The cell-specific anti-proliferative effect of reduced glutathione is mediated by gamma-glutamyl transpeptidase-dependent extracellular pro-oxidant reactions.

abstract：:Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowe...

journal_title：International journal of cancer

authors： Tavani A,Pelucchi C,Parpinel M,Negri E,Franceschi S,Levi F,La Vecchia C

更新日期：2003-05-20 00:00:00

abstract：:We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (0.01-1 microg/ml) r...

journal_title：International journal of cancer

authors： Williams BA,Makrigiannis AP,Blay J,Hoskin DW

更新日期：1997-11-04 00:00:00

abstract：:The modifying effects of a Kunitz trypsin inhibitor (KTI) and a Bowman-Birk trypsin inhibitor (BBI), purified from soybean trypsin inhibitor, as dietary supplements on experimental and spontaneous pulmonary metastasis of murine Lewis lung carcinoma 3LL cells as well as peritoneal disseminated metastasis model in human...

journal_title：International journal of cancer

authors： Kobayashi H,Fukuda Y,Yoshida R,Kanada Y,Nishiyama S,Suzuki M,Kanayama N,Terao T

更新日期：2004-11-10 00:00:00

abstract：:Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...

journal_title：International journal of cancer

authors： Dai C,Zhang B,Liu X,Guo K,Ma S,Cai F,Yang Y,Yao Y,Feng M,Bao X,Deng K,Jiao Y,Wei Z,Junji W,Xing B,Lian W,Wang R

更新日期：2013-10-15 00:00:00

abstract：:Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was...

journal_title：International journal of cancer

authors： Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KW

更新日期：1998-08-12 00:00:00

abstract：:Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried o...

journal_title：International journal of cancer

authors： Lynch HT,Kosoko-Lasaki O,Leslie SW,Rendell M,Shaw T,Snyder C,D'Amico AV,Buxbaum S,Isaacs WB,Loeb S,Moul JW,Powell I

更新日期：2016-06-01 00:00:00

abstract：:Pancreatic cancer remains the fourth most common cause of cancer related death in the United States. Therefore, novel strategies for the prevention and treatment are urgently needed. Genistein is a prominent isoflavonoid found in soy products and has been proposed to be responsible for lowering the rate of pancreatic ...

journal_title：International journal of cancer

authors： Wang Z,Zhang Y,Banerjee S,Li Y,Sarkar FH

更新日期：2006-04-15 00:00:00

abstract：:The development of reliable gene expression profiling technology is having an increasing impact on our understanding of lung cancer biology. Our study aimed to determine any correlation between the phenotypic heterogeneity and genetic diversity of lung cancer. Microarray analysis was performed on a set of 46 tumor sam...

journal_title：International journal of cancer

authors： Sanchez-Palencia A,Gomez-Morales M,Gomez-Capilla JA,Pedraza V,Boyero L,Rosell R,Fárez-Vidal ME

更新日期：2011-07-15 00:00:00

abstract：:A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...

journal_title：International journal of cancer

authors： Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein G

更新日期：1982-01-15 00:00:00

abstract：:It is generally assumed that inflammation influences carcinogenesis. We previously reported that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the Apc(Min/+) mice and the over-expression of inducible nitric oxide synthase (iNOS) contributes to this enhancement. In the current study, we investi...

journal_title：International journal of cancer

authors： Kohno H,Takahashi M,Yasui Y,Suzuki R,Miyamoto S,Kamanaka Y,Naka M,Maruyama T,Wakabayashi K,Tanaka T

更新日期：2007-08-01 00:00:00

abstract：:Recent clinical trials have indicated that addition of tamoxifen (TAM) to a combination of cisplatin (DDP), carmustine and dacarbazine markedly increases the overall objective response rate of patients with metastatic malignant melanoma. Previous studies have determined that there is remarkable synergy between TAM and...

journal_title：International journal of cancer

authors： McClay EF,Albright KD,Jones JA,Christen RD,Howell SB

更新日期：1993-12-02 00:00:00

abstract：:Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...

journal_title：International journal of cancer

authors： Dracopoli NC,Turner TR,Else JG,Jolly CJ,Anthony R,Gallo RC,Saxinger WC

更新日期：1986-10-15 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical tes...

journal_title：International journal of cancer

authors： Yin X,Zhang H,Lundgren K,Wilson L,Burrows F,Shores CG

更新日期：2010-03-01 00:00:00

abstract：:Primary mediastinal B-cell lymphoma is a locally highly aggressive but poorly disseminating tumor composed of medium sized or large cells most probably of thymic medullary origin. It has a mature B-cell phenotype, typically lacks immunoglobulin expression and has variable defects in expression of HLA-molecules. We pre...

journal_title：International journal of cancer

authors： Möller P,Brüderlein S,Sträter J,Leithäuser F,Hasel C,Bataille F,Moldenhauer G,Pawlita M,Barth TF

更新日期：2001-05-01 00:00:00

abstract：:We have addressed the role of bacterial co-infection in viral oncogenesis using as model Epstein-Barr virus (EBV), a human herpesvirus that causes lymphoid malignancies and epithelial cancers. Infection of EBV carrying epithelial cells with the common oral pathogenic Gram-negative bacterium Aggregatibacter actinomycet...

journal_title：International journal of cancer

authors： Frisan T,Nagy N,Chioureas D,Terol M,Grasso F,Masucci MG

更新日期：2019-01-01 00:00:00

abstract：:NK cell recognition of tumor cells is mediated by a delicate balance of signals received by MHC class I-binding inhibitory NK cell receptors and activating NK cell receptors, which mainly bind to virus-, stress- or tumor-induced ligands. In addition, adhesion molecules such as the intercellular adhesion molecule-1 (IC...

