Clinical significance of CXCR3 and CXCR4 expression in primary melanoma.

abstract：:A mammographic breast cancer screening programme has been ongoing in the Florence District (Italy) since 1970 and a favourable impact of screening on breast cancer mortality of women aged 50-70 has been shown by means of a case-control study. Two hundred and eleven screen- and 116 interval-detected cancers in the peri...

journal_title：International journal of cancer

authors： Paci E,Ciatto S,Buiatti E,Cecchini S,Palli D,Rosselli del Turco M

更新日期：1990-08-15 00:00:00

abstract：:Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG-CoA reductase also results in the depletion of intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim of the present study was to compare the effects of the individual com...

journal_title：International journal of cancer

authors： Gbelcová H,Lenícek M,Zelenka J,Knejzlík Z,Dvoráková G,Zadinová M,Poucková P,Kudla M,Balaz P,Ruml T,Vítek L

更新日期：2008-03-15 00:00:00

abstract：:Recent reports suggest that autoantibodies directed to aberrantly glycosylated mucins, in particular MUC1 and MUC4, are found in patients with colorectal cancer. There is, however, limited information on the autoantibody levels before clinical diagnosis, and their utility in cancer screening in the general population....

journal_title：International journal of cancer

authors： Pedersen JW,Gentry-Maharaj A,Nøstdal A,Fourkala EO,Dawnay A,Burnell M,Zaikin A,Burchell J,Papadimitriou JT,Clausen H,Jacobs I,Menon U,Wandall HH

更新日期：2014-05-01 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC), and is involved in the invasive characteristics of OSCC, such as growth, antiapoptotic activity and protease production. However, the cellular mechanism underlying NF-κB's promotion of bone invasion by...

journal_title：International journal of cancer

authors： Furuta H,Osawa K,Shin M,Ishikawa A,Matsuo K,Khan M,Aoki K,Ohya K,Okamoto M,Tominaga K,Takahashi T,Nakanishi O,Jimi E

更新日期：2012-09-01 00:00:00

abstract：:We investigated the inhibitory effect of sunitinib, a newly approved multitargeted tyrosine kinase inhibitor, against the progression of renal cell cancer (RCC) bone metastases in vivo. In vitro cell proliferation was determined using the MTS assay. To investigate the inhibitory effects of sunitinib in vivo, we establ...

journal_title：International journal of cancer

authors： Maita S,Yuasa T,Tsuchiya N,Mitobe Y,Narita S,Horikawa Y,Hatake K,Fukui I,Kimura S,Maekawa T,Habuchi T

更新日期：2012-02-01 00:00:00

abstract：:We used oligonucleotide microarrays to investigate gene expression changes associated with multi-step human papillomavirus type 16 (HPV16)-mediated carcinogenesis in vitro. Gene expression profiles in 4 early passage HPV16-immortalized human keratinocyte (HKc) lines derived from different donors were compared with the...

journal_title：International journal of cancer

authors： Wan F,Miao X,Quraishi I,Kennedy V,Creek KE,Pirisi L

更新日期：2008-07-01 00:00:00

abstract：:Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...

journal_title：International journal of cancer

authors： Dalstein V,Riethmuller D,Prétet JL,Le Bail Carval K,Sautière JL,Carbillet JP,Kantelip B,Schaal JP,Mougin C

更新日期：2003-09-01 00:00:00

abstract：:Leukemia stem cells (LSCs) might originate from malignant transformation of normal hematopoietic stem cells (HSCs), or alternatively, of progenitors in which the acquired mutations have re-installed a dysregulated self-renewal program. LSCs are on top of a hierarchy and generate leukemia cells with more differentiated...

journal_title：International journal of cancer

authors： Buss EC,Ho AD

更新日期：2011-11-15 00:00:00

abstract：:Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...

journal_title：International journal of cancer

authors： Tsen AR,Long PM,Driscoll HE,Davies MT,Teasdale BA,Penar PL,Pendlebury WW,Spees JL,Lawler SE,Viapiano MS,Jaworski DM

更新日期：2014-03-15 00:00:00

abstract：:Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...

journal_title：International journal of cancer

authors： Keeble S,Abel GA,Saunders CL,McPhail S,Walter FM,Neal RD,Rubin GP,Lyratzopoulos G

