The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.

abstract：:The cytogenetic response to G2-phase X-irradiation was examined in phytohemagglutinin-stimulated peripheral-blood lymphocytes from 69 individuals, a few of whom were cancer patients. The cancer patients had not received radiation or chemotherapy. The responses of cells arrested by Colcemid 30 to 90 min after X-irradia...

journal_title：International journal of cancer

authors： Knight RD,Parshad R,Price FM,Tarone RE,Sanford KK

更新日期：1993-06-19 00:00:00

abstract：:Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...

journal_title：International journal of cancer

authors： Shen X,Shen X

更新日期：2021-03-15 00:00:00

abstract：:We have investigated the comparative initial DNA binding properties of 7 platinum-based anticancer drugs: 5 cis-oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [cis ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bisacetato cis ammine dichloro (cyclohexylamine) platinum (IV)] and JM149 [cis amm...

journal_title：International journal of cancer

authors： Mellish KJ,Barnard CF,Murrer BA,Kelland LR

更新日期：1995-09-15 00:00:00

abstract：:Tumor cell migration involved in metastases is a tightly regulated, nonrandom process. Chemokines have been identified as critical molecules guiding cell migration. We performed a prospective study to analyze a possible association between the expression of chemokine receptors CXCR3 and CXCR4 by primary melanoma and c...

journal_title：International journal of cancer

authors： Longo-Imedio MI,Longo N,Treviño I,Lázaro P,Sánchez-Mateos P

更新日期：2005-12-10 00:00:00

abstract：:The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the ...

journal_title：International journal of cancer

authors： Peer PG,Werre JM,Mravunac M,Hendriks JH,Holland R,Verbeek AL

更新日期：1995-03-16 00:00:00

abstract：:Normal thyroid epithelial cells lack major histocompatibility complex (MHC) Class II antigen. Oncogenic kinases involved in papillary thyroid carcinoma (PTC) trigger the expression of Class II transactivator and MHC Class II complex. However, the relationship between MHC Class II antigen expression and clinical outcom...

journal_title：International journal of cancer

authors： Jo YS,Lee JC,Li S,Choi YS,Bai YS,Kim YJ,Lee IS,Rha SY,Ro HK,Kim JM,Shong M

更新日期：2008-02-15 00:00:00

abstract：:Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...

journal_title：International journal of cancer

authors： Sanjoaquin MA,Allen N,Couto E,Roddam AW,Key TJ

更新日期：2005-02-20 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a solid neoplasm exhibiting aggressive tumor phenotypes with unpredictable biological behavior. Recent studies suggested that high expression of the antiapoptotic protein survivin might be associated with adverse outcome in oral cancer patients. To investigate, whether increased ...

journal_title：International journal of cancer

authors： Freier K,Pungs S,Sticht C,Flechtenmacher C,Lichter P,Joos S,Hofele C

更新日期：2007-02-15 00:00:00

abstract：:In an ongoing case-control study in Athens on the etiology of hepatocellular carcinoma (HCC), an analysis was made in order to assess whether HCV genotype 1b is associated with hepatocellular carcinoma (HCC). The HCV genotype was determined in 17 HCC patients, 87 patients with chronic hepatitis C (CHC) without cirrhos...

journal_title：International journal of cancer

authors： Hatzakis A,Katsoulidou A,Kaklamani E,Touloumi G,Koumantaki Y,Tassopoulos NC,Karvountzis G,Gioustozi A,Hadziyannis S,Trichopoulos D

更新日期：1996-09-27 00:00:00

abstract：:Human papillomavirus (HPV) vaccines protect against infections with the most oncogenic HPV types, cervical intraepithelial neoplasia (CIN) and cervical cancer. We investigated whether development of cervical intraepithelial neoplasia (CIN) lesions in HPV-vaccinated women is associated with vaccine-targeted HPV types o...

journal_title：International journal of cancer

authors： Kann H,Hortlund M,Eklund C,Dillner J,Faust H

更新日期：2020-05-01 00:00:00

abstract：:Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...

journal_title：International journal of cancer

authors： Buergy D,Wenz F,Groden C,Brockmann MA

更新日期：2012-06-15 00:00:00

abstract：:Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated as the cellular ori...

journal_title：International journal of cancer

authors： Meder L,König K,Ozretić L,Schultheis AM,Ueckeroth F,Ade CP,Albus K,Boehm D,Rommerscheidt-Fuss U,Florin A,Buhl T,Hartmann W,Wolf J,Merkelbach-Bruse S,Eilers M,Perner S,Heukamp LC,Buettner R

更新日期：2016-02-15 00:00:00

abstract：:IL-15 is an immunostimulatory cytokine with IL-2-like activities. To exploit the potential role of IL-15 in cancer immuno-/gene therapy, we engineered murine TS/A cells with different IL-15 cDNA constructs. Significant IL-15 secretion was achieved only by the use of a modified cDNA encoding for an IL-15 pre-protein be...

journal_title：International journal of cancer

authors： Meazza R,Lollini PL,Nanni P,De Giovanni C,Gaggero A,Comes A,Cilli M,Di Carlo E,Ferrini S,Musiani P

更新日期：2000-08-15 00:00:00

abstract：:Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...

