Abstract:
:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to amplify 10 microsatellites on the short arm and 8 microsatellites on the long arm of chromosome 1 to assess allelic loss in 22 medulloblastomas. Loss of heterozygosity (LOH) on chromosome 1 was found in 9 cases. Eight medulloblastomas (36%) showed an interstitial LOH on chromosome 1q. The common region of overlap was mapped between D1S 1604 and D1S237 and included the locus F13B in the chromosomal region 1q31-q32.1. An additional tumor had LOH in a proximal region of 1p, but did not exhibit LOH on 1q. None of the medulloblastomas exhibited LOH of the telomeric portion of chromosome 1p, which has been associated with several other human malignancies. Our data suggest the presence of a putative tumor suppressor gene located near the locus F13B on chromosome arm 1q that appears to be involved in the pathogenesis of medulloblastoma.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch Tdoi
10.1002/(SICI)1097-0215(19960703)67:1<11::AID-IJC3subject
Has Abstractpub_date
1996-07-03 00:00:00pages
11-5issue
1eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19960703)67:1<11::AID-IJC3journal_volume
67pub_type
杂志文章abstract::The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
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abstract::Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM leve...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
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abstract::Endometrial carcinoma (EC) is traditionally characterized as endometrioid and nonendometrioid based on histopathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between Mar...
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journal_title:International journal of cancer
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abstract::Oncogenic activation of MYC occurs often in breast carcinoma and is associated with poor prognosis. Loss or inactivation of mechanisms that restrain MYC may therefore be involved in tumor progression. In this study, we show that the MYC-interacting adaptor protein BIN1 is frequently missing in malignant breast cells a...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620622
更新日期:1995-09-15 00:00:00
abstract::Paraffin sections from 190 epithelial ovarian tumours, including 159 malignant and 31 benign epithelial tumours, were analysed immunohistochemically for expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16INK4A (p16). Most benign tumours showed no p16 expression in the tumour cells, whereas only...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970220)74:1<57::aid-ijc1
更新日期:1997-02-20 00:00:00
abstract::The cellular tumor suppressor p16 is strongly overexpressed in cervical cancers and precancers. We have previously demonstrated that infiltrating T lymphocytes reactive against p16 can be found in cervical cancer patients. Here, we analyzed whether p16 induces humoral immune responses. Sera of patients with cervical c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23837
更新日期:2008-12-01 00:00:00
abstract::Marine omega-3 polyunsaturated fatty acids (MO3PUFAs) have anticancer properties and may improve colon cancer survival. However, it remains unknown whether the benefit differs by tumor molecular subtype. We examined data from a phase III randomized trial of FOLFOX or FOLFOX + cetuximab among 1,735 stage III colon canc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-07-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971104)73:3<416::aid-ijc
更新日期:1997-11-04 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001120)89:6<475::aid-ijc2>3.0.
更新日期:2000-11-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22508
更新日期:2007-04-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1997-03-04 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
abstract::Recently, air pollution has been classified as a carcinogen largely on the evidence of epidemiological studies of lung cancer. However, there have been few prospective studies that have evaluated associations between fine particulate matter (PM2.5 ) and cancer at lower concentrations. We conducted a prospective analys...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose se...
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abstract::Prostate-specific antigen (PSA) has been characterized as a specific prostate marker, although recent studies have suggested the existence of PSA of nonprostatic sources. We have assessed the presence of PSA by an ultrasensitive assay in 276 serum and nonserum samples from women. Our data show the presence of PSA in 9...
journal_title:International journal of cancer
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更新日期:1996-11-15 00:00:00
abstract::Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. We used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigeneti...
journal_title:International journal of cancer
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abstract::Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2010-10-15 00:00:00
abstract::Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
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更新日期:2009-03-15 00:00:00