当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells.

miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells.

Abstract：

:miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and progression. In the present study, we have identified miR-137 as a potential regulator of Cdc42 expression. A bioinformatics search revealed a putative target-site for miR-137 within the Cdc42 3' UTR at nt 792-798, which is highly conserved across different species. Expression of miR-137 in colorectal cancer cell lines was found inversely correlated with Cdc42 expression. miR-137 could significantly suppress Cdc42 3' UTR luciferase-reporter activity, and this effect was not detectable when the putative 3' UTR target-site was mutated. Consistent with the results of the reporter assay, ectopic expression of miR-137 reduced both mRNA and protein expression levels of Cdc42 and mimicked the effect of Cdc42 knockdown in inhibiting proliferation, inducing G1 cell cycle arrest, and blocking invasion of the colorectal cancer cells, whereas anti-miR-137 expression led to the opposite effect. Furthermore, expression of miR-137 suppressed the immediate downstream effector of Cdc42, PAK signaling. Our results suggest that miR-137 may have a tumor suppressor function by directly targeting Cdc42 to inhibit the proliferation and invasion activities of colorectal cancer cells. They raise an interesting possibility that Cdc42 activity and function can be controlled by miRNAs in addition to the classic regulators such as guanine nucleotide exchange factors and GTPase-activating proteins.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Liu M,Lang N,Qiu M,Xu F,Li Q,Tang Q,Chen J,Chen X,Zhang S,Liu Z,Zhou J,Zhu Y,Deng Y,Zheng Y,Bi F

doi

10.1002/ijc.25452

subject

Has Abstract

pub_date

2011-03-15 00:00:00

pages

1269-79

issue

6

eissn

0020-7136

issn

1097-0215

journal_volume

128

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time.

    abstract：:Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...

    journal_title：International journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1002/ijc.24506

    authors： Shabo I,Olsson H,Sun XF,Svanvik J

    更新日期：2009-10-15 00:00:00

  • Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.

    abstract：:The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23834

    authors： Ghosh S,Ghosh A,Maiti GP,Alam N,Roy A,Roy B,Roychoudhury S,Panda CK

    更新日期：2008-12-01 00:00:00

  • Tumor-associated macrophage-targeted therapeutics in ovarian cancer.

    abstract：:Ovarian cancer is one of the most common gynecological malignancies. The tumor microenvironment plays an important role in regulating the progression of ovarian cancer. Macrophages, which are important immune cells in the tumor microenvironment, participate in the regulation of various biological behaviors and influen...

    journal_title：International journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1002/ijc.33408

    authors： An Y,Yang Q

    更新日期：2020-11-24 00:00:00

  • TP53 mutation and survival in aggressive B cell lymphoma.

    abstract：:TP53 is mutated in 20-25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B-NHL, we investigated TP53 gene mutations within the RICOVER-60 trial. Of...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1002/ijc.30838

    authors： Zenz T,Kreuz M,Fuge M,Klapper W,Horn H,Staiger AM,Winter D,Helfrich H,Huellein J,Hansmann ML,Stein H,Feller A,Möller P,Schmitz N,Trümper L,Loeffler M,Siebert R,Rosenwald A,Ott G,Pfreundschuh M,Stilgenbauer S,Ger

    更新日期：2017-10-01 00:00:00

  • Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer.

    abstract：:We assessed whether split dosing with the methylating agent DTIC is an effective strategy for inactivating the DNA repair protein O6-alkylguanine DNA-ATase in order to decrease tumour resistance to BCNU. ATase levels in PBMCs were used as a surrogate for tumour ATase depletion to determine whether this correlated with...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10849

    authors： Clemons M,Ranson M,Margison JM,El Teraifi H,Griffiths A,Kelly J,Morris CQ,Howell A,Margison GP

    更新日期：2003-02-20 00:00:00

  • miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis.

