当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells.

Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells.

Abstract：

:Epidemiological and animal studies have demonstrated that vitamin A and its natural and synthetic derivatives, retinoids, are effective agents in preventing the development of tobacco-associated cancers. Unfortunately, clinical trials of retinoids on cigarette smokers have shown lack of efficacy in preventing lung cancer. In our study, we investigated the effect of nicotine on the anti-cancer activity of all trans-retinoic acid (trans-RA) in human lung cancer cells. Our results demonstrated that nicotine could abrogate the growth inhibitory effect of trans-RA by suppressing its ability to induce the expression of RA receptor beta (RAR beta), a tumor suppressor. The inhibitory effect of nicotine was accompanied with induction of orphan receptor TR3. Inhibition of TR3 expression by overexpression of TR3 anti-sense RNA in H460 lung cancer cells strongly prevented the suppressive effect of nicotine on trans-RA activity. Treatment with nicotine or the cotransfection of TR3 expression vector inhibited the induction of RAR beta promoter activity by trans-RA in transient transfection assays. The inhibition of RAR beta promoter activity was due to the interaction of TR3 with orphan receptor COUP-TF, resulting in inhibition of COUP-TF DNA binding and transactivation on the RAR beta promoter. Furthermore, we found that nicotine failed to suppress the effect of a retinoid X receptor (RXR)-selective retinoid SR11237 on inducing both growth inhibition and RAR beta promoter activity, due to the ability of SR11237 to activate the RAR beta promoter through the RXR/TR3 heterodimer. Together, our results demonstrate that nicotine suppresses the growth inhibitory effects of trans-RA by inhibiting RAR beta expression through its induction of TR3 expression and suggest that RXR-selective retinoids may be more effective than classical retinoids for preventing and treating tobacco-associated cancers.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Chen GQ,Lin B,Dawson MI,Zhang XK

doi

10.1002/ijc.10304

keywords:

subject

Has Abstract

pub_date

2002-05-10 00:00:00

pages

171-8

issue

2

eissn

0020-7136

issn

1097-0215

journal_volume

99

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • Deficiency in surface expression of E-selectin ligand promotes lung colonization in a mouse model of breast cancer.

    abstract：:Expression of sialyl Lewis(x) (sLe(x)) and sLe(a) on tumor cells is thought to facilitate metastasis by promoting cell adhesion to selectins on vascular endothelial cells. Experiments supporting this concept usually bypass the early steps of the metastatic process by employing tumor cells that are injected directly in...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.21192

    authors： Monzavi-Karbassi B,Whitehead TL,Jousheghany F,Artaud C,Hennings L,Shaaf S,Slaughter A,Korourian S,Kelly T,Blaszczyk-Thurin M,Kieber-Emmons T

    更新日期：2005-11-10 00:00:00

  • Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma.

    abstract：:Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in indirect immunofluorescence tests ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910170102

    authors： Henle G,Henle W

    更新日期：1976-01-15 00:00:00

  • Enhancement of thermal killing by polyamines. I. Survival of Chinese hamster cells.

    abstract：:Exposure of Chinese hamster cells to polyamines at an elevated temperature (42 degrees C) results in synergistic cell killing. The effectiveness of polyamines in potentiating thermal killing decreases in the following order: spermine greater than spermidine greater than cadaverine greater than putrescine. The magnitud...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910220515

    authors： Ben-Hur E,Prager A,Riklis E

    更新日期：1978-11-15 00:00:00

  • Induction of 2.5 OAS gene expression and activity is not sufficient for IFN-gamma-induced neuroblastoma cell differentiation.

    abstract：:We showed earlier that interferon-gamma is a powerful inducer of differentiation of human neuroblastoma (NB) cells. Although 2',5' oligo-adenylate synthetase (2,5 OAS) may play a role in mediating the anti-proliferative and/or differentiative effects of interferons (IFNs), direct evidence is lacking. We have investiga...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910620219

    authors： Corrias MV,Gribaudo G,Guarnaccia F,Ponzoni M

    更新日期：1995-07-17 00:00:00

  • Heterogeneity of HLA and EBER expression in Epstein-Barr virus-associated nasopharyngeal carcinoma.

    abstract：:Nasopharyngeal carcinoma (NPC) is an aggressive tumour of multifactorial aetiology that, although rare in most parts of the world, poses a significant mortality problem in its high incidence area of Southern China. Improved therapies are an urgent requirement and, towards this end, immunotherapeutic methods are being ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(20001215)88:6<949::aid-ijc18>3.0

    authors： Yao Y,Minter HA,Chen X,Reynolds GM,Bromley M,Arrand JR

    更新日期：2000-12-15 00:00:00

  • Postsurgical chemotherapy in stage IB nonsmall cell lung cancer: Long-term survival in a randomized study.

    abstract：:Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...

    journal_title：International journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1002/ijc.21933

    authors： Roselli M,Mariotti S,Ferroni P,Laudisi A,Mineo D,Pompeo E,Ambrogi V,Mineo TC