更新日期：2014-09-01 00:00:00

abstract：:Although tumor-specific T lymphocytes recognize tumor-associated antigens (TAA) present on their cell surface via major histocompatibility complex (MHC) molecules, T cells require other activating signals. These are provided by costimulatory molecules, including B7-1 (CD80), B7-2 (CD86) and intercellular adhesive mole...

journal_title：International journal of cancer

authors： Joki T,Kikuchi T,Akasaki Y,Saitoh S,Abe T,Ohno T

更新日期：1999-08-27 00:00:00

abstract：:Primary mediastinal B-cell lymphoma is a locally highly aggressive but poorly disseminating tumor composed of medium sized or large cells most probably of thymic medullary origin. It has a mature B-cell phenotype, typically lacks immunoglobulin expression and has variable defects in expression of HLA-molecules. We pre...

journal_title：International journal of cancer

authors： Möller P,Brüderlein S,Sträter J,Leithäuser F,Hasel C,Bataille F,Moldenhauer G,Pawlita M,Barth TF

更新日期：2001-05-01 00:00:00

abstract：:Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (n ...

journal_title：International journal of cancer

authors： Messerschmidt C,Obermayer B,Klinghammer K,Ochsenreither S,Treue D,Stenzinger A,Glimm H,Fröhling S,Kindler T,Brandts CH,Schulze-Osthoff K,Weichert W,Tinhofer I,Klauschen F,Keilholz U,Beule D,Rieke DT

更新日期：2020-10-15 00:00:00

abstract：:The neural crest gives rise to a variety of tissues, including peripheral neurons, Schwann cells, melanocytes and ectomesenchymal cells, which include the smooth-muscle cells of large arteries. Cell lines derived from neuroblastoma (a neural-crest tumor) exhibit at least 2 distinct morphological cell types, a neurobla...

journal_title：International journal of cancer

authors： Sugimoto T,Ueyama H,Hosoi H,Inazawa J,Kato T,Kemshead JT,Reynolds CP,Gown AM,Mine H,Sawada T

更新日期：1991-05-10 00:00:00

abstract：:The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...

journal_title：International journal of cancer

authors： Hemminki K,Jiang Y,Dong C

更新日期：2001-07-15 00:00:00

abstract：:Tissue recombinants (TRs) composed of mouse urogenital mesenchyme (mUGM) plus an immortalized nontumorigenic human prostatic epithelial cell line (BPH-1) were grown under the kidney capsule of male athymic nude mice under different hormonal conditions. The objectives were to determine temporal plasma concentrations of...

journal_title：International journal of cancer

authors： Ricke WA,Ishii K,Ricke EA,Simko J,Wang Y,Hayward SW,Cunha GR

更新日期：2006-05-01 00:00:00

abstract：:The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...

journal_title：International journal of cancer

authors： Ishikawa M,Koga Y,Hosokawa M,Kobayashi H

更新日期：1986-06-15 00:00:00

abstract：:Signal transduction pathways controlling tumor cell locomotion are not yet well understood. We have studied the role of protein kinase C (PKC)-dependent protein phosphorylation associated with changes in cell shape and locomotor activity of Walker carcinosarcoma cells in culture. We show that the inhibitory effect of ...

journal_title：International journal of cancer

authors： Niggli V,Zimmermann A,Keller H

更新日期：1996-02-08 00:00:00

abstract：:A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....

journal_title：International journal of cancer

authors： Welander CE,Morgan TM,Homesley HD,Trotta PP,Spiegel RJ

更新日期：1985-06-15 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...

journal_title：International journal of cancer

authors： Raffaghello L,Pagnan G,Pastorino F,Cosimo E,Brignole C,Marimpietri D,Montaldo PG,Gambini C,Allen TM,Bogenmann E,Ponzoni M

更新日期：2003-05-01 00:00:00

abstract：:Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant p53 with the PRIMA...

journal_title：International journal of cancer

authors： Ramraj SK,Elayapillai SP,Pelikan RC,Zhao YD,Isingizwe ZR,Kennedy AL,Lightfoot SA,Benbrook DM

