Determining MDR1/P-glycoprotein expression in breast cancer.

abstract：:The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. However, not much is known about the presence and function of Treg within tumors. Here we show in a syngeneic murine glioma model a time-dependent accumulation of CD4+Fo...

journal_title：International journal of cancer

authors： Grauer OM,Nierkens S,Bennink E,Toonen LW,Boon L,Wesseling P,Sutmuller RP,Adema GJ

更新日期：2007-07-01 00:00:00

abstract：:Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratif...

journal_title：International journal of cancer

authors： Gustafson LW,Booth BB,Kahlert J,Ørtoft G,Mejlgaard E,Clarke MA,Wentzensen N,Rositch AF,Hammer A

更新日期：2021-02-01 00:00:00

abstract：:Endometrial cancer (EC) shares some environmental or genetic risk factors with colorectal cancer (CRC). It represents a risk factor for CRC. Furthermore, EC is the most frequent extracolonic neoplasm in HNPCC (hereditary nonpolyposis colorectal cancer) and, in this syndrome, it has the same inheritance pattern as CRC....

journal_title：International journal of cancer

authors： Fornasarig M,Campagnutta E,Talamini R,Franceschi S,Boz G,Scarabelli C,Andreaus CM,Scozzari G,Valentini M

更新日期：1998-07-03 00:00:00

abstract：:Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis in several cancers. The aim of this study was to assess the prognostic value of endostatin in bladde...

journal_title：International journal of cancer

authors： Szarvas T,László V,Vom Dorp F,Reis H,Szendröi A,Romics I,Tilki D,Rübben H,Ergün S

更新日期：2012-06-15 00:00:00

abstract：:We have established 3 new EBV-negative cell lines, designated Sc-1, Ri-1 and Ci-1, from patients with B-cell lymphoma/leukemia. We characterized them by cytogenetics and by study of surface membrane antigens with a panel of monoclonal antibodies (MAbs), surface and cytoplasmic immunoglobulin (Ig) expression and Ig hea...

journal_title：International journal of cancer

authors： Th'ng KH,Garewal G,Kearney L,Rassool F,Melo JV,White H,Catovsky D,Foroni L,Luzzatto L,Goldman JM

更新日期：1987-01-15 00:00:00

abstract：:In order to clarify the frequency of p16 gene inactivation and its relationship with Rb expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 paraffin-embedded sections of primary non-small cell lung cancers (NSCLCs). From immunohistochemical results, abnormal p16 expression was observe...

journal_title：International journal of cancer

authors： Kashiwabara K,Oyama T,Sano T,Fukuda T,Nakajima T

更新日期：1998-06-19 00:00:00

abstract：:Stage 4 neuroblastoma (NB) is a devastating childhood cancer whose poor outcome has remained essentially unchanged in the last 20 years. Receptor tyrosine kinases have important roles in the control of proliferation, differentiation and apoptosis of NB cells. Thus, we tested the activity of second-generation tyrosine ...

journal_title：International journal of cancer

authors： Vitali R,Mancini C,Cesi V,Tanno B,Piscitelli M,Mancuso M,Sesti F,Pasquali E,Calabretta B,Dominici C,Raschellà G

更新日期：2009-12-01 00:00:00

abstract：:Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...

journal_title：International journal of cancer

authors： Chatterjee M,van Golen KL

更新日期：2011-07-01 00:00:00

abstract：:EMT6 is a transplantable mouse mammary tumor cell line that has been utilized widely as a model system to study the effects of various treatments on local tumor growth and pulmonary metastasis. In this study, we examined the cellular mechanisms by which scatter factor (SF), a fibroblast-derived cytokine that stimulate...

journal_title：International journal of cancer

authors： Rosen EM,Knesel J,Goldberg ID,Jin L,Bhargava M,Joseph A,Zitnik R,Wines J,Kelley M,Rockwell S

更新日期：1994-06-01 00:00:00

abstract：:Apc gene-deficient Min and Apc(1309) mice feature a hyperlipidemic state with a markedly low expression level of lipoprotein lipase (LPL) compared to their wild-type counterparts. We previously showed that induction of LPL mRNA by peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonists or an LPL sel...

