The expression of hematopoietic progenitor cell antigen CD34 is regulated by DNA methylation in a site-dependent manner in gastrointestinal stromal tumours.

abstract：:Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3'-triiodo-L-thyronine (T3) are involved in the progression o...

journal_title：International journal of cancer

authors： Aksoy O,Pencik J,Hartenbach M,Moazzami AA,Schlederer M,Balber T,Varady A,Philippe C,Baltzer PA,Mazumder B,Whitchurch JB,Roberts CJ,Haitel A,Herac M,Susani M,Mitterhauser M,Marculescu R,Stangl-Kremser J,Hassler MR,Kr

更新日期：2021-02-01 00:00:00

abstract：:Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

journal_title：International journal of cancer

authors： Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

更新日期：1996-03-01 00:00:00

abstract：:A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...

journal_title：International journal of cancer

authors： Hansson LE,Nyrén O,Bergström R,Wolk A,Lindgren A,Baron J,Adami HO

更新日期：1994-06-01 00:00:00

abstract：:The acyclic nucleoside phosphonate analogue cidofovir is a broad-spectrum anti-DNA virus agent, which also possesses potent inhibitory activity against various tumors associated with papillomaviruses in animal models and patients. Moreover, we recently described the potent inhibition of polyomavirus (PyV)-induced hema...

journal_title：International journal of cancer

authors： Liekens S,Verbeken E,De Clercq E,Neyts J

更新日期：2001-04-15 00:00:00

abstract：:IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D122 clone. Both high and low D122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumorigenicity as compared...

journal_title：International journal of cancer

authors： Porgador A,Gansbacher B,Bannerji R,Tzehoval E,Gilboa E,Feldman M,Eisenbach L

更新日期：1993-02-01 00:00:00

abstract：:Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to tumorigenesis. microRNA-125b (miR-125b) was implicated to have close relationship with cell proliferation and differentiation, and downregulation of miR-125b was observed in various types of cancers. However, the biolo...

journal_title：International journal of cancer

authors： Huang L,Luo J,Cai Q,Pan Q,Zeng H,Guo Z,Dong W,Huang J,Lin T

更新日期：2011-04-15 00:00:00

abstract：:Dietary carbohydrates have different glycemic and insulinemic potentials depending on type (glycemic index, GI) and amount (glycemic load, GL) of carbohydrate consumed or both. Insulin in turn has been implicated as a risk factor for several cancers, including that of the prostate. We assessed the relationship of GI a...

journal_title：International journal of cancer

authors： Augustin LS,Galeone C,Dal Maso L,Pelucchi C,Ramazzotti V,Jenkins DJ,Montella M,Talamini R,Negri E,Franceschi S,La Vecchia C

更新日期：2004-11-10 00:00:00

abstract：:In order to evaluate whether the SCID mouse can provide the microenvironment for the growth of human immature T-cell leukemias and if in vivo growth alters their phenotype, we examined the behavior of 3 well-characterized T-cell acute lymphoblastic leukemia (T-ALL)-derived T-cell lines which are at different stages of...

journal_title：International journal of cancer

authors： Uittenbogaart CH,Anisman DJ,Tary-Lehmann M,Vollger LW,Breit TM,Van Dongen JJ,Saxon A

更新日期：1994-02-15 00:00:00

abstract：:Aberrant promoter methylation of normally unmethylated CpG-islands offers a promising tool for the development of molecular biomarkers. We investigated bronchial aspirates of patients admitted for suspected lung cancer with regard to the prevalence of aberrant methylation of potential marker genes. Applying quantitati...

journal_title：International journal of cancer

authors： Grote HJ,Schmiemann V,Geddert H,Rohr UP,Kappes R,Gabbert HE,Böcking A

更新日期：2005-09-20 00:00:00

abstract：:Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...

journal_title：International journal of cancer

authors： Belardelli F,Gresser I,Maury C,Duvillard P,Prade M,Maunoury MT

更新日期：1983-05-15 00:00:00

abstract：:LiSa-2 is a stable cell line derived from a poorly differentiated, pleomorphic liposarcoma. In serum-containing medium, LiSa-2 cells are fibroblastoid and rapidly dividing. In a serum-free, chemically defined culture medium containing physiological concentrations of insulin, triiodothyronine and cortisol, LiSa-2 cells...