更新日期：2020-08-15 00:00:00

abstract：:Dietary patterns reflect combinations of dietary exposures, and here we examine these in relation to prostate cancer risk. In a case-control study, 80 incident primary prostate cancer cases and 334 urology clinic controls were enrolled from 1997 through 1999 in Kingston, Ontario, Canada. Food-frequency questionnaires ...

journal_title：International journal of cancer

authors： Walker M,Aronson KJ,King W,Wilson JW,Fan W,Heaton JP,MacNeily A,Nickel JC,Morales A

更新日期：2005-09-10 00:00:00

abstract：:Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism and opposing influence...

journal_title：International journal of cancer

authors： Qin N,de Cubas AA,Garcia-Martin R,Richter S,Peitzsch M,Menschikowski M,Lenders JW,Timmers HJ,Mannelli M,Opocher G,Economopoulou M,Siegert G,Chavakis T,Pacak K,Robledo M,Eisenhofer G

更新日期：2014-11-01 00:00:00

abstract：:Many studies have focused on global hypomethylation or hypermethylation of tumor suppressor genes, but less is known about the impact of promoter hypomethylation of oncogenes. We previously showed that promoter methylation may gradually increase or decrease during the transition from gastric mucosa (GM) to intestinal ...

journal_title：International journal of cancer

authors： Seo EH,Kim HJ,Kim JH,Lim B,Park JL,Kim SY,Lee SI,Jeong HY,Song KS,Kim YS

更新日期：2020-06-15 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine tumor of the skin. Cytogenetic studies have indicated that deletions and unbalanced translocations involving chromosome 1 short arm material occur in 40% of the investigated cases. Recurrent chromosomal imbalances detected by comparative genomic hybridiza...

journal_title：International journal of cancer

authors： Van Gele M,Leonard JH,Van Roy N,Van Limbergen H,Van Belle S,Cocquyt V,Salwen H,De Paepe A,Speleman F

更新日期：2002-09-10 00:00:00

abstract：:Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...

journal_title：International journal of cancer

authors： Dijkgraaf I,Kruijtzer JA,Frielink C,Corstens FH,Oyen WJ,Liskamp RM,Boerman OC

更新日期：2007-02-01 00:00:00

abstract：:It is thought that TIL can be activated in vitro by rIL-2 and acquire specific anti-tumor activity. In this study, we investigated this possibility, using lymphocytes isolated from primary lung cancer tissues. In a first series of experiments, TILs and autologous PBLs from 16 patients were cultured in rIL-2 from 7 to ...

journal_title：International journal of cancer

authors： Yano T,Yasumoto K,Togami M,Ishida T,Kimura G,Sugimachi K,Nomoto K

更新日期：1989-04-15 00:00:00

abstract：:We report the relative frequency of sucrase-isomaltase (SI) antigen expression in human colonic adenocarcinoma (22/57), in peritumoral mucosa taken next to the tumor (31/41) or distant from it (29/42) as well as in 21/23 polyps. Our results are based on indirect immunofluorescence with a monoclonal antibody (MAb) spec...

journal_title：International journal of cancer

authors： Czernichow B,Simon-Assmann P,Kedinger M,Arnold C,Parache M,Marescaux J,Zweibaum A,Haffen K

更新日期：1989-08-15 00:00:00

abstract：:We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. We have previously shown that the expression of exogenous Egr-1 in human breast and other tumor cells markedly reduces transformed growth and tumorigenicity. We ther...

journal_title：International journal of cancer

authors： Huang RP,Fan Y,de Belle I,Niemeyer C,Gottardis MM,Mercola D,Adamson ED

更新日期：1997-07-03 00:00:00

abstract：:Endometrial serous adenocarcinoma (ESC) is aggressive and carries a poor prognosis. p53 is frequently mutated in ESC. microRNAs (miRNAs) are a direct p53 target and have been implicated in cancer cell behavior. In this study, we compared miRNA expression levels in ESC with the levels in endometrial endometrioid adenoc...

journal_title：International journal of cancer

authors： Hiroki E,Suzuki F,Akahira J,Nagase S,Ito K,Sugawara J,Miki Y,Suzuki T,Sasano H,Yaegashi N

更新日期：2012-08-15 00:00:00