Abstract:
:Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who had a newly detected HPV31 infection during a two-year follow-up with six-month intervals. HPV31 isolates were characterized by sequencing and assigned to one of three variant lineages. Loss of the newly detected HPV31 infection was detected in 76 (47.5%) of the 160 women (32/67 with A variants, 16/27 with B variants and 28/66 with C variants). The adjusted hazard ratio associating loss of the infection was 1.2 (95% CI, 0.7-2.1) for women with A variants and 2.1 (95% CI, 1.2-3.5) for women with B variants when compared with those with C variants. Infections with A and C variants were detected in 50 and 41 Caucasian women and in 15 and 23 African-American women, respectively. The likelihood of clearance of the infection was significantly lower in African-American women with C variants than in African-American women with A variants (p = 0.05). There was no difference in the likelihood of clearance between A and C variants among Caucasian women. Our data indicated that infections with B variants were more likely to resolve than those with C variants. The difference in clearance of A vs. C variants in African-Americans, but not in Caucasians, suggests a possibility of the race-related influence in retaining the variant-specific infection.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Xi LF,Schiffman M,Koutsky LA,He Z,Winer RL,Hulbert A,Lee SK,Ke Y,Kiviat NBdoi
10.1002/ijc.27689subject
Has Abstractpub_date
2013-02-01 00:00:00pages
549-55issue
3eissn
0020-7136issn
1097-0215journal_volume
132pub_type
杂志文章abstract::Alterations in TGF-beta signaling appear to be associated with an altered risk of developing cancer, including breast cancer. We carried out a case-control study on 8 polymorphisms, including 5 in the TGF-beta1 gene (G-800A, C-509T, Leu10-->Pro, Arg25-->Pro and Thr263-->Ile), a polyalanine polymorphism (9A-->6A) in th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20370
更新日期:2004-10-20 00:00:00
abstract::Regression of EB-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus-infected T-cell-depleted population in order to e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230505
更新日期:1979-05-15 00:00:00
abstract::Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610420
更新日期:1995-05-16 00:00:00
abstract::DNA repair is a complicated biological process, consisting of several distinct pathways, that plays a fundamental role in the maintenance of genomic integrity. The very important field of DNA repair and cancer risk has developed rapidly in the past decades. In this review of selected published data from our laboratory...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.24126
更新日期:2009-03-01 00:00:00
abstract::Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31261
更新日期:2018-08-15 00:00:00
abstract::Oesophageal squamous cell carcinoma (ESCC) has markedly high incidence rates in Kenya and much of East Africa, with a dire prognosis and poorly understood aetiology. Consumption of hot beverages-a probable carcinogen to humans-is associated with increased ESCC risk in other settings and is habitually practiced in Keny...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32032
更新日期:2019-06-01 00:00:00
abstract::Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that sever...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32138
更新日期:2019-08-15 00:00:00
abstract::We have shown in the preceding paper that AKR mice are highly resistant to M-MSV tumor development, and that resistance is transmitted as a dominant character. In the present studies the tumor-response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and B10BR) following injection w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160310
更新日期:1975-09-15 00:00:00
abstract::The diagnostic specificity of the detection of disseminated prostatic cells by reverse-transcriptase polymerase chain reaction (RT-PCR) of PSA mRNA was investigated. A sensitive nested PCR was developed. In blood samples from 10 healthy female and 10 healthy male persons examined by RT-PCR, mRNA of PSA was detected 3 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970106)70:1<52::aid-ijc8
更新日期:1997-01-06 00:00:00
abstract::The authors analyzed the HER2 status in early-stage nonrecurrent and recurrent breast cancer groups following breast-conserving treatment. Retrospective analyses of a group of 36 invasive early breast cancer (IBC) patients who developed a local recurrence as a first event and of a random control group of 69 IBC patien...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21497
更新日期:2006-04-01 00:00:00
abstract::The influence of elevated lactate concentrations, as found in tumor microregions, on cellular growth, viability, and metabolic state was studied employing the multicellular spheroid model. Spheroids of EMT6/Ro cells were cultured at 37 degrees C in 5% or 20% (v/v) oxygen, using stirred media with various concentration...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470528
更新日期:1991-03-12 00:00:00
abstract::The ability of endogenously synthesized protoporphyrin IX (PpIX) to damage Chinese hamster lung fibroblasts of the line V79 by exposure to light was examined. This treatment induced reduction of cellular ATP, GTP, of the NADH/NAD+ ratio and of oxygen consumption. The present results indicate a close relationship betwe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960917)67:6<791::AID-IJC
