Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells.

abstract：:ET-743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is hepatotoxic in animals and patients. We tested the hypothesis that indole-3-carbinol (I3C), the hydrolysis product of glucosinolates occurring in cruciferous ve...

journal_title：International journal of cancer

authors： Donald S,Verschoyle RD,Greaves P,Colombo T,Zucchetti M,Falcioni C,Zaffaroni M,D'Incalci M,Manson MM,Jimeno J,Steward WP,Gescher AJ

更新日期：2004-10-10 00:00:00

abstract：:Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

journal_title：International journal of cancer

authors： Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

更新日期：2007-10-15 00:00:00

abstract：:The presented results show the effect of targeting of collagen receptor, alpha1beta1 integrin expressed on the endothelial cells on the development of experimental melanoma and pathological angiogenesis. Obtustatin, a snake venom KTS-disintegrin, was applied as a specific inhibitor of this integrin. This low molecular...

journal_title：International journal of cancer

authors： Brown MC,Staniszewska I,Del Valle L,Tuszynski GP,Marcinkiewicz C

更新日期：2008-11-01 00:00:00

abstract：:A novel non-phorbol-ester-like tumor promoter, okadaic acid (OA) has been shown to be an inhibitor of protein phosphatase I and IIA and, thus, to cause an "apparent activation" of protein kinase C (PKC). We previously showed that cis-diamminedichloroplatinum(II) (CDDP)-resistant cells, PC-9/CDDP, were cross-resistant ...

journal_title：International journal of cancer

authors： Nishio K,Sugimoto Y,Kasahara K,Fujiwara Y,Nishiwaki S,Fujiki H,Ohata M,Saijo N

更新日期：1992-02-01 00:00:00

abstract：:Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...

journal_title：International journal of cancer

authors： Perez C,Jukica A,Listopad JJ,Anders K,Kühl AA,Loddenkemper C,Blankenstein T,Charo J

更新日期：2015-07-15 00:00:00

abstract：:Gastric cancer is the second most common cause of cancer deaths worldwide. The identification of molecular genetic parameters that are associated with response to chemotherapy and prognosis is of utmost interest. We examined methylation of the apoptosis-related genes, TMS1 and DAPK, in 81 primary gastric cancers using...

journal_title：International journal of cancer

authors： Kato K,Iida S,Uetake H,Takagi Y,Yamashita T,Inokuchi M,Yamada H,Kojima K,Sugihara K

更新日期：2008-02-01 00:00:00

abstract：:While enhanced platelet activation may drive cancer progression and metastases, less is known about its role in early cancer development. Thus, we evaluated whether pre-diagnostic biomarkers of platelet activation and coagulation are related to the risks of common cancers in the prospective EPIC-Heidelberg Study using...

journal_title：International journal of cancer

authors： Graf ME,Sookthai D,Johnson T,Schübel R,Maldonado SG,Pletsch-Borba L,Katzke V,Bugert P,Hoffmeister M,Kaaks R,Kühn T

更新日期：2018-12-01 00:00:00

abstract：:Changes in the length of a polymorphic trinucleotide (CAG) repeat in the androgen receptor (AR) gene, which may lead to altered transactivation of the AR gene, have been implicated to play a role in the pathogenesis of several forms of endocrine cancer and certain reproductive disorders. Subjects with reproductive dis...

journal_title：International journal of cancer

authors： Rajpert-De Meyts E,Leffers H,Daugaard G,Andersen CB,Petersen PM,Hinrichsen J,Pedersen LG,Skakkebaek NE

更新日期：2002-11-10 00:00:00

abstract：:Kaposi's sarcoma is currently the most common tumor in Zimbabwe. The purpose of our study is to compare the effectiveness of supportive care vs. 3 intervention approaches, namely oral Etoposide, a 3-drug combination, and radiotherapy using quality of life (QOL) as the primary measure of success. In addition, our study...

journal_title：International journal of cancer

authors： Olweny CL,Borok M,Gudza I,Clinch J,Cheang M,Kiire CF,Levy L,Otim-Oyet D,Nyamasve J,Schipper H

更新日期：2005-02-10 00:00:00

abstract：:The 26S proteasome, consisting of the 20S core and 19S regulatory complexes, regulates intracellular protein concentration through proteolytic degradation of targeted substrates. Composition of the 19S regulatory complex as well as posttranslational modifications of the 19S subunits can effectively regulate the activi...