journal_title：International journal of cancer

authors： Niho N,Mutoh M,Komiya M,Ohta T,Sugimura T,Wakabayashi K

更新日期：2007-10-15 00:00:00

abstract：:We describe an innovative strategy to quantify risk of cancer associated with varying levels of exposure to chronic parasitic infection through the identification of asymptomatic cases of cholangiocarcinoma within a population-based survey of Opisthorchis viverrini infection. Stool samples from 12,311 adults over age ...

journal_title：International journal of cancer

authors： Haswell-Elkins MR,Mairiang E,Mairiang P,Chaiyakum J,Chamadol N,Loapaiboon V,Sithithaworn P,Elkins DB

更新日期：1994-11-15 00:00:00

abstract：:The roles of fibroblast growth factor-2 (FGF-2) in the hepatocellular carcinoma (HCC) development are still controversial. In this study, we investigated the expression of FGF-2 in chronic hepatitis (CH) type C patients with or without HCC and the immunoregulation of FGF-2 in NK sensitivity of HCC cells. The FGF-2 exp...

journal_title：International journal of cancer

authors： Tsunematsu H,Tatsumi T,Kohga K,Yamamoto M,Aketa H,Miyagi T,Hosui A,Hiramatsu N,Kanto T,Hayashi N,Takehara T

更新日期：2012-01-15 00:00:00

abstract：:The aim of this register-based follow-up study was to evaluate the long-term cumulative incidence of second primary tumors (SPT) among survivors of hereditary retinoblastoma, with special interest for the incidence of pineoblastoma in retinoblastoma patients born after 1970. The Dutch Retinoblastoma Register was compl...

journal_title：International journal of cancer

authors： Moll AC,Imhof SM,Bouter LM,Kuik DJ,Den Otter W,Bezemer PD,Koten JW,Tan KE

更新日期：1996-08-07 00:00:00

abstract：:The application of glucocorticoids (GC3) in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.R1-R5, isolated from the GC-sensitive human acute-T-cell-leukemic line, CCRF-CEM-C7, by se...

journal_title：International journal of cancer

authors： Hala M,Hartmann BL,Böck G,Geley S,Kofler R

更新日期：1996-11-27 00:00:00

abstract：:We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9,...

journal_title：International journal of cancer

authors： Kawamata H,Nakashiro K,Uchida D,Harada K,Yoshida H,Sato M

更新日期：1997-01-06 00:00:00

abstract：:People living with lymphohematopoietic neoplasms (LHNs) are known to have increased risks of second cancer; however, the incidence of second cancers after LHNs has not been studied extensively in Australia. The Australian Cancer Database was used to analyze site-specific risk of second primary cancer after LHNs in 127...

journal_title：International journal of cancer

authors： Royle JS,Baade P,Joske D,Fritschi L

更新日期：2011-08-15 00:00:00

abstract：:Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prosta...

journal_title：International journal of cancer

authors： Norrish AE,Jackson RT,McRae CU

更新日期：1998-08-12 00:00:00

abstract：:We evaluated cell survival, DNA double strand breaks (dsbs), and DNA synthesis following camptothecin (CPT) alone or concurrent CPT and X-radiation treatments in exponential-phase cultures of a radioresistant human melanoma cell line. Cell survival was measured by a clonogenic assay. DNA dsbs were measured by pulsed-f...

journal_title：International journal of cancer

authors： Ng CE,Mazaheri K,Payant C,Raaphorst GP

更新日期：2001-10-20 00:00:00

abstract：:The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...

journal_title：International journal of cancer

authors： Hartman DJ,Davison JM,Foxwell TJ,Nikiforova MN,Chiosea SI

更新日期：2012-10-15 00:00:00

abstract：:Retinoids modulate several cell functions and especially inhibit the growth of a wide variety of cells including breast cancer. Retinoic acid receptor-gamma (RAR-gamma) has been shown to mediate the antiproliferative activity of retinoids. To further test this hypothesis we examined the effects of different RAR-gamma ...

journal_title：International journal of cancer

authors： Widschwendter M,Daxenbichler G,Culig Z,Michel S,Zeimet AG,Mörtl MG,Widschwendter A,Marth C