journal_title：International journal of cancer

authors： Wabitsch M,Brüderlein S,Melzner I,Braun M,Mechtersheimer G,Möller P

更新日期：2000-12-15 00:00:00

abstract：:The partition-defective 3 (PAR-3) protein is implicated in the development and maintenance of cell polarity and is associated with proteins that mediate the changes in cytoskeleton organization required for cell polarity establishment. In this work, we used two original primary cell lines (R-180 and R-305) derived fro...

journal_title：International journal of cancer

authors： Dugay F,Le Goff X,Rioux-Leclerq N,Chesnel F,Jouan F,Henry C,Cabillic F,Verhoest G,Vigneau C,Arlot-Bonnemains Y,Belaud-Rotureau MA

更新日期：2014-05-01 00:00:00

abstract：:Clinical case reports have suggested that specific bacterial infections are associated with certain non-Hodgkin lymphoma (NHL) subtypes. Epidemiological case-control studies have been conducted using antibiotics as a proxy for bacterial infections, but with inconclusive results. The aim of this study was, in a cohort ...

journal_title：International journal of cancer

authors： Rasmussen ML,Hjalgrim H,Mølgaard-Nielsen D,Wohlfahrt J,Melbye M

更新日期：2012-10-01 00:00:00

abstract：:Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 pla...

journal_title：International journal of cancer

authors： Wu WK,Wang G,Coffelt SB,Betancourt AM,Lee CW,Fan D,Wu K,Yu J,Sung JJ,Cho CH

更新日期：2010-10-15 00:00:00

abstract：:To identify genes associated with radioresistant oral squamous cell carcinoma (OSCC), we compared gene expression signatures between OSCC cell lines exhibiting radioresistance and cells with radiosensitivity after X-ray irradiation in a dose-dependent manner using Affymetrix GeneChip analysis with Human Genome-U133 pl...

journal_title：International journal of cancer

authors： Ishigami T,Uzawa K,Higo M,Nomura H,Saito K,Kato Y,Nakashima D,Shiiba M,Bukawa H,Yokoe H,Kawata T,Ito H,Tanzawa H

更新日期：2007-05-15 00:00:00

abstract：:Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....

journal_title：International journal of cancer

authors： Bjerrum A,Lindebjerg J,Andersen O,Fischer A,Lynge E

更新日期：2020-08-15 00:00:00

abstract：:The UBE1L gene isolated from the chromosome 3p21 region has an extremely reduced level of mRNA in lung cancer. Sequence analysis showed a 45% homology to the human ubiquitin-activating enzyme E1 at the amino acid level. To further characterize the protein product, we generated UBE1L protein-specific antibodies. Immuno...

journal_title：International journal of cancer

authors： McLaughlin PM,Helfrich W,Kok K,Mulder M,Hu SW,Brinker MG,Ruiters MH,de Leij LF,Buys CH

更新日期：2000-03-15 00:00:00

abstract：:Clinical features, 8 histological variables, 7 nuclear morphometric variables, 2 mitotic indices, oestrogen-receptor (ER) and progesterone-receptor content (PR), DNA ploidy and S-phase fraction (SPF) were entered in a Cox's model to assess their independent predictive value in 216 breast-cancer patients followed up fo...

journal_title：International journal of cancer

authors： Eskelinen M,Lipponen P,Papinaho S,Aaltomaa S,Kosma VM,Klemi P,Syrjänen K

更新日期：1992-06-19 00:00:00

abstract：:In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...

journal_title：International journal of cancer

authors： Asleh K,Lyck Carstensen S,Tykjaer Jørgensen CL,Burugu S,Gao D,Won JR,Jensen MB,Balslev E,Laenkholm AV,Nielsen DL,Ejlertsen B,Nielsen TO

更新日期：2019-05-15 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasi...

journal_title：International journal of cancer

authors： Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna C

更新日期：2009-05-01 00:00:00

abstract：:Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma. The aim of this study was to elucidate the role of hepatocyte growth-factor-scatter factor (HGF-SF) in this phenomenon. Markedly increased serum levels...

