Cholera-toxin-enhanced growth of human breast cancer cell lines in vitro and in vivo: interaction with estrogen.

abstract：:The c-KIT protooncogene encodes a tyrosine kinase receptor, KIT, that is expressed in many normal and cancerous tissues. In this study, we have examined the expression of c-KIT and its ligand, stem cell factor (SCF), in human epithelial ovarian tumors, in normal ovaries and in cultured ovarian surface epithelium (OSE)...

journal_title：International journal of cancer

authors： Tonary AM,Macdonald EA,Faught W,Senterman MK,Vanderhyden BC

更新日期：2000-05-20 00:00:00

abstract：:MicroRNA-9-1(miR-9-1) plays an important role in the mechanism that regulates the lineage fate of differentiating hematopoietic cells. Recent studies have shown that miR-9-1 is downregulated in t (8; 21) AML. However, the pathogenic mechanisms underlying miR-9-1 downregulation and the RUNX1-RUNX1T1 fusion protein, gen...

journal_title：International journal of cancer

authors： Fu L,Shi J,Liu A,Zhou L,Jiang M,Fu H,Xu K,Li D,Deng A,Zhang Q,Pang Y,Guo Y,Hu K,Zhou J,Wang Y,Huang W,Jing Y,Dou L,Wang L,Xu K,Ke X,Nervi C,Li Y,Yu L

更新日期：2017-02-01 00:00:00

abstract：:We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...

journal_title：International journal of cancer

authors： Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA

更新日期：1995-04-10 00:00:00

abstract：:In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...

journal_title：International journal of cancer

authors： Asleh K,Lyck Carstensen S,Tykjaer Jørgensen CL,Burugu S,Gao D,Won JR,Jensen MB,Balslev E,Laenkholm AV,Nielsen DL,Ejlertsen B,Nielsen TO

更新日期：2019-05-15 00:00:00

abstract：:Testicular germ cell tumors (TGCTs) are a clinically and pathologically heterogeneous disease, and little is known of its genetic basis. Only low susceptibility risk loci have been identified for both sporadic and familial cases. Therefore, we tried to identify new susceptibility genes responsible for familial testicu...

journal_title：International journal of cancer

authors： Paumard-Hernández B,Calvete O,Inglada Pérez L,Tejero H,Al-Shahrour F,Pita G,Barroso A,Carlos Triviño J,Urioste M,Valverde C,González Billalabeitia E,Quiroga V,Francisco Rodríguez Moreno J,Fernández Aramburo A,López C,Maroto

更新日期：2018-10-15 00:00:00

abstract：:Ubiquitin-conjugated proteins in human colorectal cancer tissues were analyzed by the immunoprecipitation with the antibody FK2 against conjugated ubiquitin followed with SDS-PAGE. In these immunoprecipitable proteins, a 38-kDa protein was abundant in the tumor regions but almost absent in the adjacent normal regions ...

journal_title：International journal of cancer

authors： Usuba T,Ishibashi Y,Okawa Y,Hirakawa T,Takada K,Ohkawa K

更新日期：2001-12-01 00:00:00

abstract：:In a previous study, we showed that targeted delivery of bovine liver catalase to hepatocytes by direct galactosylation augmented the inhibitory effect of the enzyme on experimental hepatic metastasis of colon carcinoma cells (unpublished data). Here, we examined the ability of catalase to inhibit tumor metastasis to ...

journal_title：International journal of cancer

authors： Nishikawa M,Tamada A,Kumai H,Yamashita F,Hashida M

更新日期：2002-05-20 00:00:00

abstract：:It has been proposed that the timing of breast-cancer surgery in relation to menstrual phase has a prognostic impact on outcome. We carefully evaluated a combined 2-center series of 385 pre-menopausal women operated on for stage-I and stage-II breast cancer with a median follow-up of 5 years for a possible impact on o...

journal_title：International journal of cancer

authors： Gnant MF,Seifert M,Jakesz R,Adler A,Mittlboeck M,Sevelda P

更新日期：1992-11-11 00:00:00

abstract：:Antioxidants, primarily from fruits and vegetables, have been hypothesized to protect against non-Hodgkin lymphoma (NHL). The oxygen radical absorbance capacity (ORAC) assay, which measures total antioxidant capacity of individual foods and accounts for synergism, can be estimated using a food-frequency questionnaire ...

