Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response.

abstract：:The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...

journal_title：International journal of cancer

authors： Haranaka K,Satomi N,Sakurai A

更新日期：1984-08-15 00:00:00

abstract：:Oral leukoplakia is a heterogeneous lesion with risk of cancer development; there are no biomarkers to predict its potential of malignant transformation. Tissue proteomic analysis of oral leukoplakia using iTRAQ labeling liquid chromatography-mass spectrometry showed overexpression of heterogeneous ribonucleoprotein K...

journal_title：International journal of cancer

authors： Matta A,Tripathi SC,DeSouza LV,Grigull J,Kaur J,Chauhan SS,Srivastava A,Thakar A,Shukla NK,Duggal R,DattaGupta S,Ralhan R,Michael Siu KW

更新日期：2009-09-15 00:00:00

abstract：:Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...

journal_title：International journal of cancer

authors： Moss DJ,Burrows SR,Castelino DJ,Kane RG,Pope JH,Rickinson AB,Alpers MP,Heywood PF

更新日期：1983-06-15 00:00:00

abstract：:The incidence of breast cancer among women in Shanghai, a traditionally low-risk population, has increased substantially over the past 20 years. To evaluate the association of menstrual and reproductive factors with breast cancer risk and the influence of these factors on the temporal trend of breast cancer incidence,...

journal_title：International journal of cancer

authors： Gao YT,Shu XO,Dai Q,Potter JD,Brinton LA,Wen W,Sellers TA,Kushi LH,Ruan Z,Bostick RM,Jin F,Zheng W

更新日期：2000-07-15 00:00:00

abstract：:The translation-initiation factor eIF4E is rate-limiting for protein synthesis, and its over-expression results in oncogenic transformation of mammalian cells. eIF4E facilitates the synthesis of several powerful tumor angiogenic factors (FGF-2 and VEGF) by selectively enhancing their translation. In breast carcinomas,...

journal_title：International journal of cancer

authors： DeFatta RJ,Turbat-Herrera EA,Li BD,Anderson W,De Benedetti A

更新日期：1999-02-09 00:00:00

abstract：:Although tobacco habits have been associated with the risk of oral leukoplakia, alcohol drinking and body mass index (BMI) as risk factors have not been well established. The purpose of this study is to evaluate the independent effects of drinking, BMI, tobacco chewing and smoking on the risk of oral leukoplakia. A ca...

journal_title：International journal of cancer

authors： Hashibe M,Sankaranarayanan R,Thomas G,Kuruvilla B,Mathew B,Somanathan T,Parkin DM,Zhang ZF

更新日期：2000-10-01 00:00:00

abstract：:Several tumour-derived factors have recently been identified which induce tissue factor (TF) expression in endothelial cells in vitro. However, there is only limited evidence that endothelial cells lining tumour blood vessels express elevated procoagulant activity (PCA) in vivo. We have investigated the effects of hum...

journal_title：International journal of cancer

authors： Hewett PW,Murray C

更新日期：1996-06-11 00:00:00

abstract：:Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who ...

journal_title：International journal of cancer

authors： Xi LF,Schiffman M,Koutsky LA,He Z,Winer RL,Hulbert A,Lee SK,Ke Y,Kiviat NB

更新日期：2013-02-01 00:00:00

abstract：:Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...

journal_title：International journal of cancer

authors： Lou PJ,Lai PS,Shieh MJ,Macrobert AJ,Berg K,Bown SG

更新日期：2006-12-01 00:00:00

abstract：:Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...

journal_title：International journal of cancer

authors： van Dijk J,Uemura H,Beniers AJ,Peelen WP,Zegveld ST,Fleuren GJ,Warnaar SO,Oosterwijk E

更新日期：1994-01-15 00:00:00

abstract：:By serologic identification of antigens by recombinant expression cloning (SEREX) analysis using an autologous lung adenocarcinoma cell line, OU-LU-6, as a cDNA library source, we demonstrated that XAGE-1 was the dominant antigen recognized by serum from a patient. By immunoscreening, we obtained 38 positive cDNA clon...

journal_title：International journal of cancer

authors： Ali Eldib AM,Ono T,Shimono M,Kaneko M,Nakagawa K,Tanaka R,Noguchi Y,Nakayama E

更新日期：2004-02-10 00:00:00

abstract：:We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells...

journal_title：International journal of cancer

authors： Yamaji Y,Matsubara S,Yamadori I,Sato M,Fujita T,Fujita J,Takahara J

更新日期：1996-03-01 00:00:00

abstract：:Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...

journal_title：International journal of cancer

authors： Saito K,Takeha S,Shiba K,Matsuno S,Sorsa T,Nagura H,Ohtani H

更新日期：2000-04-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threate...

journal_title：International journal of cancer

authors： To YF,Sun RW,Chen Y,Chan VS,Yu WY,Tam PK,Che CM,Lin CL

更新日期：2009-04-15 00:00:00

abstract：:Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...

journal_title：International journal of cancer

authors： Sheffield LG,Welsch CW

更新日期：1985-10-15 00:00:00

abstract：:JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation. Notabl...

journal_title：International journal of cancer

authors： Wang Y,Xia Y,Hu K,Zeng M,Zhi C,Lai M,Wu L,Liu S,Zeng S,Huang Z,Ma S,Yuan Z

更新日期：2019-11-01 00:00:00

abstract：:miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...