journal_title：International journal of cancer

authors： Thompson HG,Harris JW,Brody JP

更新日期：2004-09-01 00:00:00

abstract：:To understand the mechanisms underlying increased expression of Myc protein in human urinary bladder cancer, expression of c-myc mRNA and the copy number of the c-myc gene were determined. Expression of mRNA was measured by quantitative RT-PCR in 40 urothelial carcinomas and in 18 histologically normal mucosae. Mean e...

journal_title：International journal of cancer

authors： Christoph F,Schmidt B,Schmitz-Dräger BJ,Schulz WA

更新日期：1999-04-20 00:00:00

abstract：:Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of ...

journal_title：International journal of cancer

authors： Eikawa S,Kakimi K,Isobe M,Kuzushima K,Luescher I,Ohue Y,Ikeuchi K,Uenaka A,Nishikawa H,Udono H,Oka M,Nakayama E

更新日期：2013-01-15 00:00:00

abstract：:Since no large descriptive studies of incident cancers in HIV-infected patients are available in France, the nationwide cross-sectional ONCOVIH study aimed to prospectively report new malignancies diagnosed in HIV-infected patients in cancer centers and HIV/AIDS centers. We estimated the number of cancers in France fo...

journal_title：International journal of cancer

authors： Lanoy E,Spano JP,Bonnet F,Guiguet M,Boué F,Cadranel J,Carcelain G,Couderc LJ,Frange P,Girard PM,Oksenhendler E,Poizot-Martin I,Semaille C,Agut H,Katlama C,Costagliola D,ONCOVIH study group.

更新日期：2011-07-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...

journal_title：International journal of cancer

authors： Miao J,Chen GG,Chun SY,Yun JP,Chak EC,Ho RL,Lai PB

更新日期：2006-10-15 00:00:00

abstract：:Human blood monocytes are very potent to take up antigens. Like macrophages in tissue, they efficiently degrade exogenous protein and are less efficient than dendritic cells (DCs) at cross-presenting antigens to CD8+ T cells. Although it is generally accepted that DCs take up tissue antigens and then migrate to lymph ...

journal_title：International journal of cancer

authors： Faure F,Jouve M,Lebhar-Peguillet I,Sadaka C,Sepulveda F,Lantz O,Berre S,Gaudin R,Sánchez-Ramón S,Amigorena S

更新日期：2018-01-01 00:00:00

abstract：:Colibactin-producing E. coli (CoPEC) are frequently detected in colorectal cancer (CRC) and exhibit procarcinogenic properties. Because increasing evidence show the role of immune environment and especially of antitumor T-cells in CRC development, we investigated the impact of CoPEC on these cells in human CRC and in ...

journal_title：International journal of cancer

authors： Lopès A,Billard E,Casse AH,Villéger R,Veziant J,Roche G,Carrier G,Sauvanet P,Briat A,Pagès F,Naimi S,Pezet D,Barnich N,Dumas B,Bonnet M

更新日期：2020-06-01 00:00:00

abstract：:In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...

journal_title：International journal of cancer

authors： Reinholdt K,Thomsen LT,Dehlendorff C,Larsen HK,Sørensen SS,Haedersdal M,Kjaer SK

更新日期：2020-05-01 00:00:00

abstract：:The effects of androgen manipulation on epidermal growth factor (EGF) receptor, p185erbB-2 and transforming growth factor-alpha (TGF-alpha) levels were examined in prostatic adenocarcinoma. Male nude mice were inoculated with the CWR22 androgen-dependent human prostatic tumor or an androgen-independent (CWR22R) deriva...

journal_title：International journal of cancer

authors： Myers RB,Oelschlager D,Manne U,Coan PN,Weiss H,Grizzle WE

更新日期：1999-07-30 00:00:00

abstract：:In vitro, tumor-selective Hsp70 plasma membrane localization correlates with increased sensitivity to lysis mediated by a subpopulation of human natural killer (NK) cells that adhere to plastic following cytokine stimulation. In the present study, we analyzed the capacity of adoptively transferred human NK cells in SC...

journal_title：International journal of cancer

authors： Multhoff G,Pfister K,Botzler C,Jordan A,Scholz R,Schmetzer H,Burgstahler R,Hiddemann W

更新日期：2000-12-01 00:00:00

abstract：:Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...

