Nutrients and gastric cancer risk. A population-based case-control study in Sweden.

Abstract:

:A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to interview was estimated, together with life-time intake of vitamin supplements. Ascorbic acid and beta-carotene had an unequivocal protective effect, but alpha-tocopherol and nitrate were also negatively associated with gastric-cancer risk. In a multivariate analysis including all of these factors, only ascorbic acid remained a significant protective factor. The only macronutrient positively associated with the risk of gastric cancer was fat: intake 20 years prior to interview, but not during adolescence, was found to have a significant impact. Supplementation with vitamins almost halved the risk after adjustment for dietary intake of the corresponding vitamins. While the protective effect of vitamin C and beta-carotene could conceivably be ascribed to other agents in the diet, the strong negative association between supplementation with vitamin C and risk of gastric cancer supports the hypothesis of a protective role of this anti-oxidant.

journal_name

Int J Cancer

authors

Hansson LE,Nyrén O,Bergström R,Wolk A,Lindgren A,Baron J,Adami HO

doi

10.1002/ijc.2910570505

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

638-44

issue

5

eissn

0020-7136

issn

1097-0215

journal_volume

57

pub_type

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