journal_title：International journal of cancer

authors： Liu M,Lang N,Qiu M,Xu F,Li Q,Tang Q,Chen J,Chen X,Zhang S,Liu Z,Zhou J,Zhu Y,Deng Y,Zheng Y,Bi F

更新日期：2011-03-15 00:00:00

abstract：:To generate broad eating patterns, which could explain more adequately the breast cancer etiology, we conducted an exploratory factor analysis in Montevideo, Uruguay. The study included 442 newly diagnosed and microscopically confirmed cases with breast cancer and 442 hospitalized controls, with non-neoplastic disease...

journal_title：International journal of cancer

authors： Ronco AL,De Stefani E,Boffetta P,Deneo-Pellegrini H,Acosta G,Mendilaharsu M

更新日期：2006-10-01 00:00:00

abstract：:The major obstacle preventing effective treatment of melanoma is the biological heterogeneity of tumor cells. This study was performed to determine clonal genetic heterogeneity within primary melanoma and the evolution of these heterogeneous sub-clones during disease progression. DNA samples were obtained from 44 morp...

journal_title：International journal of cancer

authors： Takata M,Morita R,Takehara K

更新日期：2000-02-15 00:00:00

abstract：:We conducted a retrospective cohort study to investigate the colorectal cancer (CRC) incidence and mortality prevention achievable in clinical practice with an optimized colonoscopy protocol targeting near-complete polyp clearance. The protocol consisted of: (i) telephonic reinforcement of bowel preparation instructio...

journal_title：International journal of cancer

authors： Xirasagar S,Li YJ,Hurley TG,Tsai MH,Hardin JW,Hurley DM,Hebert JR,de Groen PC

更新日期：2015-03-15 00:00:00

abstract：:Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...

journal_title：International journal of cancer

authors： Dent BM,Ogle LF,O'Donnell RL,Hayes N,Malik U,Curtin NJ,Boddy AV,Plummer ER,Edmondson RJ,Reeves HL,May FE,Jamieson D

更新日期：2016-01-01 00:00:00

abstract：:In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...

journal_title：International journal of cancer

authors： Hombach A,Jung W,Pohl C,Renner C,Sahin U,Schmits R,Wolf J,Kapp U,Diehl V,Pfreundschuh M

更新日期：1993-11-11 00:00:00

abstract：:We have studied the relationship between tumor necrosis factor (TNF)-sensitivity and doxorubicin-resistance in our doxorubicin-resistant cell line panel consisting of the parental cell line GLC4 plus GLC4-Adr2x and GLC4-Adr350x with respective resistance factors of 2 and 350 compared with GLC4. At the highest dose of ...

journal_title：International journal of cancer

authors： Sleijfer S,Asschert JG,Timmer-Bosscha H,Mulder NH

更新日期：1998-07-03 00:00:00

abstract：:RAS, TP53 (p53) and MYC are among the most frequently altered driver genes in cancer. Thus, RAS is the most frequently mutated oncogene, MYC the most frequently amplified gene and TP53 the most frequently mutated tumor suppressor gene and overall the most frequently mutated gene in cancer. Theoretically, therefore, th...

journal_title：International journal of cancer

authors： Duffy MJ,Crown J

更新日期：2021-01-01 00:00:00

abstract：:The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

journal_title：International journal of cancer

authors： Woodruff MF,Ghaffar A,Whitehead VL

更新日期：1976-05-15 00:00:00

abstract：:Experimental and epidemiological evidence supports a role for sex steroid hormones in the pathogenesis of ovarian cancer. We investigated the association between ovarian cancer risk and pre-diagnostic blood concentrations of testosterone, androstenedione, DHEAS, estrone and SHBG. A case-control study nested within 3 c...

journal_title：International journal of cancer

authors： Lukanova A,Lundin E,Akhmedkhanov A,Micheli A,Rinaldi S,Zeleniuch-Jacquotte A,Lenner P,Muti P,Biessy C,Krogh V,Berrino F,Hallmans G,Riboli E,Kaaks R,Toniolo P

更新日期：2003-05-01 00:00:00

abstract：:Maspin is a Class II tumor suppressor protein and plays a role in tumor growth by inhibiting cellular invasion and motility. It is a member of the serpin family of protease inhibitors and has been shown to reduce angiogenesis. Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-relat...

journal_title：International journal of cancer

authors： Spiesbach K,Tannapfel A,Mössner J,Engeland K

更新日期：2005-04-20 00:00:00

abstract：:Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

journal_title：International journal of cancer

authors： Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

更新日期：2009-07-01 00:00:00

abstract：:Cell lines derived from 13 different human colon adenocarcinomas were examined for production of fibronectin by ELISA and for cell-surface expression of fibronectin by indirect immunofluorescence. Two squamous epithelial cell lines obtained from tumors of the upper aerodigestive tract were used as controls. None of th...

journal_title：International journal of cancer

authors： Varani J,Schuger L,Fligiel SE,Inman DR,Chakrabarty S

更新日期：1991-02-01 00:00:00

abstract：:Suramin has been shown to have antiproliferative activity, either by blocking the binding of growth factors to their receptors or by inhibiting critical cellular enzymes. In 6 different cell lines from 5 tumour types (MCF-7, MCF-7/ADRR, PC3, HT-29, UM-SCC-11B and SW-1573/IR500), we studied the effect of scheduling of ...

journal_title：International journal of cancer

authors： Lopez Lopez R,Peters GJ,van Loenen AC,Pizao PE,van Rijswijk RE,Wagstaff J,Pinedo HM

更新日期：1992-07-30 00:00:00