    abstract：:Glioblastoma multiforme (GBM) is the most lethal brain malignancy which involves multi-gene abnormality. Unfortunately, effective therapy against GBM remains lacking. Previously, we found that NRP-1 and its downstream NRP-1/GIPC1 pathway played an important role in GBM. In our study, we further investigated the upstre...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.31329

    authors： Zhang G,Chen L,Khan AA,Li B,Gu B,Lin F,Su X,Yan J

    更新日期：2018-08-01 00:00:00

  • Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells.

    abstract：:Although human NK cells lyse a wide spectrum of target cells, the precise target structure recognized by NK cells has not yet been elucidated. In order to define a possible relationship between gangliosides on human target cells and susceptibility to NK lysis, 14 human leukemia and lymphoma cell lines were studied. A ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910400104

    authors： Ando I,Hoon DS,Suzuki Y,Saxton RE,Golub SH,Irie RF

    更新日期：1987-07-15 00:00:00

  • Analysis of the p53 gene in relation to tobacco and alcohol in cancers of the upper aero-digestive tract.

    abstract：:To elucidate the relationship, if any, of p53 gene expression according to smoking and drinking habits, 135 subjects with cancer of the upper aero-digestive tract were sampled from a case-control investigation conducted in Pordenone province, Northeast Italy, between 1986 and 1991. Adequate pathological material for i...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910600625

    authors： Franceschi S,Gloghini A,Maestro R,Barzan L,Bidoli E,Talamini R,Vukosavljevic T,Carbone A,Boiocchi M

    更新日期：1995-03-16 00:00:00

  • Risk of invasive cervical cancer in relation to clinical investigation and treatment after abnormal cytology: a population-based case-control study.

    abstract：:A substantial proportion of women with cervical cancer that have participated in cervical screening have a history of an abnormal cytology result. Our objective was to assess the impact of histological investigation and treatment of women with abnormal cytology on the subsequent risk of invasive cervical cancer. All i...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.25749

    authors： Silfverdal L,Kemetli L,Sparén P,Andrae B,Strander B,Ryd W,Dillner J,Törnberg S

    更新日期：2011-09-15 00:00:00

  • Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies. The International Melanoma Analysis Group (IMAGE).

    abstract：:Using individual subject data from 10 case-control studies, comprising over 3000 cases and almost 4000 controls, we have estimated the relative risk of melanoma associated with aspects of complexion, namely, hair, eye and skin colour and freckling in adulthood, and have examined the relationships between these factors...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910620402

    authors： Bliss JM,Ford D,Swerdlow AJ,Armstrong BK,Cristofolini M,Elwood JM,Green A,Holly EA,Mack T,MacKie RM

    更新日期：1995-08-09 00:00:00

  • Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality.

    abstract：:This study profiles testicular cancer incidence and mortality across Europe, and the effects of age, period and generational influences, using age-period-cohort modeling. Despite a 5-fold variation in incidence rates, there were consistent mean increases in incidence in each of the 12 European countries studied, rangi...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.21747

    authors： Bray F,Richiardi L,Ekbom A,Pukkala E,Cuninkova M,Møller H

    更新日期：2006-06-15 00:00:00

  • Prevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC).

    abstract：:We report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK)....

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910520328

    authors： Cerny T,Fey MF,Oppliger R,Castiglione M,Nachbur B,Gertsch M,Gasser A,Joss RA,Thatcher N,Lind M

    更新日期：1992-09-30 00:00:00

  • Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer.

    abstract：:There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.25479

    authors： Hong AM,Dobbins TA,Lee CS,Jones D,Fei J,Clark JR,Armstrong BK,Harnett GB,Milross CG,Tran N,Peculis LD,Ng C,Milne AG,Loo C,Hughes LJ,Forstner DF,O'Brien CJ,Rose BR

    更新日期：2011-04-01 00:00:00

  • A synergistic effect between anti-idiotype antibodies and anti-neoplastic drugs in the therapy of a murine B-cell tumor.