更新日期:1996-09-17 00:00:00
abstract::Tissue factor (TF)-mediated protease-activated receptor (PAR)-2 signaling is associated with a promigratory, invasive and proangiogenic phenotype in experimental models of breast cancer and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24921
更新日期:2010-05-15 00:00:00
abstract::Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29600
更新日期:2015-11-15 00:00:00
abstract::We evaluated the associations of such lifestyle factors as alcohol drinking, coffee consumption and medical history with risk of death from pancreatic cancer in a large-scale prospective cohort study [the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC study)] in Japan. Subjects were 110,792 (46,4...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10402
更新日期:2002-06-10 00:00:00
abstract::Histone deacetylase inhibitors, such as phenylbutyrate, are currently undergoing clinical trials as potential anticancer agents. Phenylbutyrate can induce cell differentiation and apoptosis in a number of cancer cell types and can act in synergy with ionizing radiation and chemotherapy to induce apoptosis. We used the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10609
更新日期:2002-10-10 00:00:00
abstract::Human papilloma virus (HPV) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ASCC) but is not sufficient for tumour progression. This carcinoma is poorly understood at the molecular level. Using the largest cohort of cases to date we investigated the molecular mechanisms un...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23028
更新日期:2007-12-15 00:00:00
abstract::Dendritic cells (DC) have gained much interest in the field of anticancer vaccine development because of their central function in immune regulation. However, the clinical application of ex vivo cultured DC has significant disadvantages. A vaccine that targets dendritic cells in vivo and enhances antigen presentation ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23101
更新日期:2008-02-15 00:00:00
abstract::Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000301)85:5<691::aid-ijc
更新日期:2000-03-01 00:00:00
abstract::A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390304
更新日期:1987-03-15 00:00:00
abstract::The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Immunohistochemical studies have shown that this overexpression is linked to higher aggressiveness of colorectal carcinoma and to enhanced metastatic potential of melanoma cells. However, the antibodies so far developed against Nup88 have the draw...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20034
更新日期:2004-05-01 00:00:00
abstract::Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11018
更新日期:2003-05-20 00:00:00
abstract::140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300507
更新日期:1982-11-15 00:00:00
abstract::To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182R-1, MCF-7/182R-6 and MCF-7/182R-7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breast-cancer MCF-7 cell line by long-term ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970917)72:6<1129::aid-ij
更新日期:1997-09-17 00:00:00
abstract::We evaluated RS5444, a thiazolidinedione high affinity PPARgamma agonist, for the ability to inhibit colon carcinogenesis in azoxymethane (AOM)-treated mice. In our initial experiment, mice were treated with RS5444 during AOM treatment, and the drug was withdrawn 12 weeks after the last injection of AOM. RS5444 signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23640
更新日期:2008-09-01 00:00:00
abstract::The in vitro sponge-gel-supported three-dimensional histoculture chemosensitivity assay (Hoffman assay) allows the in vivo-like culture of human tumors. In this study, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) end point was applied to the Hoffman assay in an attempt to increase in vitr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510325
更新日期:1992-05-28 00:00:00
abstract::We examined the expression of tumor-suppressor protein p53 in a variety of laryngeal carcinomas from 43 patients (25 primary, 13 metastatic and 5 recurrent cases), 13 normal laryngeal tissues and 7 benign laryngeal nodule biopsy specimens, using the polyclonal antibody CM-1. Previously we have reported a high incidenc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530615
更新日期:1993-04-01 00:00:00
abstract::In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c-kit expression on survival. Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections. c-kit was observed in 87.7% of SCLC tumors. Using the Kaplan-Mei...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20252
更新日期:2004-08-20 00:00:00
abstract::We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and to develop a novel cytokine-based prognostic classifier (CBPC) for prognostic prediction. A total of 176 patients were divided into two cohorts based on the date of first-line chemoth...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29017
更新日期:2015-02-01 00:00:00
abstract::Previous studies indicate that the nonclassical class I HLA-G antigen, whose physiologic expression is mainly restricted to placenta, is upregulated in melanoma, renal carcinoma, lung carcinoma, glioblastoma and ovarian carcinoma, where its inhibitory effect on cytotoxic effector cells function is thought to participa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11456
更新日期:2004-01-10 00:00:00