journal_title：International journal of cancer

authors： Franco J,Pérez-Hoyos S,Plaza P

更新日期：2002-01-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL th...

journal_title：International journal of cancer

authors： Thapa B,Bahadur Kc R,Uludağ H

更新日期：2018-02-01 00:00:00

abstract：:Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...

journal_title：International journal of cancer

authors： Okamura R,Kurzrock R,Mallory RJ,Fanta PT,Burgoyne AM,Clary BM,Kato S,Sicklick JK

更新日期：2021-02-01 00:00:00

abstract：:Active, structurally unrelated tumor promoters (12-0-tetradecanoyl-phorbol-13-acetate (TPA), teleocidin and aplysiatoxin) inhibit growth of mammary carcinoma cells (MCF7- greater than BT-20 greater than MDA-MB-231 greater than = ZR-75-1 greater than HBL-100). This efficiency in inhibiting cell growth correlates with t...

journal_title：International journal of cancer

authors： Regazzi R,Fabbro D,Costa SD,Borner C,Eppenberger U

更新日期：1986-05-15 00:00:00

abstract：:We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4,...

journal_title：International journal of cancer

authors： Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G

更新日期：2001-05-15 00:00:00

abstract：:The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

journal_title：International journal of cancer

authors： Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

更新日期：1995-05-04 00:00:00

abstract：:Development of targeted therapeutics is still at its early stage for hepatocellular carcinoma (HCC) due to the incomplete understanding of the confounding regulations at signaling pathway level. In this investigation, gene co-expression-based networking and integrative functional genomic modeling of HCC mRNA profiles ...

journal_title：International journal of cancer

authors： Ramesh V,Ganesan K

更新日期：2016-10-01 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:The epithelial ovarian carcinoma (EOC) is an aggressive malignant tumor, and is currently the leading cause of gynecologic cancer death. CA125 is the most commonly used serum marker for EOC, but shows a high-false-positive rate for several benign diseases such as endometriosis. The purpose of our study is therefore to...

journal_title：International journal of cancer

authors： Sasaki A,Akita K,Ito F,Mori T,Kitawaki J,Nakada H

更新日期：2015-04-15 00:00:00

abstract：:The translation-initiation factor eIF4E is rate-limiting for protein synthesis, and its over-expression results in oncogenic transformation of mammalian cells. eIF4E facilitates the synthesis of several powerful tumor angiogenic factors (FGF-2 and VEGF) by selectively enhancing their translation. In breast carcinomas,...

journal_title：International journal of cancer

authors： DeFatta RJ,Turbat-Herrera EA,Li BD,Anderson W,De Benedetti A

更新日期：1999-02-09 00:00:00

abstract：:The purpose of this study was to induce in postnatal life the selective growth of altered hepatocytic populations which had been induced in utero by various chemicals. Pregnant rats of a Wistar strain were given a single dose of various chemical carcinogens on the 18th gestational day. From two months postpartum, both...

journal_title：International journal of cancer

authors： Ogawa K,Yokokawa K,Tomoyori T,Onoé T

更新日期：1982-03-15 00:00:00

abstract：:In the past, it has been impossible to carry out immunohistological staining as part of a rapid histopathological diagnosis during surgery because the available methods were too time-consuming. The present report introduces a rapid indirect immunoperoxidase method that requires only 10-12 min. Thus, the immunological ...

journal_title：International journal of cancer

authors： Gerdes J

更新日期：1985-02-15 00:00:00

abstract：:The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...

journal_title：International journal of cancer

authors： Guerreiro AS,Boller D,Shalaby T,Grotzer MA,Arcaro A

更新日期：2006-12-01 00:00:00

abstract：:Epidemiological and animal studies have demonstrated that vitamin A and its natural and synthetic derivatives, retinoids, are effective agents in preventing the development of tobacco-associated cancers. Unfortunately, clinical trials of retinoids on cigarette smokers have shown lack of efficacy in preventing lung can...

journal_title：International journal of cancer

authors： Chen GQ,Lin B,Dawson MI,Zhang XK

更新日期：2002-05-10 00:00:00

abstract：:Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowe...

journal_title：International journal of cancer

authors： Tavani A,Pelucchi C,Parpinel M,Negri E,Franceschi S,Levi F,La Vecchia C

更新日期：2003-05-20 00:00:00

abstract：:During 1984-88 a population-based case-control study was carried out in The Netherlands in collaboration with the International Agency for Research on Cancer in order to further explore the possible relationship between diet and exocrine pancreatic carcinoma. Past habitual dietary intake was assessed in 164 cases and ...

journal_title：International journal of cancer

authors： Bueno de Mesquita HB,Moerman CJ,Runia S,Maisonneuve P

更新日期：1990-09-15 00:00:00

abstract：:The synthetic retinoid fenretinide [N-(4-hydroxyphenyl)retinamide, 4-HPR] has demonstrated growth inhibition and induction of apoptosis of various malignant cells, including lung cancer cell lines. 4-HPR is now being investigated in several clinical trials. In our study, we show that 4-HPR inhibits growth on a broad p...

journal_title：International journal of cancer

authors： Ohlmann CH,Jung C,Jaques G

更新日期：2002-08-10 00:00:00