    abstract：:Antibodies directed against idiotypic determinants of the cell-surface IgM of a B lymphoma, 38c, were effective in delaying development of the tumor and in some instances in preventing its growth. The efficacity of the anti-idiotype antibodies was markedly increased when they were injected in combination with anti-neo...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910370515

    authors： Hurwitz E,Burowski D,Kashi R,Hollander N,Haimovich J

    更新日期：1986-05-15 00:00:00

  • FOXO transcription factors at the interface of metabolism and cancer.

    abstract：:Diabetes refers to a group of metabolic diseases characterized by impaired insulin signalling and high blood glucose. A growing body of epidemiological evidence links diabetes to several types of cancer but the underlying molecular mechanisms are poorly understood. The signalling cascade connecting insulin and FOXO pr...

    journal_title：International journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1002/ijc.30840

    authors： Link W,Fernandez-Marcos PJ

    更新日期：2017-12-15 00:00:00

  • Effect of NSAIDs on the recurrence of nonmelanoma skin cancer.

    abstract：:Experimental studies have consistently shown a protective effect of nonsteroidal antiinflammatory drugs (NSAIDs) against nonmelanoma skin cancers (NMSC). However, little human epidemiological research has been done in this regard. We used data from the Skin Cancer Chemoprevention Study to explore the association of NS...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.21878

    authors： Grau MV,Baron JA,Langholz B,Karagas M,Greenberg ER,Stukel TA,Mandel JS

    更新日期：2006-08-01 00:00:00

  • Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients.

    abstract：:We investigated the expression pattern of the breast cancer associated gene LIV-1 on mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.21235

    authors： Kasper G,Weiser AA,Rump A,Sparbier K,Dahl E,Hartmann A,Wild P,Schwidetzky U,Castaños-Vélez E,Lehmann K

    更新日期：2005-12-20 00:00:00

  • c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line.

    abstract：:Transcription factor c-Jun serves for cellular proliferation, survival, differentiation and transformation and is recognized as an important factor in cancer development, including hepatocellular carcinoma (HCC). The purpose of present study is to determine the involvement of c-Jun in matrix metalloproteinase-1 (MMP-1...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.20095

    authors： Sugioka Y,Watanabe T,Inagaki Y,Kushida M,Niioka M,Endo H,Higashiyama R,Okazaki I

    更新日期：2004-05-10 00:00:00

  • Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer.

    abstract：:Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapy-refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumoral expression of key signaling mo...

    journal_title：International journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1002/ijc.20550

    authors： Han SW,Hwang PG,Chung DH,Kim DW,Im SA,Kim YT,Kim TY,Heo DS,Bang YJ,Kim NK

    更新日期：2005-01-01 00:00:00

  • Use of benzodiazepine and risk of cancer: A meta-analysis of observational studies.

    abstract：:Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publicatio...

    journal_title：International journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1002/ijc.30443

    authors： Kim HB,Myung SK,Park YC,Park B

    更新日期：2017-02-01 00:00:00

  • Studies on clonal heterogeneity in two spontaneously metastasizing mammary carcinomas of recent origin.

    abstract：:We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910350220

    authors： Brodt P,Parhar R,Sankar P,Lala PK

    更新日期：1985-02-15 00:00:00

  • Tumor production of angiostatin is enhanced after exposure to TNF-alpha.

    abstract：:Infection of tumors with an adenoviral vector expressing a chimeric gene composed of the CArG elements of the Egr-1 promoter and a cDNA encoding TNF-alpha (Ad.Egr-TNF) has previously been shown to result in the production of high intratumoral levels of TNF-alpha and thereby tumor regression. The antitumor effects of T...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.1629

    authors： Mauceri HJ,Seetharam S,Beckett MA,Lee JY,Gupta VK,Gately S,Stack MS,Brown CK,Swedberg K,Kufe DW,Weichselbaum RR

    更新日期：2002-02-01 00:00:00

  • Large scale in vivo micro-RNA loss of function screen identified miR-29a, miR-100 and miR-155 as modulators of radioresistance and tumor-stroma communication.

