Abstract:
:IL-10 mRNA expression and protein production in established melanoma cell lines and freshly cultured primary and metastatic melanoma cells was examined. The in situ distribution of IL-10 in native melanoma tissue was also investigated by immunohistochemistry in primary tumors, metastases, benign melanocytic nevi and normal skin of healthy persons and melanoma patients. IL-10 mRNA, but not IL-10 protein in the culture supernatant, was found in 1 of 4 cultured melanoma cells of primary tumors, while 3 of 6 melanoma-metastasis-derived cultures expressed both IL-10 mRNA and protein. No IL-10 was detected in skin biopsies of healthy volunteers or in the healthy skin of melanoma patients; nor was IL-10 found in congenital melanocytic nevi. In only 1 of the 11 examined primary malignant melanomas was IL-10 immunoreactivity detected within the cytoplasm of cells in the tumor. On the other hand, 4 of 9 metastases clearly displayed scattered IL-1O+ cells. In all sections with IL-10-positive cells, the cells were positive for HMB-45. No co-expression of CD3 and IL-10 was observed. The data suggest that melanoma cells themselves are the main origin of IL-10 in tumor specimens in vivo. The preferential expression of IL-10 in metastatic lesions and in cultured cells from metastases might indicate an increased spreading potential of IL-10-secreting melanoma-cell clones.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Dummer W,Bastian BC,Ernst N,Schänzle C,Schwaaf A,Bröcker EBdoi
10.1002/(SICI)1097-0215(19960529)66:5<607::AID-IJCsubject
Has Abstractpub_date
1996-05-29 00:00:00pages
607-10issue
5eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19960529)66:5<607::AID-IJCjournal_volume
66pub_type
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journal_title:International journal of cancer
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