Abstract:
:The growth of a spontaneous adenocarcinoma (ADK-1t) of BALB/c mice (H-2d, MIsb) induces progressive hyporesponsiveness of spleen cells stimulated with PHA or irradiated leukocytes from DBA/2 strain (H-2d, MIsa) in mixed leukocyte culture. This hyporesponsiveness is due to the suppressor activity of macrophage-like cells, since it is abrogated by passage over nylon-wool columns, pretreatment with carrageenans, or carbonyl iron and magnet. BALB/c mice bearing greater than 20 mm mean diameter ADK-1t tumors, and displaying a drastic impairment of T lymphocyte reactivity in vitro, were challenged with the P815 mastocytoma of the DBA/2 strain. These mice rejected increasing numbers of P815 cells to the same extent as normal BALB/c mice. The reactivity towards P815 is abrogated by 450 rad, and can be reconstituted by the adoptive transfer of 2 X 10(7) normal T lymphocytes in either normal or ADK-1t bearing BALB/c mice. These data show that a discrepancy exists between the capacity of T lymphocytes from ADK-1t bearing mice to react against DBA/2 cells tested in vitro or in vivo, and indicates that great caution should be exercised in predicting the responsiveness of the immune system on the basis of in vitro data on the suppressor activity of macrophages.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Forni G,Giovarelli M,Lanfrancone L,Varesio Ldoi
10.1002/ijc.2910290616subject
Has Abstractpub_date
1982-06-15 00:00:00pages
695-8issue
6eissn
0020-7136issn
1097-0215journal_volume
29pub_type
杂志文章abstract::The reported beverage habits of 569 lung cancer patients and 569 control patients admitted to Roswell Park Memorial Institute (RPMI) were studied, 355 male cases and 214 female cases being matched to controls within strata of age and residence. Smoking history and an index of vitamin A from vegetables had significant,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430412
更新日期:1989-04-15 00:00:00
abstract::Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11634
更新日期:2004-03-01 00:00:00
abstract::Chile's gallbladder cancer rates are among the highest in the world, being the leading cause of cancer deaths among Chilean women. To provide insights into the etiology of gallbladder cancer, we conducted an ecologic study examining the geographical variation of gallbladder cancer and several putative risk factors. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23662
更新日期:2008-09-15 00:00:00
abstract::Malignant cells possess a high degree of proteolytic activity in which the plasminogen activator system plays an important role. An increased expression of urokinase type plasminogen activator (uPA) is of significance for degradation of the extracellular tumor matrix, facilitating invasiveness and growth. Inhibition o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610419
更新日期:1995-05-16 00:00:00
abstract::Pancreatic cancer remains the fourth most common cause of cancer related death in the United States. Therefore, novel strategies for the prevention and treatment are urgently needed. Genistein is a prominent isoflavonoid found in soy products and has been proposed to be responsible for lowering the rate of pancreatic ...
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.21589
更新日期:2006-04-15 00:00:00
abstract::Immunological studies are presented on a patient with a long clinical history suggesting the existence of a tumor-specific immune response. His tumor, first considered benign, progressed to a highly malignant osteosarcoma. Cell-mediated immune reactivity against biopsy cells and against tumor extract was detected in v...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180304
更新日期:1976-09-15 00:00:00
abstract::Microspheres containing cisplatin (CDDP) embedded in poly-d,l-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS) were developed to improve treatment of malignant effusions. In vitro studies demonstrated that CDDP was released continuously for more than 4 weeks from CDDP-PPMS without initial burst. CDDP-PPMS wa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980529)76:5<709::aid-ijc
更新日期:1998-05-29 00:00:00
abstract::The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20771
更新日期:2005-04-10 00:00:00
abstract::To understand the mechanisms underlying increased expression of Myc protein in human urinary bladder cancer, expression of c-myc mRNA and the copy number of the c-myc gene were determined. Expression of mRNA was measured by quantitative RT-PCR in 40 urothelial carcinomas and in 18 histologically normal mucosae. Mean e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990420)84:2<169::aid-ijc
更新日期:1999-04-20 00:00:00
abstract::By serologic identification of antigens by recombinant expression cloning (SEREX) analysis using an autologous lung adenocarcinoma cell line, OU-LU-6, as a cDNA library source, we demonstrated that XAGE-1 was the dominant antigen recognized by serum from a patient. By immunoscreening, we obtained 38 positive cDNA clon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11587
更新日期:2004-02-10 00:00:00
abstract::No animal model exists for the in vivo growth of Hodgkin's-lymphoma-derived cells. Neither unmanipulated Hodgkin's-disease(HD)-derived cell lines nor primary biopsy tissue could be grown in nude mice. Since the severe combined immunodeficient (SCID) mouse has been reported to be a better recipient for transplanted hum...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520610
更新日期:1992-12-02 00:00:00
abstract::The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25342
更新日期:2011-01-15 00:00:00
abstract::Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010320)95:2<102::aid-ijc1018>3
更新日期:2001-03-20 00:00:00