journal_title：International journal of cancer

authors： Holtan SG,O'Connor HM,Fredericksen ZS,Liebow M,Thompson CA,Macon WR,Micallef IN,Wang AH,Slager SL,Habermann TM,Call TG,Cerhan JR

更新日期：2012-09-01 00:00:00

abstract：:The annual incidence of non-Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited by the use of the ICD classifi...

journal_title：International journal of cancer

authors： Masala G,Di Lollo S,Picoco C,Crosignani P,Demicheli V,Fontana A,Funtó I,Miligi L,Nanni O,Papucci A,Ramazzotti V,Rodella S,Stagnaro E,Tumino R,Viganó C,Vindigni C,Seniori Costantini A,Vineis P

更新日期：1996-10-09 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. In vitro proliferation assays demonstrated that belinostat potently inhibited the growth of prostate canc...

journal_title：International journal of cancer

authors： Qian X,Ara G,Mills E,LaRochelle WJ,Lichenstein HS,Jeffers M

更新日期：2008-03-15 00:00:00

abstract：:Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEE...

journal_title：International journal of cancer

authors： McGee EE,Castro FA,Engels EA,Freedman ND,Pfeiffer RM,Nogueira L,Stolzenberg-Solomon R,McGlynn KA,Hemminki K,Koshiol J

更新日期：2019-02-15 00:00:00

abstract：:This large population-based study compared breast-conserving surgery with radiation therapy (BCT) with mastectomy on (long-term) breast cancer-specific (BCSS) and overall survival (OS), and investigated the influence of several prognostic factors. Patients with primary T1-2N0-2M0 breast cancer, diagnosed between 1999 ...

journal_title：International journal of cancer

authors： Lagendijk M,van Maaren MC,Saadatmand S,Strobbe LJA,Poortmans PMP,Koppert LB,Tilanus-Linthorst MMA,Siesling S

更新日期：2018-01-01 00:00:00

abstract：:Nude athymic rats of Rowett genetic background were injected subcutaneously with cells from a poorly differentiated human pulmonary adenocarcinoma, following propagation in nude mice. The tumour cells were obtained by thoracentesis and by pleural biopsy during thoracoscopy. So far, we have heterotransplanted 13 differ...

journal_title：International journal of cancer

authors： Korsgaard R,Lindén CJ,Willén R,Willén H,Svensson G,Simonsson BG

更新日期：1983-12-15 00:00:00

abstract：:Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...

journal_title：International journal of cancer

authors： Wang J,Yu F,Jia X,Iwanowycz S,Wang Y,Huang S,Ai W,Fan D

更新日期：2015-03-15 00:00:00

abstract：:Six distinct cell surface antigens of human trophoblast and choriocarcinoma were defined with MAbs. The distribution of the antigens was determined by MHA assays on 150 tumor cell lines and normal cell cultures and by immunofluorescence tests with a wide range of normal adult and fetal tissues and a tumor panel. Antig...

journal_title：International journal of cancer

authors： Rettig WJ,Cordon-Cardo C,Koulos JP,Lewis JL Jr,Oettgen HF,Old LJ

更新日期：1985-04-15 00:00:00

abstract：:Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis in several cancers. The aim of this study was to assess the prognostic value of endostatin in bladde...

journal_title：International journal of cancer

authors： Szarvas T,László V,Vom Dorp F,Reis H,Szendröi A,Romics I,Tilki D,Rübben H,Ergün S

更新日期：2012-06-15 00:00:00

abstract：:When effector cells from most individuals are tested directly against a number of target cells for cell-mediated cytotoxicity, most of the reactivity is non-selective. This apparent non-selectiveness is a result of specific activity against multiple antigens on target cells by each effector suspension. The specific re...

journal_title：International journal of cancer

authors： Akira D,Takasugi M

更新日期：1977-06-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays an important role in essential cellular processes such as proliferation, survival and migration. Aberrant activation of EGFR is frequently found in human cancers of various origins and has been implicated in cancer pathogenesis. The therapeutic antibody cetuximab (Erbitux)...

