Krause FS,Datta K,Muders MH

更新日期：2015-01-15 00:00:00

abstract：:Biliary glycoprotein I (BGP I) is a member of carcinoembryonic antigen (CEA) gene family consisting of at least 11 related genes. The transcription of BGP I gene was analysed in malignant and non-malignant human liver tissues with a 396-bp 3'-untranslated region probe from a cDNA clone 4-13 which was newly isolated fr...

journal_title：International journal of cancer

authors： Hinoda Y,Imai K,Nakagawa N,Ibayashi Y,Nakano T,Paxton RJ,Shively JE,Yachi A

更新日期：1990-05-15 00:00:00

abstract：:We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...

journal_title：International journal of cancer

authors： Brodt P,Parhar R,Sankar P,Lala PK

更新日期：1985-02-15 00:00:00

abstract：:Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...

journal_title：International journal of cancer

authors： Sheffield LG,Welsch CW

更新日期：1985-10-15 00:00:00

abstract：:Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic...

journal_title：International journal of cancer

authors： Huberman E,Bartsch H,Sachs L

更新日期：1975-10-15 00:00:00

abstract：:DNA synthesis in heterokaryons of mouse peritoneal macrophages and various proliferating cultured cells was analyzed. Macrophages did not inhibit replication in the nuclei of non-immortalized and spontaneously immortalized cells (rat fibroblasts and macrophages, mouse pre-macrophages, NIH3T3 cells). On the contrary, t...

journal_title：International journal of cancer

authors： Prudovsky IA,Gumeniuk RR,Yegorov YE,Zelenin AV

更新日期：1989-12-15 00:00:00

abstract：:Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/molecular interactions leading to TNF gene expression in macrophages are unknown. The in vitro system in which human blood monocytes are stimulated with human cancer cells for TNF release was used ...

journal_title：International journal of cancer

authors： Zembala M,Siedlar M,Ruggiero I,Wieckiewicz J,Mytar B,Mattei M,Colizzi V

更新日期：1994-01-15 00:00:00

abstract：:Cyclic AMP (cAMP) analogues that selectively bind to either one of the two binding sites of cAMP-dependent protein kinase demonstrate a potent inhibition of the growth stimulated by estrogen in MCF-7 human breast-cancer cells in culture. The site-selective analogues, which are more potent activators of protein kinase ...

journal_title：International journal of cancer

authors： Katsaros D,Ally S,Cho-Chung YS

更新日期：1988-06-15 00:00:00

abstract：:Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

journal_title：International journal of cancer

authors： Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

更新日期：2009-07-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing ...

journal_title：International journal of cancer

authors： Lu CC,Chen JC,Tsai ST,Jin YT,Tsai JC,Chan SH,Su IJ

更新日期：2005-07-10 00:00:00

abstract：:Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing,...

journal_title：International journal of cancer

authors： Anantharaman D,Abedi-Ardekani B,Beachler DC,Gheit T,Olshan AF,Wisniewski K,Wunsch-Filho V,Toporcov TN,Tajara EH,Levi JE,Moyses RA,Boccia S,Cadoni G,Rindi G,Ahrens W,Merletti F,Conway DI,Wright S,Carreira C,Renard H

更新日期：2017-05-01 00:00:00