Abstract:
:A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TPA). Seven cell lines underwent multiple phenotypic alterations in response to TPA but were unresponsive to synthetic thymic hormones (TP5, FTS) or to other compounds (e.g. DMSO, retinoic acid) which induce maturation in other types of leukaemia. The changes parallel those observed in normal T-cell differentiation and partly reflect alterations in glycosyl transferase activity, altered synthesis of proteins and regulation of cell surface receptors (for transferrin) associated with rapid growth and metabolism. These studies further illustrate the reversibility of maturation arrest in human leukaemia and provide support for the view that leukaemia may involve regulatory defects in the coupling of proliferation and maturation. Induction of promotion of terminal differentiation in leukaemic equivalents of T-cell precursors may provide a convenient system for the study of biochemical and molecular events involved in T-cell development and diversification.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein Gdoi
10.1002/ijc.2910290106subject
Has Abstractpub_date
1982-01-15 00:00:00pages
23-31issue
1eissn
0020-7136issn
1097-0215journal_volume
29pub_type
杂志文章abstract::Dickkopf1 (DKK1), a secreted inhibitor of the Wnt/β-catenin pathway, is a negative regulator of bone formation. DKK1 acts as a switch that transitions prostate cancer bone metastases from osteolytic to osteoblastic and also is an active indicator of poor outcome for multiple myeloma. However, in other tumor types, DKK...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.26449
更新日期:2012-04-01 00:00:00
abstract::A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ijc.2910170404
更新日期:1976-04-15 00:00:00
abstract::Using data from a large health plan, we performed a cohort study of thyroid cancer among 204,964 persons (aged 10--89 at baseline in 1964--1973, 54% female) followed for a median of 20 years. There were 196 incident thyroid cancers (73 in men, 123 in women). Risk was independently and positively related to female gend...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1377
更新日期:2001-09-01 00:00:00
abstract::Folate is required for biological methylation and nucleotide synthesis, aberrations of which are thought to be the mechanisms that enhance colorectal carcinogenesis produced by folate inadequacy. These functions of folate also depend on the availability of other B-vitamins that participate in "one-carbon metabolism," ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23599
更新日期:2008-08-01 00:00:00
abstract::High dietary intakes of calcium and dairy products have been hypothesized to enhance prostate cancer risk, but available prospective data regarding these associations are inconsistent. We examined dietary intakes of calcium and dairy products in relation to risk of prostate cancer in the Alpha-Tocopherol, Beta-Caroten...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22553
更新日期:2007-06-01 00:00:00
abstract::We examined cancer-associated fibroblasts (CAFs) and a panel of immunohistochemical markers of epithelial-mesenchymal transition (EMT) in 19 pair-matched oral tongue squamous cell carcinoma (SCC) and metastatic tumors to regional lymph nodes (RLNs). alpha-Smooth muscle actin (alpha-SMA) was studied to identify CAFs. E...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25358
更新日期:2010-09-01 00:00:00
abstract::The growth of a spontaneous adenocarcinoma (ADK-1t) of BALB/c mice (H-2d, MIsb) induces progressive hyporesponsiveness of spleen cells stimulated with PHA or irradiated leukocytes from DBA/2 strain (H-2d, MIsa) in mixed leukocyte culture. This hyporesponsiveness is due to the suppressor activity of macrophage-like cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290616
更新日期:1982-06-15 00:00:00
abstract::Our study investigated the association of breast cancer risk as assessed by mammographic density with insulin-like growth factor I (IGF-I) and one of its binding proteins (IGFBP-3) in healthy premenopausal women with different ethnic backgrounds. In a cross-sectional design, we analyzed the baseline mammograms and fas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11505
更新日期:2003-12-20 00:00:00
abstract::Mantle cell lymphoma (MCL) is an aggressive form of Non-Hodgkin-lymphoma (NHL) with an ongoing need for novel treatments. Apart from the translocation t(11:14), which facilitates constitutive transcription of cyclin D1, additional aberrations are frequently observed in MCL, including a recurrent dysregulation of the p...
journal_title:International journal of cancer
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更新日期:2013-10-15 00:00:00
abstract::This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Col...