journal_title：International journal of cancer

authors： Dokun OY,Florl AR,Seifert HH,Wolff I,Schulz WA

更新日期：2008-12-15 00:00:00

abstract：:Photodynamic therapy using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX is a promising tool in bladder-cancer therapy. However, little is known about the cellular mechanisms of phototoxicity. Our aim was to characterize the cellular damage and to optimize differential photodynamic effectiveness between tumo...

journal_title：International journal of cancer

authors： Seidl J,Rauch J,Krieg RC,Appel S,Baumgartner R,Knuechel R

更新日期：2001-06-01 00:00:00

abstract：:Non-neoplastic mesenchymal cells, along with 33 benign and 87 malignant soft-tissue tumors (STT) were examined for expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). Serial frozen sections were immunostained using monoclonal antibodies...

journal_title：International journal of cancer

authors： Mechtersheimer G,Staudter M,Majdic O,Dörken B,Moldenhauer G,Möller P

更新日期：1990-11-15 00:00:00

abstract：:Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...

journal_title：International journal of cancer

authors： Mizuguchi A,Takai A,Shimizu T,Matsumoto T,Kumagai K,Miyamoto S,Seno H,Marusawa H

更新日期：2018-10-15 00:00:00

abstract：:Although tobacco habits have been associated with the risk of oral leukoplakia, alcohol drinking and body mass index (BMI) as risk factors have not been well established. The purpose of this study is to evaluate the independent effects of drinking, BMI, tobacco chewing and smoking on the risk of oral leukoplakia. A ca...

journal_title：International journal of cancer

authors： Hashibe M,Sankaranarayanan R,Thomas G,Kuruvilla B,Mathew B,Somanathan T,Parkin DM,Zhang ZF

更新日期：2000-10-01 00:00:00

abstract：:Using antisera for two specific basement membrane (b.m.) antigens such as laminin and collagen type-IV, together with electron microscopy, we have shown that fully antigenic b.m. and morphologically typical basal lamina (b.l.) are associated with normal and transformed cells of the melanocyte lineage in different ways...

journal_title：International journal of cancer

authors： Natali PG,Nicotra MR,Bellocci M,Cavaliere R,Bigotti A

更新日期：1985-04-15 00:00:00

abstract：:Breast cancers diagnosed between screening examinations among women who attend a breast cancer screening program are defined as interval cancers. The Norwegian Breast Cancer Screening Program started as a pilot project in 1996, and data from the first 2-year interval are available. Our study quantifies interval cancer...

journal_title：International journal of cancer

authors： Wang H,Bjurstam N,Bjørndal H,Braaten A,Eriksen L,Skaane P,Vitak B,Hofvind S,Thoresen SØ

更新日期：2001-11-01 00:00:00

abstract：:We previously reported that ganglioside GD1a, which is highly expressed in poorly metastatic FBJ-S1 cells, inhibits the serum-induced motility of FBJ-LL cells and that the metastatic potential of FBJ-LL cells is completely suppressed by enforced GD1a expression (Hyuga et al., Int J Cancer 1999;83:685-91). We recently ...

journal_title：International journal of cancer

authors： Hyuga S,Kawasaki N,Hyuga M,Ohta M,Shibayama R,Kawanishi T,Yamagata S,Yamagata T,Hayakawa T

更新日期：2001-11-01 00:00:00

abstract：:Colorectal cancer (CRC) screening rates are currently suboptimal. Blood-based screening could improve rates of earlier detection for CRC and adenomatous colorectal polyps. In this study, we evaluated the feasibility of plasma-based detection of early CRC and adenomatous polyps using array-mediated analysis methylation...

journal_title：International journal of cancer

authors： Cassinotti E,Melson J,Liggett T,Melnikov A,Yi Q,Replogle C,Mobarhan S,Boni L,Segato S,Levenson V

更新日期：2012-09-01 00:00:00

abstract：:Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of ...

journal_title：International journal of cancer

authors： Mohamed NK,Hamad MA,Hafez MZ,Wooley KL,Elsabahy M

更新日期：2017-04-01 00:00:00

abstract：:Sexually transmitted genital human papillomavirus (HPV) infection, most often HPV 16, is considered the major etiologic determinant of cervical cancer. However, some studies have found relatively low prevalences of genital tract HPV DNA in some geographical areas, such as Greenland, that have high rates of cervical ca...

journal_title：International journal of cancer

authors： Nonnenmacher B,Kruger Kjaer S,Svare EI,Scott JD,Hubbert NL,van den Brule AJ,Kirnbauer R,Walboomers JM,Lowy DR,Schiller JT

更新日期：1996-12-11 00:00:00