journal_title：International journal of cancer

authors： Textor S,Accardi R,Havlova T,Hussain I,Sylla BS,Gissmann L,Cerwenka A

更新日期：2011-03-01 00:00:00

abstract：:In vivo TSTA induction in Syrian hamsters was studied with the use of SV40 ts mutants (A, B, C, BC and D). The ts A30, TS A239 and possibly also the ts BC210 mutants were defective in resistance-inducing activity in hamsters in contrast to wild type SV40 and other ts mutnats. At the permissive temperature ts A30 and t...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Kashkina LM

更新日期：1977-10-15 00:00:00

abstract：:Physical activity might reduce the risk for lung cancer by various mechanisms, but the evidence is inconclusive. We therefore examined the relationship between physical activity and risk for lung cancer in a large population-based Danish cohort with detailed information about number of hours per week spent on specific...

journal_title：International journal of cancer

authors： Bak H,Christensen J,Thomsen BL,Tjønneland A,Overvad K,Loft S,Raaschou-Nielsen O

更新日期：2005-09-01 00:00:00

abstract：:The cell-cycle regulator p16 inhibits the complex cdk4-cyclin D1 and controls G1-S transition. In human tumors, p16 inactivation is often accomplished by homozygous deletion (HD) of its encoding gene, CDKN2A. Methylation of the 5' CpG island promoter has been proposed as an alternative mechanism of inactivation. Expre...

journal_title：International journal of cancer

authors： Bortolotto S,Chiadò-Piat L,Cavalla P,Bosone I,Chiò A,Mauro A,Schiffer D

更新日期：2000-11-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Little is known about its molecular pathogenesis and the relevance of DNA methylation for disease initiation and progression. Nevertheless, promoter methylation of some genes has been implicated as potential marker for HCC. Thirty-four HCC, 34...

journal_title：International journal of cancer

authors： Harder J,Opitz OG,Brabender J,Olschewski M,Blum HE,Nomoto S,Usadel H

更新日期：2008-06-15 00:00:00

abstract：:Chromosome 17 is a frequent target during breast-cancer formation and progression. It has been shown to be affected by allele losses at multiple sites, as well as by DNA amplification. Our aim was to delineate a map of the genetic alterations on chromosome 17 in a given set of breast tumors. To this end we analyzed 15...

journal_title：International journal of cancer

authors： Kirchweger R,Zeillinger R,Schneeberger C,Speiser P,Louason G,Theillet C

更新日期：1994-01-15 00:00:00

abstract：:The interactions which occur between antigenic tumor cells and normal or immune lymphoid cells in a 3-day in vitro culture, have been studied with a murine sarcoma virus (MSV)-induced tumor. The 3H-thymidine incorporation of lymphoma cells growing in suspension, and the radioactive-chromium release of freshly sampled ...

journal_title：International journal of cancer

authors： Senik A,Hebrero FP,Levy JP

更新日期：1975-12-15 00:00:00

abstract：:In order to define technical limitations of conventional external beam irradiation for clinically localized prostate cancer, we evaluated the impact of several reduced-field treatment factors, such as reduced-field (RF) irradiated volume, RF technique, photon energy of treatment, and dose on survival endpoints and loc...

journal_title：International journal of cancer

authors： Gagnon GJ,Harter KW,Berg CD,Lynch JH,Cornell DR,Kuettel MR,Dritschilo A

更新日期：2000-10-20 00:00:00

abstract：:To test whether alloimmunization with H-2 or/and non-H-2 different normal tissues may increase the immunity to syngeneic tumors, groups of BALB/c (H-2d) mice were immunized with a series of allogeneic lymphoid cells and then challenged i.p. with syngeneic lymphoma cells. The outgrowth of otherwise lethal doses of the ...

journal_title：International journal of cancer

authors： Parmiani G,Sensi ML,Carbone G,Colombo M,Pierotti M,Ballinari D,Hilgers J,Hilkens J

更新日期：1982-03-15 00:00:00

abstract：:Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI ...

journal_title：International journal of cancer

authors： Harding MW,Yang TJ

更新日期：1981-03-15 00:00:00

abstract：:Numbers of B, T and total lymphocytes, monocytes, heterophils, eosinophils and basophils have been examined in the peripheral blood of chickens between 2 and 42 days after infection with Marek's disease virus. During the stage of the acute restrictively productive virus infection of lymphoid tissues at 2-9 days after ...

journal_title：International journal of cancer

authors： Payne LN,Rennie M

更新日期：1976-10-15 00:00:00

abstract：:Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 sa...

journal_title：International journal of cancer

authors： Patard JJ,Brasseur F,Gil-Diez S,Radvanyi F,Marchand M,François P,Abi-Aad A,Van Cangh P,Abbou CC,Chopin D

更新日期：1995-02-20 00:00:00

abstract：:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDACs) are well known. This study investigates genetic and epigenetic data together with tumor biology to find specific alterations responsible for metastasis formation. Using 16 human PDAC cell lines in a murine orthotopic PDA...

journal_title：International journal of cancer

authors： Mees ST,Mardin WA,Wendel C,Baeumer N,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

更新日期：2010-01-01 00:00:00

abstract：:Myf-3 is the human homologue of the murine Myo-D1 gene involved in muscle-cell differentiation. Using Southern blot analysis, we examined methylation of Myf-3 in histologically normal colonic mucosae, adenomas and carcinomas from a large series of patients with primary colorectal cancer. Hypermethylation of this gene ...

journal_title：International journal of cancer

authors： Shannon B,Kay P,House A,Iacopetta B

更新日期：1999-04-20 00:00:00

abstract：:Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...

journal_title：International journal of cancer

authors： Dai W,Liu H,Xu X,Ge J,Luo S,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Li C,Wei Q

更新日期：2019-11-15 00:00:00