journal_title：International journal of cancer

authors： von Schweinitz D,Faundez A,Teichmann B,Birnbaum T,Koch A,Hecker H,Glüer S,Fuchs J,Pietsch T

更新日期：2000-01-15 00:00:00

abstract：:In an ongoing case-control study in Athens on the etiology of hepatocellular carcinoma (HCC), an analysis was made in order to assess whether HCV genotype 1b is associated with hepatocellular carcinoma (HCC). The HCV genotype was determined in 17 HCC patients, 87 patients with chronic hepatitis C (CHC) without cirrhos...

journal_title：International journal of cancer

authors： Hatzakis A,Katsoulidou A,Kaklamani E,Touloumi G,Koumantaki Y,Tassopoulos NC,Karvountzis G,Gioustozi A,Hadziyannis S,Trichopoulos D

更新日期：1996-09-27 00:00:00

abstract：:The purpose of our study was to develop specific, sensitive, objective assays for early detection of disseminated tumour cells in patients with colorectal cancer (CRC). Carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20) were chosen as markers because they are selectively expressed in epithelial cells with mainta...

journal_title：International journal of cancer

authors： Oberg AN,Lindmark GE,Israelsson AC,Hammarström SG,Hammarström ML

更新日期：2004-08-10 00:00:00

abstract：:The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and Adna...

journal_title：International journal of cancer

authors： Andreopoulou E,Yang LY,Rangel KM,Reuben JM,Hsu L,Krishnamurthy S,Valero V,Fritsche HA,Cristofanilli M

更新日期：2012-04-01 00:00:00

abstract：:There is growing evidence suggesting that cytotoxic activity of cisplatin is closely associated with increased generation of reactive oxygen species (ROS). Therefore, this study was undertaken to examine oxidative DNA damage, which arises as a result of chemotherapy with cisplatin. Using HPLC prepurification/isotope d...

journal_title：International journal of cancer

authors： Siomek A,Tujakowski J,Gackowski D,Rozalski R,Foksinski M,Dziaman T,Roszkowski K,Olinski R

更新日期：2006-11-01 00:00:00

abstract：:A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched ...

journal_title：International journal of cancer

authors： Satake N,Urakami S,Hirayama Y,Izumi K,Hino O

更新日期：1998-09-11 00:00:00

abstract：:The ability to monitor breast cancer initiation and progression on the molecular level would provide an effective tool for early diagnosis and therapy. In the present study, we focused on the underglycosylated MUC-1 tumor antigen (uMUC-1), which is directly linked to tumor progression from pre-malignancy to advanced m...

journal_title：International journal of cancer

authors： Ghosh SK,Uchida M,Yoo B,Ross AW,Gendler SJ,Gong J,Moore A,Medarova Z

更新日期：2013-04-15 00:00:00

abstract：:CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...

journal_title：International journal of cancer

authors： Ferrini S,Prigione I,Miotti S,Ciccone E,Cantoni C,Chen Q,Colnaghi MI,Moretta L

更新日期：1991-05-10 00:00:00

abstract：:The variants within the human melanocortin 1 receptor (MC1R) gene are associated with an increased risk of different skin cancers. In this study, we genotyped by direct sequencing, 529 cases of basal cell carcinoma of the skin (BCC) and 533 healthy controls for polymorphisms in the entire MC1R gene. In addition to 10 ...

journal_title：International journal of cancer

authors： Scherer D,Bermejo JL,Rudnai P,Gurzau E,Koppova K,Hemminki K,Kumar R

更新日期：2008-04-15 00:00:00

abstract：:Epigenome-wide association studies have established methylation patterns related to smoking, the major risk factor of lung cancer (LC), which are distinct from methylation profiles disclosed in LC patients. This study simultaneously investigated associations of smoking-associated and LC-related methylation markers wit...

journal_title：International journal of cancer

authors： Zhang Y,Breitling LP,Balavarca Y,Holleczek B,Schöttker B,Brenner H

更新日期：2016-12-01 00:00:00