journal_title:International journal of cancer
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doi:10.1002/(SICI)1097-0215(19960328)66:1<70::AID-IJC1
更新日期:1996-03-28 00:00:00
abstract::The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylation may also play an important role in genomic instability. However, the relation between global DN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23470
更新日期:2008-06-15 00:00:00
abstract::A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also posses...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550323
更新日期:1993-09-30 00:00:00
abstract::T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580311
更新日期:1994-08-01 00:00:00
abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500605
更新日期:1992-04-01 00:00:00
abstract::Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360411
更新日期:1985-10-15 00:00:00
abstract::9-cis-Retinoic acid (9cRA) and 1alpha,25-dihydroxyvitamin D3 (1,25D) show promise as potential chemopreventive agents. We examined 9cRA and 1,25D, alone and in combination, for their potential to inhibit carcinogen (NNK)-induced lung carcinogenesis in A/J mice. A/J mice (n=14/group) were treated with 9cRA (7.5, 15, or...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22462
更新日期:2007-04-01 00:00:00
abstract::Although menopausal hormone therapy (MHT) seemingly increases the risk of ovarian cancer, evidence is insufficient whether the risk varies between various MHT formulations, regimens and administration modes. With the aim of filling these knowledge gaps, we investigated the effect of different MHT treatment options on ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32706
更新日期:2020-07-01 00:00:00
abstract::The relation between human papillomavirus type 16 (HPV 16) viral load in cervical scrapes and development of high-grade cervical intraepithelial neoplasia (CIN II or III) was studied in a nested case-control study of women with normal cytology (group A) and in a cohort of women with abnormal cytology (group B). HPV 16...
journal_title:International journal of cancer
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abstract::Somatic mutations in the E-cadherin (CDH1) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate ca...
journal_title:International journal of cancer
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abstract::Using a direct binding liquid competition radioimmunoassay, the amount of the ras oncogene protein product, p21, was quantitated in a variety of human tumors and adjacent apparently normal tissues. In 48 of 50 matched tumor and normal tissue biopsy specimens from 50 patients, more ras p21 was detected in the tumor tha...
journal_title:International journal of cancer
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abstract::Human malignant mesothelioma (HMM) is resistant to many anticancer drugs, including doxorubicin. Mevastatin and simvastatin, 2 inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, potentiated the intracellular accumulation and the cytotoxicity of doxorubicin in HMM cells constitutively expressing P-...
journal_title:International journal of cancer
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doi:10.1002/ijc.21832
更新日期:2006-07-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1996-05-29 00:00:00
abstract::Experimental studies have consistently shown a protective effect of nonsteroidal antiinflammatory drugs (NSAIDs) against nonmelanoma skin cancers (NMSC). However, little human epidemiological research has been done in this regard. We used data from the Skin Cancer Chemoprevention Study to explore the association of NS...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21878
更新日期:2006-08-01 00:00:00
abstract::Epigenetic inactivation by aberrant DNA methylation has been reported for many microRNA genes in various human malignancies. However, relatively little is known about microRNA gene methylation in hepatocellular carcinoma (HCC). Therefore, a systematic screen for identification of aberrantly hypermethylated microRNA ge...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
abstract::A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390206
更新日期:1987-02-15 00:00:00
abstract::The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts)...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-05-15 00:00:00
abstract::Tyrosine kinase inhibitors are effective treatments for cancers. Knowing the specific kinase mutants that drive the underlying cancers predict therapeutic response to these inhibitors. Thus, the current protocol for personalized cancer therapy involves genotyping tumors in search of various driver mutations and subseq...
journal_title:International journal of cancer
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abstract::C57BL/6J mice immunized with devitalized Ehrlich tumor (ET) cells produce high serum levels of IgM antibodies to ET cell-surface carbohydrates that are critical in the observed resistance against this tumor. However, this response is not found in ET-bearing mice at any stage of tumor development. Since previous studie...
journal_title:International journal of cancer
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abstract::Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...
journal_title:International journal of cancer
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更新日期:2020-08-01 00:00:00
abstract::T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10424
更新日期:2002-06-10 00:00:00