更新日期：1997-05-02 00:00:00

abstract：:Oral tongue squamous cell carcinoma (OTSCC) is associated with poor prognosis. To improve prognostication, we analyzed four gene probes (TERC, CCND1, EGFR and TP53) and the centromere probe CEP4 as a marker of chromosomal instability, using fluorescence in situ hybridization (FISH) in single cells from the tumors of s...

journal_title：International journal of cancer

authors： Wangsa D,Chowdhury SA,Ryott M,Gertz EM,Elmberger G,Auer G,Åvall Lundqvist E,Küffer S,Ströbel P,Schäffer AA,Schwartz R,Munck-Wikland E,Ried T,Heselmeyer-Haddad K

更新日期：2016-01-01 00:00:00

abstract：:The irregular vasculature and high interstitial pressure of solid tumors hinder the delivery of cytotoxic agents to cancer cells. As a consequence, the doses of chemotherapy necessary to achieve complete tumor eradication are associated with unacceptably high toxicities. The selective thrombosis of tumor blood vessels...

journal_title：International journal of cancer

authors： Fabbrini M,Trachsel E,Soldani P,Bindi S,Alessi P,Bracci L,Kosmehl H,Zardi L,Neri D,Neri P

更新日期：2006-04-01 00:00:00

abstract：:Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...

journal_title：International journal of cancer

authors： Cowell JK,Franks LM

更新日期：1984-05-15 00:00:00

abstract：:Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a c...

journal_title：International journal of cancer

authors： Murtola TJ,Karppa EK,Taari K,Talala K,Tammela TL,Auvinen A

更新日期：2016-06-15 00:00:00

abstract：:Two groups of rabbits were inoculated on the day of birth or at 4 weeks of age with a human T-cell leukemia virus type-I (HTLV-I)-infected and transformed rabbit cell line (Ra-I). Rabbits seroconverted to HTLV-I, as determined by indirect immunofluorescence, by 3 weeks after inoculation and remained persistently serop...

journal_title：International journal of cancer

authors： Cockerell GL,Lairmore M,De B,Rovnak J,Hartley TM,Miyoshi I

更新日期：1990-01-15 00:00:00

abstract：:Oncogene-transformed fibroblasts which expressed IL-1, spontaneously or after activation with conditioned medium (CM) and lipopolysaccharide (LPS), regressed in the syngeneic host. Since regression was significantly influenced by the immune competence of the host (see companion report), we speculated that regression w...

journal_title：International journal of cancer

authors： Zöller M,Douvdevani A,Segal S,Apte RN

更新日期：1992-02-01 00:00:00

abstract：:We evaluated the therapeutic potential of the replication competent vector VA7-EGFP, which is based on the avirulent Semliki Forest virus (SFV) strain A7 (74) carrying the EGFP marker gene in an orthotopic lung cancer tumor model in nude mice. We have previously shown that this oncolytic vector destroys tumor cells ef...

journal_title：International journal of cancer

authors： Määttä AM,Mäkinen K,Ketola A,Liimatainen T,Yongabi FN,Vähä-Koskela M,Pirinen R,Rautsi O,Pellinen R,Hinkkanen A,Wahlfors J

更新日期：2008-10-01 00:00:00

abstract：:Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...

journal_title：International journal of cancer

authors： Maskarinec G,Nagata C,Shimizu H,Kashiki Y

更新日期：2002-11-01 00:00:00

abstract：:Dimethylarsinic acid (DMA) is a major metabolite of inorganic arsenicals, which are epidemiologically significant chemicals in relation to liver cancer in mammals. The present study was conducted to determine the promoting effects of organic arsenicals related to DMA [monomethylarsonic acid (MMA) and trimethylarsine o...

journal_title：International journal of cancer

authors： Nishikawa T,Wanibuchi H,Ogawa M,Kinoshita A,Morimura K,Hiroi T,Funae Y,Kishida H,Nakae D,Fukushima S

更新日期：2002-07-10 00:00:00

abstract：:Tumor cell migration involved in metastases is a tightly regulated, nonrandom process. Chemokines have been identified as critical molecules guiding cell migration. We performed a prospective study to analyze a possible association between the expression of chemokine receptors CXCR3 and CXCR4 by primary melanoma and c...

journal_title：International journal of cancer

authors： Longo-Imedio MI,Longo N,Treviño I,Lázaro P,Sánchez-Mateos P

更新日期：2005-12-10 00:00:00