journal_title：International journal of cancer

authors： Müller N,Hartmann C,Genssler S,Koch J,Kinner A,Grez M,Wels WS

更新日期：2014-06-01 00:00:00

abstract：:The expression of two discrete cell properties related to the host natural effector mechanisms, i.e., resistance to damage by H2O2, a cytotoxic product of activated macrophages, and the ability to secrete PGE, which inhibits NK-cell cytotoxicity, has been examined in parental Syrian hamster embryo cells spontaneously ...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Matveeva VA,Kushlinsky NE,Bassalyk LS,Vendrov EL

更新日期：1989-11-15 00:00:00

abstract：:The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher...

journal_title：International journal of cancer

authors： Suter L,Brüggen J,Bröcker EB,Sorg C

更新日期：1985-06-15 00:00:00

abstract：:Micro RNAs (miR) are master regulators of cellular transcriptome. We aimed to investigate the role of miR regulation on tumor radiosensitivity and development of local tumor recurrence by a novel large-scale in vivo loss of function screen. For stable miR silencing, human A431 tumor cells were transduced with lentivir...

journal_title：International journal of cancer

authors： Fahim Golestaneh A,Lecker LSM,Schlegel J,Nowrouzi A,Schwager C,Meister S,Weichert W,Debus J,Abdollahi A

更新日期：2019-06-01 00:00:00

abstract：:The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific luminometric immunoa...

journal_title：International journal of cancer

authors： Norberg T,Lennerstrand J,Inganäs M,Bergh J

更新日期：1998-08-21 00:00:00

abstract：:A major objective of peptide vaccination is the induction of tumor-reactive CD8+ T-cells. We have shown that HLA-A2 positive cancer patients frequently develop an antigen-specific CD8+ T-cell response after vaccination with NY-ESO-1 peptides p157-165/p157-167. These T-cells are highly reactive with the peptides used f...

journal_title：International journal of cancer

authors： Karbach J,Gnjatic S,Pauligk C,Bender A,Maeurer M,Schultze JL,Nadler K,Wahle C,Knuth A,Old LJ,Jäger E

更新日期：2007-11-01 00:00:00

abstract：:The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain-containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF-beta tumor suppressor pathway. To characterize the role of WWP1 in breast cancer, we analyzed WWP1 gene d...

journal_title：International journal of cancer

authors： Chen C,Zhou Z,Ross JS,Zhou W,Dong JT

更新日期：2007-07-01 00:00:00

abstract：:Cyclic AMP (cAMP) analogues that selectively bind to either one of the two binding sites of cAMP-dependent protein kinase demonstrate a potent inhibition of the growth stimulated by estrogen in MCF-7 human breast-cancer cells in culture. The site-selective analogues, which are more potent activators of protein kinase ...

journal_title：International journal of cancer

authors： Katsaros D,Ally S,Cho-Chung YS

更新日期：1988-06-15 00:00:00

abstract：:For patients with brain tumors identification of diagnostic and prognostic markers in easy accessible biological material, such as plasma or cerebrospinal fluid (CSF), would greatly facilitate patient management. MIC-1/GDF15 (growth differentiation factor 15) is a secreted protein of the TGF-beta superfamily and emerg...

journal_title：International journal of cancer

authors： Shnaper S,Desbaillets I,Brown DA,Murat A,Migliavacca E,Schluep M,Ostermann S,Hamou MF,Stupp R,Breit SN,de Tribolet N,Hegi ME

更新日期：2009-12-01 00:00:00

abstract：:Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to...

journal_title：International journal of cancer

authors： Reker S,Becker JC,Svane IM,Ralfkiaer E,Straten PT,Andersen MH

更新日期：2004-03-01 00:00:00

abstract：:In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. However, whereas IL-6 phosphorylates STAT3 within 15 min, stimulat...

journal_title：International journal of cancer

authors： Rozovski U,Harris DM,Li P,Liu Z,Jain P,Veletic I,Ferrajoli A,Burger J,Thompson P,Jain N,Wierda W,Keating MJ,Estrov Z

更新日期：2017-11-15 00:00:00

abstract：:We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

journal_title：International journal of cancer

authors： Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

更新日期：1986-01-15 00:00:00