    更新日期：2006-08-15 00:00:00

  • Loss of heterozygosity at locus F13B on chromosome 1q in human medulloblastoma.

    abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-0215(19960703)67:1<11::AID-IJC3

    authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

    更新日期：1996-07-03 00:00:00

  • Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1.

    abstract：:The role of transcript variants of cyclin D1 in cancer biology is unclear. Most tumors with high levels of cyclin D1 express 2 transcripts due to alternative splicing: one full-length transcript of 4.4 kb and one short transcript of approximately 1.7 kb. The short transcript lacks part of the 3'UTR region regulating m...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.21166

    authors： Sander B,Flygare J,Porwit-Macdonald A,Smith CI,Emanuelsson E,Kimby E,Liden J,Christensson B

    更新日期：2005-11-10 00:00:00

  • Experimental radiotherapy of receptor-positive human prostate adenocarcinoma with 188Re-RC-160, a directly-radiolabeled somatostatin analogue.

    abstract：:The therapeutic potential of the somatostatin analogue RC-160 radiolabeled with 188Re was evaluated in nude mice bearing xenografts of human prostate adenocarcinoma. 188Re-RC-160 was selectively retained in both DU-145 and PC-3 tumors following direct intra-tumor injection at all time points examined (2, 6 and 24 hr p...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-0215(19960117)65:2<214::AID-IJC

    authors： Zamora PO,Gulhke S,Bender H,Diekmann D,Rhodes BA,Biersack HJ,Knapp FF Jr

    更新日期：1996-01-17 00:00:00

  • Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition.

    abstract：:Transforming growth factor-beta (TGF-beta) receptors constitute a family of transmembrane proteins that bind TGF-beta ligands. In this study we assessed the growth responsiveness to TGF-beta 1 in pancreatic cancer cell lines and characterized the levels of expression of TGF-beta receptors in these cell lines and in hu...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-0215(19960717)67:2<283::AID-IJC

    authors： Baldwin RL,Friess H,Yokoyama M,Lopez ME,Kobrin MS,Büchler MW,Korc M

    更新日期：1996-07-17 00:00:00

  • A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens.

    abstract：:Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regardin...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23551

    authors： Keimling M,Kaur J,Bagadi SA,Kreienberg R,Wiesmüller L,Ralhan R

    更新日期：2008-08-01 00:00:00

  • Geographical epidemiology of prostate cancer in Great Britain.

    abstract：:Prostate cancer incidence has increased during recent years, possibly linked to environmental exposures. Exposure to environmental carcinogens is unlikely to be evenly distributed geographically, which may give rise to variations in disease occurrence that is detectable in a spatial analysis. The aim of our study was ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10113

    authors： Jarup L,Best N,Toledano MB,Wakefield J,Elliott P

    更新日期：2002-02-10 00:00:00

  • A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX.

    abstract：:The human tumor line LOX was established as an s.c. xenograft in nude mice from a lymph-node metastasis of a patient with malignant melanoma. I.v. injection into adult nude mice of single-cell suspensions prepared from xenografts resulted in progressively growing lung tumor colonies that killed the animals. No differe...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910410322

    authors： Fodstad O,Aamdal S,McMenamin M,Nesland JM,Pihl A

    更新日期：1988-03-15 00:00:00

  • Postdiagnosis weight change is associated with poorer survival in breast cancer survivors: A prospective population-based patient cohort study.

    abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.33181

    authors： Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

    更新日期：2021-01-01 00:00:00

  • Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.

    abstract：:Transcriptional profiling was performed on 452 RNA preparations isolated from various types of pancreatic tissue from tumour patients and healthy donors, with a particular focus on peritumoral samples. Pancreatic ductal adenocarcinomas (PDAC) and cystic tumours were most different in these non-tumorous tissues surroun...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.31087

    authors： Bauer AS,Nazarov PV,Giese NA,Beghelli S,Heller A,Greenhalf W,Costello E,Muller A,Bier M,Strobel O,Hackert T,Vallar L,Scarpa A,Büchler MW,Neoptolemos JP,Kreis S,Hoheisel JD

    更新日期：2018-03-01 00:00:00

  • Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region.

    abstract：:Previous studies have reported that poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum (Por & Muc) show a low incidence and poor prognosis. However, genetic alterations and tumourigenesis of Por & Muc remain unclear. In our study, we analyzed the genetic and epigenetic alterations of P...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10690

    authors： Kanazawa T,Watanabe T,Kazama S,Tada T,Koketsu S,Nagawa H

    更新日期：2002-11-20 00:00:00

  • Analysis of chromosome 10 aberrations in rat endometrial cancer-evidence for a tumor suppressor locus distal to Tp53.

    abstract：:We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.22533

    authors： Nordlander C,Karlsson S,Karlsson A,Sjöling A,Winnes M,Klinga-Levan K,Behboudi A

    更新日期：2007-04-01 00:00:00

  • International renal-cell cancer study. IV. Occupation.

    abstract：:The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found wit...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.2910610503

    authors： Mandel JS,McLaughlin JK,Schlehofer B,Mellemgaard A,Helmert U,Lindblad P,McCredie M,Adami HO