    abstract：:Micro RNAs (miR) are master regulators of cellular transcriptome. We aimed to investigate the role of miR regulation on tumor radiosensitivity and development of local tumor recurrence by a novel large-scale in vivo loss of function screen. For stable miR silencing, human A431 tumor cells were transduced with lentivir...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32019

    authors： Fahim Golestaneh A,Lecker LSM,Schlegel J,Nowrouzi A,Schwager C,Meister S,Weichert W,Debus J,Abdollahi A

    更新日期：2019-06-01 00:00:00

  • TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics.

    abstract：:Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10567

    authors： Simão TA,Ribeiro FS,Amorim LM,Albano RM,Andrada-Serpa MJ,Cardoso LE,Mendonça GA,de Moura-Gallo CV

    更新日期：2002-09-01 00:00:00

  • A novel high-affinity human monoclonal antibody to mesothelin.

    abstract：:Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of mesothelioma, ovarian cancer and other malignant tumors. The interaction between mesothelin and CA125 (also called MUC16) may facilitate the implantation and metastasis of tumors in the peritoneal cavity....

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.25557

    authors： Ho M,Feng M,Fisher RJ,Rader C,Pastan I

    更新日期：2011-05-01 00:00:00

  • Inhibition of prostate cancer metastatic colonization by approximately 4.2 Mb of human chromosome 12.

    abstract：:Our previous studies demonstrate that introduction of a approximately 70 cM region (now estimated at 63.75 Mb by the Human Genome Project) of human chromosome 12 into the highly metastatic Dunning rat prostate cancer cell line AT6.1 results in >30-fold (>/=90%) reduction in the number of overt metastases in spontaneou...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.11483

    authors： Jaeger EB,Chekmareva MA,Tennant TR,Luu HH,Hickson JA,Chen SL,Samant RS,Sokoloff MH,Rinker-Schaeffer CW

    更新日期：2004-01-01 00:00:00

  • LAGE-1, a new gene with tumor specificity.

    abstract：:Representational difference analysis was used to identify genes that are expressed in a human melanoma cell line and not in normal skin. A cDNA clone that appeared to be specific for tumors was obtained and the corresponding gene was sequenced. This new gene was named LAGE-I. Using a LAGE-I probe to screen a cDNA libr...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19980610)76:6<903::aid-ijc

    authors： Lethé B,Lucas S,Michaux L,De Smet C,Godelaine D,Serrano A,De Plaen E,Boon T

    更新日期：1998-06-10 00:00:00

  • A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and beta1-integrin point contact distribution.

    abstract：:Spreading is a critical process involved in motility and growth of tumor cells during the metastatic cascade. Focal adhesion kinase, src-proteins and PKC have been reported to participate in the regulation of cytoskeleton organization in both normal and transformed cells during spreading. The role of other signaling e...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19970529)71:5<881::aid-ijc

    authors： Aguirre Ghiso JA,Farías EF,Alonso DF,Arregui C,Bal de Kier Joffé E

    更新日期：1997-05-29 00:00:00

  • Elevated levels of angiogenic cytokines in the plasma of cancer patients.

    abstract：:Although in the normal healthy organism angiogenesis is a tightly regulated process, under a variety of circumstances it may contribute to disease states. These include the growth of solid tumors, the hematogenous spread of tumor cells and the growth of metastasis. Our aim was to measure the levels of 5 angiogenic cyt...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(20000101)85:1<40::aid-ijc7

    authors： Fuhrmann-Benzakein E,Ma MN,Rubbia-Brandt L,Mentha G,Ruefenacht D,Sappino AP,Pepper MS

    更新日期：2000-01-01 00:00:00

  • Familial and second primary pancreatic cancers: a nationwide epidemiologic study from Sweden.

    abstract：:Familial risk of pancreatic cancer has been mainly assessed through case-control studies based on reported but not medically verified cancers in family members. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 21,000 pancreatic cancers to calculate standardized incidence ratios (SI...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10863

    authors： Hemminki K,Li X

    更新日期：2003-02-10 00:00:00