abstract::Physiological concentrations of insulin support the in vitro growth of LB T-cell lymphoma. We could not detect similar insulin dependence in other tumor cell lines. This study reports that insulin also enhances the growth of LB cells in vivo. Mice treated with Streptozotocin (SZ) developed partial resistance to LB lym...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530523
更新日期:1993-03-12 00:00:00
abstract::Dendritic cells (DCs) and natural killer (NK) cells are key players at the interface between innate resistance and acquired immunity. NK cells can induce DC maturation, a differentiation process whereby DCs respond to a environmental stimulus and acquire the ability of eliciting adaptive immunity. Conversely, maturing...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22279
更新日期:2006-12-15 00:00:00
abstract::A panel of eight conditionally immortal lines derived by infection of human breast epithelial cells with an amphotropic retrovirus transducing a ts mutant of SV40 large T-antigen was analyzed with respect to individual retroviral integration patterns. Each line contained multiple integration sites which were clonal an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570616
更新日期:1994-06-15 00:00:00
abstract::Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were studied to evaluate the reversibility of Adriamycin resistance in human colon cancer. Two groups of cell lines were studied. In the first, including a series o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490512
更新日期:1991-11-11 00:00:00
abstract::An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative ris...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11466
更新日期:2003-12-10 00:00:00
abstract::Human colon cancer cells produce and secrete a variety of polypeptide growth factors. The functional role of these growth factors, however, is poorly understood. Though the secretion of epidermal growth factor (EGF)-like activity and EGF-related molecules by human colon cancer cells in culture has been reported, it is...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520625
更新日期:1992-12-02 00:00:00
abstract::Peripheral blood lymphocytes from 32 patients with malignant melanoma were tested for cell-mediated cytotoxicity (CMC) against cultured autologous melanoma cells. Effector cells were prepared from venous blood by defibrination, gel sedimentation, nylon column filtration, and lysis of remaining erythrocytes with NH4Cl....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910240107
更新日期:1979-07-15 00:00:00
abstract::The colo-rectum and stomach are the 2 sites for which the role of diet in the etiology of cancer is most heavily implicated. Quantitative estimates as to the proportion of cancer deaths attributable to diet vary considerably. This may be partially due to the application of the concept of population attributable risk w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400509
更新日期:1987-11-15 00:00:00
abstract::The annual incidence of non-Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited by the use of the ICD classifi...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(SICI)1097-0215(19961009)68:2<156::AID-IJC
更新日期:1996-10-09 00:00:00
abstract::Using data from a large health plan, we performed a cohort study of thyroid cancer among 204,964 persons (aged 10--89 at baseline in 1964--1973, 54% female) followed for a median of 20 years. There were 196 incident thyroid cancers (73 in men, 123 in women). Risk was independently and positively related to female gend...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1377
更新日期:2001-09-01 00:00:00
abstract::Despite the substantial benefit of androgen deprivation therapy (ADT) for metastatic prostate cancer, patients often progress to castration-resistant disease (CRPC) that is more difficult to treat. CRPC is associated with renewed androgen receptor activity in tumor cells and restoration of tumor androgen levels throug...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30450
更新日期:2017-01-15 00:00:00
abstract::The anatomic site-dependent expression of hematopoietic progenitor cell antigen CD34 is a feature of gastrointestinal stromal tumours (GISTs). The basis for the differential CD34 expression is only incompletely understood. This study aimed at understanding the regulation of CD34 in GISTs and clarification of its site-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30905
更新日期:2017-12-01 00:00:00
abstract::As a part of an assessment of the potential use of retinoids in preventive and adjuvant treatment of HNSCC, we examined the effects of beta-all-trans retinoic acid (RA) on the growth and cell-surface glycoconjugates of 2 HNSCC cell lines. These lines, designated 1483 and 183A, were established from an untreated patien...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400217
更新日期:1987-08-15 00:00:00
abstract::There is an unexplained strong male predominance in the aetiology of oesophageal adenocarcinoma (OAC). The hypothesis that oestrogens are protective, deserves attention. A potential protective influence of exogenous oestrogen exposure, that is, hormone replacement therapy (HRT) and oral contraceptives (OC) has been ad...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/ijc.28869
更新日期:2014-11-01 00:00:00
abstract::Human epidermoid carcinoma A431 cells attach more rapidly to collagen type-I and -IV substrates than to surfaces coated with laminin or fibronectin. The diminished intercellular interaction and rounding up manifested when these cells are exposed to epidermal growth factor (EGF) in tissue culture plastic or collagen fi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370313
更新日期:1986-03-15 00:00:00
abstract::Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC versus SDC among screened women...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30427
更新日期:2017-01-01 00:00:00
abstract::The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230318
更新日期:1979-03-15 00:00:00