    更新日期：1995-05-29 00:00:00

  • Chromothripsis in cancer cells: An update.

    abstract：:In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous forma...

    journal_title：International journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1002/ijc.29888

    authors： Rode A,Maass KK,Willmund KV,Lichter P,Ernst A

    更新日期：2016-05-15 00:00:00

  • Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells.

    abstract：:IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D122 clone. Both high and low D122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumorigenicity as compared...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910530320

    authors： Porgador A,Gansbacher B,Bannerji R,Tzehoval E,Gilboa E,Feldman M,Eisenbach L

    更新日期：1993-02-01 00:00:00

  • Chemical transformation of human revertant cells induced by murine sarcoma virus.

    abstract：:A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (c...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910210106

    authors： Cho HY,Arnstein P,Rhim JS

    更新日期：1978-01-15 00:00:00

  • In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity.

    abstract：:Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vitro chemosensitivity of the cells...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910260604

    authors： Tveit KM,Fodstad O,Olsnes S,Pihl A

    更新日期：1980-12-15 00:00:00

  • Propagation of a poorly differentiated human pulmonary adenocarcinoma in nude athymic rats.

    abstract：:Nude athymic rats of Rowett genetic background were injected subcutaneously with cells from a poorly differentiated human pulmonary adenocarcinoma, following propagation in nude mice. The tumour cells were obtained by thoracentesis and by pleural biopsy during thoracoscopy. So far, we have heterotransplanted 13 differ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910320621

    authors： Korsgaard R,Lindén CJ,Willén R,Willén H,Svensson G,Simonsson BG

    更新日期：1983-12-15 00:00:00

  • Direct cytolysis by partially-purified preparations of immune interferon.

    abstract：:Mouse IFN gamma preparations purified 30-fold were found to have direct cytolytic activity against a number of tumor and normal cells. Cell killing was determined using a sensitive, rapid and accurate assay which employed very low numbers of cells and very small quantities of interferon. The cytolytic activity of IFN ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910300111

    authors： Tyring S,Klimpel GR,Fleischmann WR Jr,Baron S

    更新日期：1982-07-15 00:00:00

  • Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM-1 and DCC tumor suppressor genes on the long arm of chromosome 18.

    abstract：:We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4,...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.1219

    authors： Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G

    更新日期：2001-05-15 00:00:00

  • Reverse transcription-polymerase chain reaction assay for multiple mRNA markers in the detection of breast cancer metastases in sentinel lymph nodes.

    abstract：:The identification of specific tumor mRNA markers by reverse transcription-polymerase chain reaction might be a valuable diagnostic adjunct for the detection of breast cancer metastases in axillary sentinel lymph nodes (SLNs). In this study we have compared the diagnostic accuracy of an extensive histopathologic exami...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(20010920)95:5<307::aid-ijc0153>3

    authors： Manzotti M,Dell'Orto P,Maisonneuve P,Zurrida S,Mazzarol G,Viale G

    更新日期：2001-09-20 00:00:00

  • Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion.

    abstract：:Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, due mainly to the prevalence of undetected metastatic disease. The process of cell invasion during intraperitoneal anchoring of metastatic lesions requires concerted regulation of many processes, including modulation of adhes...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.24347

    authors： Barbolina MV,Adley BP,Kelly DL,Shepard J,Fought AJ,Scholtens D,Penzes P,Shea LD,Stack MS

    更新日期：2009-08-15 00:00:00

  • Human ovarian carcinoma lysis by cytotoxic T cells targeted by bispecific monoclonal antibodies: analysis of the antibody components.

    abstract：:In the perspective of in vivo therapeutic applications, the monoclonal antibody (MAb) MOv18 was selected for its restricted reactivity with human ovarian carcinoma. Using the pH 2.8 desorption assay, we found that the antigen recognized by MOv18 had a high stability on the cell membrane and poor internalization. There...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910410422

    authors： Mezzanzanica D,Canevari S,Ménard S,Pupa SM,Tagliabue E,Lanzavecchia A,Colnaghi MI

    更新日期：1988-04-15 00:00:00

  • Glycan modification of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells.

    abstract：:Dendritic cells (DC) have gained much interest in the field of anticancer vaccine development because of their central function in immune regulation. However, the clinical application of ex vivo cultured DC has significant disadvantages. A vaccine that targets dendritic cells in vivo and enhances antigen presentation ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23101

    authors： Aarnoudse CA,Bax M,Sánchez-Hernández M,García-Vallejo JJ,van Kooyk Y

    更新日期：2008-02-15 00:00:00

  • Breast cancer and microbial cancer incidence in female populations around the world: a surprising hyperbolic association.

    abstract：:Current literature on cancer epidemiology typically discusses etiology of cancer by cancer type. Risks of different cancer types are, however, correlated at population level and may provide etiological clues. We showed previously an unexpected very high positive correlation between breast cancer (BC) and young-adult H...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23595

    authors： Savu A,Potter J,Li S,Yasui Y

    更新日期：2008-09-01 00:00:00