Abstract:
:Pancreatic cancer remains the fourth most common cause of cancer related death in the United States. Therefore, novel strategies for the prevention and treatment are urgently needed. Genistein is a prominent isoflavonoid found in soy products and has been proposed to be responsible for lowering the rate of pancreatic cancer in Asians. However, the molecular mechanism(s) by which genistein elicits its effects on pancreatic cancer cells has not been fully elucidated. We have previously shown that genistein induces apoptosis and inhibits the activation of nuclear factor kappaB (NF-kappaB) pathway. Moreover, Notch signaling is known to play a critical role in maintaining the balance between cell proliferation, differentiation and apoptosis, and thereby may contribute to the development of pancreatic cancer. Hence, in our study, we investigated whether there is any cross talk between Notch and NF-kappaB during genistein-induced apoptosis in BxPC-3 pancreatic cancer cells. We used multiple cellular and molecular approaches such as MTT assay, apoptosis assay, gene transfection, Western blotting and EMSA for measuring DNA binding activity of NF-kappaB. We found that genistein inhibits cell growth and induces apoptotic processes in BxPC-3 pancreatic cancer cells. This was partly due to inhibition of Notch-1 activity. BxPC-3 cells transfected with Notch-1 cDNA showed induction of NF-kappaB activity, and this was inhibited by genistein treatment. From these results, we conclude that the inhibition of Notch-1 and NF-kappaB activity and their cross talk provides a novel mechanism by which genistein inhibits cell growth and induces apoptotic processes in pancreatic cancer cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Wang Z,Zhang Y,Banerjee S,Li Y,Sarkar FHdoi
10.1002/ijc.21589keywords:
subject
Has Abstractpub_date
2006-04-15 00:00:00pages
1930-6issue
8eissn
0020-7136issn
1097-0215journal_volume
118pub_type
杂志文章,收录出版abstract::Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1575
更新日期:2002-01-01 00:00:00
abstract::BALB/c peritoneal plasmacytomas induced by a variety of agents are invariably associated with a c-myc translocation. In contrast, naturally arising bone marrow plasma cell tumors in C57BL/KaLwRij mice lack this translocation. This difference has led to the suggestion that these are 2 fundamentally different plasma cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970904)72:5<892::aid-ijc
更新日期:1997-09-04 00:00:00
abstract::Although the incidence of, and deaths due to, malignant melanoma are rising at a rapid rate, few experimental models mimic the highly metastatic properties associated with the pathogenesis of the human disease, making study of the disease difficult. Thus, new human models are required to understand melanoma biology, e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470211
更新日期:1991-01-21 00:00:00
abstract::Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990301)80:5<764::aid-ijc
更新日期:1999-03-01 00:00:00
abstract::With low cure rates but increasing diverse treatment options that provide variable remission times, ovarian cancer is increasingly being recognized as a chronic disease. This reality indicates the need for a better understanding of factors influencing disease progression. In a previous global analysis of gene expressi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22054
更新日期:2006-11-01 00:00:00
abstract::The presence of carcinogen-DNA adducts in human tissues is evidence of exposure to carcinogens and may be an indicator of cancer risk. DNA was isolated from non-tumorous bronchial tissue of 37 cigarette smokers, 8 former smokers and 8 non-smokers and analyzed for the presence of aromatic and/or hydrophobic DNA adducts...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460403
更新日期:1990-10-15 00:00:00
abstract::Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27394
更新日期:2012-10-01 00:00:00
abstract::Intraductal papillary-mucinous carcinoma (IPMC) of the pancreas, a new entity of pancreatic cancer with a favorable prognosis, has shown a gradual increase in the number of reported cases. Patients with high-frequency microsatellite instability (MSI-H) tumors have been shown to survive longer than those with low-frequ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10771
更新日期:2002-12-20 00:00:00
abstract::MEK1/2 inhibitors like U0126 can potentiate or antagonize the antitumor activity of cytotoxic agents such as cisplatin, paclitaxel or vinblastine, depending on the drug or the target cells. We now investigated whether U0126, differentially regulates melanoma signaling in response to UV radiation or betulinic acid, a d...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21478
更新日期:2006-03-01 00:00:00
abstract::Human epidemiological studies suggest that 1,25(OH)2 D3 deficiency might increase cancer incidence, but no spontaneous tumors have been reported in mice lacking 1,25(OH)2 D3 or deficient in its receptor. In our study, we detected, for the first time, diverse types of spontaneous tumors in l,25(OH)2 D3 deficient mice m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31317
更新日期:2018-07-15 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated lymphoepithelioma. The aim of this study was to characterize the homogeneity and distinctness of the T-cell repertoires within and between primary and metastatic NPCs. We used ultra-deep sequencing of the hypervariably rearranged antigen-binding ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31336
更新日期:2018-08-01 00:00:00
abstract::Both retinoids and anti-estrogens inhibit breast cancer cell proliferation with accumulation of cells in the G1 phase of the cell cycle, but the effect of retinoids is delayed compared to that of anti-estrogens. To determine whether this temporal difference is due to a simple delay in the action of retinoids on a comm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970127)70:3<291::aid-ijc
更新日期:1997-01-27 00:00:00
abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960703)67:1<24::AID-IJC6
更新日期:1996-07-03 00:00:00
abstract::Using antisera for two specific basement membrane (b.m.) antigens such as laminin and collagen type-IV, together with electron microscopy, we have shown that fully antigenic b.m. and morphologically typical basal lamina (b.l.) are associated with normal and transformed cells of the melanocyte lineage in different ways...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350408
更新日期:1985-04-15 00:00:00
abstract::In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450623
更新日期:1990-06-15 00:00:00
abstract::In sub-Saharan Africa, invasive cervical cancer (ICC) incidence and mortality are among the highest in the world. This cross-sectional epidemiological study assessed human papillomavirus (HPV) prevalence and type distribution in women with ICC in Ghana, Nigeria, and South Africa. Cervical biopsy specimens were obtaine...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.28425
更新日期:2014-03-15 00:00:00
abstract::A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29188
更新日期:2015-03-15 00:00:00
abstract::Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.20648
更新日期:2005-02-20 00:00:00
abstract::The purpose of this study was to assess the relationship between progression-free survival (PFS) in patients treated with DFMO + PCV (procarbazine, CCNU, vincristine) chemotherapy for malignant gliomas with tumor cell ornithine decarboxylase (ODC) activity. Formalin-fixed slides were obtained for study patients with a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22914
更新日期:2007-11-15 00:00:00
abstract::To generate broad eating patterns, which could explain more adequately the breast cancer etiology, we conducted an exploratory factor analysis in Montevideo, Uruguay. The study included 442 newly diagnosed and microscopically confirmed cases with breast cancer and 442 hospitalized controls, with non-neoplastic disease...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22021
更新日期:2006-10-01 00:00:00
abstract::In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outcome remains limited. In our study, we aim to assess the outcome of screen-detected lesions diagnose...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25801
更新日期:2011-09-15 00:00:00
abstract::N-Nitroso compounds (NOCs) have been proposed as possible bladder carcinogens. The main sources of exogenous exposure to NOCs are cigarette smoke and diet, particularly processed (i.e., nitrite-treated) meats. Perhaps more importantly, NOCs can be formed endogenously from dietary precursors such as nitrate, nitrite an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28331
更新日期:2014-01-01 00:00:00
abstract::Seven human ocular melanoma cell lines were established in vitro and 3 of these, GU-4, LLN-40 and its subline C17-11, were characterized. Mice were immunized with these ocular melanoma cell lines, and 2 hybridomas producing monoclonal IgG1 antibodies (MAb) were produced. MAb 2/10SN recognizes a 44-kDa monomeric protei...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510510
更新日期:1992-07-09 00:00:00
abstract::Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11049
更新日期:2003-06-10 00:00:00
abstract::With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33394
更新日期:2020-11-13 00:00:00
abstract::In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32361
更新日期:2019-11-15 00:00:00
abstract::Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25318
更新日期:2011-01-01 00:00:00
abstract::Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29463
更新日期:2015-08-15 00:00:00
abstract::The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330210
更新日期:1984-02-15 00:00:00
abstract::We have shown earlier that extracellular GSH can exert a cell-specific growth-inhibitory effect on human tumor cells. In the present study, 2 human ovarian carcinoma cell lines (A2780 and IGROV-1) were used to investigate the biochemical basis of the GSH growth-inhibitory effect. Whereas cells were resistant, A2780 ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970410)71:2<246::aid-ijc
更新日期:1997-04-10 00:00:00